Visual analysis of tumor apoptosis and autophagy research based on VOSviewer and CiteSpace_West China Medical Journal

Authors：

MA Lingli ^1,2 , LI Zhuo ² , MA Zhongren ² , MA Jianbo ² ,  ZHAO Fei ^1,2

1. Key Laboratory of Environmental Ecology and Population Health in Northwest Minority Areas, Medical College of Northwest Minzu University, Lanzhou, Gansu 730030, P. R. China;
2. College of Life Science and Engineering, Northwest Minzu University, Lanzhou, Gansu 730030, P. R. China;

Corresponding author：

ZHAO Fei, Email: runfor710@163.com

Keywords：

Apoptosis; autophagy; VOSviewer; CiteSpace; visual analysis

DOI：

10.7507/1002-0179.202202077

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the hotspots and development trends in the research field of tumor cell apoptosis and autophagy. Methods Relevant literature on tumor apoptosis and autophagy published between January 2012 and December 2021 were searched through the Web of Science core collection database, and CiteSpace 5.8.R3 software and VOSviewer version 1.6.10 software were used to analyze the country/region, institution, keywords and citation node information of the literature. Results A total of 6716 foreign-language articles were included in the study after searching and screening, and the number of papers showed a linear upward trend year by year. China published the largest number of articles and cooperated closely with other research institutions, but there were not many high-quality and influential articles. The two journals Autophagy and Cell were more authoritative in the field of tumor apoptosis and autophagy research. The signaling pathways and related proteins of apoptosis and autophagy, and the study of tumor suppressor mechanisms based on apoptosis/autophagy were current research hot topics. The migration, apoptosis and epithelial mesenchymal transformation of cancer cells would be the research focus and direction in the future. Conclusions In the past 10 years, the research on tumor apoptosis and autophagy has continued to develop. With the in-depth research on the molecular level, the study of its mechanism is expected to further reveal the mystery of tumor apoptosis and autophagy.

Citation： MA Lingli, LI Zhuo, MA Zhongren, MA Jianbo, ZHAO Fei. Visual analysis of tumor apoptosis and autophagy research based on VOSviewer and CiteSpace. West China Medical Journal, 2023, 38(1): 56-64. doi: 10.7507/1002-0179.202202077 Copy

1.	阚月一, 王娅杰, 李琦, 等. 肿瘤发展过程中自噬与凋亡的相互作用. 中国比较医学杂志, 2018, 28(2): 106-112.
2.	史方富, 崔红旺, 孙博. 自噬在肿瘤坏死因子-α 诱导成骨细胞凋亡中的作用. 临床骨科杂志, 2021, 24(4): 601-604.
3.	邵乐宁, 杨晓东, 邢春根, 等. 调控肿瘤相关巨噬细胞自噬对大肠癌移植瘤放疗后凋亡的影响. 中华实验外科杂志, 2020, 37(8): 1469-1471.
4.	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
5.	张玉, 徐明怡, 冷海楠, 等. 基于 VOSviewer 和 CiteSpace 的生态基因组学研究进展. 国土与自然资源研究, 2021(6): 77-81.
6.	Chen C. CiteSpace Ⅱ: detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci Tec, 2006, 57(3): 359-377.
7.	Chen S, Lu Q, Bai J, et al. Global publications on stigma between 1998-2018: a bibliometric analysis. J Affect Disord, 2020, 274: 363-371.
8.	Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 2016, 12(1): 1-222.
9.	Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012, 8(4): 445-544.
10.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
11.	Marino G, Niso-Santano M, Baehrecke EH, et al. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol, 2014, 15(2): 81-94.
12.	Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Cancer, 2017, 17(9): 528-542.
13.	Green DR, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell, 2014, 157(1): 65-75.
14.	Galluzzi L, Pietrocola F, Levine B, et al. Metabolic control of autophagy. Cell, 2014, 159(6): 1263-1276.
15.	O’Donovan TR, O’Sullivan GC, McKenna SL. Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy, 2011, 7(5): 509-524.
16.	Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science, 2011, 331: 456-461.
17.	Li HY, Zhang J, Sun LL, et al. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study. Cell Death Dis, 2015, 6(1): e1604.
18.	Liu G, Pei F, Yang F, et al. Role of autophagy and apoptosis in non-small-cell lung cancer. Int J Mol Sci, 2017, 18(2): 367.
19.	赵美玲, 季宇彬, 毕明刚. 细胞凋亡的死亡受体途径. 黑龙江医药, 2013, 26(2): 196-199.
20.	谢昆, 李兴权. 细胞凋亡的信号通路. 山东农业大学学报(自然科学版), 2015(4): 514-518.
21.	Kuang H, Yang P, Yang L, et al. Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver. J Hazard Mater, 2016, 317: 119-126.
22.	李建丽, 李永梅, 康鸿斌, 等. Anxa2 在乳腺癌细胞侵袭转移中的作用机制及对 STAT3 信号通路的影响研究. 中华普外科手术学杂志(电子版), 2021, 15(2): 199-202.
23.	马春兰, 张宝亮, 张常虹. 莪术醇对乳腺癌细胞增殖凋亡及 JAK2/STAT3 信号通路的影响. 肿瘤学杂志, 2020, 26(7): 616-620.
24.	刘艳华, 王明权, 朱伟英, 等. CDK4/6 抑制剂在消化道肿瘤中的临床研究进展. 中国现代应用药学, 2021, 38(18): 2333-2336.
25.	Liu W, Li S, Qu Z, et al. Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma. Am J Transl Res, 2019, 11(11): 6952-6964.
26.	Mi Y, Xiao C, Du Q, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med, 2016, 90: 230-242.
27.	Yuan L, Wei S, Wang J, et al. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. J Agric Food Chem, 2014, 62(23): 5390-5400.
28.	Jin Z, Jia BX, Tan LD, et al. Combination therapy with metformin and IL-12 to inhibit the growth of hepatic carcinoma by promoting apoptosis and autophagy in HepG2-bearing mice. Eur Rev Med Pharmacol Sci, 2020, 24(23): 12368-12379.
29.	Cheng X, Zhong F, He K, et al. EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells. Oncol Lett, 2016, 12(5): 3739-3748.
30.	Zhou XT, Pu ZJ, Liu LX, et al. Inhibition of autophagy enhances adenosine-induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep, 2019, 41(2): 829-838.
31.	Lin CH, Chang CY, Lee KR, et al. Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo. Exp Biol Med (Maywood), 2016, 241(13): 1374-1385.
32.	Zhao F, Zhao J, Song L, et al. The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis, 2017, 22(11): 1461-1472.
33.	Shui L, Wang W, Xie M, et al. Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway. Aging (Albany NY), 2020, 12(23): 24318-24332.
34.	Alers S, Löffler AS, Wesselborg S, et al. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol, 2012, 32(1): 2-11.
35.	Happy KP, Dhanang PTR, Muhammad NH, et al. Eugenol-loaded chitosan nanoparticle induces apoptosis, inhibits cell migration and epithelial to mesenchymal transitionprocess in human cervical cancer cell line hela cells. Eur J Mol Clin Med, 2020, 7(9): 1184-1189.
36.	Min L, Wang H, Zeng Y. CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells. Front Biosci (Landmark Ed), 2019, 24(5): 819-832.

1. 阚月一, 王娅杰, 李琦, 等. 肿瘤发展过程中自噬与凋亡的相互作用. 中国比较医学杂志, 2018, 28(2): 106-112.
2. 史方富, 崔红旺, 孙博. 自噬在肿瘤坏死因子-α 诱导成骨细胞凋亡中的作用. 临床骨科杂志, 2021, 24(4): 601-604.
3. 邵乐宁, 杨晓东, 邢春根, 等. 调控肿瘤相关巨噬细胞自噬对大肠癌移植瘤放疗后凋亡的影响. 中华实验外科杂志, 2020, 37(8): 1469-1471.
4. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
5. 张玉, 徐明怡, 冷海楠, 等. 基于 VOSviewer 和 CiteSpace 的生态基因组学研究进展. 国土与自然资源研究, 2021(6): 77-81.
6. Chen C. CiteSpace Ⅱ: detecting and visualizing emerging trends and transient patterns in scientific literature. J Am Soc Inf Sci Tec, 2006, 57(3): 359-377.
7. Chen S, Lu Q, Bai J, et al. Global publications on stigma between 1998-2018: a bibliometric analysis. J Affect Disord, 2020, 274: 363-371.
8. Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 2016, 12(1): 1-222.
9. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 2012, 8(4): 445-544.
10. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
11. Marino G, Niso-Santano M, Baehrecke EH, et al. Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol, 2014, 15(2): 81-94.
12. Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Cancer, 2017, 17(9): 528-542.
13. Green DR, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell, 2014, 157(1): 65-75.
14. Galluzzi L, Pietrocola F, Levine B, et al. Metabolic control of autophagy. Cell, 2014, 159(6): 1263-1276.
15. O’Donovan TR, O’Sullivan GC, McKenna SL. Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy, 2011, 7(5): 509-524.
16. Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science, 2011, 331: 456-461.
17. Li HY, Zhang J, Sun LL, et al. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study. Cell Death Dis, 2015, 6(1): e1604.
18. Liu G, Pei F, Yang F, et al. Role of autophagy and apoptosis in non-small-cell lung cancer. Int J Mol Sci, 2017, 18(2): 367.
19. 赵美玲, 季宇彬, 毕明刚. 细胞凋亡的死亡受体途径. 黑龙江医药, 2013, 26(2): 196-199.
20. 谢昆, 李兴权. 细胞凋亡的信号通路. 山东农业大学学报(自然科学版), 2015(4): 514-518.
21. Kuang H, Yang P, Yang L, et al. Size dependent effect of ZnO nanoparticles on endoplasmic reticulum stress signaling pathway in murine liver. J Hazard Mater, 2016, 317: 119-126.
22. 李建丽, 李永梅, 康鸿斌, 等. Anxa2 在乳腺癌细胞侵袭转移中的作用机制及对 STAT3 信号通路的影响研究. 中华普外科手术学杂志(电子版), 2021, 15(2): 199-202.
23. 马春兰, 张宝亮, 张常虹. 莪术醇对乳腺癌细胞增殖凋亡及 JAK2/STAT3 信号通路的影响. 肿瘤学杂志, 2020, 26(7): 616-620.
24. 刘艳华, 王明权, 朱伟英, 等. CDK4/6 抑制剂在消化道肿瘤中的临床研究进展. 中国现代应用药学, 2021, 38(18): 2333-2336.
25. Liu W, Li S, Qu Z, et al. Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma. Am J Transl Res, 2019, 11(11): 6952-6964.
26. Mi Y, Xiao C, Du Q, et al. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med, 2016, 90: 230-242.
27. Yuan L, Wei S, Wang J, et al. Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells. J Agric Food Chem, 2014, 62(23): 5390-5400.
28. Jin Z, Jia BX, Tan LD, et al. Combination therapy with metformin and IL-12 to inhibit the growth of hepatic carcinoma by promoting apoptosis and autophagy in HepG2-bearing mice. Eur Rev Med Pharmacol Sci, 2020, 24(23): 12368-12379.
29. Cheng X, Zhong F, He K, et al. EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells. Oncol Lett, 2016, 12(5): 3739-3748.
30. Zhou XT, Pu ZJ, Liu LX, et al. Inhibition of autophagy enhances adenosine-induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep, 2019, 41(2): 829-838.
31. Lin CH, Chang CY, Lee KR, et al. Cold-water extracts of Grifola frondosa and its purified active fraction inhibit hepatocellular carcinoma in vitro and in vivo. Exp Biol Med (Maywood), 2016, 241(13): 1374-1385.
32. Zhao F, Zhao J, Song L, et al. The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Apoptosis, 2017, 22(11): 1461-1472.
33. Shui L, Wang W, Xie M, et al. Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway. Aging (Albany NY), 2020, 12(23): 24318-24332.
34. Alers S, Löffler AS, Wesselborg S, et al. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol, 2012, 32(1): 2-11.
35. Happy KP, Dhanang PTR, Muhammad NH, et al. Eugenol-loaded chitosan nanoparticle induces apoptosis, inhibits cell migration and epithelial to mesenchymal transitionprocess in human cervical cancer cell line hela cells. Eur J Mol Clin Med, 2020, 7(9): 1184-1189.
36. Min L, Wang H, Zeng Y. CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells. Front Biosci (Landmark Ed), 2019, 24(5): 819-832.

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