Application of poly(styrene-<i>block</i>-isobutylene-<i>block</i>-styrene) and its crosslinked product in ophthalmic diseases_West China Medical Journal

Authors：

ZHANG Ying , GUO Bo ,  TANG Li

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

TANG Li, Email: tangli-1a@163.com

Keywords：

Poly(styrene-block-isobutylene-block-styrene); crosslinked polyisobutylene; glaucoma; cataract; ophthalmology

DOI：

10.7507/1002-0179.202203113

Video：

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Poly(styrene-block-isobutylene-block-styrene) (SIBS) and its crosslinked product crosslinked polyisobutylene (xPIB) are a kind of novel thermoplastic elastomer. They have excellent biocompatibility and stability, which are suitable for long-term implantation in human body. At present, SIBS is widely used in cardiovascular diseases, and also has preliminary application in ophthalmology. This article reviews the application and research progress of SIBS and xPIB in ophthalmic glaucoma minimally drainage tube material, intraocular lens material, new sclera buckle material and orbital defect filler, with a view of providing reference for the clinical application of such biomedical materials in ophthalmology.

Citation： ZHANG Ying, GUO Bo, TANG Li. Application of poly(styrene-block-isobutylene-block-styrene) and its crosslinked product in ophthalmic diseases. West China Medical Journal, 2023, 38(2): 316-320. doi: 10.7507/1002-0179.202203113 Copy

1.	Pinchuk L. The use of polyisobutylene-based polymers in ophthalmology. Bioact Mater, 2021, 10: 185-194.
2.	Zhu JZ, Xiong XW, Du R, et al. Hemocompatibility of drug-eluting coronary stents coated with sulfonated poly (styrene-block-isobutylene-block-styrene). Biomaterials, 2012, 33(33): 8204-8212.
3.	Antosik AK, Piątek A, Wilpiszewska K. Carboxymethylated starch and cellulose derivatives-based film as human skin equivalent for adhesive properties testing. Carbohydr Polym, 2019, 222: 115014.
4.	Huang Q, He P, Wan J, et al. Synthesis of high molecular weight polyisobutylene via cationic polymerize at elevated temperatures. Chin J Polym Sci, 2013, 31(8): 1139-1114.
5.	Kaszas G, Puskas JE, Kennedy JP, et al. Polyisobutylene-containing block copolymers by sequential monomer addition(II): polystyrene-polyisobutylene-polystyrene triblock polymers: synthesis, characterization, and physical properties. J Polym Sci, Part A: Polym Chem Ed, 1991, 29(3): 427.
6.	Barczikai D, Domokos J, Szabó D, et al. Polyisobutylene-new opportunities for medical applications. Molecules, 2021, 26(17): 5207.
7.	姜力, 方小娟, 潘邦伦, 等. 聚异丁烯及其热塑性弹性体: 怎样从工业走向医疗. 中国组织工程研究, 2020, 24(22): 3559-3565.
8.	Sheriff J, Claiborne TE, Tran PL, et al. Physical characterization and platelet interactions under shear flows of a novel thermoset polyisobutylene-based co-polymer. ACS Appl Mater Interfaces, 2015, 7(39): 22058-22066.
9.	Pinchuk L, Wilson GJ, Barry JJ, et al. Medical applications of poly(styrene-block-isobutylene-block-styrene) (“SIBS”). Biomaterials, 2008, 29(4): 448-460.
10.	Kamath KR, Barry JJ, Miller KM. The Taxus drug-eluting stent: a new paradigm in controlled drug delivery. Adv Drug Deliv Rev, 2006, 58(3): 412-436.
11.	Waseda K, Ako J, Kume T, et al. Characteristics of late-acquired incomplete stent apposition: a comparison with first-generation and second-generation drug-eluting stents. J Invasive Cardiol, 2016, 28(8): 323-329.
12.	Gallocher SL, Aguirre AF, Kasyanov V, et al. A novel polymer for potential use in a trileaflet heart valve. J Biomed Mater Res B Appl Biomater, 2006, 79(2): 325-334.
13.	Ono M, Serruys PW, Hara H, et al. 10-year follow-up after revascularization in elderly patients with complex coronary artery disease. J Am Coll Cardiol, 2021, 77(22): 2761-2773.
14.	Teck Lim G, Valente SA, Hart-Spicer CR, et al. New biomaterial as a promising alternative to silicone breast implants. J Mech Behav Biomed Mater, 2013, 5(21): 47-56.
15.	Shauly O, Gould DJ, Patel KM. Microtexture and the cell/biomaterial interface: a systematic review and meta-analysis of capsular contracture and prosthetic breast implants. Aesthet Surg J, 2019, 39(6): 603-614.
16.	Cozzens D, Ojha U, Kulkarni P, et al. Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes. J Biomed Mater Res A, 2010, 95A(3): 774-782.
17.	Puskas JE, Chen Y. Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement. Biomacromolecules, 2004, 5(4): 1141-1154.
18.	邵毅. 青光眼诊断与治疗规范—2017 年英国专家共识解读. 眼科新进展, 2018, 38(11): 1001-1004.
19.	乔云圣, 陈君毅. 晶状体手术在原发性闭角型青光眼治疗中的发展现状. 国际眼科杂志, 2020, 20(9): 1533-1538.
20.	王宁利, 王怀洲. 新型微创抗青光眼手术推广过程中应严格掌握适应证. 中华眼科杂志, 2021, 57(9): 641-643.
21.	Richter GM, Coleman AL. Minimally invasive glaucoma surgery: current status and future prospects. Clin Ophthalmol, 2016, 28(10): 189-206.
22.	Batlle JF, Corona A, Albuquerque R. Long-term results of the PRESERFLO microshunt in patients with primary open-angle glaucoma from a single-center nonrandomized study. J Glaucoma, 2021, 30(3): 281-286.
23.	Acosta AC, Espana EM, Yamamoto H, et al. A newly designed glaucoma drainage implant made of poly(styrene-b-isobutylene-b-styrene): biocompatibility and function in normal rabbit eyes. Arch Ophthalmol, 2006, 124(12): 1742-1749.
24.	Pinchuk L, Riss I, Batlle JF, et al. The development of a micro-shunt made from poly(styrene-block-isobutylene-block-styrene) to treat glaucoma. J Biomed Mater Res B Appl Biomater, 2017, 105(1): 211-221.
25.	Sadruddin O, Pinchuk L, Angeles R, et al. Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-block-styrene) surgical device for the treatment of primary open-angle glaucoma: a review. Eye Vis (Lond), 2019, 15(6): 36.
26.	Durr GM, Schlenker MB, Samet S, et al. One-year outcomes of stand-alone ab externo SIBS microshunt implantation in refractory glaucoma. Br J Ophthalmol, 2022, 106(1): 71-79.
27.	Batlle JF, Fantes F, Riss I, et al. Three-year follow-up of a novel aqueous humor MicroShunt. J Glaucoma, 2016, 25(2): e58-e65.
28.	Schlenker MB, Durr GM, Michaelov E, et al. Intermediate outcomes of a novel standalone Ab externo SIBS microshunt with mitomycin C. Am J Ophthalmol, 2020, 215: 141-153.
29.	Gedde SJ, Schiffman JC, Feuer WJ, et al. Three-year follow-up of the tube versus trabeculectomy study. Am J Ophthalmol, 2009, 148(5): 670-684.
30.	Rauscher FM, Gedde SJ, Schiffman JC, et al. Motility disturbances in the tube versus trabeculectomy study during the first year of follow-up. Am J Ophthalmol, 2009, 147(3): 458-466.
31.	Pinchuk L, Riss I, Batlle JF, et al. The use of poly(styrene-block-isobutylene-block-styrene) as a microshunt to treat glaucoma. Regen Biomater, 2016, 3(2): 137-142.
32.	中华医学会眼科学分会白内障及人工晶状体学组. 中国人工晶状体分类专家共识(2021 年). 中华眼科杂志, 2021, 57(7): 495-501.
33.	Matsushima H, Mukai K, Nagata M, et al. Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 2009, 35(11): 1927-1934.
34.	Matsushima H, Nagata M, Katsuki Y, et al. Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: a retrospective analysis of 5 cases. Saudi J Ophthalmol, 2015, 29(4): 259-263.
35.	Colin J, Orignac I, Touboul D. Glistenings in a large series of hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 2009, 35(12): 2121-2126.
36.	西安眼得乐医疗科技有限公司. 用于生物医学用途的交联聚烯烃及其制造方法: CN105330775B. 2018-09-07.
37.	Maedel S, Evans JR, Harrer-Seely A, et al. Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery. Cochrane Database Syst Rev, 2021, 8(8): CD012516.
38.	van der Mooren M, Franssen L, Piers P. Effects of glistenings in intraocular lenses. Biomed Opt Express, 2013, 4(8): 1294-1304.
39.	Kirwan C, Nolan JM, Stack J, et al. Determinants of patient satisfaction and function related to vision following cataract surgery in eyes with no visually consequential ocular co-morbidity. Graefes Arch Clin Exp Ophthalmol, 2015, 253(10): 1735-1744.
40.	Saylor DM, Coleman Richardson D, Dair BJ, et al. Osmotic cavitation of elastomeric intraocular lenses. Acta Biomater, 2010, 6(3): 1090-1098.
41.	Tse DT, Pinchuk L, Davis S, et al. Evaluation of an integrated orbital tissue expander in an anophthalmic feline model. Am J Ophthalmol, 2007, 143(2): 317-327.
42.	Zetterberg M. Age-related eye disease and gender. Maturitas, 2016, 83: 19-26.
43.	Fittipaldi M, Grace LR. Modeling the effects of lipid contamination in poly(styrene-isobutylene-styrene) (SIBS). J Mech Behav Biomed Mater, 2018, 80: 97-103.

1. Pinchuk L. The use of polyisobutylene-based polymers in ophthalmology. Bioact Mater, 2021, 10: 185-194.
2. Zhu JZ, Xiong XW, Du R, et al. Hemocompatibility of drug-eluting coronary stents coated with sulfonated poly (styrene-block-isobutylene-block-styrene). Biomaterials, 2012, 33(33): 8204-8212.
3. Antosik AK, Piątek A, Wilpiszewska K. Carboxymethylated starch and cellulose derivatives-based film as human skin equivalent for adhesive properties testing. Carbohydr Polym, 2019, 222: 115014.
4. Huang Q, He P, Wan J, et al. Synthesis of high molecular weight polyisobutylene via cationic polymerize at elevated temperatures. Chin J Polym Sci, 2013, 31(8): 1139-1114.
5. Kaszas G, Puskas JE, Kennedy JP, et al. Polyisobutylene-containing block copolymers by sequential monomer addition(II): polystyrene-polyisobutylene-polystyrene triblock polymers: synthesis, characterization, and physical properties. J Polym Sci, Part A: Polym Chem Ed, 1991, 29(3): 427.
6. Barczikai D, Domokos J, Szabó D, et al. Polyisobutylene-new opportunities for medical applications. Molecules, 2021, 26(17): 5207.
7. 姜力, 方小娟, 潘邦伦, 等. 聚异丁烯及其热塑性弹性体: 怎样从工业走向医疗. 中国组织工程研究, 2020, 24(22): 3559-3565.
8. Sheriff J, Claiborne TE, Tran PL, et al. Physical characterization and platelet interactions under shear flows of a novel thermoset polyisobutylene-based co-polymer. ACS Appl Mater Interfaces, 2015, 7(39): 22058-22066.
9. Pinchuk L, Wilson GJ, Barry JJ, et al. Medical applications of poly(styrene-block-isobutylene-block-styrene) (“SIBS”). Biomaterials, 2008, 29(4): 448-460.
10. Kamath KR, Barry JJ, Miller KM. The Taxus drug-eluting stent: a new paradigm in controlled drug delivery. Adv Drug Deliv Rev, 2006, 58(3): 412-436.
11. Waseda K, Ako J, Kume T, et al. Characteristics of late-acquired incomplete stent apposition: a comparison with first-generation and second-generation drug-eluting stents. J Invasive Cardiol, 2016, 28(8): 323-329.
12. Gallocher SL, Aguirre AF, Kasyanov V, et al. A novel polymer for potential use in a trileaflet heart valve. J Biomed Mater Res B Appl Biomater, 2006, 79(2): 325-334.
13. Ono M, Serruys PW, Hara H, et al. 10-year follow-up after revascularization in elderly patients with complex coronary artery disease. J Am Coll Cardiol, 2021, 77(22): 2761-2773.
14. Teck Lim G, Valente SA, Hart-Spicer CR, et al. New biomaterial as a promising alternative to silicone breast implants. J Mech Behav Biomed Mater, 2013, 5(21): 47-56.
15. Shauly O, Gould DJ, Patel KM. Microtexture and the cell/biomaterial interface: a systematic review and meta-analysis of capsular contracture and prosthetic breast implants. Aesthet Surg J, 2019, 39(6): 603-614.
16. Cozzens D, Ojha U, Kulkarni P, et al. Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes. J Biomed Mater Res A, 2010, 95A(3): 774-782.
17. Puskas JE, Chen Y. Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement. Biomacromolecules, 2004, 5(4): 1141-1154.
18. 邵毅. 青光眼诊断与治疗规范—2017 年英国专家共识解读. 眼科新进展, 2018, 38(11): 1001-1004.
19. 乔云圣, 陈君毅. 晶状体手术在原发性闭角型青光眼治疗中的发展现状. 国际眼科杂志, 2020, 20(9): 1533-1538.
20. 王宁利, 王怀洲. 新型微创抗青光眼手术推广过程中应严格掌握适应证. 中华眼科杂志, 2021, 57(9): 641-643.
21. Richter GM, Coleman AL. Minimally invasive glaucoma surgery: current status and future prospects. Clin Ophthalmol, 2016, 28(10): 189-206.
22. Batlle JF, Corona A, Albuquerque R. Long-term results of the PRESERFLO microshunt in patients with primary open-angle glaucoma from a single-center nonrandomized study. J Glaucoma, 2021, 30(3): 281-286.
23. Acosta AC, Espana EM, Yamamoto H, et al. A newly designed glaucoma drainage implant made of poly(styrene-b-isobutylene-b-styrene): biocompatibility and function in normal rabbit eyes. Arch Ophthalmol, 2006, 124(12): 1742-1749.
24. Pinchuk L, Riss I, Batlle JF, et al. The development of a micro-shunt made from poly(styrene-block-isobutylene-block-styrene) to treat glaucoma. J Biomed Mater Res B Appl Biomater, 2017, 105(1): 211-221.
25. Sadruddin O, Pinchuk L, Angeles R, et al. Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-block-styrene) surgical device for the treatment of primary open-angle glaucoma: a review. Eye Vis (Lond), 2019, 15(6): 36.
26. Durr GM, Schlenker MB, Samet S, et al. One-year outcomes of stand-alone ab externo SIBS microshunt implantation in refractory glaucoma. Br J Ophthalmol, 2022, 106(1): 71-79.
27. Batlle JF, Fantes F, Riss I, et al. Three-year follow-up of a novel aqueous humor MicroShunt. J Glaucoma, 2016, 25(2): e58-e65.
28. Schlenker MB, Durr GM, Michaelov E, et al. Intermediate outcomes of a novel standalone Ab externo SIBS microshunt with mitomycin C. Am J Ophthalmol, 2020, 215: 141-153.
29. Gedde SJ, Schiffman JC, Feuer WJ, et al. Three-year follow-up of the tube versus trabeculectomy study. Am J Ophthalmol, 2009, 148(5): 670-684.
30. Rauscher FM, Gedde SJ, Schiffman JC, et al. Motility disturbances in the tube versus trabeculectomy study during the first year of follow-up. Am J Ophthalmol, 2009, 147(3): 458-466.
31. Pinchuk L, Riss I, Batlle JF, et al. The use of poly(styrene-block-isobutylene-block-styrene) as a microshunt to treat glaucoma. Regen Biomater, 2016, 3(2): 137-142.
32. 中华医学会眼科学分会白内障及人工晶状体学组. 中国人工晶状体分类专家共识(2021 年). 中华眼科杂志, 2021, 57(7): 495-501.
33. Matsushima H, Mukai K, Nagata M, et al. Analysis of surface whitening of extracted hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 2009, 35(11): 1927-1934.
34. Matsushima H, Nagata M, Katsuki Y, et al. Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: a retrospective analysis of 5 cases. Saudi J Ophthalmol, 2015, 29(4): 259-263.
35. Colin J, Orignac I, Touboul D. Glistenings in a large series of hydrophobic acrylic intraocular lenses. J Cataract Refract Surg, 2009, 35(12): 2121-2126.
36. 西安眼得乐医疗科技有限公司. 用于生物医学用途的交联聚烯烃及其制造方法: CN105330775B. 2018-09-07.
37. Maedel S, Evans JR, Harrer-Seely A, et al. Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery. Cochrane Database Syst Rev, 2021, 8(8): CD012516.
38. van der Mooren M, Franssen L, Piers P. Effects of glistenings in intraocular lenses. Biomed Opt Express, 2013, 4(8): 1294-1304.
39. Kirwan C, Nolan JM, Stack J, et al. Determinants of patient satisfaction and function related to vision following cataract surgery in eyes with no visually consequential ocular co-morbidity. Graefes Arch Clin Exp Ophthalmol, 2015, 253(10): 1735-1744.
40. Saylor DM, Coleman Richardson D, Dair BJ, et al. Osmotic cavitation of elastomeric intraocular lenses. Acta Biomater, 2010, 6(3): 1090-1098.
41. Tse DT, Pinchuk L, Davis S, et al. Evaluation of an integrated orbital tissue expander in an anophthalmic feline model. Am J Ophthalmol, 2007, 143(2): 317-327.
42. Zetterberg M. Age-related eye disease and gender. Maturitas, 2016, 83: 19-26.
43. Fittipaldi M, Grace LR. Modeling the effects of lipid contamination in poly(styrene-isobutylene-styrene) (SIBS). J Mech Behav Biomed Mater, 2018, 80: 97-103.

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