Research status of islet transplantation site_West China Medical Journal

Authors：

WU Nianwei ¹ ,  TONG Nanwei ^1,2

1. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Center for Diabetes and Metabolism Research, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

TONG Nanwei, Email: tongnw@scu.edu.cn

Keywords：

Diabetes; islets; transplantation; islet transplantation site

DOI：

10.7507/1002-0179.202204097

Video：

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Abstract Full text Figures/Tables Video References Cited by

The islet transplantation site can be divided into two categories: orthotopic islet transplantation and ectopic islet transplantation. Orthotopic islet transplantation refers to that the insulin secreted and released from the transplanted islet will be metabolized into the liver through the hepatic portal vein system, which does not change the original insulin metabolic pathway, including the portal vein of the liver, the greater omentum. The insulin secreted by the ectopic islet transplantation changes the original metabolic pathway of insulin. The ideal islet transplantation site generally has the following characteristics: high success rate transplantation, high long-term survival rate of graft, simple operation, less trauma, less complications, low risk, easy to repeat detection and so on. This article provides a review of the current research status of each islet transplantation site, in order to provide reference for future related research.

Citation： WU Nianwei, TONG Nanwei. Research status of islet transplantation site. West China Medical Journal, 2023, 38(12): 1929-1933. doi: 10.7507/1002-0179.202204097 Copy

1.	Gruessner RW, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol, 2013, 9(9): 555-562.
2.	Barton FB, Rickels MR, Alejandro R, et al. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care, 2012, 35(7): 1436-1445.
3.	Addison P, Fatakhova K, Rodriguez Rilo HL. Considerations for an alternative site of islet cell transplantation. J Diabetes Sci Technol, 2020, 14(2): 338-344.
4.	Kemp CB, Knight MJ, Scharp DW, et al. Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia, 1973, 9(6): 486-491.
5.	程颖, 王树森. 胰岛移植临床技术操作规范(2019 版). 器官移植, 2019, 10(6): 621-627.
6.	段金良, 庄博文, 白芳, 等. 全程超声引导下经皮门静脉穿刺胰岛移植治疗糖尿病 16 例报道. 中华器官移植杂志, 2021, 42(12): 733-737.
7.	Litbarg NO, Gudehithlu KP, Sethupathi P, et al. Activated omentum becomes rich in factors that promote healing and tissue regeneration. Cell Tissue Res, 2007, 328(3): 487-497.
8.	Bartholomeus K, Jacobs-Tulleneers-Thevissen D, Shouyue S, et al. Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine β-cell implants in immunodeficient rats. Transplantation, 2013, 96(12): 1026-1033.
9.	Espes D, Lau J, Quach M, et al. Rapid restoration of vascularity and oxygenation in mouse and human islets transplanted to omentum may contribute to their superior function compared to intraportally transplanted islets. Am J Transplant, 2016, 16(11): 3246-3254.
10.	Kin T, Korbutt GS, Rajotte RV. Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch. Am J Transplant, 2003, 3(3): 281-285.
11.	王树森, 裴广辉, 王金山, 等. 经大网膜生物支架胰岛移植技术的探讨. 实用器官移植电子杂志, 2016, 4(6): 378-380.
12.	Saudek F, Hladiková Z, Hagerf B, et al. Transplantation of pancreatic islets into the omentum using a biocompatible plasma-thrombin gel: first experience at the institute for clinical and experimental medicine in prague. Transplant Proc, 2022, 54(3): 806-810.
13.	Echeverri GJ, McGrath K, Bottino R, et al. Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. Am J Transplant, 2009, 9(11): 2485-2496.
14.	Yin ZZ, Wang SS, Li Q, et al. Gastric submucosa is inferior to the liver as transplant site for autologous islet transplantation in pancreatectomized diabetic beagles. J Huazhong Univ Sci Technolog Med Sci, 2016, 36(4): 529-533.
15.	Wszola M, Berman A, Ostaszewska A, et al. Islets allotransplantation into gastric submucosa in a patient with portal hypertension: 4-year follow-up. Transplant Proc, 2018, 50(6): 1910-1913.
16.	Song J, Millman JR. Economic 3D-printing approach for transplantation of human stem cell- derived β-like cells. Biofabrication, 2016, 9(1): 015002.
17.	Motsumoto S, Tomiya M, Sawamoto O. Current status and future of clinical islet xenotransplantation. Diabetes, 2016, 8(4): 483-493.
18.	Perez VL, Caicedo A, Berman DM, et al. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. Diabetologia, 2011, 54(5): 1121-1126.
19.	Tun SBB, Chua M, Hasan R, et al. Islet transplantation to the anterior chamber of the eye-a future treatment option for insulin-deficient type-2 diabetics? A case report from a nonhuman type-2 diabetic primate. Cell Transplant, 2020, 29: 963689720913256.
20.	刘定志, 罗诗樵, 杜成友, 等. 移植部位对移植胰岛长期存活的影响. 上海交通大学学报 (医学版), 2012, 32(3): 257-262.
21.	Karakose M, Pinarli FA, Arslan MS, et al. Comparison of the ovary and kidney as sites for islet transplantation in diabetic rats. Transplant Proc, 2016, 48(6): 2216-2220.
22.	Margolis RN, Holup JJ, Selawry HP. Effects of intratesticular islet transplantation on hepatic glycogen metabolism in the rat. Diabetes Res Clin Pract, 1986, 2(5): 291-299.
23.	Wang C, Du X, He S, et al. A preclinical evaluation of alternative site for islet allotransplantation. PLoS One, 2017, 12(3): e0174505.
24.	Stagner JI, Rilo HL, White KK. The pancreas as an islet transplantation site. Confirmation in a syngeneic rodent and canine autotransplant model. JOP, 2007, 8(5): 628-636.
25.	Schubert U, Schmid J, Lehmann S, et al. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc Natl Acad Sci U S A, 2013, 110(6): 2288-2293.

1. Gruessner RW, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol, 2013, 9(9): 555-562.
2. Barton FB, Rickels MR, Alejandro R, et al. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care, 2012, 35(7): 1436-1445.
3. Addison P, Fatakhova K, Rodriguez Rilo HL. Considerations for an alternative site of islet cell transplantation. J Diabetes Sci Technol, 2020, 14(2): 338-344.
4. Kemp CB, Knight MJ, Scharp DW, et al. Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia, 1973, 9(6): 486-491.
5. 程颖, 王树森. 胰岛移植临床技术操作规范(2019 版). 器官移植, 2019, 10(6): 621-627.
6. 段金良, 庄博文, 白芳, 等. 全程超声引导下经皮门静脉穿刺胰岛移植治疗糖尿病 16 例报道. 中华器官移植杂志, 2021, 42(12): 733-737.
7. Litbarg NO, Gudehithlu KP, Sethupathi P, et al. Activated omentum becomes rich in factors that promote healing and tissue regeneration. Cell Tissue Res, 2007, 328(3): 487-497.
8. Bartholomeus K, Jacobs-Tulleneers-Thevissen D, Shouyue S, et al. Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine β-cell implants in immunodeficient rats. Transplantation, 2013, 96(12): 1026-1033.
9. Espes D, Lau J, Quach M, et al. Rapid restoration of vascularity and oxygenation in mouse and human islets transplanted to omentum may contribute to their superior function compared to intraportally transplanted islets. Am J Transplant, 2016, 16(11): 3246-3254.
10. Kin T, Korbutt GS, Rajotte RV. Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch. Am J Transplant, 2003, 3(3): 281-285.
11. 王树森, 裴广辉, 王金山, 等. 经大网膜生物支架胰岛移植技术的探讨. 实用器官移植电子杂志, 2016, 4(6): 378-380.
12. Saudek F, Hladiková Z, Hagerf B, et al. Transplantation of pancreatic islets into the omentum using a biocompatible plasma-thrombin gel: first experience at the institute for clinical and experimental medicine in prague. Transplant Proc, 2022, 54(3): 806-810.
13. Echeverri GJ, McGrath K, Bottino R, et al. Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. Am J Transplant, 2009, 9(11): 2485-2496.
14. Yin ZZ, Wang SS, Li Q, et al. Gastric submucosa is inferior to the liver as transplant site for autologous islet transplantation in pancreatectomized diabetic beagles. J Huazhong Univ Sci Technolog Med Sci, 2016, 36(4): 529-533.
15. Wszola M, Berman A, Ostaszewska A, et al. Islets allotransplantation into gastric submucosa in a patient with portal hypertension: 4-year follow-up. Transplant Proc, 2018, 50(6): 1910-1913.
16. Song J, Millman JR. Economic 3D-printing approach for transplantation of human stem cell- derived β-like cells. Biofabrication, 2016, 9(1): 015002.
17. Motsumoto S, Tomiya M, Sawamoto O. Current status and future of clinical islet xenotransplantation. Diabetes, 2016, 8(4): 483-493.
18. Perez VL, Caicedo A, Berman DM, et al. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. Diabetologia, 2011, 54(5): 1121-1126.
19. Tun SBB, Chua M, Hasan R, et al. Islet transplantation to the anterior chamber of the eye-a future treatment option for insulin-deficient type-2 diabetics? A case report from a nonhuman type-2 diabetic primate. Cell Transplant, 2020, 29: 963689720913256.
20. 刘定志, 罗诗樵, 杜成友, 等. 移植部位对移植胰岛长期存活的影响. 上海交通大学学报 (医学版), 2012, 32(3): 257-262.
21. Karakose M, Pinarli FA, Arslan MS, et al. Comparison of the ovary and kidney as sites for islet transplantation in diabetic rats. Transplant Proc, 2016, 48(6): 2216-2220.
22. Margolis RN, Holup JJ, Selawry HP. Effects of intratesticular islet transplantation on hepatic glycogen metabolism in the rat. Diabetes Res Clin Pract, 1986, 2(5): 291-299.
23. Wang C, Du X, He S, et al. A preclinical evaluation of alternative site for islet allotransplantation. PLoS One, 2017, 12(3): e0174505.
24. Stagner JI, Rilo HL, White KK. The pancreas as an islet transplantation site. Confirmation in a syngeneic rodent and canine autotransplant model. JOP, 2007, 8(5): 628-636.
25. Schubert U, Schmid J, Lehmann S, et al. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc Natl Acad Sci U S A, 2013, 110(6): 2288-2293.

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