Research progress on modification of polyetheretherketone materials for bone repair_West China Medical Journal

Authors：

ZHU Ce , FENG Ganjun , LIU Limin ,  SONG Yueming

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

SONG Yueming, Email: hx_sym@163.com

Keywords：

Polyetheretherketone; modification; bone repair; material

DOI：

10.7507/1002-0179.202207078

Video：

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Abstract Full text Figures/Tables Video References Cited by

Polyetheretherketone is one of the most commonly used materials for the production of orthopaedic implants, but the osseointegration capacity of polyetheretherketone is poor because of its bioinert surface, which greatly limits its clinical application. In recent years, scholars have carried out a lot of research on the modification of polyetheretherketone materials in order to improve its osseointegration capacity. At present, the modification of polyetheretherketone is mainly divided into surface modification and blend modification. Therefore, this paper summarizes the research progress of polyetheretherketone material modification technology and its influence on osseointegration from two aspects of surface modification and blend modification for polyetheretherketone materials used in the field of bone repair, so as to provide a reference for the improvement and transformation of polyetheretherketone materials for bone repair in the future.

Citation： ZHU Ce, FENG Ganjun, LIU Limin, SONG Yueming. Research progress on modification of polyetheretherketone materials for bone repair. West China Medical Journal, 2022, 37(10): 1441-1449. doi: 10.7507/1002-0179.202207078 Copy

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1. Eschbach L. Nonresorbable polymers in bone surgery. Injury, 2000, 31(Suppl 4): 22-27.
2. Kurtz SM, Devine JN. PEEK biomaterials in trauma, orthopedic, and spinal implants. Biomaterials, 2007, 28(32): 4845-4869.
3. Buck E, Li H, Cerruti M. Surface modification strategies to improve the osseointegration of poly(etheretherketone) and its composites. Macromol Biosci, 2020, 20(2): e1900271.
4. Bathala L, Majeti V, Rachuri N, et al. The role of polyether ether ketone (peek) in dentistry - a review. J Med Life, 2019, 12(1): 5-9.
5. Xu X, Li Y, Wang L, et al. Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application. Biomaterials, 2019, 212: 98-114.
6. Schätzle M, Männchen R, Balbach U, et al. Stability change of chemically modified sandblasted/acid-etched titanium palatal implants. A randomized-controlled clinical trial. Clin Oral Implants Res, 2009, 20(5): 489-495.
7. Sunarso, Tsuchiya A, Fukuda N, et al. Effect of micro-roughening of poly (ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration. J Biomater Sci Polym Ed, 2018, 29(12): 1375-1388.
8. Mahjoubi H, Buck E, Manimunda P, et al. Surface phosphonation enhances hydroxyapatite coating adhesion on polyetheretherketone and its osseointegration potential. Acta Biomater, 2017, 47: 149-158.
9. Shimizu T, Fujibayashi S, Yamaguchi S, et al. Bioactivity of sol-gel-derived TiO2 coating on polyetheretherketone: in vitro and in vivo studies. Acta Biomater, 2016, 35: 305-317.
10. Torstrick FB, Evans NT, Stevens HY, et al. Do surface porosity and pore size influence mechanical properties and cellular response to PEEK?. Clin Orthop Relat Res, 2016, 474(11): 2373-2383.
11. Cordero D, López-Álvarez M, Rodríguez-Valencia C, et al. In vitro response of pre-osteoblastic cells to laser microgrooved PEEK. Biomed Mater, 2013, 8(5): 055006.
12. Zheng Y, Xiong C, Wang Z, et al. A combination of CO₂ laser and plasma surface modification of poly (etheretherketone) to enhance osteoblast response. Appl Surf Sci, 2015, 344: 79-88.
13. 王悦, 刘红. 聚醚醚酮生物复合材料表面改性的研究进展. 现代口腔医学杂志, 2019, 33(6): 360-364.
14. 肖天华, 刘荣涛, 庞贻宇, 等. 骨植入聚醚醚酮材料表面改性的研究进展. 广东工业大学学报, 2021, 38(2): 73-82.
15. Wang S, Deng Y, Yang L, et al. Enhanced antibacterial property and osteo-differentiation activity on plasma treated porous polyetheretherketone with hierarchical micro/nano-topography. J Biomater Sci Polym Ed, 2018, 29(5): 520-542.
16. Lu T, Wen J, Qian S, et al. Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus. Biomaterials, 2015, 51: 173-183.
17. Zheng Y, Liu L, Ma Y, et al. Enhanced osteoblasts responses to surface-sulfonated polyetheretherketone via a single-step ultraviolet-initiated graft polymerization. Ind Eng Chem Res, 2018, 57(31): 10403-10410.
18. Khoury J, Maxwell M, Cherian RE, et al. Enhanced bioactivity and osseointegration of PEEK with accelerated neutral atom beam technology. J Biomed Mater Res B Appl Biomater, 2017, 105(3): 531-543.
19. Khoury J, Kirkpatrick S, Maxwell M, et al. Neutral atom beam technique enhances bioactivity of PEEK. Nucl Instrum Meth B, 2013, 307: 630-634.
20. Wang S, Yang Y, Li Y, et al. Strontium/adiponectin co-decoration modulates the osteogenic activity of nano-morphologic polyetheretherketone implant. Colloids Surf B Biointerfaces, 2019, 176: 38-46.
21. Ouyang L, Zhao Y, Jin G, et al. Influence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK. Biomaterials, 2016, 83: 115-126.
22. Hieda A, Uemura N, Hashimoto Y, et al. In vivo bioactivity of porous polyetheretherketone with a foamed surface. Dent Mater J, 2017, 36(2): 222-229.
23. 李中杰, 潘宇, 吴晓敏, 等. 聚醚醚酮材料表面改性后成骨效能的研究进展. 广东医学, 2019, 40(24): 3481-3484, 3488.
24. Mahjoubi H, Kinsella JM, Murshed M, et al. Surface modification of poly (D, L-lactic acid) scaffolds for orthopedic applications: a biocompatible, nondestructive route via diazonium chemistry. ACS Appl Mater Interfaces, 2014, 6(13): 9975-9987.
25. Wu J, Li L, Fu C, et al. Micro-porous polyetheretherketone implants decorated with BMP-2 via phosphorylated gelatin coating for enhancing cell adhesion and osteogenic differentiation. Colloids Surf B Biointerfaces, 2018, 169: 233-241.
26. Zheng Y, Liu L, Xiong C, et al. Enhancement of bioactivity on modified polyetheretherketone surfaces with -COOH, -OH and -PO4H2 functional groups. Mater Lett, 2017, 213: 84-87.
27. Zhu C, He M, Mao L, et al. Titanium-interlayer mediated hydroxyapatite coating on polyetheretherketone: a prospective study in patients with single-level cervical degenerative disc disease. J Transl Med, 2021, 19(1): 14.
28. Assem Y, Mobbs RJ, Pelletier MH, et al. Radiological and clinical outcomes of novel Ti/PEEK combined spinal fusion cages: a systematic review and preclinical evaluation. Eur Spine J, 2017, 26(3): 593-605.
29. Zhu C, He M, Mao L, et al. Titanium interlayer-mediated hydroxyapatite-coated polyetheretherketone cage in transforaminal lumbar interbody fusion surgery. BMC Musculoskelet Disord, 2021, 22(1): 918.
30. Devine DM, Hahn J, Richards RG, et al. Coating of carbon fiber-reinforced polyetheretherketone implants with titanium to improve bone apposition. J Biomed Mater Res B Appl Biomater, 2013, 101(4): 591-598.
31. Liu X, Gan K, Liu H, et al. Antibacterial properties of nano-silver coated PEEK prepared through magnetron sputtering. Dent Mater, 2017, 33(9): e348-e360.
32. Yang YJ, Tsou HK, Chen YH, et al. Enhancement of bioactivity on medical polymer surface using high power impulse magnetron sputtered titanium dioxide film. Mater Sci Eng C Mater Biol Appl, 2015, 57: 58-66.
33. Tsou HK, Hsieh PY, Chi MH, et al. Improved osteoblast compatibility of medical-grade polyetheretherketone using arc ionplated rutile/anatase titanium dioxide films for spinal implants. J Biomed Mater Res A, 2012, 100(10): 2787-2792.
34. Wen J, Lu T, Wang X, et al. In vitro and in vivo evaluation of silicate-coated polyetheretherketone fabricated by electron beam evaporation. ACS Appl Mater Interfaces, 2016, 8(21): 13197-13206.
35. Han CM, Jang TS, Kim HE, et al. Creation of nanoporous TiO2 surface onto polyetheretherketone for effective immobilization and delivery of bone morphogenetic protein. J Biomed Mater Res A, 2014, 102(3): 793-800.
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