Visual analysis of the correlation between obesity and neuroinflammation_West China Medical Journal

Authors：

ZHOU Ye ,  ZHAO Bei

School of Basic Medicine Sciences, Dali University, Dali, Yunnan 617000, P. R. China;

Corresponding author：

ZHAO Bei, Email: zaozhui@163.com

Keywords：

Obesity; neuroinflammation; visual analysis

DOI：

10.7507/1002-0179.202207104

Video：

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Objective To summarize the current status and hotspots of research on obesity and neuroinflammation in the last decade through bibliometric analysis. Method Web of Science database was searched for English literature on obesity and neuroinflammation published between 2011 and 2021. The CiteSpace software was applied to analyze the number of publications, authors, institutions, countries and collaborations, and keywords in the field of obesity and neuroinflammation research.Results A total of 548 articles were included, and the number of articles had been increasing year by year. The top three countries in the field of obesity and neuroinflammation research were the United States, China, and Brazil. University of Toronto was the core research institution. Keywords formed 16 clusters, and there were a total of 15 emergent words.Conclusions Over the past decade, research on obesity and neuroinflammation has shown an upward trend. The research hotspots in the field of obesity and neuroinflammation mainly focus on insulin resistance, obesity, Alzheimer’s disease, high fat diet, inflammation, neuroinflammation, and other aspects. The prefrontal cortex and memory impairment are future hotspots.

Citation： ZHOU Ye, ZHAO Bei. Visual analysis of the correlation between obesity and neuroinflammation. West China Medical Journal, 2023, 38(4): 518-524. doi: 10.7507/1002-0179.202207104 Copy

1.	Lainez NM, Coss D. Obesity, neuroinflammation, and reproductive function. Endocrinology, 2019, 160(11): 2719-2736.
2.	Frühbeck G, Toplak H, Woodward E, et al. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts, 2013, 6(2): 117-120.
3.	Rhea EM, Salameh TS, Logsdon AF, et al. Blood-brain barriers in obesity. AAPS J, 2017, 19(4): 921-930.
4.	Gómez-Apo E, Mondragón-Maya A, Ferrari-Díaz M, et al. Structural brain changes associated with overweight and obesity. J Obes, 2021, 2021: 6613385.
5.	Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?. Nat Rev Neurol, 2021, 17(3): 157-172.
6.	Van Dyken P, Lacoste B. Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci, 2018, 12: 930.
7.	Karczewski J, Zielińska A, Staszewski R, et al. Obesity and the Brain. Int J Mol Sci, 2022, 23(11): 6145.
8.	邱均平, 沈恝谌, 宋艳辉. 近十年国内外计量经济学研究进展与趋势—基于 Citespace 的可视化对比研究. 现代情报, 2019, 39(2): 26-37.
9.	陈悦, 陈超美, 刘则渊, 等. CiteSpace 知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
10.	Liang C, Luo A, Zhong Z. Knowledge mapping of medication literacy study: a visualized analysis using CiteSpace. SAGE Open Med, 2018, 6: 2050312118800199.
11.	范杨阳, 王天芳, 董俭, 等. 2014 年至 2018 年国内中医英译研究的文献计量与可视化分析. 中华中医药杂志, 2020, 35(6): 3094-3097.
12.	秦晓楠, 卢小丽, 武春友. 国内生态安全研究知识图谱—基于 Citespace 的计量分析. 生态学报, 2014, 34(13): 3693-3703.
13.	Kang DH, Heo RW, Yi CO, et al. High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death. Bmc Neurosci, 2015, 16: 72.
14.	Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci, 2014, 8: 375.
15.	Alexaki VI. The impact of obesity on microglial function: immune, metabolic and endocrine perspectives. Cells, 2021, 10(7): 1584.
16.	Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol, 2021, 18(11): 2489-2501.
17.	Cheng J, Dong Y, Ma J, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Sci Adv, 2021, 7(35): eabe3600.
18.	Olsthoorn L, Vreeken D, Kiliaan AJ. Gut microbiome, inflammation, and cerebrovascular function: link between obesity and cognition. Front Neurosci, 2021, 15: 761456.
19.	Dalile B, Van Oudenhove L, Vervliet B, et al. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 461-478.
20.	Lorena FB, do Nascimento BPP, Camargo ELRA, et al. Long-term obesity is associated with depression and neuroinflammation. Arch Endocrinol Metab, 2021, 65(5): 537-548.
21.	de Oliveira S, Feijó GDS, Neto J, et al. Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity (Silver Spring), 2021, 29(1): 116-124.
22.	Lituma PJ, Woo E, O’Hara BF, et al. Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1. Proc Natl Acad Sci USA, 2021, 118(46): e2115539118.
23.	Forte N, Fernández-Rilo AC, Palomba L, et al. Obesity affects the microbiota-gut-brain axis and the regulation thereof by endocannabinoids and related mediators. Int J Mol Sci, 2020, 21(5): 1554.
24.	Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, et al. Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids. Cell Metab, 2020, 32(4): 548-560.e7.
25.	Zeng Q, Li D, He Y, et al. Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Sci Rep, 2019, 9(1): 13424.

1. Lainez NM, Coss D. Obesity, neuroinflammation, and reproductive function. Endocrinology, 2019, 160(11): 2719-2736.
2. Frühbeck G, Toplak H, Woodward E, et al. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts, 2013, 6(2): 117-120.
3. Rhea EM, Salameh TS, Logsdon AF, et al. Blood-brain barriers in obesity. AAPS J, 2017, 19(4): 921-930.
4. Gómez-Apo E, Mondragón-Maya A, Ferrari-Díaz M, et al. Structural brain changes associated with overweight and obesity. J Obes, 2021, 2021: 6613385.
5. Leng F, Edison P. Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?. Nat Rev Neurol, 2021, 17(3): 157-172.
6. Van Dyken P, Lacoste B. Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci, 2018, 12: 930.
7. Karczewski J, Zielińska A, Staszewski R, et al. Obesity and the Brain. Int J Mol Sci, 2022, 23(11): 6145.
8. 邱均平, 沈恝谌, 宋艳辉. 近十年国内外计量经济学研究进展与趋势—基于 Citespace 的可视化对比研究. 现代情报, 2019, 39(2): 26-37.
9. 陈悦, 陈超美, 刘则渊, 等. CiteSpace 知识图谱的方法论功能. 科学学研究, 2015, 33(2): 242-253.
10. Liang C, Luo A, Zhong Z. Knowledge mapping of medication literacy study: a visualized analysis using CiteSpace. SAGE Open Med, 2018, 6: 2050312118800199.
11. 范杨阳, 王天芳, 董俭, 等. 2014 年至 2018 年国内中医英译研究的文献计量与可视化分析. 中华中医药杂志, 2020, 35(6): 3094-3097.
12. 秦晓楠, 卢小丽, 武春友. 国内生态安全研究知识图谱—基于 Citespace 的计量分析. 生态学报, 2014, 34(13): 3693-3703.
13. Kang DH, Heo RW, Yi CO, et al. High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death. Bmc Neurosci, 2015, 16: 72.
14. Nguyen JC, Killcross AS, Jenkins TA. Obesity and cognitive decline: role of inflammation and vascular changes. Front Neurosci, 2014, 8: 375.
15. Alexaki VI. The impact of obesity on microglial function: immune, metabolic and endocrine perspectives. Cells, 2021, 10(7): 1584.
16. Galea I. The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol, 2021, 18(11): 2489-2501.
17. Cheng J, Dong Y, Ma J, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology. Sci Adv, 2021, 7(35): eabe3600.
18. Olsthoorn L, Vreeken D, Kiliaan AJ. Gut microbiome, inflammation, and cerebrovascular function: link between obesity and cognition. Front Neurosci, 2021, 15: 761456.
19. Dalile B, Van Oudenhove L, Vervliet B, et al. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol, 2019, 16(8): 461-478.
20. Lorena FB, do Nascimento BPP, Camargo ELRA, et al. Long-term obesity is associated with depression and neuroinflammation. Arch Endocrinol Metab, 2021, 65(5): 537-548.
21. de Oliveira S, Feijó GDS, Neto J, et al. Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity (Silver Spring), 2021, 29(1): 116-124.
22. Lituma PJ, Woo E, O’Hara BF, et al. Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1. Proc Natl Acad Sci USA, 2021, 118(46): e2115539118.
23. Forte N, Fernández-Rilo AC, Palomba L, et al. Obesity affects the microbiota-gut-brain axis and the regulation thereof by endocannabinoids and related mediators. Int J Mol Sci, 2020, 21(5): 1554.
24. Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, et al. Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids. Cell Metab, 2020, 32(4): 548-560.e7.
25. Zeng Q, Li D, He Y, et al. Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities. Sci Rep, 2019, 9(1): 13424.

West China Medical Journal

Visual analysis of the correlation between obesity and neuroinflammation

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