Visual analysis of the current state and trends of global research in continuous renal replacement therapy_West China Medical Journal

Authors：

HOU Qinlan ¹ ,  ZHAO Shuangping ^1,2,3

1. Department of Critical Care Medicine, Xiangya Hospital Central South University, Changsha, Hunan 410008, P. R. China;
2. National Clinical Research Center for Geriatric Disorders, Changsha, Hunan 410008, P. R. China;
3. Hunan Provincial Clinical Research Center of Intensive Care Medicine, Changsha, Hunan 410008, P. R. China;

Corresponding author：

ZHAO Shuangping, Email: zhshping@csu.edu.cn

Keywords：

Continuous renal replacement therapy; renal injury; research trends; visualization analysis; bibliometrics

DOI：

10.7507/1002-0179.202307026

Video：

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Objective To explore the global research status and trends of continuous renal replacement therapy (CRRT) based on knowledge visualization analysis. Methods Based on the Web of Science Core Collection, studies reporting CRRT research that were published between June 2014 and June 2023 were retrieved and collected after manual review. VOSviewer and CiteSpace softwares were used for bibliometric visualization analysis, including publication trends, geographical distribution characteristics, journal distribution characteristics, author contributions, citations, funding source characteristics, and keyword clustering. Results A total of 2708 papers were analyzed, with an increasing trend in the number of articles and citation frequency from 2015 to 2021. The United States was the most prolific country and France was the most influential country. The University of Pittsburgh in the United States had the highest number of publications among research institutions and showed higher motivation for inter-institutional collaboration. The University of Queensland in the Australia had the highest average citation frequency. Professor Rinaldo Bellomo of Australia was the most productive author and Professor Jeffrey Lipman was the most influential. Jason A. Roberts, Jeffrey Lipman and Claudio Ronco were the three authors who had the highest number of collaborations with other authors. Keyword cluster analysis showed that the prognosis of CRRT for renal disease was the focus of research, with hotspots of research being antibiotics, citrate accumulation, plasma replacement, lactate clearance, acute respiratory distress syndrome, and coronavirus disease 2019. Coupling analysis of the literature showed that exploring the indications for CRRT and optimizing treatment prescription were at the forefront of research. Conclusions The present study of CRRT has generally shown an upward trend in the last decade. The management and efficacy of CRRT remains a hot topic of research. Exploring the indications for CRRT and optimizing treatment prescriptions may be a popular research direction and trend in the future.

Citation： HOU Qinlan, ZHAO Shuangping. Visual analysis of the current state and trends of global research in continuous renal replacement therapy. West China Medical Journal, 2023, 38(7): 987-995. doi: 10.7507/1002-0179.202307026 Copy

1.	Cerdá J, Ronco C. Modalities of continuous renal replacement therapy: technical and clinical considerations. Semin Dial, 2009, 22(2): 114-122.
2.	Ronco C, Ricci Z. Renal replacement therapies: physiological review. Intensive Care Med, 2008, 34(12): 2139-2146.
3.	Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet, 2000, 356(9223): 26-30.
4.	Alvarez G, Chrusch C, Hulme T, et al. Renal replacement therapy: a practical update. Can J Anaesth, 2019, 66(5): 593-604.
5.	中国医院协会血液净化中心分会和中关村肾病血液净化创新联盟“血液净化模式选择工作组”. 血液净化模式选择专家共识. 中国血液净化, 2019, 18(7): 442-472.
6.	Connor MJ Jr, Karakala N. Continuous renal replacement therapy: reviewing current best practice to provide high-quality extracorporeal therapy to critically ill patients. Adv Chronic Kidney Dis, 2017, 24(4): 213-218.
7.	Ronco C, Ricci Z, De Backer D, et al. Renal replacement therapy in acute kidney injury: controversy and consensus. Crit Care, 2015, 19(1): 146.
8.	Smith DR, Rivett DA. Bibliometrics, impact factors and manual therapy: balancing the science and the art. Man Ther, 2009, 14(4): 456-459.
9.	van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
10.	van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics, 2017, 111(2): 1053-1070.
11.	Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021, 372: n71.
12.	Zarbock A, Kellum JA, Schmidt C, et al. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA, 2016, 315(20): 2190-2199.
13.	Gaudry S, Hajage D, Schortgen F, et al. Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med, 2016, 375(2): 122-133.
14.	Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med, 2017, 43(3): 304-377.
15.	VA/NIH Acute Renal Failure Trial Network, Palevsky PM, Zhang JH, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med, 2008, 359(1): 7-20.
16.	Claure-Del Granado R, Mehta RL. Fluid overload in the ICU: evaluation and management. BMC Nephrol, 2016, 17(1): 109.
17.	Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med, 2015, 41(8): 1411-1423.
18.	Tandukar S, Palevsky PM. Continuous renal replacement therapy: who, when, why, and how. Chest, 2019, 155(3): 626-638.
19.	STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med, 2020, 383(3): 240-251.
20.	Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med, 2018, 379(15): 1431-1442.
21.	Monard C, Rimmelé T, Ronco C. Extracorporeal blood purification therapies for sepsis. Blood Purif, 2019, 47(Suppl 3): 1-14.
22.	Zarbock A, Küllmar M, Kindgen-Milles D, et al. Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial. JAMA, 2020, 324(16): 1629-1639.
23.	Zeng X, Zhang L, Wu T, et al. Continuous renal replacement therapy (CRRT) for rhabdomyolysis. Cochrane Database Syst Rev, 2014, (6): CD008566.
24.	Zuccari S, Damiani E, Domizi R, et al. Changes in cytokines, haemodynamics and microcirculation in patients with sepsis/septic shock undergoing continuous renal replacement therapy and blood purification with CytoSorb. Blood Purif, 2020, 49(1/2): 107-113.
25.	Davenport A. Renal replacement therapy in the patient with acute brain injury. Am J Kidney Dis, 2001, 37(3): 457-466.
26.	Riegel W. Continuous renal replacement therapy in acute renal failure. Kidney Blood Press Res, 2003, 26(2): 123-127.
27.	Heung M, Mueller BA. Prevention of hypophosphatemia during continuous renal replacement therapy-An overlooked problem. Semin Dial, 2018, 31(3): 213-218.
28.	Tsujimoto Y, Fujii T. How to prolong filter life during continuous renal replacement therapy?. Crit Care, 2022, 26(1): 62.
29.	Karkar A, Ronco C. Prescription of CRRT: a pathway to optimize therapy. Ann Intensive Care, 2020, 10(1): 32.
30.	Li L, Li X, Xia Y, et al. Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy. Front Pharmacol, 2020, 11: 786.

1. Cerdá J, Ronco C. Modalities of continuous renal replacement therapy: technical and clinical considerations. Semin Dial, 2009, 22(2): 114-122.
2. Ronco C, Ricci Z. Renal replacement therapies: physiological review. Intensive Care Med, 2008, 34(12): 2139-2146.
3. Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet, 2000, 356(9223): 26-30.
4. Alvarez G, Chrusch C, Hulme T, et al. Renal replacement therapy: a practical update. Can J Anaesth, 2019, 66(5): 593-604.
5. 中国医院协会血液净化中心分会和中关村肾病血液净化创新联盟“血液净化模式选择工作组”. 血液净化模式选择专家共识. 中国血液净化, 2019, 18(7): 442-472.
6. Connor MJ Jr, Karakala N. Continuous renal replacement therapy: reviewing current best practice to provide high-quality extracorporeal therapy to critically ill patients. Adv Chronic Kidney Dis, 2017, 24(4): 213-218.
7. Ronco C, Ricci Z, De Backer D, et al. Renal replacement therapy in acute kidney injury: controversy and consensus. Crit Care, 2015, 19(1): 146.
8. Smith DR, Rivett DA. Bibliometrics, impact factors and manual therapy: balancing the science and the art. Man Ther, 2009, 14(4): 456-459.
9. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2): 523-538.
10. van Eck NJ, Waltman L. Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics, 2017, 111(2): 1053-1070.
11. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 2021, 372: n71.
12. Zarbock A, Kellum JA, Schmidt C, et al. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA, 2016, 315(20): 2190-2199.
13. Gaudry S, Hajage D, Schortgen F, et al. Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med, 2016, 375(2): 122-133.
14. Rhodes A, Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med, 2017, 43(3): 304-377.
15. VA/NIH Acute Renal Failure Trial Network, Palevsky PM, Zhang JH, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med, 2008, 359(1): 7-20.
16. Claure-Del Granado R, Mehta RL. Fluid overload in the ICU: evaluation and management. BMC Nephrol, 2016, 17(1): 109.
17. Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med, 2015, 41(8): 1411-1423.
18. Tandukar S, Palevsky PM. Continuous renal replacement therapy: who, when, why, and how. Chest, 2019, 155(3): 626-638.
19. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med, 2020, 383(3): 240-251.
20. Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med, 2018, 379(15): 1431-1442.
21. Monard C, Rimmelé T, Ronco C. Extracorporeal blood purification therapies for sepsis. Blood Purif, 2019, 47(Suppl 3): 1-14.
22. Zarbock A, Küllmar M, Kindgen-Milles D, et al. Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial. JAMA, 2020, 324(16): 1629-1639.
23. Zeng X, Zhang L, Wu T, et al. Continuous renal replacement therapy (CRRT) for rhabdomyolysis. Cochrane Database Syst Rev, 2014, (6): CD008566.
24. Zuccari S, Damiani E, Domizi R, et al. Changes in cytokines, haemodynamics and microcirculation in patients with sepsis/septic shock undergoing continuous renal replacement therapy and blood purification with CytoSorb. Blood Purif, 2020, 49(1/2): 107-113.
25. Davenport A. Renal replacement therapy in the patient with acute brain injury. Am J Kidney Dis, 2001, 37(3): 457-466.
26. Riegel W. Continuous renal replacement therapy in acute renal failure. Kidney Blood Press Res, 2003, 26(2): 123-127.
27. Heung M, Mueller BA. Prevention of hypophosphatemia during continuous renal replacement therapy-An overlooked problem. Semin Dial, 2018, 31(3): 213-218.
28. Tsujimoto Y, Fujii T. How to prolong filter life during continuous renal replacement therapy?. Crit Care, 2022, 26(1): 62.
29. Karkar A, Ronco C. Prescription of CRRT: a pathway to optimize therapy. Ann Intensive Care, 2020, 10(1): 32.
30. Li L, Li X, Xia Y, et al. Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy. Front Pharmacol, 2020, 11: 786.

West China Medical Journal

Visual analysis of the current state and trends of global research in continuous renal replacement therapy

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