LIANG Yuwen 1,2,3 , DU Xiaobo 1,2,3
  • 1. Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;
  • 2. Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;
  • 3. Sichuan Clinical Research Center for Radiation and Therapy, Mianyang, Sichuan 621000, P. R. China;
DU Xiaobo, Email: duxiaobo2005@126.com
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The standard treatment for locally advanced rectal cancer is neoadjuvant chemoradiotherapy combined with surgery, but patients after the same treatment regimen show a large difference in outcomes. For patients with good response to neoadjuvant therapy, the waiting & observation scheme can be selected to avoid surgery and other complications. Therefore, accurate assessment of the response of patients with locally advanced rectal cancer after neoadjuvant therapy can better develop personalized treatment strategies. Current studies have found that blood sample detection, endoscopy, imaging examination and artificial intelligence have their own advantages and disadvantages in evaluating the response of neoadjuvant therapy. Therefore, this article reviews the application of different clinical tools in evaluating and predicting the response of neoadjuvant therapy for locally advanced rectal cancer, and looks forward to the future development direction.

Citation: LIANG Yuwen, DU Xiaobo. Research progress on response evaluation and prediction of neoadjuvant therapy for locally advanced rectal cancer. West China Medical Journal, 2024, 39(5): 825-832. doi: 10.7507/1002-0179.202401286 Copy

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