Early warning value of selenium binding protein 1 on acute kidney injury and its risk factor exposure_West China Medical Journal

Authors：

ZHAO Weihao ¹ ^共 , DUAN Xuyao ² , CUI Chenkai ¹ , LI Yuxin ¹ , SHI Jiahui ¹ , LU Jiamei ¹ , CHEN Zhao ¹ , JING Lanmei ¹ , YAO Tian ¹ ,  FU Rongguo ¹ ,  TIAN Lifang ¹

1. Department of Nephrology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, P. R. China;
2. Department of Nephrology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi 710068, P. R. China;

Corresponding author：

FU Rongguo, Email: furongguo@xjtu.edu.cn; TIAN Lifang, Email: tianlifang0316@sina.com

Keywords：

Selenium binding protein 1; acute kidney injury; risk factors; warning value

DOI：

10.7507/1002-0179.202406156

Video：

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Objective To investigate the early warning value of urinary selenium binding protein 1 (SBP1) in acute kidney injury (AKI) and its risk factor exposure, and compare it with urinary neutrophil gelatinase-associated lipocalin (NGAL). Methods Adult AKI inpatients and medical workers from the Department of Nephrology of the Second Affiliated Hospital of Xi’an Jiaotong University between April 2023 and April 2024 were selected. Patients who underwent percutaneous coronary intervention (PCI) in the Department of Cardiology of the Second Affiliated Hospital of Xi’an Jiaotong University were selected in June 2023. Patients who received cisplatin treatment in the Respiratory Department of the Second Affiliated Hospital of Xi’an Jiaotong University were selected in June 2023. Urinary SBP1 and NGAL levels of patients and medical workers were detected by enzyme-linked immunosorbent assay. Results A total of 14 medical workers and 36 AKI patients were included. Except for gender, alanine aminotransferase, aspartate aminotransferase, total cholesterol (P>0.05), there were statistically significant differences in other indicators between the medical workers and the AKI patients (P<0.05). The urine SBP1 [100.30 (71.50, 138.75) vs.75.60 (65.90, 80.08) pg/mL; U=2.918, P=0.004] and NGAL [423.70 (73.93, 839.80) vs. 14.80 (5.83, 29.98) ng/mL; U=4.668, P<0.001] levels in the AKI group were higher than those in the control group. But the area under the curve of receiver operative characteristic curve of urine SBP1 was smaller than that of urine NGAL (0.768 vs. 0.929). The urine SBP1 level in AKI patients was positively correlated with alanine aminotransferase, aspartate aminotransferase, serum creatinine, and serum glucose (P＜0.05), but negatively correlated with estimated glomerular filtration rate and total cholesterol (P＜0.05). A total of 14 patients who underwent PCI were included. The urinary SBP1/creatinine levels of PCI patients increased 6 hours after surgery compared to preoperative levels [(39.54 ± 8.00) vs. (19.34±2.90) pg/μmol; F=8.862, P=0.011]. The urea nitrogen level decreased 72 hours after surgery compared to preoperative levels (P=0.036), while there were no statistically significant differences in other indicators at other time points (P>0.05). There was no significant change in urinary NGAL levels before and after PCI treatment in patients. A total of 19 patients received cisplatin treatment were included. After cisplatin treatment, the level of urinary SBP1 increased compared to before treatment (P=0.024), while there was no significant change in the level of urinary NGAL after treatment compared to before treatment (P=0.350). After treatment, the levels of urea nitrogen (P=0.041) and cystatin C (P=0.002) increased compared to before surgery, while there was no statistically significant difference in blood creatinine and estimated glomerular filtration rate compared to before treatment (P>0.05). Conclusions Urinary SBP1 levels have certain diagnostic value for AKI, but the diagnostic efficacy is not as good as urinary NGAL. Urinary SBP1 is more sensitive to renal tubular injury caused by nephrotoxic drugs than urinary NGAL.

Citation： ZHAO Weihao, DUAN Xuyao, CUI Chenkai, LI Yuxin, SHI Jiahui, LU Jiamei, CHEN Zhao, JING Lanmei, YAO Tian, FU Rongguo, TIAN Lifang. Early warning value of selenium binding protein 1 on acute kidney injury and its risk factor exposure. West China Medical Journal, 2024, 39(7): 1056-1062. doi: 10.7507/1002-0179.202406156 Copy

1.	Al-Jaghbeer M, Dealmeida D, Bilderback A, et al. Clinical decision support for in-hospital AKI. J Am Soc Nephrol, 2018, 29(2): 654-660.
2.	Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med, 2015, 41(8): 1411-1423.
3.	Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers, 2021, 7(1): 52.
4.	Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet, 2019, 394(10212): 1949-1964.
5.	Chan L, Chaudhary K, Saha A, et al. AKI in hospitalized patients with COVID-19. J Am Soc Nephrol, 2021, 32(1): 151-160.
6.	Wen Y, Parikh CR. Current concepts and advances in biomarkers of acute kidney injury. Crit Rev Clin Lab Sci, 2021, 58(5): 354-368.
7.	刘丹, 刘纪宁, 朱伦刚, 等. 多发伤早期急性肾损伤新型生物标志物的变化及预测效能研究. 华西医学, 2021, 36(11): 1528-1532.
8.	Ostermann M, Zarbock A, Goldstein S, et al. Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Netw Open, 2020, 3(10): e2019209.
9.	Devarajan P. Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant, 2008, 23(12): 3737-3743.
10.	Kümpers P, Hafer C, Lukasz A, et al. Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury. Crit Care, 2010, 14(1): R9.
11.	Han YC, Tu Y, Liu H, et al. Hospital-acquired acute kidney injury: an analysis of baseline estimated glomerular filtration rate and in-hospital mortality. J Nephrol, 2016, 29(3): 411-418.
12.	Raucci R, Colonna G, Guerriero E, et al. Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma. Biochim Biophys Acta, 2011, 1814(4): 513-522.
13.	Lee EK, Shin YJ, Park EY, et al. Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity. Arch Toxicol, 2017, 91(4): 1635-1648.
14.	Kim KS, Yang HY, Song H, et al. Identification of a sensitive urinary biomarker, selenium-binding protein 1, for early detection of acute kidney injury. J Toxicol Environ Health A, 2017, 80(9): 453-464.
15.	Yang L, Xing G, Wang L, et al. Acute kidney injury in China: a cross-sectional survey. Lancet, 2015, 386(10002): 1465-1471.
16.	冯哲, 陈香美. 中国急性肾损伤的防治策略. 华西医学, 2018, 33(7): 777-781.
17.	Iguchi H, Ikeda M, Kojo S. Early decreases in pulmonary, hepatic and renal glutathione levels in response to cadmium instillation into rat trachea. J Appl Toxicol, 1991, 11(3): 211-217.
18.	Jeong JY, Wang Y, Sytkowski AJ. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. Biochem Biophys Res Commun, 2009, 379(2): 583-588.
19.	Porat A, Sagiv Y, Elazar Z. A 56-kDa selenium-binding protein participates in intra-Golgi protein transport. J Biol Chem, 2000, 275(19): 14457-14465.
20.	Kohl JB, Mellis AT, Schwarz G. Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism. Br J Pharmacol, 2019, 176(4): 554-570.
21.	Elhodaky M, Diamond AM. Selenium-binding protein 1 in human health and disease. Int J Mol Sci, 2018, 19(11): 3437.
22.	Chau EJ, Mostaid MS, Cropley V, et al. Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 2018, 85: 1-6.
23.	Wang J, Qu D, An J, et al. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Mol Med Rep, 2017, 16(6): 8735-8746.
24.	Zhao W, Nikolic-Paterson DJ, Li K, et al. Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4. Chem Biol Interact, 2024, 393: 110944.

1. Al-Jaghbeer M, Dealmeida D, Bilderback A, et al. Clinical decision support for in-hospital AKI. J Am Soc Nephrol, 2018, 29(2): 654-660.
2. Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med, 2015, 41(8): 1411-1423.
3. Kellum JA, Romagnani P, Ashuntantang G, et al. Acute kidney injury. Nat Rev Dis Primers, 2021, 7(1): 52.
4. Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet, 2019, 394(10212): 1949-1964.
5. Chan L, Chaudhary K, Saha A, et al. AKI in hospitalized patients with COVID-19. J Am Soc Nephrol, 2021, 32(1): 151-160.
6. Wen Y, Parikh CR. Current concepts and advances in biomarkers of acute kidney injury. Crit Rev Clin Lab Sci, 2021, 58(5): 354-368.
7. 刘丹, 刘纪宁, 朱伦刚, 等. 多发伤早期急性肾损伤新型生物标志物的变化及预测效能研究. 华西医学, 2021, 36(11): 1528-1532.
8. Ostermann M, Zarbock A, Goldstein S, et al. Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Netw Open, 2020, 3(10): e2019209.
9. Devarajan P. Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury. Nephrol Dial Transplant, 2008, 23(12): 3737-3743.
10. Kümpers P, Hafer C, Lukasz A, et al. Serum neutrophil gelatinase-associated lipocalin at inception of renal replacement therapy predicts survival in critically ill patients with acute kidney injury. Crit Care, 2010, 14(1): R9.
11. Han YC, Tu Y, Liu H, et al. Hospital-acquired acute kidney injury: an analysis of baseline estimated glomerular filtration rate and in-hospital mortality. J Nephrol, 2016, 29(3): 411-418.
12. Raucci R, Colonna G, Guerriero E, et al. Structural and functional studies of the human selenium binding protein-1 and its involvement in hepatocellular carcinoma. Biochim Biophys Acta, 2011, 1814(4): 513-522.
13. Lee EK, Shin YJ, Park EY, et al. Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity. Arch Toxicol, 2017, 91(4): 1635-1648.
14. Kim KS, Yang HY, Song H, et al. Identification of a sensitive urinary biomarker, selenium-binding protein 1, for early detection of acute kidney injury. J Toxicol Environ Health A, 2017, 80(9): 453-464.
15. Yang L, Xing G, Wang L, et al. Acute kidney injury in China: a cross-sectional survey. Lancet, 2015, 386(10002): 1465-1471.
16. 冯哲, 陈香美. 中国急性肾损伤的防治策略. 华西医学, 2018, 33(7): 777-781.
17. Iguchi H, Ikeda M, Kojo S. Early decreases in pulmonary, hepatic and renal glutathione levels in response to cadmium instillation into rat trachea. J Appl Toxicol, 1991, 11(3): 211-217.
18. Jeong JY, Wang Y, Sytkowski AJ. Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. Biochem Biophys Res Commun, 2009, 379(2): 583-588.
19. Porat A, Sagiv Y, Elazar Z. A 56-kDa selenium-binding protein participates in intra-Golgi protein transport. J Biol Chem, 2000, 275(19): 14457-14465.
20. Kohl JB, Mellis AT, Schwarz G. Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism. Br J Pharmacol, 2019, 176(4): 554-570.
21. Elhodaky M, Diamond AM. Selenium-binding protein 1 in human health and disease. Int J Mol Sci, 2018, 19(11): 3437.
22. Chau EJ, Mostaid MS, Cropley V, et al. Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 2018, 85: 1-6.
23. Wang J, Qu D, An J, et al. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Mol Med Rep, 2017, 16(6): 8735-8746.
24. Zhao W, Nikolic-Paterson DJ, Li K, et al. Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4. Chem Biol Interact, 2024, 393: 110944.

West China Medical Journal

Early warning value of selenium binding protein 1 on acute kidney injury and its risk factor exposure

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