Research progress on venous thromboembolism in patients with cerebral hemorrhage_West China Medical Journal

Authors：

YE Hongmin ,  GAN Xiuni

Department of Nursing, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400000, P. R. China;

Corresponding author：

GAN Xiuni, Email: 300650@cqmu.edu.cn

Keywords：

Cerebral hemorrhage; venous thromboembolism; risk factors; assessment tools; literature review

DOI：

10.7507/1002-0179.202407084

Video：

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Abstract Full text Figures/Tables Video References Cited by

Cerebral hemorrhage is a common clinical critical disease, and venous thromboembolism is one of its common complications. How to diagnose and treat venous thromboembolism early is still the main problem in the management of patients with cerebral hemorrhage. This article reviews the concept, pathogenesis, risk factors, evaluation tools, prevention and treatment of venous thromboembolism in patients with cerebral hemorrhage. Suggestions are put forward on the development of evaluation tools and improvement of prevention and treatment, in order to provide reference for clinical management and related research of patients with cerebral hemorrhage complicated with venous thromboembolism.

Citation： YE Hongmin, GAN Xiuni. Research progress on venous thromboembolism in patients with cerebral hemorrhage. West China Medical Journal, 2024, 39(12): 1958-1963. doi: 10.7507/1002-0179.202407084 Copy

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1. Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am, 2012, 30(3): 771-794.
2. Naidech AM. Intracranial hemorrhage. Am J Respir Crit Care Med, 2011, 184(9): 998-1006.
3. 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2019). 中华神经科杂志, 2019, 52(12): 994-1005.
4. 何菁, 王芳, 熊璐璐, 等. 脑卒中并发静脉血栓栓塞症的发生情况及危险因素分析. 四川大学学报(医学版), 2023, 54(3): 638-641.
5. 张萍. 神经重症患者危重病情的精准量化评估. 武汉: 华中科技大学, 2018.
6. Liu S, Wang Y, Gao B, et al. A nomogram for predicting venous thromboembolism in critically ill patients with primary intracerebral hemorrhage. World Neurosurg, 2022, 157: e301-e307.
7. Chu Q, Liao L, Wei W, et al. Venous thromboembolism in ICU patients with intracerebral hemorrhage: risk factors and the prognosis after anticoagulation therapy. Int J Gen Med, 2021, 14: 5397-5404.
8. 杜伟, 周辉, 魏新亭. AHA/ASA《自发性脑出血诊疗指南(2022 版)》解读. 中华神经医学杂志, 2023, 22(3): 217-221.
9. Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke Vasc Neurol, 2017, 2(1): 21-29.
10. van Asch CJ, Luitse MJ, Rinkel GJ, et al. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol, 2010, 9(2): 167-176.
11. 中华医学会呼吸病学分会肺栓塞与肺血管病学组, 中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会, 全国肺栓塞与肺血管病防治协作组. 肺血栓栓塞症诊治与预防指南. 中华医学杂志, 2018, 98(14): 1060-1087.
12. 倪莹莹, 王首红, 宋为群, 等. 神经重症康复中国专家共识(下). 中国康复医学杂志, 2018, 33(3): 264-268.
13. 中华医学会重症医学分会. 重症监护病房患者深静脉血栓形成预防指南. 中国危重病急救医学, 2009, 21(9): 514-517.
14. 陈颖. 危重症患者下肢深静脉血栓影响因素分析及风险预测模型构建. 青岛: 青岛大学, 2021.
15. 宫蓓蕾, 许启霞, 庞颖颖, 等. 静脉血栓栓塞症患者临床特征: 10 年 177 例病例分析. 中华危重病急救医学, 2019, 31(4): 453-457.
16. Malone PC, Agutter PS. The aetiology of deep venous thrombosis. QJM, 2006, 99(9): 581-593.
17. 高亮, 陈宋育. 美国神经重症学会预防神经重症患者静脉血栓栓塞指南的解读. 中华神经创伤外科电子杂志, 2016, 2(5): 261-270.
18. 袁春艳, 彭卫平, 邓娟娟. 脑出血老年患者术后发生静脉血栓栓塞的危险因素. 吉林医学, 2023, 44(7): 1985-1987.
19. Dong C, Li Y, Ma Z. Venous thromboembolism after spontaneous intracerebral hemorrhage and the status quo of anticoagulation in this population: a retrospective casecontrol study from a tertiary hospital in China. Clin Neurol Neurosurg, 2023, 231: 107839.
20. Miao L, Shi J, Yu H, et al. Studies on atrial fibrillation and venous thromboembolism in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer. J Am Heart Assoc, 2023, 12(17): e029810.
21. Melmed KR, Boehme A, Ironside N, et al. Respiratory and blood stream infections are associated with subsequent venous thromboembolism after primary intracerebral hemorrhage. Neurocrit Care, 2021, 34(1): 85-91.
22. 王荣荣, 周乾宇, 郭园丽, 等. 脑卒中患者静脉血栓栓塞症风险预测模型的构建及验证. 中华疾病控制杂志, 2023, 27(10): 1161-1166.
23. 石琼娅, 周立宇, 张娇, 等. 预测老年自发性脑出血患者深静脉血栓——基于 MIMIC-Ⅳ数据库回顾性分析. 临床神经外科杂志, 2023, 20(3): 327-331.
24. Koch V, Biener M, Müller-Hennessen M, et al. Diagnostic performance of D-dimer in predicting venous thromboembolism and acute aortic dissection. Eur Heart J Acute Cardiovasc Care, 2021, 10(5): 559-566.
25. Wolberg AS, Sang Y. Fibrinogen and factor XIII in venous thrombosis and thrombus stability. Arterioscler Thromb Vasc Biol, 2022, 42(8): 931-941.
26. Ding J, Yue X, Tian X, et al. Association between inflammatory biomarkers and venous thromboembolism: a systematic review and meta-analysis. Thromb J, 2023, 21(1): 82.
27. Wang G, Zhao W, Zhao Z, et al. Leukocyte as an independent predictor of lower-extremity deep venous thrombosis in elderly patients with primary intracerebral hemorrhage. Frontiers in Neurol, 2022, 13: 899849.
28. Spasić I, Ubavić M, Šumarac Z, et al. Influence of lipid metabolism disorders on venous thrombosis risk. J Med Biochem, 2021, 40(3): 245-251.
29. Ren W, Huang Q, Fan K, et al. Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke. Nutr Metab Cardiovasc Dis, 2021, 31(9): 2700-2706.
30. 汤厅均, 张翔, 耿保伟, 等. 脑出血术后下肢深静脉血栓形成的临床特点及危险因素. 血管与腔内血管外科杂志, 2023, 9(2): 250-253, 256.
31. Kelly J, Hunt BJ, Lewis RR, et al. Dehydration and venous thromboembolism after acute stroke. QJM, 2004, 97(5): 293-296.
32. 张红玲, 许佑冬, 刘正东. 急性脑出血患者 ICU 期间下肢深静脉血栓发生的危险因素分析. 中华神经医学杂志, 2020, 19(5): 488-492.
33. 林鸿辉, 田原卿. 脑出血患者在 ICU 期间下肢深静脉血栓形成的影响因素及中西医结合预防策略. 黑龙江医药, 2023, 36(3): 607-610.
34. Hallan DR, Simion C, Rizk E. Early versus late tracheostomy in spontaneous intracerebral hemorrhage. Cureus, 2022, 14(4): e24059.
35. 郝广志, 董玉书, 张冰莹, 等. 基于 LASSO-logistic 回归构建脑出血术后下肢静脉血栓的风险预测模型. 中华神经外科疾病研究杂志, 2024, 18(4): 1-6.
36. Benincasa G, Costa D, Infante T, et al. Interplay between genetics and epigenetics in modulating the risk of venous thromboembolism: a new challenge for personalized therapy. Thromb Res, 2019, 177: 145-153.
37. 姚漪婷. 静脉血栓栓塞症遗传特征分析. 广州: 广州医科大学, 2023.
38. 周佳, 严静, 李莉. 重症医学科患者深静脉血栓形成预防现状的研究进展. 中华重症医学电子杂志(网络版), 2020, 6(3): 314-317.
39. Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon, 2005, 51(2/3): 70-78.
40. 周鑫飞, 严静. 静脉血栓栓塞症风险评估模型在重症监护室中的应用. 心脑血管病防治, 2022, 22(6): 66-70.
41. 刘阳. Caprini 风险评估模型对高血压脑出血住院患者静脉血栓栓塞症的预测价值. 慢性病学杂志, 2022, 23(12): 1817-1820.
42. 张亚斌, 马丹, 李蕊, 等. 危重症患者静脉血栓栓塞症风险预测模型的研究进展. 中国护理管理, 2022, 22(7): 1116-1120.
43. Barbar S, Noventa F, Rossetto V, et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. J Thromb Haemost, 2010, 8(11): 2450-2457.
44. 李巍, 王莉莉. Padua 血栓评估模型对脑卒中患者静脉血栓栓塞症的评估价值. 中国现代神经疾病杂志, 2020, 20(8): 727-732.
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