Research progress of glucocorticoid therapy for delayed encephalopathy due to acute carbon monoxide poisoning_West China Medical Journal

Authors：

TANG Yu ¹ ,  ZENG Xianrong ^1,2

1. School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610056, P. R. China;
2. Department of Neurology (Hyperbaric Oxygen), Sichuan Academy of Medical Sciences-Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

ZENG Xianrong, Email: 570574804@qq.com

Keywords：

Delayed encephalopathy due to acute carbon monoxide poisoning; glucocorticoid; therapeutic mechanism; risk factor; research progress

DOI：

10.7507/1002-0179.202505046

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Abstract Full text Figures/Tables Video References Cited by

Delayed encephalopathy due to acute carbon monoxide poisoning (DEACMP) is a serious complication of acute carbon monoxide poisoning. Patients with DEACMP often present with cognitive impairment, abnormal mental behavior, extrapyramidal system symptoms, pyramidal system symptoms, and may also have focal cortical dysfunction, which is closely related to the poor prognosis of the patients. Current research shows that the occurrence of DEACMP is related to multiple factors such as immune disorders, and glucocorticoids can exert certain therapeutic effects through immunosuppression. This article reviews the risk factors of DEACMP, the clinical research progress and possible mechanisms of glucocorticoid treatment for DEACMP, providing more references for the clinical treatment of DEACMP.

Citation： TANG Yu, ZENG Xianrong. Research progress of glucocorticoid therapy for delayed encephalopathy due to acute carbon monoxide poisoning. West China Medical Journal, 2025, 40(9): 1518-1521. doi: 10.7507/1002-0179.202505046 Copy

1.
2.	Raub JA, Mathieu-Nolf M, Hampson NB, et al. Carbon monoxide poisoning--a public health perspective. Toxicology, 2000, 145(1): 1-14.
3.
4.
5.
6.	胡春妍. 急性一氧化碳中毒迟发性脑病危险因素的回顾性分析. 沈阳: 中国医科大学, 2024.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.	潘燕, 张保朝. 鞘内注入激素治疗急性一氧化碳中毒后迟发性脑病 63 例. 中国医学工程, 2010, 18(2): 61, 64.
20.
21.	高春锦, 葛环, 赵立明, 等. 一氧化碳中毒临床治疗指南(三). 中华航海医学与高气压医学杂志, 2013, 20(1): 72-74.
22.
23.
24.
25.
26.
27.
28.
29.	Ashcroft J, Fraser E, Krishnamoorthy S, et al. Carbon monoxide poisoning. BMJ, 2019, 365: l2299.Ashcroft J, Fraser E, Krishnamoorthy S, et al. Carbon monoxide poisoning. BMJ, 2019, 365: l2299.
30.	Du JJ, Liu ZQ, Yan Y, et alThe cannabinoid Win 55,212-2 reduces delayed neurologic sequelae after carbon monoxide poisoning by promoting microglial M2 polarization through ST2 signaling. J Mol Neurosci, 2020, 70(3): 422-432.Du JJ, Liu ZQ, Yan Y, et alThe cannabinoid Win 55,212-2 reduces delayed neurologic sequelae after carbon monoxide poisoning by promoting microglial M2 polarization through ST2 signaling. J Mol Neurosci, 2020, 70(3): 422-432.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.

1.
2. Raub JA, Mathieu-Nolf M, Hampson NB, et al. Carbon monoxide poisoning--a public health perspective. Toxicology, 2000, 145(1): 1-14.
3.
4.
5.
6. 胡春妍. 急性一氧化碳中毒迟发性脑病危险因素的回顾性分析. 沈阳: 中国医科大学, 2024.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19. 潘燕, 张保朝. 鞘内注入激素治疗急性一氧化碳中毒后迟发性脑病 63 例. 中国医学工程, 2010, 18(2): 61, 64.
20.
21. 高春锦, 葛环, 赵立明, 等. 一氧化碳中毒临床治疗指南(三). 中华航海医学与高气压医学杂志, 2013, 20(1): 72-74.
22.
23.
24.
25.
26.
27.
28.
29. Ashcroft J, Fraser E, Krishnamoorthy S, et al. Carbon monoxide poisoning. BMJ, 2019, 365: l2299.Ashcroft J, Fraser E, Krishnamoorthy S, et al. Carbon monoxide poisoning. BMJ, 2019, 365: l2299.
30. Du JJ, Liu ZQ, Yan Y, et alThe cannabinoid Win 55,212-2 reduces delayed neurologic sequelae after carbon monoxide poisoning by promoting microglial M2 polarization through ST2 signaling. J Mol Neurosci, 2020, 70(3): 422-432.Du JJ, Liu ZQ, Yan Y, et alThe cannabinoid Win 55,212-2 reduces delayed neurologic sequelae after carbon monoxide poisoning by promoting microglial M2 polarization through ST2 signaling. J Mol Neurosci, 2020, 70(3): 422-432.
31.
32.
33.
34.
35.
36.
37.
38.
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40.
41.
42.
43.

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