• 1. Department of Cardiovascular Medicine, Nanchang Jiangxi, 330006, P. R. China;
  • 2. Department of Burns Center, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P. R. China;
LIUDewu, Email: dewuliu@126.com
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Objective To review the role of microRNA (miRNA) in skin development and wound healing. Methods The recent literature about miRNA in skin development and wound healing was reviewed and analyzed. Results miRNA extensively involved in the development of the skin,including epidermal cell proliferation,differentiation,aging and hair follicle development;miR-203 known as the "skin-specific miRNA" can directly inhibit the expression of p63 and promote the differentiation of the epidermis.Meanwhile,miRNA also involved in various stages of skin regeneration and wound healing.Abnormal expression of miRNA is closely related with abnormal wound healing. Conclusion miRNA play an important role in maintaining normal skin physiology and skin regeneration.To explore their roles in the healing of skin wounds and their regulatory mechanism can provide a new target for the treatment,which has a potential value and broad prospects.

Citation: SONGZhifang, LIUDewu. ROLE OF microRNA IN SKIN DEVELOPMENT AND WOUND HEALING. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(7): 913-918. doi: 10.7507/1002-1892.20140200 Copy

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