- 1. Department of Cardiovascular Medicine, Nanchang Jiangxi, 330006, P. R. China;
- 2. Department of Burns Center, the First Affiliated Hospital of Nanchang University, Nanchang Jiangxi, 330006, P. R. China;
Citation: SONGZhifang, LIUDewu. ROLE OF microRNA IN SKIN DEVELOPMENT AND WOUND HEALING. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(7): 913-918. doi: 10.7507/1002-1892.20140200 Copy
1. | Botchkareva NV.MicroRNA/mRNA regulatory networks in the control of skin development and regeneration.Cell Cycle,2012,11(3):468-474. |
2. | Yi R,Fuchs E.MicroRNA-mediated control in the skin.Cell Death Differ,2010,17(2):229-235. |
3. | Bostjancic E,Glavac D.Importance of microRNAs in skin morphogenesis and diseases.Acta Dermatovenerol Alp Panonica Adriat,2008,17(3):95-102. |
4. | Xu L,Yang BF,Ai J.MicroRNA transport:a new way in cell communication.J Cell Physiol,2013,228(8):1713-1719. |
5. | Vera J,Lai X,Schmitz U,et al.MicroRNA-regulated networks:the perfect storm for classical molecular biology,the ideal scenario for systems biology.Adv Exp Med Biol,2013,774:55-76. |
6. | Finnegan EF,Pasquinelli AE.MicroRNA biogenesis:regulating the regulators.Crit Rev Biochem Mol Biol,2013,48(1):51-68. |
7. | Fabian MR,Sonenberg N.The mechanics of miRNA-mediated gene silencing:a look under the hood of miRISC.Nat Struct Mol Biol,2012,19(6):586-593. |
8. | Ul Hussain M.Micro-RNAs (miRNAs):genomic organisation,biogenesis and mode of action.Cell Tissue Res,2012,349(2):405-413. |
9. | Friedman RC,Farh KK,Burge CB,et al.Most mammalian mRNAs are conserved targets of microRNAs.Genome Res,2009,19(1):92-105. |
10. | Reczko M,Maragkakis M,Alexiou P,et al.Functional microRNA targets in protein coding sequences.Bioinformatics,2012,28(6):771-776. |
11. | Zhang R,Wang D,Xia Z,et al.The role of microRNAs in adipocyte differentiation.Front Med,2013,7(2):223-230. |
12. | Bernstein E,Kim SY,Carmell MA,et al.Dicer is essential for mouse development.Nat Genet,2003,35(3):215-217. |
13. | Wang Y,Medvid R,Melton C,et al.DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Nat Genet,2007,39(3):380-385. |
14. | Yi R,Pasolli HA,Landthaler M,et al.DGCR8-dependent microRNA biogenesis is essential for skin development.Proc Natl Acad Sci U S A,2009,106(2):498-502. |
15. | Andl T,Murchison EP,Liu F,et al.The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.Curr Biol,2006,16(10):1041-1049. |
16. | Ning MS,Andl T.Control by a hair's breadth:the role of microRNAs in the skin.Cell Mol Life Sci,2013,70(7):1149-1169. |
17. | Sonkoly E,Wei T,Janson PC,et al.MicroRNAs:novel regulators involved in the pathogenesis of psoriasis? PLoS One,2007,2(7):e610. |
18. | Yi R,Poy MN,Stoffel M,et al.A skin microRNA promotes differentiation by repressing ‘stemness’.Nature,2008,452(7184):225-229. |
19. | Wienholds E,Kloosterman WP,Miska E,et al.MicroRNA expression in zebrafish embryonic development.Science,2005,309(5732):310-311. |
20. | Wei T,Orfanidis K,Xu N,et al.The expression of microRNA-203 during human skin morphogenesis.Exp Dermatol,2010,19(9):854-856. |
21. | McKenna DJ,McDade SS,Patel D,et al.MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.J Virol,2010,84(20):10644-10652. |
22. | Sonkoly E,Wei T,Pavez Loriè E,et al.Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes.J Invest Dermatol,2010,130(1):124-134. |
23. | Lena AM,Shalom-Feuerstein R,Rivetti Di Val Cervo P,et al.miR-203 represses ‘stemness’ by repressing DeltaNp63.Cell Death Differ,2008,15(7):1187-1195. |
24. | Suzuki D,Senoo M.Increased p63 phosphorylation marks early transition of epidermal stem cells to progenitors.J Invest Dermatol,2012,132(10):2461-2464. |
25. | Jackson SJ,Zhang Z,Feng D,et al.Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation.Development,2013,140(9):1882-1891. |
26. | Chikh A,Matin RN,Senatore V,et al.iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.EMBO J,2011,30(20):4261-4273. |
27. | Antonini D,Russo MT,De Rosa L,et al.Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells.J Invest Dermatol,2010,130(5):1249-1257. |
28. | Su X,Chakravarti D,Cho MS,et al.TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.Nature,2010,467(7318):986-990. |
29. | Zhang L,Stokes N,Polak L,et al.Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment.Cell Stem Cell,2011,8(3):294-308. |
30. | Giglio S,Cirombella R,Amodeo R,et al.MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.J Cell Physiol,2013,228(10):2015-2023. |
31. | Wang X,Tredget EE,Wu Y.Dynamic signals for hair follicle development and regeneration.Stem Cells Dev,2012,21(1):7-18. |
32. | Mardaryev AN,Ahmed MI,Vlahov NV,et al.Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle.FASEB J,2010,24(10):3869-3881. |
33. | Peng H,Kaplan N,Hamanaka RB,et al.microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation.Proc Natl Sci U S A,2012,109(35):14030-14034. |
34. | Shin KH,Pucar A,Kim RH,et al.Identification of senescence-inducing microRNAs in normal human keratinocytes.Int J Oncol,2011,39(5):1205-1211. |
35. | Lena AM,Mancini M,Rivetti di Val Cervo P,et al.MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation.Biochem Biophys Res Commun,2012,423(3):509-514. |
36. | Lee YS,Wysocki A,Warburton D,et al.Wound healing in development.Birth Defects Res C Embryo Today,2012,96(3):213-222. |
37. | Roy S,Sen CK.miRNA in wound inflammation and angiogenesis.Microcirculation,2012,19(3):224-232. |
38. | Schulte LN,Westermann AJ,Vogel J.Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing.Nucleic Acids Res,2013,41(1):542-553. |
39. | Olivieri F,Spazzafumo L,Santini G,et al.Age-related differences in the expression of circulating microRNAs:miR-21 as a new circulating marker of inflammating.Mech Ageing Dev,2012,133(11-12):675-685. |
40. | Tili E,Michaille JJ,Cimino A,et al.Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock.J Immunol,2007,179(8):5082-5089. |
41. | DiPietro LA.Angiogenesis and scar formation in healing wounds.Curr Opin Rheumatol,2013,25(1):87-91. |
42. | Caporali A,Emanueli C.MicroRNA regulation in angiogenesis.Vascul Pharmacol,2011,55(4):79-86. |
43. | Yang WJ,Yang DD,Na S,et al.Dicer is required for embryonic angiogenesis during mouse development.J Biol Chem,2005,280(10):9330-9335. |
44. | Fiedler J,Thum T.MicroRNAs looping around angiogenesis.Arterioscler Thromb Vasc Biol,2011,31(11):2367-2368. |
45. | Chen JJ,Zhou SH.Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway.Cardiol J,2011,18(6):675-681. |
46. | Chen Y,Gorski DH.Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5.Blood,2008,111(3):1217-1226. |
47. | Pulkkinen K,Malm T,Turunen M,et al.Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.FEBS Lett,2008,582(16):2397-2401. |
48. | Fasanaro P,D'Alessandra Y,Di Stefano V,et al.MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.J Biol Chem,2008,283(23):15878-15883. |
49. | Langenkamp E,Zwiers PJ,Moorlag HE,et al.Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.Anticancer Drugs,2012,23(2):161-172. |
50. | Chen LT,Xu SD,Xu H,et al.MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration,invasion and tumor angiogenesis.Med Oncol,2012,29(3):1673-1680. |
51. | Ando H,Okamoto A,Yokota M,et al.Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy.J Gene Med,2013,15(1):20-27. |
52. | Ohyagi-Hara C,Sawada K,Kamiura S,et al.miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.Am J Pathol,2013,182(5):1876-1889. |
53. | Doebele C,Bonauer A,Fischer A,et al.Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.Blood,2010,115(23):4944-4950. |
54. | Roy S,Sen CK.miRNA in wound inflammation and angiogenesis.Microcirculation,2012,19(3):224-232. |
55. | Wang XH,Qian RZ,Zhang W,et al.MicroRNA-320 expression in myocardial microvascular endothelial cellsand its relationship with insulin-like growth factor-1 in type 2 diabetic rats.Clin Exp Pharmacol Physiol,2009,36(2):181-188. |
56. | Patella F,Rainaldi G.MicroRNAs mediate metabolic stresses and angiogenesis.Cell Mol Life Sci,2012,69(7):1049-1065. |
57. | Shibata S,Tada Y,Asano Y,et al.Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.J Immunol,2012,189(6):3231-3241. |
58. | Yu J,Peng H,Ruan Q,et al.MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2.FASEB J,2010,24(10):3950-3959. |
59. | Yu J,Ryan DG,Getsios S,et al.MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia.Proc Natl Acad Sci U S A,2008,105(49):19300-19305. |
60. | Biswas S,Roy S,Banerjee J,et al.Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds.Proc Natl Acad Sci U S A,2010,107(15):6976-6981. |
61. | Fasanaro P,Greco S,Lorenzi M,et al.An integrated approach for experimental target identification of hypoxia-induced miR-210.J Biol Chem,2009,284(50):35134-35143. |
62. | Yang X,Wang J,Guo SL,et al.miR-21 promotes keratinocyte migration and re-epithelialization during wound healing.Int J Biol Sci,2011,7(5):685-690. |
63. | Larson BJ,Longaker MT,Lorenz HP.Scarless fetal wound healing:a basic science review.Plast Reconstr Surg,2010,126(4):1172-1180. |
64. | Leung A,Crombleholme TM,Keswani SG.Fetal wound healing:implications for minimal scar formation.Curr Opin Pediatr,2012,24(3):371-378. |
65. | Cheng J,Yu H,Deng S,et al.MicroRNA profiling in mid- and late-gestational fetal skin:implication for scarless wound healing.Tohoku J Exp Med,2010,221(3):203-209. |
66. | Li Z,Hassan MQ,Jafferji M,et al.Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.J Biol Chem,2009,284(23):15676-15684. |
67. | Kato M,Zhang J,Wang M,et al.MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.Proc Natl Acad Sci U S A,2007,104(9):3432-3437. |
68. | Maurer B,Stanczyk J,Jüngel A,et al.MicroRNA-29,a key regulator of collagen expression in systemic sclerosis.Arthritis Rheum,2010,62(6):1733-1743. |
69. | Kashiyama K,Mitsutake N,Matsuse M,et al.miR-196a downregulation increases the expression of type I and Ⅲ collagens in keloid fibroblasts.J Invest Dermatol,2012,132(6):1597-1604. |
70. | Bertero T,Gastaldi C,Bourget-Ponzio I,et al.miR-483-3p controls proliferation in wounded epithelial cells.FASEB J,2011,25(9):3092-3105. |
- 1. Botchkareva NV.MicroRNA/mRNA regulatory networks in the control of skin development and regeneration.Cell Cycle,2012,11(3):468-474.
- 2. Yi R,Fuchs E.MicroRNA-mediated control in the skin.Cell Death Differ,2010,17(2):229-235.
- 3. Bostjancic E,Glavac D.Importance of microRNAs in skin morphogenesis and diseases.Acta Dermatovenerol Alp Panonica Adriat,2008,17(3):95-102.
- 4. Xu L,Yang BF,Ai J.MicroRNA transport:a new way in cell communication.J Cell Physiol,2013,228(8):1713-1719.
- 5. Vera J,Lai X,Schmitz U,et al.MicroRNA-regulated networks:the perfect storm for classical molecular biology,the ideal scenario for systems biology.Adv Exp Med Biol,2013,774:55-76.
- 6. Finnegan EF,Pasquinelli AE.MicroRNA biogenesis:regulating the regulators.Crit Rev Biochem Mol Biol,2013,48(1):51-68.
- 7. Fabian MR,Sonenberg N.The mechanics of miRNA-mediated gene silencing:a look under the hood of miRISC.Nat Struct Mol Biol,2012,19(6):586-593.
- 8. Ul Hussain M.Micro-RNAs (miRNAs):genomic organisation,biogenesis and mode of action.Cell Tissue Res,2012,349(2):405-413.
- 9. Friedman RC,Farh KK,Burge CB,et al.Most mammalian mRNAs are conserved targets of microRNAs.Genome Res,2009,19(1):92-105.
- 10. Reczko M,Maragkakis M,Alexiou P,et al.Functional microRNA targets in protein coding sequences.Bioinformatics,2012,28(6):771-776.
- 11. Zhang R,Wang D,Xia Z,et al.The role of microRNAs in adipocyte differentiation.Front Med,2013,7(2):223-230.
- 12. Bernstein E,Kim SY,Carmell MA,et al.Dicer is essential for mouse development.Nat Genet,2003,35(3):215-217.
- 13. Wang Y,Medvid R,Melton C,et al.DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Nat Genet,2007,39(3):380-385.
- 14. Yi R,Pasolli HA,Landthaler M,et al.DGCR8-dependent microRNA biogenesis is essential for skin development.Proc Natl Acad Sci U S A,2009,106(2):498-502.
- 15. Andl T,Murchison EP,Liu F,et al.The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.Curr Biol,2006,16(10):1041-1049.
- 16. Ning MS,Andl T.Control by a hair's breadth:the role of microRNAs in the skin.Cell Mol Life Sci,2013,70(7):1149-1169.
- 17. Sonkoly E,Wei T,Janson PC,et al.MicroRNAs:novel regulators involved in the pathogenesis of psoriasis? PLoS One,2007,2(7):e610.
- 18. Yi R,Poy MN,Stoffel M,et al.A skin microRNA promotes differentiation by repressing ‘stemness’.Nature,2008,452(7184):225-229.
- 19. Wienholds E,Kloosterman WP,Miska E,et al.MicroRNA expression in zebrafish embryonic development.Science,2005,309(5732):310-311.
- 20. Wei T,Orfanidis K,Xu N,et al.The expression of microRNA-203 during human skin morphogenesis.Exp Dermatol,2010,19(9):854-856.
- 21. McKenna DJ,McDade SS,Patel D,et al.MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.J Virol,2010,84(20):10644-10652.
- 22. Sonkoly E,Wei T,Pavez Loriè E,et al.Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes.J Invest Dermatol,2010,130(1):124-134.
- 23. Lena AM,Shalom-Feuerstein R,Rivetti Di Val Cervo P,et al.miR-203 represses ‘stemness’ by repressing DeltaNp63.Cell Death Differ,2008,15(7):1187-1195.
- 24. Suzuki D,Senoo M.Increased p63 phosphorylation marks early transition of epidermal stem cells to progenitors.J Invest Dermatol,2012,132(10):2461-2464.
- 25. Jackson SJ,Zhang Z,Feng D,et al.Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation.Development,2013,140(9):1882-1891.
- 26. Chikh A,Matin RN,Senatore V,et al.iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.EMBO J,2011,30(20):4261-4273.
- 27. Antonini D,Russo MT,De Rosa L,et al.Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells.J Invest Dermatol,2010,130(5):1249-1257.
- 28. Su X,Chakravarti D,Cho MS,et al.TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs.Nature,2010,467(7318):986-990.
- 29. Zhang L,Stokes N,Polak L,et al.Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment.Cell Stem Cell,2011,8(3):294-308.
- 30. Giglio S,Cirombella R,Amodeo R,et al.MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.J Cell Physiol,2013,228(10):2015-2023.
- 31. Wang X,Tredget EE,Wu Y.Dynamic signals for hair follicle development and regeneration.Stem Cells Dev,2012,21(1):7-18.
- 32. Mardaryev AN,Ahmed MI,Vlahov NV,et al.Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle.FASEB J,2010,24(10):3869-3881.
- 33. Peng H,Kaplan N,Hamanaka RB,et al.microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation.Proc Natl Sci U S A,2012,109(35):14030-14034.
- 34. Shin KH,Pucar A,Kim RH,et al.Identification of senescence-inducing microRNAs in normal human keratinocytes.Int J Oncol,2011,39(5):1205-1211.
- 35. Lena AM,Mancini M,Rivetti di Val Cervo P,et al.MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation.Biochem Biophys Res Commun,2012,423(3):509-514.
- 36. Lee YS,Wysocki A,Warburton D,et al.Wound healing in development.Birth Defects Res C Embryo Today,2012,96(3):213-222.
- 37. Roy S,Sen CK.miRNA in wound inflammation and angiogenesis.Microcirculation,2012,19(3):224-232.
- 38. Schulte LN,Westermann AJ,Vogel J.Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing.Nucleic Acids Res,2013,41(1):542-553.
- 39. Olivieri F,Spazzafumo L,Santini G,et al.Age-related differences in the expression of circulating microRNAs:miR-21 as a new circulating marker of inflammating.Mech Ageing Dev,2012,133(11-12):675-685.
- 40. Tili E,Michaille JJ,Cimino A,et al.Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock.J Immunol,2007,179(8):5082-5089.
- 41. DiPietro LA.Angiogenesis and scar formation in healing wounds.Curr Opin Rheumatol,2013,25(1):87-91.
- 42. Caporali A,Emanueli C.MicroRNA regulation in angiogenesis.Vascul Pharmacol,2011,55(4):79-86.
- 43. Yang WJ,Yang DD,Na S,et al.Dicer is required for embryonic angiogenesis during mouse development.J Biol Chem,2005,280(10):9330-9335.
- 44. Fiedler J,Thum T.MicroRNAs looping around angiogenesis.Arterioscler Thromb Vasc Biol,2011,31(11):2367-2368.
- 45. Chen JJ,Zhou SH.Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway.Cardiol J,2011,18(6):675-681.
- 46. Chen Y,Gorski DH.Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5.Blood,2008,111(3):1217-1226.
- 47. Pulkkinen K,Malm T,Turunen M,et al.Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.FEBS Lett,2008,582(16):2397-2401.
- 48. Fasanaro P,D'Alessandra Y,Di Stefano V,et al.MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3.J Biol Chem,2008,283(23):15878-15883.
- 49. Langenkamp E,Zwiers PJ,Moorlag HE,et al.Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.Anticancer Drugs,2012,23(2):161-172.
- 50. Chen LT,Xu SD,Xu H,et al.MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration,invasion and tumor angiogenesis.Med Oncol,2012,29(3):1673-1680.
- 51. Ando H,Okamoto A,Yokota M,et al.Development of a miR-92a delivery system for anti-angiogenesis-based cancer therapy.J Gene Med,2013,15(1):20-27.
- 52. Ohyagi-Hara C,Sawada K,Kamiura S,et al.miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.Am J Pathol,2013,182(5):1876-1889.
- 53. Doebele C,Bonauer A,Fischer A,et al.Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.Blood,2010,115(23):4944-4950.
- 54. Roy S,Sen CK.miRNA in wound inflammation and angiogenesis.Microcirculation,2012,19(3):224-232.
- 55. Wang XH,Qian RZ,Zhang W,et al.MicroRNA-320 expression in myocardial microvascular endothelial cellsand its relationship with insulin-like growth factor-1 in type 2 diabetic rats.Clin Exp Pharmacol Physiol,2009,36(2):181-188.
- 56. Patella F,Rainaldi G.MicroRNAs mediate metabolic stresses and angiogenesis.Cell Mol Life Sci,2012,69(7):1049-1065.
- 57. Shibata S,Tada Y,Asano Y,et al.Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.J Immunol,2012,189(6):3231-3241.
- 58. Yu J,Peng H,Ruan Q,et al.MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2.FASEB J,2010,24(10):3950-3959.
- 59. Yu J,Ryan DG,Getsios S,et al.MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia.Proc Natl Acad Sci U S A,2008,105(49):19300-19305.
- 60. Biswas S,Roy S,Banerjee J,et al.Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds.Proc Natl Acad Sci U S A,2010,107(15):6976-6981.
- 61. Fasanaro P,Greco S,Lorenzi M,et al.An integrated approach for experimental target identification of hypoxia-induced miR-210.J Biol Chem,2009,284(50):35134-35143.
- 62. Yang X,Wang J,Guo SL,et al.miR-21 promotes keratinocyte migration and re-epithelialization during wound healing.Int J Biol Sci,2011,7(5):685-690.
- 63. Larson BJ,Longaker MT,Lorenz HP.Scarless fetal wound healing:a basic science review.Plast Reconstr Surg,2010,126(4):1172-1180.
- 64. Leung A,Crombleholme TM,Keswani SG.Fetal wound healing:implications for minimal scar formation.Curr Opin Pediatr,2012,24(3):371-378.
- 65. Cheng J,Yu H,Deng S,et al.MicroRNA profiling in mid- and late-gestational fetal skin:implication for scarless wound healing.Tohoku J Exp Med,2010,221(3):203-209.
- 66. Li Z,Hassan MQ,Jafferji M,et al.Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.J Biol Chem,2009,284(23):15676-15684.
- 67. Kato M,Zhang J,Wang M,et al.MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.Proc Natl Acad Sci U S A,2007,104(9):3432-3437.
- 68. Maurer B,Stanczyk J,Jüngel A,et al.MicroRNA-29,a key regulator of collagen expression in systemic sclerosis.Arthritis Rheum,2010,62(6):1733-1743.
- 69. Kashiyama K,Mitsutake N,Matsuse M,et al.miR-196a downregulation increases the expression of type I and Ⅲ collagens in keloid fibroblasts.J Invest Dermatol,2012,132(6):1597-1604.
- 70. Bertero T,Gastaldi C,Bourget-Ponzio I,et al.miR-483-3p controls proliferation in wounded epithelial cells.FASEB J,2011,25(9):3092-3105.
-
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