RESEARCH PROGRESS OF IN VIVO BIOREACTOR AS VASCULARIZATION STRATEGIES IN BONE TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANGHaifeng ,  HANDong

Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Medical School of Shanghai Jiaotong University, Shanghai, 200011, P. R. China;

Corresponding author：

HANDong, Email: handong12000@163.com

Keywords：

Bone tissue engineering; In vivo bioreactor; Vascularization; Bone defect

DOI：

10.7507/1002-1892.20140253

Video：

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Objective To review the application and research progress of in vivo bioreactor as vascularization strategies in bone tissue engineering. Methods The original articles about in vivo bioreactor that can enhance vascularization of tissue engineered bone were extensively reviewed and analyzed. Results The in vivo bioreactor can be created by periosteum, muscle, muscularis membrane, and fascia flap as well as biomaterials. Using in vivo bioreactor can effectively promote the establishment of a microcirculation in the tissue engineered bones, especially for large bone defects. However, main correlative researches, currently, are focused on animal experiments, more clinical trials will be carried out in the future. Conclusion With the rapid development of related technologies of bone tissue engineering, the use of in vivo bioreactor will to a large extent solve the bottleneck limitations and has the potential values for clinical application.

Citation： ZHANGHaifeng, HANDong. RESEARCH PROGRESS OF IN VIVO BIOREACTOR AS VASCULARIZATION STRATEGIES IN BONE TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(9): 1173-1176. doi: 10.7507/1002-1892.20140253 Copy

1.	Goldstein AS, Juarez TM, Helmke CD, et al.Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds.Biomaterials, 2001, 22(11):1279-1288.
2.	Carmeliet P, Jain RK.Angiogenesis in cancer and other diseases.Nature, 2000, 407(6801):249-257.
3.	Lee K, Chan CK, Patil N, et al.Cell therapy for bone regeneration-bench to bedside.J Biomed Mater Res B Appl Biomater, 2009, 89(1):252-263.
4.	Laschke MW, Menger MD.Vascularization in tissue engineering:angiogenesis versus inosculation.Eur Surg Res, 2012, 48(2):85-92.
5.	Lovett M, Lee K, Edwards A, et al.Vascularization strategies for tissue engineering.Tissue Eng Part B Rev, 2009, 15(3):353-370.
6.	Rouwkema J, Rivron NC, van Blitterswijk CA.Vascularization in tissue engineering.Trends Biotechnol, 2008, 26(8):434-441.
7.	Han D, Dai K.Prefabrication of a vascularized bone graft with Beta tricalcium phosphate using an in vivo bioreactor.Artif Organs, 2013, 37(10):884-893.
8.	Holt GE, Halpern JL, Dovan TT, et al.Evolution of an in vivo bioreactor.J Orthop Res, 2005, 23(4):916-923.
9.	Patel PA, Chen W, Wilkening MW, et al.Extended composite temporoparietal fascial flap:clinical implications for tissue engineering in mandibular reconstruction.J Craniofac Surg, 2013, 24(1):273-277.
10.	Han D, Guan X, Wang J, et al.Rabbit tibial periosteum and saphenous arteriovenous vascular bundle as an in vivo bioreactor to construct vascularized tissue-engineered bone:a feasibility study.Artif Organs, 2014, 38(2):167-174.
11.	Stevens MM, Marini RP, Schaefer D, et al.In vivo engineering of organs:the bone bioreactor.Proc Natl Acad Sci U S A, 2005, 102(32):11450-11455.
12.	Service RF.Tissue engineering.Technique uses body as 'bioreactor' to grow new bone.Science, 2005, 309(5735):683.
13.	Ferretti C, Ripamonti U, Tsiridis E, et al.Osteoinduction:translating preclinical promise into clinical reality.Br J Oral Maxillofac Surg, 2010, 48(7):536-539.
14.	Terheyden H, Warnke P, Dunsche A, et al.Mandibular reconstruction with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1:an experimental study in miniature pigs.Part Ⅱ:transplantation.Int J Oral Maxillofac Surg, 2001, 30(6):469-478.
15.	Casabona F, Martin I, Muraglia A, et al.Prefabricated engineered bone flaps:an experimental model of tissue reconstruction in plastic surgery.Plast Reconstr Surg, 1998, 101(3):577-581.
16.	Kokemueller H, Spalthoff S, Nolff M, et al.Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction:experimental pilot study in sheep and first clinical application.Int J Oral Maxillofac Surg, 2010, 39(4):379-387.
17.	Kokemüller H, Jehn P, Spalthoff S, et al.En bloc prefabrication of vascularized bioartificial bone grafts in sheep and complete workflow for custom-made transplants.Int J Oral Maxillofac Surg, 2014, 43(2):163-172.
18.	Terheyden H, Knak C, Jepsen S, et al.Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1:an experimental study in miniature pigs.Part I:Prefabrication.Int J Oral Maxillofac Surg, 2001, 30(5):373-379.
19.	Terheyden H, Jepsen JS, Rueger DR.Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1:a preliminary study.Int J Oral Maxillofac Surg, 1999, 28(6):461-463.
20.	Warnke PH, Springer IN, Wiltfang J, et al.Growth and transplantation of a custom vascularised bone graft in a man.Lancet, 2004, 364(9436):766-770.
21.	Warnke PH, Wiltfang J, Springer I, et al.Man as living bioreactor:fate of an exogenously prepared customized tissue-engineered mandible.Biomaterials, 2006, 27(17):3163-3167.
22.	Heliotis M, Lavery KM, Ripamonti U, et al.Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest.Int J Oral Maxillofac Surg, 2006, 35(3):265-269.
23.	MacArthur BD, Oreffo RO.Bridging the gap.Nature, 2005, 433(7021):19.
24.	陈滨, 裴国献, 王珂, 等.筋膜瓣促组织工程骨体内再血管化的实验研究.解放军医学杂志, 2002, 27(6):482-484.
25.	王耀一, 杨新明, 胡振顺, 等.带蒂筋膜瓣促非细胞型组织工程化骨血管化及其成骨的组织学变化.中国组织工程研究, 2012, 16(15):2674-2680.
26.	金丹, 陈滨, 裴国献, 等.筋膜瓣促组织工程骨再血管化及山羊长段骨缺损的修复.中华实验外科杂志, 2005, 22(3):269-271.
27.	Mizumoto S, Inada Y, Weiland AJ.Fabrication of vascularized bone grafts using ceramic chambers.J Reconstr Microsurg, 1993, 9(6):441-449.
28.	Tomin EA, Cunningham ME, Vergun-Cuomo A, et al.Molded vascularized neo-ossicle formation in silicone chambers.Clin Orthop Relat Res, 2007, (465):249-256.
29.	Salgado AJ, Coutinho OP, Reis RL.Bone tissue engineering:state of the art and future trends.Macromol Biosci, 2004, 4(8):743-765.

1. Goldstein AS, Juarez TM, Helmke CD, et al.Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds.Biomaterials, 2001, 22(11):1279-1288.
2. Carmeliet P, Jain RK.Angiogenesis in cancer and other diseases.Nature, 2000, 407(6801):249-257.
3. Lee K, Chan CK, Patil N, et al.Cell therapy for bone regeneration-bench to bedside.J Biomed Mater Res B Appl Biomater, 2009, 89(1):252-263.
4. Laschke MW, Menger MD.Vascularization in tissue engineering:angiogenesis versus inosculation.Eur Surg Res, 2012, 48(2):85-92.
5. Lovett M, Lee K, Edwards A, et al.Vascularization strategies for tissue engineering.Tissue Eng Part B Rev, 2009, 15(3):353-370.
6. Rouwkema J, Rivron NC, van Blitterswijk CA.Vascularization in tissue engineering.Trends Biotechnol, 2008, 26(8):434-441.
7. Han D, Dai K.Prefabrication of a vascularized bone graft with Beta tricalcium phosphate using an in vivo bioreactor.Artif Organs, 2013, 37(10):884-893.
8. Holt GE, Halpern JL, Dovan TT, et al.Evolution of an in vivo bioreactor.J Orthop Res, 2005, 23(4):916-923.
9. Patel PA, Chen W, Wilkening MW, et al.Extended composite temporoparietal fascial flap:clinical implications for tissue engineering in mandibular reconstruction.J Craniofac Surg, 2013, 24(1):273-277.
10. Han D, Guan X, Wang J, et al.Rabbit tibial periosteum and saphenous arteriovenous vascular bundle as an in vivo bioreactor to construct vascularized tissue-engineered bone:a feasibility study.Artif Organs, 2014, 38(2):167-174.
11. Stevens MM, Marini RP, Schaefer D, et al.In vivo engineering of organs:the bone bioreactor.Proc Natl Acad Sci U S A, 2005, 102(32):11450-11455.
12. Service RF.Tissue engineering.Technique uses body as 'bioreactor' to grow new bone.Science, 2005, 309(5735):683.
13. Ferretti C, Ripamonti U, Tsiridis E, et al.Osteoinduction:translating preclinical promise into clinical reality.Br J Oral Maxillofac Surg, 2010, 48(7):536-539.
14. Terheyden H, Warnke P, Dunsche A, et al.Mandibular reconstruction with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1:an experimental study in miniature pigs.Part Ⅱ:transplantation.Int J Oral Maxillofac Surg, 2001, 30(6):469-478.
15. Casabona F, Martin I, Muraglia A, et al.Prefabricated engineered bone flaps:an experimental model of tissue reconstruction in plastic surgery.Plast Reconstr Surg, 1998, 101(3):577-581.
16. Kokemueller H, Spalthoff S, Nolff M, et al.Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction:experimental pilot study in sheep and first clinical application.Int J Oral Maxillofac Surg, 2010, 39(4):379-387.
17. Kokemüller H, Jehn P, Spalthoff S, et al.En bloc prefabrication of vascularized bioartificial bone grafts in sheep and complete workflow for custom-made transplants.Int J Oral Maxillofac Surg, 2014, 43(2):163-172.
18. Terheyden H, Knak C, Jepsen S, et al.Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1:an experimental study in miniature pigs.Part I:Prefabrication.Int J Oral Maxillofac Surg, 2001, 30(5):373-379.
19. Terheyden H, Jepsen JS, Rueger DR.Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1:a preliminary study.Int J Oral Maxillofac Surg, 1999, 28(6):461-463.
20. Warnke PH, Springer IN, Wiltfang J, et al.Growth and transplantation of a custom vascularised bone graft in a man.Lancet, 2004, 364(9436):766-770.
21. Warnke PH, Wiltfang J, Springer I, et al.Man as living bioreactor:fate of an exogenously prepared customized tissue-engineered mandible.Biomaterials, 2006, 27(17):3163-3167.
22. Heliotis M, Lavery KM, Ripamonti U, et al.Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest.Int J Oral Maxillofac Surg, 2006, 35(3):265-269.
23. MacArthur BD, Oreffo RO.Bridging the gap.Nature, 2005, 433(7021):19.
24. 陈滨, 裴国献, 王珂, 等.筋膜瓣促组织工程骨体内再血管化的实验研究.解放军医学杂志, 2002, 27(6):482-484.
25. 王耀一, 杨新明, 胡振顺, 等.带蒂筋膜瓣促非细胞型组织工程化骨血管化及其成骨的组织学变化.中国组织工程研究, 2012, 16(15):2674-2680.
26. 金丹, 陈滨, 裴国献, 等.筋膜瓣促组织工程骨再血管化及山羊长段骨缺损的修复.中华实验外科杂志, 2005, 22(3):269-271.
27. Mizumoto S, Inada Y, Weiland AJ.Fabrication of vascularized bone grafts using ceramic chambers.J Reconstr Microsurg, 1993, 9(6):441-449.
28. Tomin EA, Cunningham ME, Vergun-Cuomo A, et al.Molded vascularized neo-ossicle formation in silicone chambers.Clin Orthop Relat Res, 2007, (465):249-256.
29. Salgado AJ, Coutinho OP, Reis RL.Bone tissue engineering:state of the art and future trends.Macromol Biosci, 2004, 4(8):743-765.

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