DEVELOPMENT RESEARCH OF BIOLOGICAL DRESSING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANGJinfeng ¹ , HAOJianbo ² , ZHANGJinpeng ³ ,  LUOBo ¹ , LIUPeng ¹

1. Department of Surgery, Songshan Hospital of Qingdao University, Qingdao Shandong, 266021, P.R.China;;
2. Department of Surgery, the Central Hospital of Qingdao;
3. Department of Rehabilitation, Shanghai Hudong Hospital;

Corresponding author：

LUOBo, Email: 135gongying@163.com

Keywords：

Biological dressing; Alginate; Chitosan; Wound healing

DOI：

10.7507/1002-1892.20150053

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To review the research progress of modern biological dressings. Methods The related literature at home and abroad was reviewed, analyzed, and summarized in the progress of biological dressing situation and various types of biological dressing research. Results Compared with the traditional dressing, the biological dressing can greatly promote wound healing. Biological dressings are mainly divided into the natural materials, artificial synthetic materials, and drug loaded dressings. The natural material dressings are mainly the alginate dressing, this kind of dressing can promote wound healing, which has been confirmed by a large number of studies. The artificial synthetic materials include film dressings, liquid, water colloids, gels, and foam, each has its own advantages and disadvantages, which can be chosen according to need. The drug dressing can play the role of drug loading, and further promote the wound healing; using microcapsule technology to construct the dressing and choosing Chinese medicine as drugs is the research direction of load. Conclusion The experiment and clinical application of biological dressing are many types, clinical application prospect is wide, but each has its own advantages and disadvantages, further study is needed to improve its efficacy.

Citation： ZHANGJinfeng, HAOJianbo, ZHANGJinpeng, LUOBo, LIUPeng. DEVELOPMENT RESEARCH OF BIOLOGICAL DRESSING. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(2): 254-259. doi: 10.7507/1002-1892.20150053 Copy

1.	Martin C, Low WL, Amin MC, et al. Current trends in the development of wound dressings, biomaterials and devices. Pharm Pat Anal, 2013, 2(3):341-359.
2.	Woo KY, Keast D, Parsons N, et al. The cost of wound debridement:a Canadian perspective. Int Wound J, 2013.[Epub ahead of print].
3.	Rivadeneira J, Di Virgilio AL, Audisio M, et al. Evaluation of antibacterial and cytotoxic effects of nano-sized bioactive glass/collagen composites releasing tetracycline hydrochloride. J Appl Microbiol, 2014, 116(6):1438-1446.
4.	Gillespie BM, Chaboyer W, Allen P, et al. Wound care practices:a survey of acute care nurses. J Clin Nurs, 2014, 23(17/18):2618-2627.
5.	Lin YH, Lin JH, Wang SH, et al. Evaluation of silver-containing activated Carbon fiber for wound healing study:In vitro and in vivo. J Biomed Mater Res B Appl Biomater, 2012, 100B(8):2288-2296.
6.	Field CK, Kerstein MD. Overview of wound healing in a moist environment. Am J Surg, 1994, 167(1 Suppl):S2-S6.
7.	沈娟, 金小宝, 丁静, 等. 非促分裂型人酸性成纤维细胞生长因子促小鼠烫伤愈合的研究. 中国生物工程杂志, 2013, 33(3):68-73.
8.	Mouës C, Heule F, Hovius SE. A review of topical negative pressure therapy in wound healing:sufficient evidence? Am J Surg, 2011, 201(4):544-556.
9.	Kamolz LP, Wild T. Wound bed preparation:The impact of debridement and wound cleansing. Wound Medicine, 2013, 1:44-50.
10.	代明盛, 王李云, 沈华强. 湿性敷料与干性敷料在中厚供皮区上应用的对比研究. 实用医学杂志, 2011, 27(1):58-60.
11.	Becker ST, Rennekampff HO, Alkatout I, et al. Comparison of vacuum and conventional wound dressings for full thickness skin grafts in the minipig model. Int J Oral Maxillofac Surg, 2010, 39(7):699-704.
12.	刘敏涛. 凡士林纱布在皮肤开放性伤口湿性换药中的应用. 临床和实验医学杂志, 2010, 9(2):145.
13.	Oliver LC, Blaine G. Haemostasis with absorbable alginates in neurosurgical practice. Br J Surg, 1950, 37(147):307-310.
14.	顾其胜, 王帅帅, 王庆生, 等. 海藻酸盐敷料应用现状与研究进展. 中国修复重建外科杂志, 2014, 28(2):255-258.
15.	Singh R, Singh D. Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing. J Mate Sci Mater Med, 2012, 23(11):2649-2658.
16.	Sun JC, Tan HP. Alginate-Based biomaterials for regenerative medicine applications. Materials (Basel), 2013, 6(4):1285-1309.
17.	Jensen J. Easy-release alginate wound healing device and method:US, 6174544[P]. 2001-1-16.
18.	Fan L, Peng K, Li M, et al. Preparation and properties of carboxymethyl κ-carrageenan/alginate blend fibers. J Biomater Sci Polym Ed, 2013, 24(9):1099-1111.
19.	Gong Y, Han GT, Zhang YM, et al. Antifungal activity and cytotoxicity of zinc, calcium, or copper alginate fibers. Biol Trace Elem Res, 2012, 148(3):415-419.
20.	Hooper SJ, Percival SL, Hill KE, et al. The visualisation and speed of kill of wound isolates on a Silver alginate dressing. Int Wound J, 2012, 9(6):633-642.
21.	Skórkowska-Telichowska K, Czemplik M, Kulma A, et al. The local treatment and available dressings designed for chronic wounds. J Am Acad Dermatol, 2013, 68(4):e117-e126.
22.	Petrulyte S. Advanced textile materials and biopolymers in wound management. Dan Med Bull, 2008, 55(1):72-77.
23.	Groves AR, Lawrence JC. Alginate dressing as a donor site haemostat. Ann R Coll Surg Engl, 1986, 68(1):27-28.
24.	Qin YM. A comparison of alginate and chitosan fibres Med Device Technol, 2004, 15(1):34-37.
25.	Uraloglu M, Livaoglu M, Agdogan O, et al. An evaluation of five different dressing materials on split-thickness skin graft donor site and full-thickness cutaneous wounds:an experimental study. Int Wound J, 2014, 11(1):85-92.
26.	O'Donoghue JM, O'Sullivan ST, Beausang ES, et al. Calcium alginate dressings promote healing of split skin graft donor sites. Acta Chir Plast, 1997, 39(2):53-55.
27.	Goh CH, Heng PW, Chan LW. Alginates as a useful natural polymer for microencapsulation and therapeutic applications. Carbohydr Polym, 2012, 88(1):1-12.
28.	Han F, Dong Y, Song AH, et al. Alginate/chitosan based bi-layer composite membrane as potential sustained-release wound dressing containing ciprofloxacin hydrochloride. Appl Surf Sci, 2014, 311(0):626-634.
29.	Sikareepaisan P, Ruktanonchai U, Supaphol P. Preparation and characterization of asiaticoside-loaded alginate films and their potential for use as effectual wound dressings. Carbohydrate Polymers, 2011, 83(4):1457-1469.
30.	王清华, 钟文菲, 何盟. 藻酸盐敷料的临床应用:与传统材料特征的比较. 中国组织工程研究与临床康复, 2010, 14(3):533-536.
31.	Kheradmand AA, Novin NR, Khazaeipour Z. Brief report:The use of dermal autograft for fascial repair of TRAM flap donor sites. J Plast Reconstr Aesthet Surg, 2011, 64(3):364-368.
32.	Vasconcelos A, Cavaco-Paulo A. Wound dressings for a proteolytic-rich environment. Appl Microbiol Biotechnol, 2011, 90(2):445-460.
33.	Dongargaonkar AA, Bowlin GL, Yang H. Electrospun blends of gelatin and gelatin-dendrimer conjugates as a wound-dressing and drug-delivery platform. Biomacromolecules, 2013, 14(11):4038-4045.
34.	Vatankhah E, Prabhakaran MP, Jin G, et al. Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications. J Biomater Appl, 2014, 28(6):909-921.
35.	Kanokpanont S, Damrongsakkul S, Ratanavaraporn J, et al. An innovative bi-layered wound dressing made of silk and gelatin for accelerated wound healing. Int J Pharm, 2012, 436(1-2):141-153.
36.	Muthukumar T, Anbarasu K, Prakash D, et al. Effect of growth factors and pro-inflammatory cytokines by the collagen biocomposite dressing material containing Macrotyloma uniflorum plant extract-In vivo wound healing. Colloids Surf B Biointerfaces, 2014, 121:178-188.
37.	Chen MM, Huang YQ, Guo H, et al. Preparation, characterization, and potential biomedical application of composite sponges based on collagen from Silver carp skin. J Appl Polym Sci, 2014, 131(21):doi:10.1002/app.40998.
38.	Lu BY, Zheng J, Chen DL, et al. Evaluation of a new type of wound dressing made from recombinant spider silk protein using rat models. Burns, 2010, 36(6):891-896.
39.	Rossi S, Faccendini A, Bonferoni MC, et al. "Sponge-like" dressings based on biopolymers for the delivery of platelet lysate to skin chronic wounds. Int J Pharm, 2013, 440(2):207-215.
40.	Abdelgawad AM, Hudson SM, Rojas OJ. Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr Polym, 2014, 100(SI):166-178.
41.	Santos TC, Hoering B, Reise K, et al. In vivo performance of chitosan/Soy-Based membranes as Wound-Dressing devices for acute skin wounds. Tissue Eng Part A, 2013, 19(7-8):860-869.
42.	Huang X, Zhang YQ, Zhang XM, et al. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4816-4824.
43.	Lin WC, Lien CC, Yeh HJ, et al. Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohydr Polym, 2013, 94(1):603-611.
44.	Cui FY, Li GD, Huang JJ, et al. Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties. Drug Deliv, 2011, 18(3):173-180.
45.	Yuvarani I, Kumar SS, Venkatesan J, et al. Preparation and characterization of curcumin coated Chitosan-Alginate blend for wound dressing application. J Biomater Tissue Eng, 2012, 2(1):54-60.
46.	Fernandes de Carvalho V, Paggiaro AO, Isaac C, et al. Clinical trial comparing 3 different wound dressings for the management of partial-thickness skin graft donor sites. J Wound Ostomy Continence Nurs, 2011, 38(6):643-647.
47.	Lee SJ, Heo DN, Moon JH, et al. Chitosan/polyurethane blended fiber sheets containing Silver sulfadiazine for use as an antimicrobial wound dressing. J Nanosci Nanotechnol, 2014, 14(10):7488-7494.
48.	赵成如, 史文红, 金刚. 医用敷料. 中国医疗器械信息, 2007, 13(7):15-21.
49.	张欣, 马莉君, 张利平. 应用液体敷料结合清创对糖尿病足伤口换药的疗效观察. 中国临床医生, 2012, 40(10):52-53.
50.	Meaume S, Ourabah Z, Cartier H, et al. Evaluation of a lipidocolloid wound dressing in the local management of leg ulcers. J Wound Care, 2005, 14(7):329-334.
51.	Kaya AZ, Turani N, Akyüz M. The effectiveness of a hydrogel dressing compared with standard management of pressure ulcers. J Wound Care, 2005, 14(1):42-44.
52.	卢祖坤, 李莉, 楚立凯, 等. PVA/PAAS/AM水凝胶伤口敷料的制备及其性能研究. 辐射研究与辐射工艺学报, 2013, 31(3):46-52.
53.	Charles H, Corser R, Varrow S, et al. A non-adhesive foam dressing for exuding venous leg ulcers and pressure ulcers:six case studies. J Wound Care, 2004, 13(2):58-64.
54.	Münter K, Beele H, Russell L, et al. Effect of a sustained silver-releasing dressing on ulcers with delayed healing:the CONTOP study. J Wound Care, 2006, 15(5):199-206.
55.	郑培. 泡沫敷料的临床应用研究进展. 护理研究, 2013, 27(19):1925-1926.
56.	De S, Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. J Control Release, 2003, 89(1):101-112.
57.	李启活, 黎飞猛, 孙鸿涛. 载药新型敷料的研究进展. 现代医药卫生, 2014, 30(12):1812-1814.
58.	Sakai S, Ono T, Ijima H, et al. In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas. Biomaterials, 2002, 23(21):4177-4183.
59.	Jaiswal M, Gupta A, Agrawal AK, et al. Bi-Layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application:In-Vitro and In-Vivo studies. J Biomed Nanotechnol, 2013, 9(9):1495-1508.

1. Martin C, Low WL, Amin MC, et al. Current trends in the development of wound dressings, biomaterials and devices. Pharm Pat Anal, 2013, 2(3):341-359.
2. Woo KY, Keast D, Parsons N, et al. The cost of wound debridement:a Canadian perspective. Int Wound J, 2013.[Epub ahead of print].
3. Rivadeneira J, Di Virgilio AL, Audisio M, et al. Evaluation of antibacterial and cytotoxic effects of nano-sized bioactive glass/collagen composites releasing tetracycline hydrochloride. J Appl Microbiol, 2014, 116(6):1438-1446.
4. Gillespie BM, Chaboyer W, Allen P, et al. Wound care practices:a survey of acute care nurses. J Clin Nurs, 2014, 23(17/18):2618-2627.
5. Lin YH, Lin JH, Wang SH, et al. Evaluation of silver-containing activated Carbon fiber for wound healing study:In vitro and in vivo. J Biomed Mater Res B Appl Biomater, 2012, 100B(8):2288-2296.
6. Field CK, Kerstein MD. Overview of wound healing in a moist environment. Am J Surg, 1994, 167(1 Suppl):S2-S6.
7. 沈娟, 金小宝, 丁静, 等. 非促分裂型人酸性成纤维细胞生长因子促小鼠烫伤愈合的研究. 中国生物工程杂志, 2013, 33(3):68-73.
8. Mouës C, Heule F, Hovius SE. A review of topical negative pressure therapy in wound healing:sufficient evidence? Am J Surg, 2011, 201(4):544-556.
9. Kamolz LP, Wild T. Wound bed preparation:The impact of debridement and wound cleansing. Wound Medicine, 2013, 1:44-50.
10. 代明盛, 王李云, 沈华强. 湿性敷料与干性敷料在中厚供皮区上应用的对比研究. 实用医学杂志, 2011, 27(1):58-60.
11. Becker ST, Rennekampff HO, Alkatout I, et al. Comparison of vacuum and conventional wound dressings for full thickness skin grafts in the minipig model. Int J Oral Maxillofac Surg, 2010, 39(7):699-704.
12. 刘敏涛. 凡士林纱布在皮肤开放性伤口湿性换药中的应用. 临床和实验医学杂志, 2010, 9(2):145.
13. Oliver LC, Blaine G. Haemostasis with absorbable alginates in neurosurgical practice. Br J Surg, 1950, 37(147):307-310.
14. 顾其胜, 王帅帅, 王庆生, 等. 海藻酸盐敷料应用现状与研究进展. 中国修复重建外科杂志, 2014, 28(2):255-258.
15. Singh R, Singh D. Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing. J Mate Sci Mater Med, 2012, 23(11):2649-2658.
16. Sun JC, Tan HP. Alginate-Based biomaterials for regenerative medicine applications. Materials (Basel), 2013, 6(4):1285-1309.
17. Jensen J. Easy-release alginate wound healing device and method:US, 6174544[P]. 2001-1-16.
18. Fan L, Peng K, Li M, et al. Preparation and properties of carboxymethyl κ-carrageenan/alginate blend fibers. J Biomater Sci Polym Ed, 2013, 24(9):1099-1111.
19. Gong Y, Han GT, Zhang YM, et al. Antifungal activity and cytotoxicity of zinc, calcium, or copper alginate fibers. Biol Trace Elem Res, 2012, 148(3):415-419.
20. Hooper SJ, Percival SL, Hill KE, et al. The visualisation and speed of kill of wound isolates on a Silver alginate dressing. Int Wound J, 2012, 9(6):633-642.
21. Skórkowska-Telichowska K, Czemplik M, Kulma A, et al. The local treatment and available dressings designed for chronic wounds. J Am Acad Dermatol, 2013, 68(4):e117-e126.
22. Petrulyte S. Advanced textile materials and biopolymers in wound management. Dan Med Bull, 2008, 55(1):72-77.
23. Groves AR, Lawrence JC. Alginate dressing as a donor site haemostat. Ann R Coll Surg Engl, 1986, 68(1):27-28.
24. Qin YM. A comparison of alginate and chitosan fibres Med Device Technol, 2004, 15(1):34-37.
25. Uraloglu M, Livaoglu M, Agdogan O, et al. An evaluation of five different dressing materials on split-thickness skin graft donor site and full-thickness cutaneous wounds:an experimental study. Int Wound J, 2014, 11(1):85-92.
26. O'Donoghue JM, O'Sullivan ST, Beausang ES, et al. Calcium alginate dressings promote healing of split skin graft donor sites. Acta Chir Plast, 1997, 39(2):53-55.
27. Goh CH, Heng PW, Chan LW. Alginates as a useful natural polymer for microencapsulation and therapeutic applications. Carbohydr Polym, 2012, 88(1):1-12.
28. Han F, Dong Y, Song AH, et al. Alginate/chitosan based bi-layer composite membrane as potential sustained-release wound dressing containing ciprofloxacin hydrochloride. Appl Surf Sci, 2014, 311(0):626-634.
29. Sikareepaisan P, Ruktanonchai U, Supaphol P. Preparation and characterization of asiaticoside-loaded alginate films and their potential for use as effectual wound dressings. Carbohydrate Polymers, 2011, 83(4):1457-1469.
30. 王清华, 钟文菲, 何盟. 藻酸盐敷料的临床应用:与传统材料特征的比较. 中国组织工程研究与临床康复, 2010, 14(3):533-536.
31. Kheradmand AA, Novin NR, Khazaeipour Z. Brief report:The use of dermal autograft for fascial repair of TRAM flap donor sites. J Plast Reconstr Aesthet Surg, 2011, 64(3):364-368.
32. Vasconcelos A, Cavaco-Paulo A. Wound dressings for a proteolytic-rich environment. Appl Microbiol Biotechnol, 2011, 90(2):445-460.
33. Dongargaonkar AA, Bowlin GL, Yang H. Electrospun blends of gelatin and gelatin-dendrimer conjugates as a wound-dressing and drug-delivery platform. Biomacromolecules, 2013, 14(11):4038-4045.
34. Vatankhah E, Prabhakaran MP, Jin G, et al. Development of nanofibrous cellulose acetate/gelatin skin substitutes for variety wound treatment applications. J Biomater Appl, 2014, 28(6):909-921.
35. Kanokpanont S, Damrongsakkul S, Ratanavaraporn J, et al. An innovative bi-layered wound dressing made of silk and gelatin for accelerated wound healing. Int J Pharm, 2012, 436(1-2):141-153.
36. Muthukumar T, Anbarasu K, Prakash D, et al. Effect of growth factors and pro-inflammatory cytokines by the collagen biocomposite dressing material containing Macrotyloma uniflorum plant extract-In vivo wound healing. Colloids Surf B Biointerfaces, 2014, 121:178-188.
37. Chen MM, Huang YQ, Guo H, et al. Preparation, characterization, and potential biomedical application of composite sponges based on collagen from Silver carp skin. J Appl Polym Sci, 2014, 131(21):doi:10.1002/app.40998.
38. Lu BY, Zheng J, Chen DL, et al. Evaluation of a new type of wound dressing made from recombinant spider silk protein using rat models. Burns, 2010, 36(6):891-896.
39. Rossi S, Faccendini A, Bonferoni MC, et al. "Sponge-like" dressings based on biopolymers for the delivery of platelet lysate to skin chronic wounds. Int J Pharm, 2013, 440(2):207-215.
40. Abdelgawad AM, Hudson SM, Rojas OJ. Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydr Polym, 2014, 100(SI):166-178.
41. Santos TC, Hoering B, Reise K, et al. In vivo performance of chitosan/Soy-Based membranes as Wound-Dressing devices for acute skin wounds. Tissue Eng Part A, 2013, 19(7-8):860-869.
42. Huang X, Zhang YQ, Zhang XM, et al. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4816-4824.
43. Lin WC, Lien CC, Yeh HJ, et al. Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications. Carbohydr Polym, 2013, 94(1):603-611.
44. Cui FY, Li GD, Huang JJ, et al. Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties. Drug Deliv, 2011, 18(3):173-180.
45. Yuvarani I, Kumar SS, Venkatesan J, et al. Preparation and characterization of curcumin coated Chitosan-Alginate blend for wound dressing application. J Biomater Tissue Eng, 2012, 2(1):54-60.
46. Fernandes de Carvalho V, Paggiaro AO, Isaac C, et al. Clinical trial comparing 3 different wound dressings for the management of partial-thickness skin graft donor sites. J Wound Ostomy Continence Nurs, 2011, 38(6):643-647.
47. Lee SJ, Heo DN, Moon JH, et al. Chitosan/polyurethane blended fiber sheets containing Silver sulfadiazine for use as an antimicrobial wound dressing. J Nanosci Nanotechnol, 2014, 14(10):7488-7494.
48. 赵成如, 史文红, 金刚. 医用敷料. 中国医疗器械信息, 2007, 13(7):15-21.
49. 张欣, 马莉君, 张利平. 应用液体敷料结合清创对糖尿病足伤口换药的疗效观察. 中国临床医生, 2012, 40(10):52-53.
50. Meaume S, Ourabah Z, Cartier H, et al. Evaluation of a lipidocolloid wound dressing in the local management of leg ulcers. J Wound Care, 2005, 14(7):329-334.
51. Kaya AZ, Turani N, Akyüz M. The effectiveness of a hydrogel dressing compared with standard management of pressure ulcers. J Wound Care, 2005, 14(1):42-44.
52. 卢祖坤, 李莉, 楚立凯, 等. PVA/PAAS/AM水凝胶伤口敷料的制备及其性能研究. 辐射研究与辐射工艺学报, 2013, 31(3):46-52.
53. Charles H, Corser R, Varrow S, et al. A non-adhesive foam dressing for exuding venous leg ulcers and pressure ulcers:six case studies. J Wound Care, 2004, 13(2):58-64.
54. Münter K, Beele H, Russell L, et al. Effect of a sustained silver-releasing dressing on ulcers with delayed healing:the CONTOP study. J Wound Care, 2006, 15(5):199-206.
55. 郑培. 泡沫敷料的临床应用研究进展. 护理研究, 2013, 27(19):1925-1926.
56. De S, Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-l-lysine-alginate nanospheres. J Control Release, 2003, 89(1):101-112.
57. 李启活, 黎飞猛, 孙鸿涛. 载药新型敷料的研究进展. 现代医药卫生, 2014, 30(12):1812-1814.
58. Sakai S, Ono T, Ijima H, et al. In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas. Biomaterials, 2002, 23(21):4177-4183.
59. Jaiswal M, Gupta A, Agrawal AK, et al. Bi-Layer composite dressing of gelatin nanofibrous mat and poly vinyl alcohol hydrogel for drug delivery and wound healing application:In-Vitro and In-Vivo studies. J Biomed Nanotechnol, 2013, 9(9):1495-1508.

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