• 1. Shanghai Qisheng Institution of Biomaterials & Technology, Shanghai, 200061, P. R. China;
  • 2. College of Engineering, Peking University;
  • 3. Shandong Enoch Biotechnology Co,. Ltd;
GUQisheng, Email: qishenggu@163.com
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Objective To summarize the current research status of alginate derivatives based on biomedical materials, and analyze several key points as novel clinical products. Methods The general preparation and application methods of alginate derivatives based on biomedical materials at home and abroad were reviewed. The present status and problems were analyzed. Results The derivation methods to prepare alginate derivatives include crosslink, sulfation, biological factors derivatization, hydrophobic modification, and graft copolymerization. With excellent bionic performance of structure and properties, many alginate derivatives are available for tissue engineering scaffolds, artificial organs, and drug delivery systems etc. However, more systematic applied basic research data should be collected and statistically analyzed for risk managements. Conclusion Alginate derivatives have good feasibility as novel medical products, meanwhile, systematic evaluation and verification should be executed for their safety, effectiveness, and suitability.

Citation: WEIXiaojuan, GUQisheng, WANGQingsheng, XIAOJimin. PROGRESS OF ALGINATE DERIVATIVES BASED ON BIOMEDICAL MATERIALS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(4): 508-512. doi: 10.7507/1002-1892.20150108 Copy

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