• Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, 430030, P. R. China;
FANGHuang, Email: fanghuangtjh@126.com
Export PDF Favorites Scan Get Citation

Objective To review the recent progress in research on the role of estrogen and estrogen receptor on the onset and progression of adolescent idiopathic scoliosis (AIS). Methods The recently published clinical and experimental 1iterature at home and abroad on abnormality of estrogen and its receptor in AIS was reviewed and summarized. Results There are many abnormal changes of estrogen and estrogen receptor in most AIS patients, including higher serum estrogen concentration, unusual cellular response to estrogen, late age at menarche, and gene polymorphisms of estrogen receptor, which are closely associated with AIS predisposition, curve severity, and scoliosis progression. Conclusion Estrogen and its receptor participate in the onset and progression of AIS by certain mechanisms, but exact mechanism remains indefinite, which needs further research to better define the role of estrogen and its receptor in AIS.

Citation: ZHOUChuankun, WANGHuan, ZOUYinshuang, FANGHuang. RESEARCH PROGRESS OF ROLE OF ESTROGEN AND ESTROGEN RECEPTOR ON ONSET AND PROGRESSION OF ADOLESCENT IDIOPATHIC SCOLIOSIS. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(11): 1441-1445. doi: 10.7507/1002-1892.20150308 Copy

  • Previous Article

    RESEARCH PROGRESS OF KLIPPEL-FEIL SYNDROME WITH EAR MALFORMATION
  • Next Article

    RESEARCH PROGRESS OF AUTOLOGOUS VEIN NERVE CONDUIT FOR REPAIR OF PERIPHERAL NERVE DEFECT