RESEARCH PROGRESS OF EXPERIMENTAL ANIMAL MODELS OF AVASCULAR NECROSIS OF FEMORAL HEAD_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YUKaifu ¹ , TANHongbo ² ,  XUYongqing ²

1. Brigade of Postgraduate Management, Third Military Medical University, Chongqing, 400038, P. R. China;
2. Department of Orthopedics, Kunming General Hospital of Chengdu Military Region;

Corresponding author：

XUYongqing, Email: xuyongqingkm@163.net

Keywords：

Avascular necrosis of femoral head; Animal model; Research progress

DOI：

10.7507/1002-1892.20150333

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the current researches and progress on experimental animal models of avascular necrosis of the femoral head. Methods Domestic and international literature concerning experimental animal models of avascular necrosis of the femoral head was reviewed and analyzed. Results The methods to prepare the experimental animal models of avascular necrosis of the femoral head can be mainly concluded as traumatic methods (including surgical, physical, and chemical insult), and non-traumatic methods (including steroid, lipopolysaccharide, steroid combined with lipopolysaccharide, steroid combined with horse serum, etc). Each method has both merits and demerits, yet no ideal methods have been developed. Conclusion There are many methods to prepare the experimental animal models of avascular necrosis of the femoral head, but proper model should be selected based on the aim of research. The establishment of ideal experimental animal models needs further research in future.

Citation： YUKaifu, TANHongbo, XUYongqing. RESEARCH PROGRESS OF EXPERIMENTAL ANIMAL MODELS OF AVASCULAR NECROSIS OF FEMORAL HEAD. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(12): 1564-1569. doi: 10.7507/1002-1892.20150333 Copy

1.	Kim HK, Bian H, Aya-ay J, et al. Hypoxia and HIF-1alpha expression in the epiphyseal cartilage following ischemic injury to the immature femoral head. Bone, 2009, 45(2):280-288.
2.	Kim HK, Stephenson N, Garces A, et al. Effects of disruption of epiphyseal vasculature on the proximal femoral growth plate. J Bone Joint Surg (Am), 2009, 91(5):1149-1158.
3.	Marker DR, Seyler TM, McGrath MS, et al. Treatment of early stage osteonecrosis of the femoral head. J Bone Joint Surg (Am), 2008, 90 Suppl 4:175-187.
4.	Okazaki S, Nagoya S, Tateda K, et al. Experimental rat model for alcohol-induced osteonecrosis of the femoral head. Int J Exp Pathol, 2013, 94(5):312-319.
5.	Wu Z, Ji C, Li H, et al. Elevated level of membrane microparticles in the disease of steroid-induced vascular osteonecrosis. J Craniofac Surg, 2013, 24(4):1252-1256.
6.	Yuan B, Liu Z. Treatment of osteonecrosis of the femoral head:combination of operation and multiple cellular mediators. Med Hypotheses, 2007, 68(3):502-505.
7.	Troy KL, Brown TD, Conzemius MG. Contact stress distributions on the femoral head of the emu (Dromaius novaehollandiae). J Biomech, 2009, 42(15):2495-2500.
8.	Peled E, Bejar J, Zinman C, et al. Prevention of distortion of vascular deprivation-induced osteonecrosis of the rat femoral head by treatment with alendronate. Arch Orthop Trauma Surg, 2009, 129(2):275-279.
9.	Hwang Y, Park J, Choi SH, et al. Traumatic and non-traumatic osteonecrosis in the femoral head of a rabbit model. Lab Anim Res, 2011, 27(2):127-131.
10.	Hofstaetter JG, Wang J, Yan J, et al. The effects of alendronate in the treatment of experimental osteonecrosis of the hip in adult rabbits. Osteoarthritis Cartilage, 2009, 17(3):362-370.
11.	Kim JM, Han TS, Park J, et al. Comparison of the degree of hip joint luxation induced by the lateral and medial surgical approaches used to generate vascular deprivation-induced necrosis of the femoral head in rats. In Vivo, 2010, 24(6):821-825.
12.	Li Y, Han R, Geng C, et al. A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop, 2009, 33(2):573-580.
13.	Long T, Xu J, McClure SR, et al. Potential femoral head osteonecrosis model induced by high-intensity focused ultrasound. Ultrasound Med Biol, 2013, 39(6):1056-1065.
14.	徐俊, 张长青, 孙建琪, 等. 计算机辅助下低温手术建立三足犬股骨头坏死模型的初步报告. 中国修复重建外科杂志, 2008, 22(3):276-280.
15.	Vélez R, Soldado F, Hernández A, et al. A new preclinical femoral head osteonecrosis model in sheep. Arch Orthop Trauma Surg, 2011, 131(1):5-9.
16.	Jiang W, Wang P, Wan Y, et al. A simple method for establishing an ostrich model of femoral head osteonecrosis and collapse. J Orthop Surg Res, 2015, (10):74.
17.	Wang D, Wang G, Liu M, et al. A novel animal model of osteonecrosis of the femoral head induced using a magnetic resonance imaging-guided argon-helium cryotherapy system. Experimental and Therapeutic Medicine, 2014, 7(6):1525-1528.
18.	Fan M, Peng J, Wang A, et al. Emu model of full-range femoral head osteonecrosis induced focally by an alternating freezing and heating insult. J Int Med Res, 2011, 39(1):187-198.
19.	Zhu ZH, Gao YS, Luo SH, et al. An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol:an experimental study. Med Sci Monit, 2011, 17(4):BR97-102.
20.	Manggold J, Sergi C, Becker K, et al. A new animal model of femoral head necrosis induced by intraosseous injection of ethanol. Lab Anim, 2002, 36(2):173-180.
21.	Wang C, Wang J, Zhang Y, et al. A canine model of femoral head osteonecrosis induced by an ethanol injection navigated by a novel template. Int J Med Sci, 2013, 10(11):1451-1458.
22.	Kerachian MA, Harvey EJ, Cournoyer D, et al. A rat model of early stage osteonecrosis induced by glucocorticoids. J Orthop Surg Res, 2011, 6:62.
23.	Miyanishi K, Yamamoto T, Irisa T, et al. Effects of different corticosteroids on the development of osteonecrosis in rabbits. Rheumatology (Oxford), 2005, 44(3):332-336.
24.	肖春生, 林娜, 林诗富, 等. 不同糖皮质激素诱导鸡股骨头坏死的实验研究. 中国骨伤, 2010, 23(3):184-187.
25.	Irisa T, Yamamoto T, Miyanishi K, et al. Osteonecrosis induced by a single administration of low-dose lipopolysaccharide in rabbits. Bone, 2001, 28(6):641-649.
26.	Zhu H, Cai X, Lin T, et al. Low-intensity pulsed ultrasound enhances bone repair in a rabbit model of steroid-associated osteonecrosis. Clin Orthop Relat Res, 2015, 473(5):1830-1839.
27.	Ryoo S, Lee S, Jo S, et al. Effect of lipopolysaccharide (LPS) on mouse model of steroid-induced avascular necrosis in the femoral head (ANFH). J Microbiol Biotechnol, 2014, 24(3):394-400.
28.	Guan XY, Han D. Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. J Orthop Sci, 2010, 15(3):365-370.
29.	Zheng LZ, Liu Z, Lei M, et al. Steroid-associated hip joint collapse in bipedal emus. PLoS One, 2013, 8(10):e76797.
30.	Wen Q, Ma L, Chen YP, et al. A rabbit model of hormone-induced early avascular necrosis of the femoral head. Biomed Environ Sci, 2008, 21(5):398-403.
31.	Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head:ten years later. J Bone Joint Surg (Am), 2006, 88(5):1117-1132.
32.	Wang Y, Yin L, Li Y, et al. Preventive effects of puerarin on alcoholinduced osteonecrosis. Clin Orthop Relat Res, 2008, 466(5):1059-1067.
33.	Chryssanthou C. Animal model of human disease:dysbaric osteonecrosis. Am J Pathol, 1981, 103(2):334-336.
34.	Lehner CE, Adams WM, Dubielzig RR, et al. Dysbaric osteonecrosis in divers and caisson workers. An animal model. Clin Orthop Relat Res, 1997, (344):320-332.
35.	Gao YS, Wang HF, Ding H, et al. A novel rat model of osteonecrosis of the femoral head induced by periarticular injection of vascular endothelial growth factor receptor 2 antibody. J Surg Res, 2013, 183(1):e1-5.
36.	Malizos KN, Quarles LD, Seaber AV, et al. An experimental canine model of osteonecrosis:characterization of the repair process. J Orthop Res, 1993, 11(3):350-357.

1. Kim HK, Bian H, Aya-ay J, et al. Hypoxia and HIF-1alpha expression in the epiphyseal cartilage following ischemic injury to the immature femoral head. Bone, 2009, 45(2):280-288.
2. Kim HK, Stephenson N, Garces A, et al. Effects of disruption of epiphyseal vasculature on the proximal femoral growth plate. J Bone Joint Surg (Am), 2009, 91(5):1149-1158.
3. Marker DR, Seyler TM, McGrath MS, et al. Treatment of early stage osteonecrosis of the femoral head. J Bone Joint Surg (Am), 2008, 90 Suppl 4:175-187.
4. Okazaki S, Nagoya S, Tateda K, et al. Experimental rat model for alcohol-induced osteonecrosis of the femoral head. Int J Exp Pathol, 2013, 94(5):312-319.
5. Wu Z, Ji C, Li H, et al. Elevated level of membrane microparticles in the disease of steroid-induced vascular osteonecrosis. J Craniofac Surg, 2013, 24(4):1252-1256.
6. Yuan B, Liu Z. Treatment of osteonecrosis of the femoral head:combination of operation and multiple cellular mediators. Med Hypotheses, 2007, 68(3):502-505.
7. Troy KL, Brown TD, Conzemius MG. Contact stress distributions on the femoral head of the emu (Dromaius novaehollandiae). J Biomech, 2009, 42(15):2495-2500.
8. Peled E, Bejar J, Zinman C, et al. Prevention of distortion of vascular deprivation-induced osteonecrosis of the rat femoral head by treatment with alendronate. Arch Orthop Trauma Surg, 2009, 129(2):275-279.
9. Hwang Y, Park J, Choi SH, et al. Traumatic and non-traumatic osteonecrosis in the femoral head of a rabbit model. Lab Anim Res, 2011, 27(2):127-131.
10. Hofstaetter JG, Wang J, Yan J, et al. The effects of alendronate in the treatment of experimental osteonecrosis of the hip in adult rabbits. Osteoarthritis Cartilage, 2009, 17(3):362-370.
11. Kim JM, Han TS, Park J, et al. Comparison of the degree of hip joint luxation induced by the lateral and medial surgical approaches used to generate vascular deprivation-induced necrosis of the femoral head in rats. In Vivo, 2010, 24(6):821-825.
12. Li Y, Han R, Geng C, et al. A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop, 2009, 33(2):573-580.
13. Long T, Xu J, McClure SR, et al. Potential femoral head osteonecrosis model induced by high-intensity focused ultrasound. Ultrasound Med Biol, 2013, 39(6):1056-1065.
14. 徐俊, 张长青, 孙建琪, 等. 计算机辅助下低温手术建立三足犬股骨头坏死模型的初步报告. 中国修复重建外科杂志, 2008, 22(3):276-280.
15. Vélez R, Soldado F, Hernández A, et al. A new preclinical femoral head osteonecrosis model in sheep. Arch Orthop Trauma Surg, 2011, 131(1):5-9.
16. Jiang W, Wang P, Wan Y, et al. A simple method for establishing an ostrich model of femoral head osteonecrosis and collapse. J Orthop Surg Res, 2015, (10):74.
17. Wang D, Wang G, Liu M, et al. A novel animal model of osteonecrosis of the femoral head induced using a magnetic resonance imaging-guided argon-helium cryotherapy system. Experimental and Therapeutic Medicine, 2014, 7(6):1525-1528.
18. Fan M, Peng J, Wang A, et al. Emu model of full-range femoral head osteonecrosis induced focally by an alternating freezing and heating insult. J Int Med Res, 2011, 39(1):187-198.
19. Zhu ZH, Gao YS, Luo SH, et al. An animal model of femoral head osteonecrosis induced by a single injection of absolute alcohol:an experimental study. Med Sci Monit, 2011, 17(4):BR97-102.
20. Manggold J, Sergi C, Becker K, et al. A new animal model of femoral head necrosis induced by intraosseous injection of ethanol. Lab Anim, 2002, 36(2):173-180.
21. Wang C, Wang J, Zhang Y, et al. A canine model of femoral head osteonecrosis induced by an ethanol injection navigated by a novel template. Int J Med Sci, 2013, 10(11):1451-1458.
22. Kerachian MA, Harvey EJ, Cournoyer D, et al. A rat model of early stage osteonecrosis induced by glucocorticoids. J Orthop Surg Res, 2011, 6:62.
23. Miyanishi K, Yamamoto T, Irisa T, et al. Effects of different corticosteroids on the development of osteonecrosis in rabbits. Rheumatology (Oxford), 2005, 44(3):332-336.
24. 肖春生, 林娜, 林诗富, 等. 不同糖皮质激素诱导鸡股骨头坏死的实验研究. 中国骨伤, 2010, 23(3):184-187.
25. Irisa T, Yamamoto T, Miyanishi K, et al. Osteonecrosis induced by a single administration of low-dose lipopolysaccharide in rabbits. Bone, 2001, 28(6):641-649.
26. Zhu H, Cai X, Lin T, et al. Low-intensity pulsed ultrasound enhances bone repair in a rabbit model of steroid-associated osteonecrosis. Clin Orthop Relat Res, 2015, 473(5):1830-1839.
27. Ryoo S, Lee S, Jo S, et al. Effect of lipopolysaccharide (LPS) on mouse model of steroid-induced avascular necrosis in the femoral head (ANFH). J Microbiol Biotechnol, 2014, 24(3):394-400.
28. Guan XY, Han D. Role of hypercoagulability in steroid-induced femoral head necrosis in rabbits. J Orthop Sci, 2010, 15(3):365-370.
29. Zheng LZ, Liu Z, Lei M, et al. Steroid-associated hip joint collapse in bipedal emus. PLoS One, 2013, 8(10):e76797.
30. Wen Q, Ma L, Chen YP, et al. A rabbit model of hormone-induced early avascular necrosis of the femoral head. Biomed Environ Sci, 2008, 21(5):398-403.
31. Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head:ten years later. J Bone Joint Surg (Am), 2006, 88(5):1117-1132.
32. Wang Y, Yin L, Li Y, et al. Preventive effects of puerarin on alcoholinduced osteonecrosis. Clin Orthop Relat Res, 2008, 466(5):1059-1067.
33. Chryssanthou C. Animal model of human disease:dysbaric osteonecrosis. Am J Pathol, 1981, 103(2):334-336.
34. Lehner CE, Adams WM, Dubielzig RR, et al. Dysbaric osteonecrosis in divers and caisson workers. An animal model. Clin Orthop Relat Res, 1997, (344):320-332.
35. Gao YS, Wang HF, Ding H, et al. A novel rat model of osteonecrosis of the femoral head induced by periarticular injection of vascular endothelial growth factor receptor 2 antibody. J Surg Res, 2013, 183(1):e1-5.
36. Malizos KN, Quarles LD, Seaber AV, et al. An experimental canine model of osteonecrosis:characterization of the repair process. J Orthop Res, 1993, 11(3):350-357.

Previous Article
RESEARCH ADVANCE OF DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS INTO Schwann CELLS IN VITRO
Next Article
RESEARCH PROGRESS OF NEURAL REGULATION MECHANISM OF VASCULOGENESIS

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF EXPERIMENTAL ANIMAL MODELS OF AVASCULAR NECROSIS OF FEMORAL HEAD

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content