• Tianjin Institute of Traumatic Brain Injury and Neurology, Brain Hospital of Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces, Tianjin Key Laboratory of Neurotrauma Repair, Tianjin, 300162, P.R.China;
ZHANGSai, Email: zhangsai718@vip.126.com
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Objective To explore a method of three-dimensional (3D) printing technology for preparation of personalized rat brain tissue cavity scaffolds so as to lay the foundation for the repair of traumatic brain injury (TBI) with tissue engineered customized cavity scaffolds. Methods Five male Sprague Dawley rats[weighing (300±10) g] were induced to TBI models by electric controlled cortical impactor. Mimics software was used to reconstruct the surface profile of the damaged cavity based on the MRI data, computer aided design to construct the internal structure. Then collagen-chitosan composite was prepared for 3D bioprinter of bionic brain cavity scaffold. Results MRI scans showed the changes of brain tissue injury in the injured side, and the position of the cavity was limited to the right side of the rat brain cortex. The 3D model of personalized cavity containing the internal structure was successfully constructed, and cavity scaffolds were prepared by 3D printing technology. The external contour of cavity scaffolds was similar to that of the injured zone in the rat TBI; the inner positive crossing structure arranged in order, and the pore connectivity was good. Conclusion Combined with 3D reconstruction based on MRI data, the appearance of cavity scaffolds by 3D printing technology is similar to that of injured cavity of rat brain tissue, and internal positive cross structure can simulate the topological structure of the extracellular matrix, and printing materials are collagen-chitosan complexes having good biocompatibility, so it will provide a new method for customized cavity scaffolds to repair brain tissue cavity after TBI.

Citation: FUFeng, ZHAOMingliang, LIXiaohong, CHENChong, WANGLina, SUNHongtao, TUYue, ZHANGSai. PREPARATION OF PERSONALIZED BRAIN CAVITY SCAFFOLD WITH THREE-DIMENSIONAL PRINTING TECHNOLOGY BASED ON MAGNETIC RESONANCE IMAGING. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(11): 1425-1430. doi: 10.7507/1002-1892.20160294 Copy

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