Research progress of adipose-derived stem cells in skin wound healing_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

TANG Shenli ^1,2 , TAN Qiuwen ^1,2 , ZHOU Yuting ^1,2 ,  LÜ Qing ¹

1. Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;
2. Division of Stem Cell and Tissue Engineering, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

LÜ Qing, Email: lvqingwestchina@163.com

Keywords：

Adipose-derived stem cells; skin wound; wound repair; research progress

DOI：

10.7507/1002-1892.201701003

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the research progress of adipose-derived stem cells (ADSCs) in skin wound healing. Methods The recent experiments and clinical studies on the role of ADSCs in skin wound healing were extensively retrieved and analyzed. Additionally, possible mechanisms and novel application strategies were proposed. Results As confirmed by in vitro and in vivo experiments and clinical studies, ADSCs promote skin wound healing mainly by two mechanisms: differentiation to target cells that participate in skin wound healing and cytokines paracrine to promote proliferation and migration of various cell lines that are mandatory to promote skin wound healing. Moreover, scaffold materials and cell sheet technology may further add to the potency of ADSCs in promoting skin wound healing. Conclusion Remarkable progress has been made in the application of ADSCs in skin wound healing. Further studies are needed to explore the application methods of ADSCs.

Citation： TANG Shenli, TAN Qiuwen, ZHOU Yuting, LÜ Qing. Research progress of adipose-derived stem cells in skin wound healing. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(6): 745-750. doi: 10.7507/1002-1892.201701003 Copy

1.	Hu MS, Maan ZN, Wu JC, et al. Tissue engineering and regenerative repair in wound healing. Ann Biomed Eng, 2014, 42(7): 1494-1507.
2.	You HJ, Han SK. Cell therapy for wound healing. J Korean Med Sci, 2014, 29(3): 311-319.
3.	Ghanem AM, Hachach-Haram N, Leung CC, et al. A systematic review of evidence for education and training interventions in microsurgery. Arch Plast Surg, 2013, 40(4): 312-319.
4.	Zou JP, Huang S, Peng Y, et al. Mesenchymal stem cells/ multipotent mesenchymal stromal cells (MSCs): potential role in healing cutaneous chronic wounds. Int J Low Extrem Wounds, 2012, 11(4): 244-253.
5.	Zahorec P, Koller J, Danisovic L, et al. Mesenchymal stem cells for chronic wounds therapy. Cell Tissue Bank, 2015, 16 (1): 19-26.
6.	Baer PC, Geiger H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int, 2012, 2012: 812693.
7.	Fathi E, Farahzadi R. Isolation, Culturing, Characterization and Aging of Adipose Tissue-derived Mesenchymal Stem Cells: A Brief Overview. Brazilian Archives of Biology and Technology, 2016, 59: e16150383.
8.	Mert T, Kurt AH, Arslan M, et al. Anti-inflammatory and Anti-nociceptive Actions of Systemically or Locally Treated Adipose-Derived Mesenchymal Stem Cells in Experimental Inflammatory Model. Inflammation, 2015, 38(3): 1302-1310.
9.	Zuk PA. The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell, 2010, 21(11): 1783-1787.
10.	Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med, 1999, 341(10): 738-746.
11.	Sivan U, Jayakumar K, Krishnan LK. Constitution of fibrin-based niche for in vitro differentiation of adipose-derived mesenchymal stem cells to keratinocytes. Biores Open Access, 2014, 3(6): 339-347.
12.	Chavez-Munoz C, Nguyen KT, Xu W, et al. Transdifferentiation of adipose-derived stem cells into keratinocyte-like cells: engineering a stratified epidermis. PLoS One, 2013, 8(12): e80587.
13.	Hasegawa T, Sakamoto A, Wada A, et al. Keratinocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS One, 2015, 10(2): e0118402.
14.	Hu R, Ling W, Xu W, et al. Fibroblast-like cells differentiated from adipose-derived mesenchymal stem cells for vocal fold wound healing. PLoS One, 2014, 9(3): e92676.
15.	Cao Y, Sun Z, Liao L, et al. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun, 2005, 332(2): 370-379.
16.	Collawn SS, Banerjee NS, de la Torre J, et al. Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model. Ann Plast Surg, 2012, 68(5): 501-504.
17.	Moon KM, Park YH, Lee JS, et al. The effect of secretory factors of adipose-derived stem cells on human keratinocytes. Int J Mol Sci, 2012, 13(1): 1239-1257.
18.	Shi Z, Neoh KG, Kang ET, et al. Enhanced endothelial differentiation of adipose-derived stem cells by substrate nanotopography. J Tissue Eng Regen Med, 2014, 8(1): 50-58.
19.	Zhang H, Ning H, Banie L, et al. Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties. Biochem Biophys Res Commun, 2010, 402(3): 560-564.
20.	Blaber SP, Webster RA, Hill CJ, et al. Analysis of in vitro secretion profiles from adipose-derived cell populations. J Transl Med, 2012, 10: 172.
21.	Pikuła M, Langa P, Kosikowska P, et al. Stem cells and growth factors in wound healing. Postepy Hig Med Dosw, 2015, 69: 874-885.
22.	Zhao J, Hu L, Liu J, et al. The effects of cytokines in adipose stem cell-conditioned medium on the migration and proliferation of skin fibroblasts in vitro. Biomed Res Int, 2013, 2013: 578479.
23.	Hsiao ST, Asgari A, Lokmic Z, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev, 2012, 21(12): 2189-2203.
24.	Cai L, Johnstone BH, Cook TG, et al. Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells, 2007, 25(12): 3234-3243.
25.	Shingyochi Y, Orbay H, Mizuno H. Adipose-derived stem cells for wound repair and regeneration. Expert Opin Biol Ther, 2015, 15(9): 1-8.
26.	Heo SC, Jeon ES, Lee IH, et al. Tumor necrosis factor-alpha-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms. J Invest Dermatol, 2011, 131(7): 1559-1567.
27.	Yoshimura K, Shigeura T, Matsumoto D, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol, 2006, 208(1): 64-76.
28.	Lindroos B, Suuronen R, Miettinen S. The potential of adipose stem cells in regenerative medicine. Stem Cell Rev, 2011, 7(2): 269-291.
29.	Liechty K, Mackenzie T, Shaaban A, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med, 2000, 6(11): 1282-1286.
30.	Altman AM, Matthias N, Yan Y, et al. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials, 2008, 29(10): 1431-1442.
31.	Atalay S, Coruh A, Deniz K. Stromal vascular fraction improves deep partial thickness burn wound healing. Burns, 2014, 40(7): 1375-1383.
32.	Ebrahimian TG, Pouzoulet F, Squiban C, et al. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol, 2009, 29(4): 503-510.
33.	Nie C, Yang D, Xu J, et al. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant, 2011, 20(2): 205-216.
34.	Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 2004, 109(10): 1292-1298.
35.	Hassan WU, Greiser U, Wang W. Role of adipose-derived stem cells in wound healing. Wound Repair Regen, 2014, 22(3): 313-325.
36.	Blanton MW, Hadad I, Johnstone BH, et al. Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing. Plast Reconstr Surg, 2009, 123(2 Suppl): 56S-64S.
37.	Huang SP. Promotion of wound healing using adipose derived stem cells in radiation ulcer of a rat model. J Biomed Sci, 2013, 20: 51.
38.	Nambu M, Kishimoto S, Nakamura S, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg, 2009, 62(3): 317-321.
39.	Lendeckel S, Jodicke A, Christophis P, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg, 2004, 32(6): 370-373.
40.	Mesimaki K, Lindroos B, Tornwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg, 2009, 38(3): 201-209.
41.	Yoshimura K, Aoi N, Suga H, et al. Ectopic fibrogenesis induced by transplantation of adipose derived progenitor cell suspension immediately after lipoinjection. Transplantation, 2008, 85(12): 1868-1869.
42.	Yamamoto T, Gotoh M, Hattori R, et al. Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases. Int J Urol, 2010, 17(1): 75-82.
43.	Zheng G, Huang L, Tong H, et al. Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells a randomized, placebo controlled pilot study. Respir Res, 2014, 15: 39.
44.	Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5): 1423-1424.
45.	Akita S, Yoshimoto H, Ohtsuru A, et al. Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries. Radiat Prot Dosimetry, 2012, 151(4): 656-660.
46.	Jeong JH. Adipose Stem Cells and Skin Repair. Curr Stem Cell Res Ther, 2015, 5(2): 137-140.
47.	Choi J, Minn KW, Chang H. The efficacy and safety of platelet-rich plasma and adipose-derived stem cells: an update. Arch Plast Surg, 2012, 39(6): 585-592.
48.	Martins PDE, Uebel CO, Machado DC, et al. Adipose tissue mature stem cells in skin healing: a controlled randomized study. Rev Bras Cir Plást, 2011, 26(3): 394-401.
49.	Sung HM, Suh IS, Lee HB, et al. Case Reports of Adipose-derived Stem Cell Therapy for Nasal Skin Necrosis after Filler Injection. Arch Plast Surg, 2012, 39(1): 51-54.
50.	Walter M, Liang S, Ghosh S, et al. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene, 2009, 28(30): 2745-2755.
51.	Karnoub AE, Dash AB, Vo AP, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature, 2007, 449(7162): 557-563.
52.	Pan Q, Fouraschen SM, de Ruiter PE, et al. Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells. Exp Biol Med (Maywood), 2014, 239(1): 105-115.
53.	Rustad KC, Wong VW, Sorkin M, et al. Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials, 2012, 33(1): 80-90.
54.	Greaves NS, Iqbal SA, Baguneid M, et al. The role of skin substitutes in the management of chronic cutaneous wounds. Wound Repair Regen, 2013, 21(2): 194-210.
55.	Huang SP, Hsu CC, Chang SC, et al. Adipose-derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murine model of a full-thickness defect. Ann Plast Surg, 2012, 69(6): 656-662.
56.	Shen T, Pan Z, Zhou X, et al. Accelerated healing of diabetic wound using artificial dermisconstructed with adipose stem cells and poly (L-glutamic acid)/chitosan scaffold. Chin Med J, 2013, 126(8): 1498-1503.
57.	Kelleher CM, Vacanti JP. Engineering extracellular matrix through nanotechnology. J R Soc Interface, 2010, 7 Suppl 6: S717-729.
58.	Machula H, Ensley B, Kellar R. Electrospun Tropoelastin for Delivery of Therapeutic Adipose-Derived Stem Cells to Full-Thickness Dermal Wounds. Adv Wound Care (New Rochelle), 2014, 3(5): 367-375.
59.	Gu J, Liu N, Yang X, et al. Adiposed-derived stem cells seeded on PLCL/P123 eletrospun nanofibrous scaffold enhance wound healing. Biomed Mater, 2014, 9(3): 035012.
60.	Cerqueira MT, Pirraco RP, Santos TC, et al. Human adipose stem cells cell sheet constructs impact epidermal morphogenesis in full-thickness excisional wounds. Biomacromolecules, 2013, 14(11): 3997-4008.
61.	Lin YC, Grahovac T, Oh SJ, et al. Evaluation of a multi-layer adipose-derived stem cell sheet in a full-thickness wound healing model. Acta Biomater, 2013, 9(2): 5243-5250.

1. Hu MS, Maan ZN, Wu JC, et al. Tissue engineering and regenerative repair in wound healing. Ann Biomed Eng, 2014, 42(7): 1494-1507.
2. You HJ, Han SK. Cell therapy for wound healing. J Korean Med Sci, 2014, 29(3): 311-319.
3. Ghanem AM, Hachach-Haram N, Leung CC, et al. A systematic review of evidence for education and training interventions in microsurgery. Arch Plast Surg, 2013, 40(4): 312-319.
4. Zou JP, Huang S, Peng Y, et al. Mesenchymal stem cells/ multipotent mesenchymal stromal cells (MSCs): potential role in healing cutaneous chronic wounds. Int J Low Extrem Wounds, 2012, 11(4): 244-253.
5. Zahorec P, Koller J, Danisovic L, et al. Mesenchymal stem cells for chronic wounds therapy. Cell Tissue Bank, 2015, 16 (1): 19-26.
6. Baer PC, Geiger H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int, 2012, 2012: 812693.
7. Fathi E, Farahzadi R. Isolation, Culturing, Characterization and Aging of Adipose Tissue-derived Mesenchymal Stem Cells: A Brief Overview. Brazilian Archives of Biology and Technology, 2016, 59: e16150383.
8. Mert T, Kurt AH, Arslan M, et al. Anti-inflammatory and Anti-nociceptive Actions of Systemically or Locally Treated Adipose-Derived Mesenchymal Stem Cells in Experimental Inflammatory Model. Inflammation, 2015, 38(3): 1302-1310.
9. Zuk PA. The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell, 2010, 21(11): 1783-1787.
10. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med, 1999, 341(10): 738-746.
11. Sivan U, Jayakumar K, Krishnan LK. Constitution of fibrin-based niche for in vitro differentiation of adipose-derived mesenchymal stem cells to keratinocytes. Biores Open Access, 2014, 3(6): 339-347.
12. Chavez-Munoz C, Nguyen KT, Xu W, et al. Transdifferentiation of adipose-derived stem cells into keratinocyte-like cells: engineering a stratified epidermis. PLoS One, 2013, 8(12): e80587.
13. Hasegawa T, Sakamoto A, Wada A, et al. Keratinocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS One, 2015, 10(2): e0118402.
14. Hu R, Ling W, Xu W, et al. Fibroblast-like cells differentiated from adipose-derived mesenchymal stem cells for vocal fold wound healing. PLoS One, 2014, 9(3): e92676.
15. Cao Y, Sun Z, Liao L, et al. Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun, 2005, 332(2): 370-379.
16. Collawn SS, Banerjee NS, de la Torre J, et al. Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model. Ann Plast Surg, 2012, 68(5): 501-504.
17. Moon KM, Park YH, Lee JS, et al. The effect of secretory factors of adipose-derived stem cells on human keratinocytes. Int J Mol Sci, 2012, 13(1): 1239-1257.
18. Shi Z, Neoh KG, Kang ET, et al. Enhanced endothelial differentiation of adipose-derived stem cells by substrate nanotopography. J Tissue Eng Regen Med, 2014, 8(1): 50-58.
19. Zhang H, Ning H, Banie L, et al. Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties. Biochem Biophys Res Commun, 2010, 402(3): 560-564.
20. Blaber SP, Webster RA, Hill CJ, et al. Analysis of in vitro secretion profiles from adipose-derived cell populations. J Transl Med, 2012, 10: 172.
21. Pikuła M, Langa P, Kosikowska P, et al. Stem cells and growth factors in wound healing. Postepy Hig Med Dosw, 2015, 69: 874-885.
22. Zhao J, Hu L, Liu J, et al. The effects of cytokines in adipose stem cell-conditioned medium on the migration and proliferation of skin fibroblasts in vitro. Biomed Res Int, 2013, 2013: 578479.
23. Hsiao ST, Asgari A, Lokmic Z, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev, 2012, 21(12): 2189-2203.
24. Cai L, Johnstone BH, Cook TG, et al. Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells, 2007, 25(12): 3234-3243.
25. Shingyochi Y, Orbay H, Mizuno H. Adipose-derived stem cells for wound repair and regeneration. Expert Opin Biol Ther, 2015, 15(9): 1-8.
26. Heo SC, Jeon ES, Lee IH, et al. Tumor necrosis factor-alpha-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms. J Invest Dermatol, 2011, 131(7): 1559-1567.
27. Yoshimura K, Shigeura T, Matsumoto D, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol, 2006, 208(1): 64-76.
28. Lindroos B, Suuronen R, Miettinen S. The potential of adipose stem cells in regenerative medicine. Stem Cell Rev, 2011, 7(2): 269-291.
29. Liechty K, Mackenzie T, Shaaban A, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med, 2000, 6(11): 1282-1286.
30. Altman AM, Matthias N, Yan Y, et al. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials, 2008, 29(10): 1431-1442.
31. Atalay S, Coruh A, Deniz K. Stromal vascular fraction improves deep partial thickness burn wound healing. Burns, 2014, 40(7): 1375-1383.
32. Ebrahimian TG, Pouzoulet F, Squiban C, et al. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol, 2009, 29(4): 503-510.
33. Nie C, Yang D, Xu J, et al. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant, 2011, 20(2): 205-216.
34. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 2004, 109(10): 1292-1298.
35. Hassan WU, Greiser U, Wang W. Role of adipose-derived stem cells in wound healing. Wound Repair Regen, 2014, 22(3): 313-325.
36. Blanton MW, Hadad I, Johnstone BH, et al. Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing. Plast Reconstr Surg, 2009, 123(2 Suppl): 56S-64S.
37. Huang SP. Promotion of wound healing using adipose derived stem cells in radiation ulcer of a rat model. J Biomed Sci, 2013, 20: 51.
38. Nambu M, Kishimoto S, Nakamura S, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg, 2009, 62(3): 317-321.
39. Lendeckel S, Jodicke A, Christophis P, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg, 2004, 32(6): 370-373.
40. Mesimaki K, Lindroos B, Tornwall J, et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg, 2009, 38(3): 201-209.
41. Yoshimura K, Aoi N, Suga H, et al. Ectopic fibrogenesis induced by transplantation of adipose derived progenitor cell suspension immediately after lipoinjection. Transplantation, 2008, 85(12): 1868-1869.
42. Yamamoto T, Gotoh M, Hattori R, et al. Periurethral injection of autologous adipose-derived stem cells for the treatment of stress urinary incontinence in patients undergoing radical prostatectomy: report of two initial cases. Int J Urol, 2010, 17(1): 75-82.
43. Zheng G, Huang L, Tong H, et al. Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells a randomized, placebo controlled pilot study. Respir Res, 2014, 15: 39.
44. Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg, 2007, 119(5): 1423-1424.
45. Akita S, Yoshimoto H, Ohtsuru A, et al. Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries. Radiat Prot Dosimetry, 2012, 151(4): 656-660.
46. Jeong JH. Adipose Stem Cells and Skin Repair. Curr Stem Cell Res Ther, 2015, 5(2): 137-140.
47. Choi J, Minn KW, Chang H. The efficacy and safety of platelet-rich plasma and adipose-derived stem cells: an update. Arch Plast Surg, 2012, 39(6): 585-592.
48. Martins PDE, Uebel CO, Machado DC, et al. Adipose tissue mature stem cells in skin healing: a controlled randomized study. Rev Bras Cir Plást, 2011, 26(3): 394-401.
49. Sung HM, Suh IS, Lee HB, et al. Case Reports of Adipose-derived Stem Cell Therapy for Nasal Skin Necrosis after Filler Injection. Arch Plast Surg, 2012, 39(1): 51-54.
50. Walter M, Liang S, Ghosh S, et al. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene, 2009, 28(30): 2745-2755.
51. Karnoub AE, Dash AB, Vo AP, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature, 2007, 449(7162): 557-563.
52. Pan Q, Fouraschen SM, de Ruiter PE, et al. Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells. Exp Biol Med (Maywood), 2014, 239(1): 105-115.
53. Rustad KC, Wong VW, Sorkin M, et al. Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials, 2012, 33(1): 80-90.
54. Greaves NS, Iqbal SA, Baguneid M, et al. The role of skin substitutes in the management of chronic cutaneous wounds. Wound Repair Regen, 2013, 21(2): 194-210.
55. Huang SP, Hsu CC, Chang SC, et al. Adipose-derived stem cells seeded on acellular dermal matrix grafts enhance wound healing in a murine model of a full-thickness defect. Ann Plast Surg, 2012, 69(6): 656-662.
56. Shen T, Pan Z, Zhou X, et al. Accelerated healing of diabetic wound using artificial dermisconstructed with adipose stem cells and poly (L-glutamic acid)/chitosan scaffold. Chin Med J, 2013, 126(8): 1498-1503.
57. Kelleher CM, Vacanti JP. Engineering extracellular matrix through nanotechnology. J R Soc Interface, 2010, 7 Suppl 6: S717-729.
58. Machula H, Ensley B, Kellar R. Electrospun Tropoelastin for Delivery of Therapeutic Adipose-Derived Stem Cells to Full-Thickness Dermal Wounds. Adv Wound Care (New Rochelle), 2014, 3(5): 367-375.
59. Gu J, Liu N, Yang X, et al. Adiposed-derived stem cells seeded on PLCL/P123 eletrospun nanofibrous scaffold enhance wound healing. Biomed Mater, 2014, 9(3): 035012.
60. Cerqueira MT, Pirraco RP, Santos TC, et al. Human adipose stem cells cell sheet constructs impact epidermal morphogenesis in full-thickness excisional wounds. Biomacromolecules, 2013, 14(11): 3997-4008.
61. Lin YC, Grahovac T, Oh SJ, et al. Evaluation of a multi-layer adipose-derived stem cell sheet in a full-thickness wound healing model. Acta Biomater, 2013, 9(2): 5243-5250.

Chinese Journal of Reparative and Reconstructive Surgery

Research progress of adipose-derived stem cells in skin wound healing

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content