Research progress of porous tantalum in bone tissue engineering_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

DING Xiaoquan , LIU Xingwang , CHEN Jun ,  CHEN Shiyi

Department of Sports Medicine and Arthroscopy, Huashan Hospital, Fudan University, Shanghai, 200040, P.R.China;

Corresponding author：

CHEN Shiyi, Email: cshiyi@163.com

Keywords：

Porous tantalum; bone tissue enginnering; osteointegration; surface modification

DOI：

10.7507/1002-1892.201711040

Video：

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Objective To review the basical research progress of porous tantalum in bone tissue engineering. Methods The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. Results The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocompatibility and osteointegration, as well as promoting cartilage and tendon tissue restoration. However, the clinical utilization of porous tantalum is somehow greatly limited by the complex and rigid commercial fabrication methods and extraordinary high cost. Along with the publication of novel fabrication and surface modification technology, the application of porous tantalum will be more extensive, the promotion in bone tissue regeneration will be more prominent. Conclusion Porous tantalum has advantage in bone defect restoration, and significant breakthrough technology is needed in fabrication methods and surface modification.

Citation： DING Xiaoquan, LIU Xingwang, CHEN Jun, CHEN Shiyi. Research progress of porous tantalum in bone tissue engineering. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(6): 753-757. doi: 10.7507/1002-1892.201711040 Copy

1.	Langer R, Vacanti JP. Tissue engineering. Science, 1993, 260(5110): 920-926.
2.	Li JJ, Ebied M, Xu J, et al. Current approaches to bone tissue engineering: The interface between biology and engineering. Adv Healthc Mater, 2018, 7(6): e1701061.
3.	Ghassemi T, Shahroodi A, Ebrahimzadeh MH, et al. Current concepts in scaffolding for bone tissue engineering. Arch Bone Jt Surg, 2018, 6(2): 90-99.
4.	Kim HD, Amirthalingam S, Kim SL, et al. Biomimetic materials and fabrication approaches for bone tissue engineering. Adv Healthc Mater, 2017, 6(23). doi: 10.1002/adhm.201700612.
5.	Asri RIM, Harun WSW, Samykano M, et al. Corrosion and surface modification on biocompatible metals: a review. Mater Sci Eng C Mater Biol Appl, 2017, 77: 1261-1274.
6.	Mohandas G, Oskolkov N, McMahon MT, et al. Porous tantalum and tantalum oxide nanoparticles for regenerative medicine. Acta Neurobiol Exp (Wars), 2014, 74(2): 188-196.
7.	Cohen R. A porous tantalum trabecular metal: basic science. Am J Orthop (Belle Mead NJ), 2002, 31(4): 216-217.
8.	Liu Y, Bao C, Wismeijer D, et al. The physicochemical/biological properties of porous tantalum and the potential surface modification techniques to improve its clinical application in dental implantology. Mater Sci Eng C Mater Biol Appl, 2015, 49: 323-329.
9.	Ling TX, Li JL, Zhou K, et al. The use of porous tantalum augments for the reconstruction of acetabular defect in primary total hip arthroplasty. J Arthroplasty, 2018, 33(2): 453-459.
10.	Gee EC, Jordan R, Hunt JA, et al. Current evidence and future directions for research into the use of tantalum in soft tissue re-attachment surgery. Journal of Materials Chemistry B, 2016, 4(6): 1020-1034.
11.	Li X, Wang L, Yu X, et al. Tantalum coating on porous ti6al4v scaffold using chemical vapor deposition and preliminary biological evaluation. Mater Sci Eng C Mater Biol Appl, 2013, 33(5): 2987-2994.
12.	Wauthle R, van der Stok J, Amin Yavari S, et al. Additively manufactured porous tantalum implants. Acta Biomater, 2015, 14: 217-225.
13.	Balla VK, Bodhak S, Bose S, et al. Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties. Acta Biomater, 2010, 6(8): 3349-3359.
14.	Bencharit S, Byrd WC, Altarawneh S, et al. Development and applications of porous tantalum trabecular metal-enhanced titanium dental implants. Clin Implant Dent Relat Res, 2014, 16(6): 817-826.
15.	Rahbek O, Kold S, Zippor B, et al. Particle migration and gap healing around trabecular metal implants. Int Orthop, 2005, 29(6): 368-374.
16.	Ninomiya JT, Struve JA, Krolikowski J, et al. Porous ongrowth surfaces alter osteoblast maturation and mineralization. J Biomed Mater Res A, 2015, 103(1): 276-281.
17.	Sagomonyants KB, Hakim-Zargar M, Jhaveri A, et al. Porous tantalum stimulates the proliferation and osteogenesis of osteoblasts from elderly female patients. J Orthop Res, 2011, 29(4): 609-616.
18.	Wang Q, Zhang H, Li Q, et al. Biocompatibility and osteogenic properties of porous tantalum. Exp Ther Med, 2015, 9(3): 780-786.
19.	Gordon WJ, Conzemius MG, Birdsall E, et al. Chondroconductive potential of tantalum trabecular metal. J Biomed Mater Res B Appl Biomater, 2005, 75(2): 229-233.
20.	Jamil K, Chua KH, Joudi S, et al. Development of a cartilage composite utilizing porous tantalum, fibrin, and rabbit chondrocytes for treatment of cartilage defect. J Orthop Surg Res, 2015, 10: 27.
21.	Reach JS Jr, Dickey ID, Zobitz ME, et al. Direct tendon attachment and healing to porous tantalum: an experimental animal study. J Bone Joint Surg (Am), 2007, 89(5): 1000-1009.
22.	Babis GC, Stavropoulos NA, Sasalos G, et al. Metallosis and elevated serum levels of tantalum following failed revision hip arthroplasty——a case report. Acta Orthop, 2014, 85(6): 677-680.
23.	Schoon J, Geissler S, Traeger J, et al. Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case. Nanomedicine, 2017, 13(8): 2415-2423.
24.	Tobin EJ. Recent coating developments for combination devices in orthopedic and dental applications: A literature review. Adv Drug Deliv Rev, 2017, 112: 88-100.
25.	Mas-Moruno C, Garrido B, Rodriguez D, et al. Biofunctionalization strategies on tantalum-based materials for osseointegrative applications. J Mater Sci Mater Med, 2015, 26(2): 109.
26.	Garcia-Gareta E, Hua J, Orera A, et al. Biomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants. Biomed Mater, 2017, 13(1): 015008.
27.	Xu HH, Wang P, Wang L, et al. Calcium phosphate cements for bone engineering and their biological properties. Bone Res, 2017, 5: 17056.
28.	Barrère F, van der Valk CM, Meijer G, et al. Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B Appl Biomater, 2003, 67(1): 655-665.
29.	Li Y, Yang W, Li X, et al. Improving osteointegration and osteogenesis of three-dimensional porous ti6al4v scaffolds by polydopamine-assisted biomimetic hydroxyapatite coating. ACS Appl Mater Interfaces, 2015, 7(10): 5715-5724.
30.	Wang Q, Zhang H, Gan H, et al. Application of combined porous tantalum scaffolds loaded with bone morphogenetic protein 7 to repair of osteochondral defect in rabbits. Int Orthop, 2018.[Epub ahead of print].
31.	Guo X, Chen M, Feng W, et al. Electrostatic self-assembly of multilayer copolymeric membranes on the surface of porous tantalum implants for sustained release of doxorubicin. Int J Nanomedicine, 2011, 6: 3057-3064.

1. Langer R, Vacanti JP. Tissue engineering. Science, 1993, 260(5110): 920-926.
2. Li JJ, Ebied M, Xu J, et al. Current approaches to bone tissue engineering: The interface between biology and engineering. Adv Healthc Mater, 2018, 7(6): e1701061.
3. Ghassemi T, Shahroodi A, Ebrahimzadeh MH, et al. Current concepts in scaffolding for bone tissue engineering. Arch Bone Jt Surg, 2018, 6(2): 90-99.
4. Kim HD, Amirthalingam S, Kim SL, et al. Biomimetic materials and fabrication approaches for bone tissue engineering. Adv Healthc Mater, 2017, 6(23). doi: 10.1002/adhm.201700612.
5. Asri RIM, Harun WSW, Samykano M, et al. Corrosion and surface modification on biocompatible metals: a review. Mater Sci Eng C Mater Biol Appl, 2017, 77: 1261-1274.
6. Mohandas G, Oskolkov N, McMahon MT, et al. Porous tantalum and tantalum oxide nanoparticles for regenerative medicine. Acta Neurobiol Exp (Wars), 2014, 74(2): 188-196.
7. Cohen R. A porous tantalum trabecular metal: basic science. Am J Orthop (Belle Mead NJ), 2002, 31(4): 216-217.
8. Liu Y, Bao C, Wismeijer D, et al. The physicochemical/biological properties of porous tantalum and the potential surface modification techniques to improve its clinical application in dental implantology. Mater Sci Eng C Mater Biol Appl, 2015, 49: 323-329.
9. Ling TX, Li JL, Zhou K, et al. The use of porous tantalum augments for the reconstruction of acetabular defect in primary total hip arthroplasty. J Arthroplasty, 2018, 33(2): 453-459.
10. Gee EC, Jordan R, Hunt JA, et al. Current evidence and future directions for research into the use of tantalum in soft tissue re-attachment surgery. Journal of Materials Chemistry B, 2016, 4(6): 1020-1034.
11. Li X, Wang L, Yu X, et al. Tantalum coating on porous ti6al4v scaffold using chemical vapor deposition and preliminary biological evaluation. Mater Sci Eng C Mater Biol Appl, 2013, 33(5): 2987-2994.
12. Wauthle R, van der Stok J, Amin Yavari S, et al. Additively manufactured porous tantalum implants. Acta Biomater, 2015, 14: 217-225.
13. Balla VK, Bodhak S, Bose S, et al. Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties. Acta Biomater, 2010, 6(8): 3349-3359.
14. Bencharit S, Byrd WC, Altarawneh S, et al. Development and applications of porous tantalum trabecular metal-enhanced titanium dental implants. Clin Implant Dent Relat Res, 2014, 16(6): 817-826.
15. Rahbek O, Kold S, Zippor B, et al. Particle migration and gap healing around trabecular metal implants. Int Orthop, 2005, 29(6): 368-374.
16. Ninomiya JT, Struve JA, Krolikowski J, et al. Porous ongrowth surfaces alter osteoblast maturation and mineralization. J Biomed Mater Res A, 2015, 103(1): 276-281.
17. Sagomonyants KB, Hakim-Zargar M, Jhaveri A, et al. Porous tantalum stimulates the proliferation and osteogenesis of osteoblasts from elderly female patients. J Orthop Res, 2011, 29(4): 609-616.
18. Wang Q, Zhang H, Li Q, et al. Biocompatibility and osteogenic properties of porous tantalum. Exp Ther Med, 2015, 9(3): 780-786.
19. Gordon WJ, Conzemius MG, Birdsall E, et al. Chondroconductive potential of tantalum trabecular metal. J Biomed Mater Res B Appl Biomater, 2005, 75(2): 229-233.
20. Jamil K, Chua KH, Joudi S, et al. Development of a cartilage composite utilizing porous tantalum, fibrin, and rabbit chondrocytes for treatment of cartilage defect. J Orthop Surg Res, 2015, 10: 27.
21. Reach JS Jr, Dickey ID, Zobitz ME, et al. Direct tendon attachment and healing to porous tantalum: an experimental animal study. J Bone Joint Surg (Am), 2007, 89(5): 1000-1009.
22. Babis GC, Stavropoulos NA, Sasalos G, et al. Metallosis and elevated serum levels of tantalum following failed revision hip arthroplasty——a case report. Acta Orthop, 2014, 85(6): 677-680.
23. Schoon J, Geissler S, Traeger J, et al. Multi-elemental nanoparticle exposure after tantalum component failure in hip arthroplasty: In-depth analysis of a single case. Nanomedicine, 2017, 13(8): 2415-2423.
24. Tobin EJ. Recent coating developments for combination devices in orthopedic and dental applications: A literature review. Adv Drug Deliv Rev, 2017, 112: 88-100.
25. Mas-Moruno C, Garrido B, Rodriguez D, et al. Biofunctionalization strategies on tantalum-based materials for osseointegrative applications. J Mater Sci Mater Med, 2015, 26(2): 109.
26. Garcia-Gareta E, Hua J, Orera A, et al. Biomimetic surface functionalization of clinically relevant metals used as orthopaedic and dental implants. Biomed Mater, 2017, 13(1): 015008.
27. Xu HH, Wang P, Wang L, et al. Calcium phosphate cements for bone engineering and their biological properties. Bone Res, 2017, 5: 17056.
28. Barrère F, van der Valk CM, Meijer G, et al. Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B Appl Biomater, 2003, 67(1): 655-665.
29. Li Y, Yang W, Li X, et al. Improving osteointegration and osteogenesis of three-dimensional porous ti6al4v scaffolds by polydopamine-assisted biomimetic hydroxyapatite coating. ACS Appl Mater Interfaces, 2015, 7(10): 5715-5724.
30. Wang Q, Zhang H, Gan H, et al. Application of combined porous tantalum scaffolds loaded with bone morphogenetic protein 7 to repair of osteochondral defect in rabbits. Int Orthop, 2018.[Epub ahead of print].
31. Guo X, Chen M, Feng W, et al. Electrostatic self-assembly of multilayer copolymeric membranes on the surface of porous tantalum implants for sustained release of doxorubicin. Int J Nanomedicine, 2011, 6: 3057-3064.

Chinese Journal of Reparative and Reconstructive Surgery

Research progress of porous tantalum in bone tissue engineering

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