Research status and progress of biomaterials for bone repair and reconstruction_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 DENG Lianfu , YAN Yufei

Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R.China;

Corresponding author：

DENG Lianfu, Email: lf_deng@126.com

Keywords：

Bone repair; biomaterial; research progress

DOI：

10.7507/1002-1892.201806028

Video：

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Artificial bone repair material is the best substitute for autologous bone transplantation. Bone repair materials are constantly being replaced and upgraded, which can be roughly divided into three generations: bioinert materials, bioactive materials, and smart materials. Research and development of bone repair materials with multiple biological activities, in vivo degradation property that perfectly fit for new bone formation, and ability of complete reconstruction of bone tissue in physiological state are the focus of future research.

Citation： DENG Lianfu, YAN Yufei. Research status and progress of biomaterials for bone repair and reconstruction. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(7): 815-820. doi: 10.7507/1002-1892.201806028 Copy

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2.	Breeze J, Patel J, Dover M, et al. Success rates and complications of autologous onlay bone grafts and sinus lifts in patients with congenital hypodontia and after trauma. Brit J Oral Mac Surg, 2017, 55(8): 830-833.
3.	Tosounidis T, Giannoudis P. Biological facet of segmental bone loss reconstruction. J Orthop Trauma, 2017, 31 Suppl 5: S27-S31.
4.	Sen MK, Miclau T. Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury, 2007, 38(1): S75-S80.
5.	Sakkas A, Wilde F, Heufelder M, et al. Autogenous bone grafts in oral implantology-is it still a " gold standard”? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent, 2017, 3(1): 3-23.
6.	Sakkas A, Schramm A, Winter K, et al. Risk factors for post-operative complications after procedures for autologous bone augmentation from different donor sites. J Craniomaxillofac Surg, 2018, 46(2): 312-322.
7.	Windhager R, Hobusch G, Matzner M. Allogeneic transplants for biological reconstruction of bone defects. Orthopade, 2017, 46(8): 656-664.
8.	Yu X, Tang X, Gohil SV, et al. Biomaterials for bone regenerative engineering. Adv. Healthcare Mater, 2015, 4(9): 1268-1285.
9.	Paiva K, Granjeiro J. Bone tissue remodeling and development: focus on matrix metalloproteinase functions. Arch BiochemBiophys, 2014, 561(2): 74-87.
10.	Kohli N, Ho S, Brown S, et al. Bone remodelling in vitro: Where are we headed?:-A review on the current understanding of physiological bone remodelling and inflammation and the strategies for testing biomaterials. Bone, 2018, 110: 38-46.
11.	Berendsen A, Olsen B. Bone development. Bone, 2015, 80: 14-18.
12.	Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater, 2008, 15(1): 53-76.
13.	Daculsi G, Fellah BH, Miramond T, et al. Osteoconduction, osteogenicity, osteoinduction, what are the fundamental properties for a smart bone substitutes. Irbm, 2013, 34(4-5): 346-348.
14.	Wu T, Yu S, Chen D, et al. Bionic design, materials and performance of bone tissue scaffolds. Materials, 2017, 10(10): 1187.
15.	Chia HN, Wu BM. Recent advances in 3D printing of biomaterials. J Biol Eng, 2015, 9: 4.
16.	de Azevedo Gonçalves Mota, Couto R, Da Silva, et al. 3D printed scaffolds as a new perspective for bone tissue regeneration: literature review. Mater Sci App, 2016, 7(8): 430-452.
17.	Urist MR. Bone: formation by autoinduction. Science, 1965, 150(3698): 893-899.
18.	Legeros RZ. Calcium phosphate-based osteoinductive materials. Chem Rev, 2008, 108(11): 4742-4753.
19.	Fujibayashi S, Neo M, Kim HM, et al. Osteoinduction of porous bioactive titanium metal. Biomaterials, 2004, 25(3): 443-450.
20.	Carlier A, Van Gastel N, Geris L, et al. Bringing regenerating tissues to life: the importance of angiogenesis in tissue engineering. Angiogenesis, 2014, 17(3): 735-735.
21.	Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature, 2014, 507(7492): 323-328.
22.	Mehta G, Mehta K, Sud D, et al. Quantitative measurement and control of oxygen levels in microfluidic poly (dimethylsiloxane) bioreactors during cell culture. Biomed Microdev, 2007, 9(2): 123-134.
23.	Jabbarzadeh E, Starnes T, Khan YM, et al. Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach. Proc Natl Acad Sci U S A, 2008, 105(32): 11099-11104.
24.	Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng, 2012, 40(5): 363-408.
25.	Hench LL. Biomaterials. Science, 1980, 208(4446): 826-831.
26.	Hench LL. Biomaterials: a forecast for the future. Biomaterials, 1998, 19(16): 1419-1423.
27.	Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg (Br), 1960, 42-B: 28-30.
28.	Gotman I. Characteristics of metals used in implants. J Endourol, 1997, 11(6): 383-389.
29.	Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J, 2001, 10(Suppl 2): S96-S101.
30.	Branemark PI. Vital microscopy of bone marrow in rabbit. Scand J Clin Lab Invest, 1959, 11 Supp 38: 1-82.
31.	Kurtz SM, Devine JN. PEEK biomaterials in trauma, orthopedic, and spinal implants. Biomaterials, 2007, 28(32): 4845-4869.
32.	Kulkarni RK, Pani KC, Neuman C, et al. Polylactic acid for surgical implants. Arch Surg, 1966, 93(5): 839-843.
33.	Shirtliff VJ, Hench LL. Bioactive materials for tissue engineering, regeneration and repair. J Mater Sci, 2003, 38(23): 4697-4707.
34.	Hench LL, Polak JM. Third-generation biomedical materials. Science, 2002, 295(5557): 1014-1017.
35.	Lorenti A. Wound healing: from epidermis culture to tissue engineering. Cell Bio, 2012, 1(2): 17-29.
36.	Lv Q, Deng M, Ulery BD, et al. Nano-ceramic composite scaffolds for bioreactor-based bone engineering. Clin Orthop Relat Res, 2013, 471(8): 2422-2433.
37.	Jia P, Chen H, Kang H, et al. Deferoxamine released from poly (lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis. J Biomed Mater Res A, 2016, 104(10): 2515-2527.
38.	Verma S, Domb AJ, Kumar N. Nanomaterials for regenerative medicine. Nanomedicine, 2011, 6(1): 157-181.
39.	Langer R, Vacanti JP. Tissue engineering. Science, 1993, 260(5110): 920-926.
40.	Laurencin CT, Khan Y. Regenerative engineering. Sci Trans Med, 2013, 4(160): 160ed9.
41.	Hvistendahl M. China’s push in tissue engineering. Science, 2012, 338(6109): 900-902.
42.	Detsch R, Boccaccini AR. The role of osteoclasts in bone tissue engineering. J Tissue Eng Regen M, 2015, 9(10): 1133-1149.
43.	Karsdal MA, Neutzsky-Wulff AV, Dziegiel MH, et al. Osteoclasts secrete non-bone derived signals that induce bone formation. Biochem Bioph Res Co, 2008, 366(2): 483-488.
44.	Han D, Zhang Q. An essential requirement for osteoclasts in refined bone-like tissue reconstruction in vitro. Med Hypotheses, 2006, 67(1): 75-78.
45.	Segar CE, Ogle ME, Botchwey EA. Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Curr Pharm Des, 2013, 19(19): 3403-3419.
46.	Lo KW, Jiang T, Gagnon KA, et al. Small-molecule based musculoskeletal regenerative engineering. Trends Biotechnol, 2014, 32(2): 74-81.
47.	Laurencin CT, Ashe KM, Henry N, et al. Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications. Drug Discov Today, 2014, 19(6): 794-800.
48.	Emara KM, Diab RA, Emara AK. Recent biological trends in management of fracture non-union. World J Orthop, 2015, 6(8): 623-628.

1. 2013-2018年中国人工骨行业市场预测深度调研及销售策略前景报告[EB/OL]. http://www.ynshangji.com/g3000000006949691/.
2. Breeze J, Patel J, Dover M, et al. Success rates and complications of autologous onlay bone grafts and sinus lifts in patients with congenital hypodontia and after trauma. Brit J Oral Mac Surg, 2017, 55(8): 830-833.
3. Tosounidis T, Giannoudis P. Biological facet of segmental bone loss reconstruction. J Orthop Trauma, 2017, 31 Suppl 5: S27-S31.
4. Sen MK, Miclau T. Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury, 2007, 38(1): S75-S80.
5. Sakkas A, Wilde F, Heufelder M, et al. Autogenous bone grafts in oral implantology-is it still a " gold standard”? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent, 2017, 3(1): 3-23.
6. Sakkas A, Schramm A, Winter K, et al. Risk factors for post-operative complications after procedures for autologous bone augmentation from different donor sites. J Craniomaxillofac Surg, 2018, 46(2): 312-322.
7. Windhager R, Hobusch G, Matzner M. Allogeneic transplants for biological reconstruction of bone defects. Orthopade, 2017, 46(8): 656-664.
8. Yu X, Tang X, Gohil SV, et al. Biomaterials for bone regenerative engineering. Adv. Healthcare Mater, 2015, 4(9): 1268-1285.
9. Paiva K, Granjeiro J. Bone tissue remodeling and development: focus on matrix metalloproteinase functions. Arch BiochemBiophys, 2014, 561(2): 74-87.
10. Kohli N, Ho S, Brown S, et al. Bone remodelling in vitro: Where are we headed?:-A review on the current understanding of physiological bone remodelling and inflammation and the strategies for testing biomaterials. Bone, 2018, 110: 38-46.
11. Berendsen A, Olsen B. Bone development. Bone, 2015, 80: 14-18.
12. Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater, 2008, 15(1): 53-76.
13. Daculsi G, Fellah BH, Miramond T, et al. Osteoconduction, osteogenicity, osteoinduction, what are the fundamental properties for a smart bone substitutes. Irbm, 2013, 34(4-5): 346-348.
14. Wu T, Yu S, Chen D, et al. Bionic design, materials and performance of bone tissue scaffolds. Materials, 2017, 10(10): 1187.
15. Chia HN, Wu BM. Recent advances in 3D printing of biomaterials. J Biol Eng, 2015, 9: 4.
16. de Azevedo Gonçalves Mota, Couto R, Da Silva, et al. 3D printed scaffolds as a new perspective for bone tissue regeneration: literature review. Mater Sci App, 2016, 7(8): 430-452.
17. Urist MR. Bone: formation by autoinduction. Science, 1965, 150(3698): 893-899.
18. Legeros RZ. Calcium phosphate-based osteoinductive materials. Chem Rev, 2008, 108(11): 4742-4753.
19. Fujibayashi S, Neo M, Kim HM, et al. Osteoinduction of porous bioactive titanium metal. Biomaterials, 2004, 25(3): 443-450.
20. Carlier A, Van Gastel N, Geris L, et al. Bringing regenerating tissues to life: the importance of angiogenesis in tissue engineering. Angiogenesis, 2014, 17(3): 735-735.
21. Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature, 2014, 507(7492): 323-328.
22. Mehta G, Mehta K, Sud D, et al. Quantitative measurement and control of oxygen levels in microfluidic poly (dimethylsiloxane) bioreactors during cell culture. Biomed Microdev, 2007, 9(2): 123-134.
23. Jabbarzadeh E, Starnes T, Khan YM, et al. Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach. Proc Natl Acad Sci U S A, 2008, 105(32): 11099-11104.
24. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng, 2012, 40(5): 363-408.
25. Hench LL. Biomaterials. Science, 1980, 208(4446): 826-831.
26. Hench LL. Biomaterials: a forecast for the future. Biomaterials, 1998, 19(16): 1419-1423.
27. Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg (Br), 1960, 42-B: 28-30.
28. Gotman I. Characteristics of metals used in implants. J Endourol, 1997, 11(6): 383-389.
29. Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J, 2001, 10(Suppl 2): S96-S101.
30. Branemark PI. Vital microscopy of bone marrow in rabbit. Scand J Clin Lab Invest, 1959, 11 Supp 38: 1-82.
31. Kurtz SM, Devine JN. PEEK biomaterials in trauma, orthopedic, and spinal implants. Biomaterials, 2007, 28(32): 4845-4869.
32. Kulkarni RK, Pani KC, Neuman C, et al. Polylactic acid for surgical implants. Arch Surg, 1966, 93(5): 839-843.
33. Shirtliff VJ, Hench LL. Bioactive materials for tissue engineering, regeneration and repair. J Mater Sci, 2003, 38(23): 4697-4707.
34. Hench LL, Polak JM. Third-generation biomedical materials. Science, 2002, 295(5557): 1014-1017.
35. Lorenti A. Wound healing: from epidermis culture to tissue engineering. Cell Bio, 2012, 1(2): 17-29.
36. Lv Q, Deng M, Ulery BD, et al. Nano-ceramic composite scaffolds for bioreactor-based bone engineering. Clin Orthop Relat Res, 2013, 471(8): 2422-2433.
37. Jia P, Chen H, Kang H, et al. Deferoxamine released from poly (lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis. J Biomed Mater Res A, 2016, 104(10): 2515-2527.
38. Verma S, Domb AJ, Kumar N. Nanomaterials for regenerative medicine. Nanomedicine, 2011, 6(1): 157-181.
39. Langer R, Vacanti JP. Tissue engineering. Science, 1993, 260(5110): 920-926.
40. Laurencin CT, Khan Y. Regenerative engineering. Sci Trans Med, 2013, 4(160): 160ed9.
41. Hvistendahl M. China’s push in tissue engineering. Science, 2012, 338(6109): 900-902.
42. Detsch R, Boccaccini AR. The role of osteoclasts in bone tissue engineering. J Tissue Eng Regen M, 2015, 9(10): 1133-1149.
43. Karsdal MA, Neutzsky-Wulff AV, Dziegiel MH, et al. Osteoclasts secrete non-bone derived signals that induce bone formation. Biochem Bioph Res Co, 2008, 366(2): 483-488.
44. Han D, Zhang Q. An essential requirement for osteoclasts in refined bone-like tissue reconstruction in vitro. Med Hypotheses, 2006, 67(1): 75-78.
45. Segar CE, Ogle ME, Botchwey EA. Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Curr Pharm Des, 2013, 19(19): 3403-3419.
46. Lo KW, Jiang T, Gagnon KA, et al. Small-molecule based musculoskeletal regenerative engineering. Trends Biotechnol, 2014, 32(2): 74-81.
47. Laurencin CT, Ashe KM, Henry N, et al. Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications. Drug Discov Today, 2014, 19(6): 794-800.
48. Emara KM, Diab RA, Emara AK. Recent biological trends in management of fracture non-union. World J Orthop, 2015, 6(8): 623-628.

Chinese Journal of Reparative and Reconstructive Surgery

Research status and progress of biomaterials for bone repair and reconstruction

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