Recent research progress of bioactivity mechanism and application of bone repair materials_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HE Wei ^1,2 ,  FAN Yubo ^1,2 ,  LI Xiaoming ^1,2

1. School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, P.R.China;
2. Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, P.R.China;

Corresponding author：

FAN Yubo, Email: yubofan@buaa.edu.cn; LI Xiaoming, Email: x.m.li@hotmail.com

Keywords：

Bone repair material; osteogenesis mechanism; osteogenic activity

DOI：

10.7507/1002-1892.201807039

Video：

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Abstract Full text Figures/Tables Video References Cited by

Large bone defect repair is a difficult problem to be solved urgently in orthopaedic field, and the application of bone repair materials is a feasible method to solve this problem. Therefore, bone repair materials have been continuously developed, and have evolved from autogenous bone grafts, allograft bone grafts, and inert materials to highly active and multifunctional bone tissue engineering scaffold materials. In this paper, the related mechanism of bone repair materials, the application of bone repair materials, and the exploration of new bone repair materials are introduced to present the research status and advance of the bone repair materials, and the development direction is also prospected.

Citation： HE Wei, FAN Yubo, LI Xiaoming. Recent research progress of bioactivity mechanism and application of bone repair materials. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(9): 1107-1115. doi: 10.7507/1002-1892.201807039 Copy

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1. Li X, van Blitterswijk CA, Feng Q, et al. The effect of calcium phosphate microstructure on bone-related cells in vitro. Biomaterials, 2008, 29(23): 3306-3316.
2. Li X, Liu H, Niu X, et al. The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro, and ectopic bone formation in vivo. Biomaterials, 2012, 33(19): 4818-4827.
3. Midha S, Murab S, Ghosh S. Osteogenic signaling on silk-based matrices. Biomaterials, 2016, 97: 133-153.
4. Chen Z, Wu C, Gu W, et al. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials, 2014, 35(5): 1507-1518.
5. Chen Z, Wu C, Yuen J, et al. Influence of osteocytes in the in vitro and in vivo β-tricalcium phosphate-stimulated osteogenesis. J Biomed Mater Res Part A, 2014, 102(8): 2813-2823.
6. Zhang X, Zu H, Zhao D, et al. Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant. Acta Biomater, 2017, 63: 369-382.
7. Liu H, Xu GW, Wang YF, et al. Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop. Biomaterials, 2015, 49: 103-112.
8. Lin Y, Huang Y, He J, et al. Role of Hedgehog-Gli1 signaling in the enhanced proliferation and differentiation of MG63 cells enabled by hierarchical micro-/nanotextured topography. Int J Nanomedicine, 2017, 12: 3267-3280.
9. Pan H, Xie Y, Zhang Z, et al. Hierarchical macropore/nano surface regulates stem cell fate through a ROCK-related signaling pathway. Rsc Advances, 2017, 7(14): 8521-8532.
10. Wang W, Liu Q, Zhang Y, et al. Involvement of ILK/ERK1/2 and ILK/p38 pathways in mediating the enhanced osteoblast differentiation by micro/nanotopography. Acta Biomater, 2014, 10(8): 3705-3715.
11. Liu N, Zhou M, Zhang Q, et al. Stiffness regulates the proliferation and osteogenic/odontogenic differentiation of human dental pulp stem cells via the WNT signalling pathway. Cell Prolif, 2018, 51(2): e12435.
12. Yuan H, Zhou Y, Lee MS, et al. A Newly Identified Mechanism Involved in Regulation of Human Mesenchymal Stem Cells by Fibrous Substrate Stiffness. Acta Biomater, 2016, 42: 247-257.
13. Chen S, Guo Y, Liu R, et al. Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the signaling pathways for the enhancement of early osseointegration. Colloids Surf B Biointerfaces, 2018, 164: 58-69.
14. Wu C, Xia L, Han P, et al. Graphene-oxide-modified β-tricalcium phosphate bioceramics stimulate in vitro and in vivo osteogenesis. Carbon, 2015, 93: 116-129.
15. Sriram M, Sainitya R, Kalyanaraman V, et al. Biomaterials mediated microRNA delivery for bone tissue engineering. Inter J Biol Macromol, 2015, 74: 404-412.
16. Ha SW, Jang HL, Nam KT, et al. Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression. Biomaterials, 2015, 65: 32-42.
17. Chen R, Wang J, Liu C. Biomaterials act as enhancers of growth factors in bone regeneration. Advanced Functional Materials, 2016, 26(48): 8810-8823.
18. Peric M, Dumic-Cule I, Grcevic D, et al. The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone, 2015, 70(1): 73-86.
19. Li X, Feng Q, Liu X, et al. Collagen-based implants reinforced by chitin fibres in a goat shank bone defect model. Biomaterials, 2006, 27(9): 1917-1923.
20. Kargozar S, Lotfibakhshaiesh N, Ai J, et al. Strontium- and cobalt-substituted bioactive glasses seeded with human umbilical cord perivascular cells to promote bone regeneration via enhanced osteogenic and angiogenic activities. Acta Biomater, 2017, 58: 502-514.
21. Durão SF, Gomes PS, Colaço BJ, et al. The biomaterial-mediated healing of critical size bone defects in the ovariectomized rat. Osteoporos Int, 2014, 25(5): 1535-1545.
22. Wopenka B, Pasteris JD. A mineralogical perspective on the apatite in bone. Materials Science and Engineering C, 2005, 25(2): 131-143.
23. Friedman CD, Costantino PD, Takagi S, et al. BoneSource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction. J Biomed Mater Res, 1998, 43(4): 428-432.
24. Zhu W, Wang D, Xiong J, et al. Study on clinical application of nano-hydroxyapatite bone in bone defect repair. Artif Cells Nanomed Biotechnol, 2015, 43(6): 361-365.
25. Rahaman MN, Day DE, Bal BS, et al. Bioactive glass in tissue engineering. Acta Biomater, 2011, 7(6): 2355-2373.
26. Nagels J, Stokdijk M, Rozing PM. Stress shielding and bone resorption in shoulder arthroplasty. J Shoulder Elbow Surg, 2003, 12(1): 35-39.
27. Jacobs JJ, Gilbert JL, Urban RM. Corrosion of metal orthopaedic implants. J Bone Joint Surg (Am), 1998, 80(2): 268-282.
28. Vormann J. Magnesium: nutrition and metabolism. Mol Aspects Med, 2003, 24(1-3): 27-37.
29. Seitz JM, Lucas A, Kirschner M. Magnesium-based compression screws: A novelty in the clinical use of implants. JOM, 2016, 68(4): 1177-1182.
30. Lee JW, Han HS, Han KJ, et al. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Proc Natl Acad Sci U S A, 2016, 113(3): 716-721.
31. Zhao D, Huang S, Lu F, et al. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. Biomaterials, 2016, 81(1): 84-92.
32. Chan BP, Hui TY, Wong MY, et al. Mesenchymal stem cell-encapsulated collagen microspheres for bone tissue engineering. Tissue Eng Part C Methods, 2010, 16(2): 225-235.
33. Winkler T, Sass FA, Duda GN, et al. A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge. Bone Joint Res, 2018, 7(3): 232-243.
34. Félix Lanao RP, Jonker AM, Wolke JG, et al. Physicochemical properties and applications of poly (lactic-co-glycolic acid) for use in bone regeneration. Tissue Eng Part B Rev, 2013, 19(4): 380-390.
35. Liu B, Song YW, Jin L, et al. Silk structure and degradation. Colloids Surf B Biointerfaces, 2015, (131): 122-128.
36. Park SY, Ki CS, Park YH, et al. Electrospun silk fibroin scaffolds with macropores for bone regeneration: an in vitro and in vivo study. Tissue Eng Part A, 2010, 16(4): 1271-1279.
37. Tatara AM, Mikos AG. Tissue Engineering in Orthopaedics. J Bone Joint Surg (Am), 2016, 98(13): 1132-1139.
38. Newman P, Minett A, Ellis-Behnke R, et al. Carbon nanotubes: their potential and pitfalls for bone tissue regeneration and engineering. Nanomedicine, 2013, 9(8): 1139-1158.
39. Zhou L, Forman HJ, Ge Y, et al. Multi-walled carbon nanotubes: A cytotoxicity study in relation to functionalization, dose and dispersion. Toxicology in Vitro, 2017, 42: 292-298.
40. Li X, Zhao T, Sun L, et al. The applications of conductive nanomaterials in the biomedical field. J Biomed Mater Res A, 2016, 104(1): 322-339.
41. Mehra NK, Mishra V, Jain NK. A review of ligand tethered surface engineered carbon nanotubes. Biomaterials, 2014, 35(4): 1267-1283.
42. Luo Y, Shen H, Fang Y, et al. Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats. ACS Appl Mater Interfaces, 2015, 7(11): 6331-6639.
43. Mo X, Wei Y, Zhang X, et al. Enhanced stem cell osteogenic differentiation by bioactive glass functionalized graphene oxide substrates. Journal of Nanomaterials, 2016, 4: 1-11.
44. Li J, Gang W, Zhu H, et al. Antibacterial activity of large-area monolayer graphene film manipulated by charge transfer. Sci Rep, 2014, 4(3): 4359-4366.
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