Research progress of scaffold materials for tissue engineered meniscus_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

FENG Ziyan ¹ , FAN Yifei ¹ , GUO Jiusi ² ,  FU Weili ³

1. West China School of Medicine, Sichuan University, Chengdu Sichuan, 610041, P.R.China;
2. West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China;
3. Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

FU Weili, Email: foxwin2008@163.com

Keywords：

Tissue engineered meniscus; scaffold material; bionic design

DOI：

10.7507/1002-1892.201810046

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize and analyze the research progress of scaffold materials used in tissue engineered meniscus. Methods The classification and bionics design of scaffold materials were summarized by consulting domestic and foreign literature related to the research of tissue engineered meniscus in recent years. Results Tissue engineered meniscus scaffolds can be roughly classified into synthetic polymers, hydrogels, extracellular matrix components, and tissue derived materials. These different materials have different characteristics, so the use of a single material has its unique disadvantages, and the use of a variety of materials composite scaffolds can learn from each other, which is a hot research area at present. In addition to material selection, material processing methods are also the focus of research. At the same time, according to the morphological structure and mechanical characteristics of the meniscus, the bionic design of tissue engineered meniscus scaffolds has great potential. Conclusion At present, there are many kinds of scaffold materials for tissue engineered meniscus. However, there is no material that can completely simulate the natural meniscus, and further research of scaffold materials is still needed.

Citation： FENG Ziyan, FAN Yifei, GUO Jiusi, FU Weili. Research progress of scaffold materials for tissue engineered meniscus. Chinese Journal of Reparative and Reconstructive Surgery, 2019, 33(8): 1019-1028. doi: 10.7507/1002-1892.201810046 Copy

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2. Turnbull G, Clarke J, Picard F, et al. 3D bioactive composite scaffolds for bone tissue engineering. Bioact Mater, 2017, 3(3): 278-314.
3. Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends Biotechnol, 2012, 30(10): 546-554.
4. Aufderheide AC, Athanasiou KA. Comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus. Tissue Eng, 2005, 11(7-8): 1095-1104.
5. Yang X, Bakaic E, Hoare T, et al. Injectable polysaccharide hydrogels reinforced with cellulose nanocrystals: morphology, rheology, degradation, and cytotoxicity. Biomacromolecules, 2013, 14(12): 4447-4455.
6. Beatty MW, Ojha AK, Cook JL, et al. Small intestinal submucosa versus salt-extracted polyglycolic acid-poly-L-lactic acid: a comparison of neocartilage formed in two scaffold materials. Tissue Eng, 2002, 8(6): 955-968.
7. Stapleton TW, Ingram J, Fisher J, et al. Investigation of the regenerative capacity of an acellular porcine medial meniscus for tissue engineering applications. Tissue Eng Part A, 2011, 17(1-2): 231-242.
8. Puetzer JL, Koo E, Bonassar LJ. Induction of fiber alignment and mechanical anisotropy in tissue engineered menisci with mechanical anchoring. J Biomech, 2015, 48(8): 1436-1443.
9. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen, 1999, 7(2): 79-89.
10. Sarasua JR, López-Rodríguez N, Zuza E, et al. Crystallinity assessment and in vitro cytotoxicity of polylactide scaffolds for biomedical applications. J Mater Sci Mater Med, 2011, 22(11): 2513-2523.
11. Oda S, Otsuki S, Kurokawa Y, et al. A new method for meniscus repair using type Ⅰ collagen scaffold and infrapatellar fat pad. J Biomater Appl, 2015, 29(10): 1439-1448.
12. Whitehouse MR, Howells NR, Parry MC, et al. Repair of torn avascular meniscal cartilage using undifferentiated autologous mesenchymal stem cells: from in vitro optimization to a first-in-human study. Stem Cells Transl Med, 2017, 6(4): 1237-1248.
13. Zitnay JL, Reese SP, Tran G, et al. Fabrication of dense anisotropic collagen scaffolds using biaxial compression. Acta Biomater, 2018, 65: 76-87.
14. Heo J, Koh RH, Shim W, et al. Riboflavin-induced photo-crosslinking of collagen hydrogel and its application in meniscus tissue engineering. Drug Deliv Transl Res, 2016, 6(2): 148-158.
15. Zellner J, Hierl K, Mueller M, et al. Stem cell-based tissue-engineering for treatment of meniscal tears in the avascular zone. J Biomed Mater Res B Appl Biomater, 2013, 101(7): 1133-1142.
16. Gosline JM, Guerette PA, Ortlepp CS, et al. The mechanical design of spider silks: from fibroin sequence to mechanical function. J Exp Biol, 1999, 202(Pt 23): 3295-3303.
17. Harkin DG, Chirila TV. Silk fibroin in ocular surface reconstruction: what is its potential as a biomaterial in ophthalmics? Future Med Chem, 2012, 4(17): 2145-2147.
18. Gruchenberg K, Ignatius A, Friemert B, et al. In vivo performance of a novel silk fibroin scaffold for partial meniscal replacement in a sheep model. Knee Surg Sports Traumatol Arthrosc, 2015, 23(8): 2218-2229.
19. Pillai MM, Gopinathan J, Indumathi B, et al. Silk-PVA hybrid nanofibrous scaffolds for enhanced primary human meniscal cell proliferation. J Membr Biol, 2016, 249(6): 813-822.
20. Pillai MM, Gopinathan J, Kumar RS, et al. Tissue engineering of human knee meniscus using functionalized and reinforced Silk-PVA composite 3D scaffolds: Understanding the in vitro and in vivo behaviour. Biomed Mater Res Part A, 2018, 106(6): 1722.
21. Iannace S, Ambrosio L, Nicolais L, et al. Thermomechanical properties of hyaluronic acid-derived products. Journal of Materials Science: Materials in Medicine, 1992, 3: 59-64.
22. Brix MO, Stelzeneder D, Chiari C, et al. Treatment of full-thickness chondral defects with hyalograft C in the knee: long-term results. Am J Sports Med, 2014, 42(6): 1426-1432.
23. Erggelet C, Endres M, Neumann K, et al. Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants. J Orthop Res, 2009, 27(10): 1353-1360.
24. Koller U, Nehrer S, Vavken P, et al. Polyethylene terephthalate (PET) enhances chondrogenic differentiation of ovine meniscocytes in a hyaluronic acid/polycaprolactone scaffold in vitro. Int Orthop, 2012, 36(9): 1953-1960.
25. Murakami T, Otsuki S, Nakagawa K, et al. Establishment of novel meniscal scaffold structures using polyglycolic and poly-l-lactic acids. J Biomater Appl, 2017, 32(2): 150-161.
26. Warnock JJ, Fox DB, Stoker AM, et al. Culture of equine fibroblast-like synoviocytes on synthetic tissue scaffolds towards meniscal tissue engineering: a preliminary cell-seeding study. PeerJ, 2014, 2: e353.
27. Baek J, Chen X, Sovani S, et al. Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel. J Orthop Res, 2015, 33(4): 572-583.
28. Zhu WH, Wang YB, Wang L, et al. Effects of canine myoblasts expressing human cartilage-derived morphogenetic protein-2 on the repair of meniscal fibrocartilage injury. Mol Med Rep, 2014, 9(5): 1767-1772.
29. Kang SW, Son SM, Lee JS, et al. Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model. Journal of Biomedical Materials Research Part A, 2010, 77A(4): 659-671.
30. Gu Y, Zhu W, Hao Y, et al. Repair of meniscal defect using an induced myoblast-loaded polyglycolic acid mesh in a canine model. Exp Ther Med, 2012, 3(2): 293-298.
31. Gu Y, Chen P, Yang Y, et al. Chondrogenesis of myoblasts in biodegradable poly-lactide-co-glycolide scaffolds. Mol Med Rep, 2013, 7(3): 1003-1009.
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Chinese Journal of Reparative and Reconstructive Surgery

Research progress of scaffold materials for tissue engineered meniscus

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