Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

SHI Kun , HUANG Yong , HUANG Leizhen , WANG Jingcheng , WANG Yuhan ,  FENG Ganjun ,  LIU Limin , SONG Yueming

Departmen of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

FENG Ganjun, Email: gjfenghx@163.com; LIU Limin, Email: 18980601394@163.com

Keywords：

Hydrogel; intervertebral disc degeneration; nucleus pulposus; regeneration; repair

DOI：

10.7507/1002-1892.201907092

Video：

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Objective To summarize the research progress of hydrogels for the regeneration and repair of degenerative intervertebral disc and to investigate the potential of hydrogels in clinical application.Methods The related literature about the role of hydrogels in intervertebral disc degeneration especially for nucleus pulposus was reviewed and analyzed.Results Hydrogels share similar properties with nucleus pulposus, and it plays an important role in the regeneration and repair of degenerative intervertebral disc, which can be mainly applied in nucleus pulposus prosthesis, hydrogel-based cell therapy, non-cellular therapy, and tissue engineering repair.Conclusion Hydrogels are widely used in the regeneration and repair of intervertebral disc, which provides a potential treatment for intervertebral disc degeneration.

Citation： SHI Kun, HUANG Yong, HUANG Leizhen, WANG Jingcheng, WANG Yuhan, FENG Ganjun, LIU Limin, SONG Yueming. Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration. Chinese Journal of Reparative and Reconstructive Surgery, 2020, 34(3): 275-284. doi: 10.7507/1002-1892.201907092 Copy

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2. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2163-2196.
3. Cheung KM, Karppinen J, Chan D, et al. Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals. Spine (Phila Pa 1976), 2009, 34(9): 934-940.
4. Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol, 2014, 10(1): 44-56.
5. Kadow T, Sowa G, Vo N, et al. Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? Clin Orthop Relat Res, 2015, 473(6): 1903-1912.
6. Baliga S, Treon K, Craig NJ. Low back pain: current surgical approaches. Asian Spine J, 2015, 9(4): 645-657.
7. Radcliff KE, Kepler CK, Jakoi A, et al. Adjacent segment disease in the lumbar spine following different treatment interventions. Spine J, 2013, 13(10): 1339-1349.
8. Colombier P, Camus A, Lescaudron L, et al. Intervertebral disc regeneration: a great challenge for tissue engineers. Trends Biotechnol, 2014, 32(9): 433-435.
9. Frauchiger DA, Tekari A, Wöltje M, et al. A review of the application of reinforced hydrogels and silk as biomaterials for intervertebral disc repair. Eur Cell Mater, 2017, 34: 271-290.
10. Ghannam M, Jumah F, Mansour S, et al. Surgical anatomy, radiological features, and molecular biology of the lumbar intervertebral discs. Clin Anat, 2017, 30(2): 251-266.
11. Adams MA, Dolan P, McNally DS. The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology. Matrix Biol, 2009, 28(7): 384-389.
12. Nerurkar NL, Elliott DM, Mauck RL. Mechanical design criteria for intervertebral disc tissue engineering. J Biomech, 2010, 43(6): 1017-1030.
13. Cheung KMC, Al Ghazi S. Current understanding of low back pain and intervertebral disc degeneration: epidemiological perspectives and phenotypes for genetic studies. Current Orthopaedics, 2008, 22(4): 237-244.
14. Maroudas A, Stockwell RA, Nachemson A, et al. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat, 1975, 120(Pt 1): 113-130.
15. Malandrino A, Lacroix D, Hellmich C, et al. The role of endplate poromechanical properties on the nutrient availability in the intervertebral disc. Osteoarthritis Cartilage, 2014, 22(7): 1053-1060.
16. Chan SC, Ferguson SJ, Gantenbein-Ritter B. The effects of dynamic loading on the intervertebral disc. Eur Spine J, 2011, 20(11): 1796-1812.
17. Chen Z, Li X, Pan F, et al. A retrospective study: Does cigarette smoking induce cervical disc degeneration? Int J Surg, 2018, 53: 269-273.
18. MacGregor AJ, Andrew T, Sambrook PN, et al. Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum, 2004, 51(2): 160-167.
19. Molladavoodi S, McMorran J, Gregory D. Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs. Cell Tissue Res, 2019. [Epub ahead of print].
20. Silagi ES, Shapiro IM, Risbud MV. Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration. Matrix Biol, 2018, 71-7: 368-379.
21. Wang F, Cai F, Shi R, et al. Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage, 2016, 24(3): 398-408.
22. Yang S, Zhang F, Ma J, et al. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing Res Rev, 2020, 57: 100978.
23. 侯孝忠, 徐林飞, 易威威, 等. 内质网应激对吸烟诱导的髓核细胞凋亡与炎性反应的影响研究. 中国修复重建外科杂志, 2019, 33(6): 736-742.
24. Frapin L, Clouet J, Delplace V, et al. Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors. Adv Drug Deliv Rev, 2019, 149-150: 49-71.
25. Chen S, Liu S, Ma K, et al. TGF-β signaling in intervertebral disc health and disease. Osteoarthritis Cartilage, 2019, 27(8): 1109-1117.
26. Emanuel KS, Mader KT, Peeters M, et al. Early changes in the extracellular matrix of the degenerating intervertebral disc, assessed by Fourier transform infrared imaging. Osteoarthritis Cartilage, 2018, 26(10): 1400-1408.
27. Chen Z, Liu M, Zhang W, et al. miR-24-3p induces human intervertebral disc degeneration by targeting insulin-like growth factor binding protein 5 and the ERK signaling pathway. Life Sci, 2020. [Epub ahead of print].
28. Ge J, Zhou Q, Niu J, et al. Melatonin protects intervertebral disc from degeneration by improving cell survival and function via activation of the ERK1/2 signaling pathway. Oxid Med Cell Longev, 2019, 2019: 5120275.
29. Huang Y, Peng Y, Sun J, et al. Nicotinamide phosphoribosyl transferase controls NLRP3 inflammasome activity through MAPK and NF-κB signaling in nucleus pulposus cells, as suppressed by melatonin. Inflammation, 2020. [Epub ahead of print].
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