Regulation of long non-coding RNA in cartilage injury of osteoarthritis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HE Lu ^1,2 ,  LI Yanlin ^1,2 , WANG Guoliang ^1,2 , LI Canzhang ^1,2

1. Kunming Medical University, Kunming Yunnan, 650000, P.R.China;
2. Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P.R.China;

Corresponding author：

LI Yanlin, Email: 852387873@qq.com

Keywords：

Osteoarthritis; long non-coding RNA; cartilage degeneration; regulation

DOI：

10.7507/1002-1892.202002109

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the regulatory effect of long non-coding RNA (lncRNA) on osteoarthritis (OA) cartilage injury.Methods The molecular functions and mechanisms of lncRNA were introduced and its regulatory effects on the pathological processes of OA were elaborated by referring to the relevant literature at domestic and abroad in recent years.Results The pathological characteristics of OA are degeneration of articular cartilage and inflammation of synovial tissue, but its etiology and pathological mechanism have not been clarified. lncRNA is a kind of heterogeneous non-coding RNA, which plays a regulatory role in many inflammation-related diseases and exerts a wide range of biological functions. lncRNA is a regulator involved in the pathogenesis of OA, and is abnormally expressed in OA cartilage, leading to the degeneration of the extracellular matrix of cartilage.Conclusion At present, there have been preliminary studies on the pathological effects of lncRNA in regulating OA and the biological functions of chondrocytes. However, the pathogenesis of lncRNA and its regulatory network in OA and the way in which it regulates inflammatory pathways are still unclear, and further exploration is needed.

Citation： HE Lu, LI Yanlin, WANG Guoliang, LI Canzhang. Regulation of long non-coding RNA in cartilage injury of osteoarthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2020, 34(11): 1486-1491. doi: 10.7507/1002-1892.202002109 Copy

1.	Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port, 2015, 28(1): 99-106.
2.	Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet, 2015, 386(9991): 376-387.
3.	Fatica A, Bozzoni I. Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet, 2014, 15(1): 7-21.
4.	Jia D, Li Y, Han R, et al. miR-146a-5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF-1-induced cartilage degradation. Mol Med Rep, 2019, 19(5): 4388-4400.
5.	Jiang SD, Lu J, Deng ZH, et al. Long noncoding RNAs in osteoarthritis. Joint Bone Spine, 2017, 84(5): 553-556.
6.	Romagnolo DF, Daniels KD, Grunwald JT, et al. Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds. Mol Nutr Food Res, 2016, 60(6): 1310-1329.
7.	Chu C, Zhang QC, da Rocha ST, et al. Systematic discovery of Xist RNA binding proteins. Cell, 2015, 161(2): 404-416.
8.	Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell, 2011, 43(6): 904-914.
9.	Dahariya S, Paddibhatla I, Kumar S, et al. Long non-coding RNA: Classification, biogenesis and functions in blood cells. Mol Immunol, 2019, 112: 82-92.
10.	Zhu J, Yu W, Wang Y, et al. lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration. Stem Cell Res Ther, 2019, 10(1): 344.
11.	Zhao C, Wang Y, Jin H, et al. Knockdown of microRNA-203 alleviates LPS-induced injury by targeting MCL-1 in C28/I2 chondrocytes. Exp Cell Res, 2017, 359(1): 171-178.
12.	Luo X, Wang J, Wei X, et al. Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccha-ride-induced osteoarthritis progression by miR-130a-3p/TCF4. Life Sci, 2020, 240: 117019.
13.	Cao L, Wang Y, Wang Q, et al. LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. Biomed Pharmacother, 2018, 106: 1220-1226.
14.	Xiao Y, Bao Y, Tang L, et al. LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis. J Orthop Surg Res, 2019, 14(1): 247.
15.	Hu J, Wang Z, Shan Y, et al. Long non-coding RNA HOTAIR promotes osteoarthritis pro-gression via miR-17-5p/FUT2/beta-catenin axis. Cell Death Dis, 2018, 9(7): 711.
16.	Yang Z, Tang Y, Lu H, et al. Long non-coding RNA reprogramming (lncRNA-ROR) regu-lates cell apoptosis and autophagy in chondrocytes. J Cell Biochem, 2018, 119(10): 8432-8440.
17.	Fan X, Yuan J, Xie J, et al. Long non-protein coding RNA DANCR functions as a compet-ing endogenous RNA to regulate osteoarthritis progression via miR-577/SphK2 axis. Biochem Biophys Res Commun, 2018, 500(3): 658-664.
18.	Liu Q, Zhang X, Dai L, et al. Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol, 2014, 66(4): 969-978.
19.	Wang T, Liu Y, Wang Y, et al. Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthri-tis. Int J Mol Med, 2019, 44(2): 630-642.
20.	Kino T, Hurt DE, Ichijo T, et al. Noncoding RNA gas5 is a growth arrest-and starva-tion-associated repressor of the glucocorticoid receptor. Scie Signal, 2010, 3(107): ra8.
21.	Song J, Ahn C, Chun CH, et al. A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. J Orthop Res, 2014, 32(12): 1628-1635.
22.	Li X, Ren W, Xiao ZY, et al. GACAT3 promoted proliferation of osteoarthritis synoviocytes by IL-6/STAT3 signaling pathway. Eur Rev Med Pharmacol Sci, 2018, 22(16): 5114-5120.
23.	Li X, Huang TL, Zhang GD, et al. LncRNA ANRIL impacts the progress of osteoarthritis via regulating proliferation and apoptosis of osteoarthritis synoviocytes. Eur Rev Med Pharmacol Sci, 2019, 23(22): 9729-9737.
24.	Kang Y, Song J, Kim D, et al. PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. J Orthop Res, 2016, 34(3): 412-418.
25.	Benetatos L, Vartholomatos G, Hatzimichael E. MEG3 imprinted gene contribution in tumor-igenesis. Int J Cancer, 2011, 129(4): 773-779.
26.	Su W, Xie W, Shang Q, et al. The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis. Biomed Res Int, 2015, 2015: 356893.
27.	Song J, Huang S, Wang K, et al. Long non-coding RNA MEG3 attenuates the angiotensin II-induced injury of human umbilical vein endothelial cells by interacting with p53. Front Genet, 2019, 10: 78.
28.	Shui X, Xie Q, Chen S, et al. Identification and functional analysis of long non-coding RNAs in the synovial membrane of osteoarthritis Patients. Cell Biochem Funct, 2020, 38(4): 460-471.
29.	Wojdasiewicz P, Poniatowski ŁA, Szukiewicz D. The role of inflammatory and an-ti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm, 2014, 2014: 561459.
30.	Zheng J, Li Q. Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA cILinc02. J Cell Biochem, 2019, 120(3): 3331-3338.
31.	Hu Y, Li S, Zou Y. Knockdown of LncRNA H19 relieves LPS-induced damage by modulating miR-130a in osteoarthritis. Yonsei Med J, 2019, 60(4): 381-388.
32.	Jahanban-Esfahlan R, Mehrzadi S, Reiter RJ, et al. Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: Involvement of circadian clock genes. Br J Pharmacol, 2018, 175(16): 3230-3238.
33.	Choi MC, Jo J, Park J, et al. NF-κB signaling pathways in osteoarthritic cartilage destruction. Cells, 2019, 8(7): 734.
34.	Hu G, Gong AY, Wang Y, et al. LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling. J Immunol, 2016, 196(6): 2799-2808.
35.	Sun T, Yu J, Han L, et al. Knockdown of long non-coding RNA RP11-445H22.4 alleviates LPS-induced injuries by regulation of MiR-301a in osteoarthritis. Cell Physiol Biochem, 2018, 45(2): 832-843.
36.	Yang DW, Qian GB, Jiang MJ, et al. Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB aignaling pathway by regulating CCL4 in osteoarthritis. Gene Ther, 2019, 26(6): 217-229.
37.	Ewendt F, Föller M. p38MAPK controls fibroblast growth factor 23 (FGF23) synthesis in UMR106-osteoblast-like cells and in IDG-SW3 osteocytes. J Endocrinol Invest, 2019, 42(12): 1477-1483.
38.	Lei J, Fu Y, Zhuang Y, et al. LncRNA SNHG1 alleviates IL-1beta-induced osteoarthritis by in-hibiting miR-16-5p-mediated p38 MAPK and NF-kappaB signaling pathways. Biosci Rep, 2019, 39(9): BSR20191523.
39.	Murata K, Uchida K, Takano S, et al. Osteoarthritis patients with high haemoglobin A1c have increased toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium. Diabetes Metab Syndr Obes, 2019, 12: 1151-1159.
40.	Liu YD, Ji CB, Li SB, et al. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways. Int Immunopharmacol, 2018, 59: 375-383.
41.	Liu YX, Wang GD, Wang X, et al. Effects of TLR-2/NF-κB signaling pathway on the occur-rence of degenerative knee osteoarthritis: An in vivo and in vitro study. Oncotarget, 2017, 8(24): 38602-38617.
42.	Qin HJ, Xu T, Wu HT, et al. SDF-1/CXCR4 axis coordinates crosstalk between subchondral bone and articular cartilage in osteoarthritis pathogenesis. Bone, 2019, 125: 140-150.
43.	Wei F, Moore DC, Wei L, et al. Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther, 2012, 14(4): R177.
44.	Wang K, Li Y, Han R, et al. T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model. PLoS One, 2017, 12(4): e0176048.

1. Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port, 2015, 28(1): 99-106.
2. Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet, 2015, 386(9991): 376-387.
3. Fatica A, Bozzoni I. Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet, 2014, 15(1): 7-21.
4. Jia D, Li Y, Han R, et al. miR-146a-5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF-1-induced cartilage degradation. Mol Med Rep, 2019, 19(5): 4388-4400.
5. Jiang SD, Lu J, Deng ZH, et al. Long noncoding RNAs in osteoarthritis. Joint Bone Spine, 2017, 84(5): 553-556.
6. Romagnolo DF, Daniels KD, Grunwald JT, et al. Epigenetics of breast cancer: Modifying role of environmental and bioactive food compounds. Mol Nutr Food Res, 2016, 60(6): 1310-1329.
7. Chu C, Zhang QC, da Rocha ST, et al. Systematic discovery of Xist RNA binding proteins. Cell, 2015, 161(2): 404-416.
8. Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell, 2011, 43(6): 904-914.
9. Dahariya S, Paddibhatla I, Kumar S, et al. Long non-coding RNA: Classification, biogenesis and functions in blood cells. Mol Immunol, 2019, 112: 82-92.
10. Zhu J, Yu W, Wang Y, et al. lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration. Stem Cell Res Ther, 2019, 10(1): 344.
11. Zhao C, Wang Y, Jin H, et al. Knockdown of microRNA-203 alleviates LPS-induced injury by targeting MCL-1 in C28/I2 chondrocytes. Exp Cell Res, 2017, 359(1): 171-178.
12. Luo X, Wang J, Wei X, et al. Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccha-ride-induced osteoarthritis progression by miR-130a-3p/TCF4. Life Sci, 2020, 240: 117019.
13. Cao L, Wang Y, Wang Q, et al. LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. Biomed Pharmacother, 2018, 106: 1220-1226.
14. Xiao Y, Bao Y, Tang L, et al. LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis. J Orthop Surg Res, 2019, 14(1): 247.
15. Hu J, Wang Z, Shan Y, et al. Long non-coding RNA HOTAIR promotes osteoarthritis pro-gression via miR-17-5p/FUT2/beta-catenin axis. Cell Death Dis, 2018, 9(7): 711.
16. Yang Z, Tang Y, Lu H, et al. Long non-coding RNA reprogramming (lncRNA-ROR) regu-lates cell apoptosis and autophagy in chondrocytes. J Cell Biochem, 2018, 119(10): 8432-8440.
17. Fan X, Yuan J, Xie J, et al. Long non-protein coding RNA DANCR functions as a compet-ing endogenous RNA to regulate osteoarthritis progression via miR-577/SphK2 axis. Biochem Biophys Res Commun, 2018, 500(3): 658-664.
18. Liu Q, Zhang X, Dai L, et al. Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol, 2014, 66(4): 969-978.
19. Wang T, Liu Y, Wang Y, et al. Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthri-tis. Int J Mol Med, 2019, 44(2): 630-642.
20. Kino T, Hurt DE, Ichijo T, et al. Noncoding RNA gas5 is a growth arrest-and starva-tion-associated repressor of the glucocorticoid receptor. Scie Signal, 2010, 3(107): ra8.
21. Song J, Ahn C, Chun CH, et al. A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. J Orthop Res, 2014, 32(12): 1628-1635.
22. Li X, Ren W, Xiao ZY, et al. GACAT3 promoted proliferation of osteoarthritis synoviocytes by IL-6/STAT3 signaling pathway. Eur Rev Med Pharmacol Sci, 2018, 22(16): 5114-5120.
23. Li X, Huang TL, Zhang GD, et al. LncRNA ANRIL impacts the progress of osteoarthritis via regulating proliferation and apoptosis of osteoarthritis synoviocytes. Eur Rev Med Pharmacol Sci, 2019, 23(22): 9729-9737.
24. Kang Y, Song J, Kim D, et al. PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. J Orthop Res, 2016, 34(3): 412-418.
25. Benetatos L, Vartholomatos G, Hatzimichael E. MEG3 imprinted gene contribution in tumor-igenesis. Int J Cancer, 2011, 129(4): 773-779.
26. Su W, Xie W, Shang Q, et al. The long noncoding RNA MEG3 is downregulated and inversely associated with VEGF levels in osteoarthritis. Biomed Res Int, 2015, 2015: 356893.
27. Song J, Huang S, Wang K, et al. Long non-coding RNA MEG3 attenuates the angiotensin II-induced injury of human umbilical vein endothelial cells by interacting with p53. Front Genet, 2019, 10: 78.
28. Shui X, Xie Q, Chen S, et al. Identification and functional analysis of long non-coding RNAs in the synovial membrane of osteoarthritis Patients. Cell Biochem Funct, 2020, 38(4): 460-471.
29. Wojdasiewicz P, Poniatowski ŁA, Szukiewicz D. The role of inflammatory and an-ti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm, 2014, 2014: 561459.
30. Zheng J, Li Q. Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA cILinc02. J Cell Biochem, 2019, 120(3): 3331-3338.
31. Hu Y, Li S, Zou Y. Knockdown of LncRNA H19 relieves LPS-induced damage by modulating miR-130a in osteoarthritis. Yonsei Med J, 2019, 60(4): 381-388.
32. Jahanban-Esfahlan R, Mehrzadi S, Reiter RJ, et al. Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: Involvement of circadian clock genes. Br J Pharmacol, 2018, 175(16): 3230-3238.
33. Choi MC, Jo J, Park J, et al. NF-κB signaling pathways in osteoarthritic cartilage destruction. Cells, 2019, 8(7): 734.
34. Hu G, Gong AY, Wang Y, et al. LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI/SNF-mediated chromatin remodeling. J Immunol, 2016, 196(6): 2799-2808.
35. Sun T, Yu J, Han L, et al. Knockdown of long non-coding RNA RP11-445H22.4 alleviates LPS-induced injuries by regulation of MiR-301a in osteoarthritis. Cell Physiol Biochem, 2018, 45(2): 832-843.
36. Yang DW, Qian GB, Jiang MJ, et al. Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB aignaling pathway by regulating CCL4 in osteoarthritis. Gene Ther, 2019, 26(6): 217-229.
37. Ewendt F, Föller M. p38MAPK controls fibroblast growth factor 23 (FGF23) synthesis in UMR106-osteoblast-like cells and in IDG-SW3 osteocytes. J Endocrinol Invest, 2019, 42(12): 1477-1483.
38. Lei J, Fu Y, Zhuang Y, et al. LncRNA SNHG1 alleviates IL-1beta-induced osteoarthritis by in-hibiting miR-16-5p-mediated p38 MAPK and NF-kappaB signaling pathways. Biosci Rep, 2019, 39(9): BSR20191523.
39. Murata K, Uchida K, Takano S, et al. Osteoarthritis patients with high haemoglobin A1c have increased toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium. Diabetes Metab Syndr Obes, 2019, 12: 1151-1159.
40. Liu YD, Ji CB, Li SB, et al. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways. Int Immunopharmacol, 2018, 59: 375-383.
41. Liu YX, Wang GD, Wang X, et al. Effects of TLR-2/NF-κB signaling pathway on the occur-rence of degenerative knee osteoarthritis: An in vivo and in vitro study. Oncotarget, 2017, 8(24): 38602-38617.
42. Qin HJ, Xu T, Wu HT, et al. SDF-1/CXCR4 axis coordinates crosstalk between subchondral bone and articular cartilage in osteoarthritis pathogenesis. Bone, 2019, 125: 140-150.
43. Wei F, Moore DC, Wei L, et al. Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther, 2012, 14(4): R177.
44. Wang K, Li Y, Han R, et al. T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model. PLoS One, 2017, 12(4): e0176048.

Previous Article
Research progress on antibacterial properties of porous medical implant materials
Next Article
5G通信技术远程指导机器人辅助全髋关节置换术两例

Chinese Journal of Reparative and Reconstructive Surgery

Regulation of long non-coding RNA in cartilage injury of osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content