Research progress of tibial transverse transport in treatment of chronic ischemic diseases of the lower extremities_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LIU Zheng ¹ ,  XU Chao ² , YU Yikang ¹ , TU Dongpeng ¹

1. The Second Clinical College of Zhejiang Traditional Chinese Medical University, Hangzhou Zhejiang, 310053, P.R.China;
2. Department of Traumatology and Orthopedics, the Second Affiliated Hospital of Zhejiang Traditional Chinese Medical University, Hangzhou Zhejiang, 310005, P.R.China;

Corresponding author：

XU Chao, Email: docxuchao@126.com

Keywords：

Tibial transverse transport; Ilizarov technique; lower extremity; ischemic disease; law of tension-stress

DOI：

10.7507/1002-1892.202004061

Video：

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Objective To summarize the research progress of tibial transverse transport (TTT) in treatment of chronic ischemic diseases of the lower extremities.Methods The related literature was systematically searched and the mechanisms, clinical treatment methods, clinical efficacy, indications, contraindications, and complications of TTT were discussed.Results Based on the law of tension-stress, TTT is a new method in the treatment of chronic ischemic diseases of the lower extremities. It can relieve the ischemic symptoms, promote the wound healing, and increase the limb salvage rate. The clinical application in recent years has shown good effectiveness, and the scope of application is expanding.Conclusion Due to the current limited clinical application, the sample size of the TTT for the chronic ischemic diseases of the lower extremities is relatively small, and the follow-up time is limited. So its validity, long-term effectiveness, and bone transport standards are need further research.

Citation： LIU Zheng, XU Chao, YU Yikang, TU Dongpeng. Research progress of tibial transverse transport in treatment of chronic ischemic diseases of the lower extremities. Chinese Journal of Reparative and Reconstructive Surgery, 2020, 34(8): 994-999. doi: 10.7507/1002-1892.202004061 Copy

1.	花奇凯, 王林, 冼呈, 等. Ilizarov 胫骨横向骨搬移微循环重建技术治疗下肢慢性缺血性疾病的临床疗效. 中国矫形外科杂志, 2015, 23(21): 2007-2011.
2.	Zhang P, Lu J, Jing Y, et al. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med, 2017, 49(2): 106-116.
3.	Kasiewicz LN, Whitehead KA. Recent advances in biomaterials for the treatment of diabetic foot ulcers. Biomater Sci, 2017, 5(10): 1962-1975.
4.	戴毅, 张瑞鹏, 王辉, 等. 自体外周血干细胞移植治疗慢性下肢缺血性疾病的临床疗效观察. 中国医药指南, 2019, 17(27): 17-18.
5.	李宏烨, 尤加省, 刘超, 等. 胫骨横向骨搬运术治疗糖尿病足溃疡的疗效. 中国修复重建外科杂志, 2019, 33(1): 23-27.
6.	曲龙, 王爱林, 汤福刚. 胫骨横向搬移血管再生术治疗血栓闭塞性脉管炎. 中华医学杂志, 2001, 81(10): 622-624.
7.	Kulkarni S, Kulkarni G, Shyam AK, et al. Management of thromboangiitis obliterans using distraction osteogenesis: A retrospective study. Indian J Orthop, 2011, 45(5): 459-464.
8.	Patwa JJ, Krishnan A. Buerger’s disease (thromboangiitis obliterans)-management by Ilizarov’s technique of horizontal distraction. A retrospective study of 60 cases. Indian J Surg, 2011, 73(1): 40-47.
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10.	Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part Ⅱ. The influence of the rate and frequency of distraction. Clin Orthop Relat Res, 1989, (239): 263-285.
11.	秦泗河. Ilizarov 技术概述. 中华骨科杂志, 2006, 26(9): 642-645.
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13.	Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature, 2008, 453(7193): 314-321.
14.	Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther, 2017, 34(3): 599-610.
15.	Kaplani K, Koutsi S, Armenis V, et al. Wound healing related agents: ongoing research and perspectives. Adv Drug Deliv Rev, 2018, 129: 242-253.
16.	Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med, 1999, 341(10): 738-746.
17.	高伟, 林震迅, 镇普祥, 等. 胫骨横向骨搬移后巨噬细胞促进重度糖尿病足创面的愈合. 中国组织工程研究, 2018, 22(36): 5811-5815.
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22.	Boucher JM, Clark RP, Chong DC, et al. Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun, 2017, 8: 15699.
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24.	欧栓机, 许长鹏, 李贵涛, 等. 胫骨横向骨搬移对血清血管生成相关因子表达的影响. 中国修复重建外科杂志, 2020, 34(1): 98-101.
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30.	贾中伟, 余建平, 苏云星, 等. 胫骨横向骨搬移结合负压引流治疗糖尿病足溃疡的临床疗效分析. 中国骨伤, 2018, 31(3): 232-236.
31.	冼呈, 赵劲民, 苏伟, 等. 外固定架骨搬移系统修复糖尿病足: 功能与影像学评价. 中国组织工程研究, 2015, 19(46): 7539-7544.
32.	叶锋, 徐浩博, 沈凯, 等. 胫骨横向骨搬移法治疗下肢血栓闭塞性脉管炎疗效分析. 中国药物与临床, 2018, 18(12): 2205-2206.
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34.	欧栓机, 齐勇, 孙鸿涛, 等. 经皮微创胫骨截骨横向骨搬移术治疗糖尿病足. 中国矫形外科杂志, 2018, 26(15): 1385-1389.
35.	镇普祥, 陈炎, 高伟, 等. 应用 Ilizarov 技术胫骨横向骨搬移术治疗合并全身性炎症反应综合征的重度糖尿病足. 中国修复重建外科杂志, 2018, 32(10): 1261-1266.
36.	何立环, 陈炎, 邝晓聪, 等. 重度糖尿病足胫骨横向骨搬移术治疗后创面愈合规律分析. 中医正骨, 2019, 31(10): 70-73.
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40.	赵威, 鲁志超, 王新栋, 等. 介入联合胫骨横向搬移治疗下肢缺血性疾病. 中国矫形外科杂志, 2019, 27(9): 809-814.
41.	刘向东, 游木荣, 甘浩然, 等. 3D 打印导板引导的胫骨横向骨搬移术治疗糖尿病足. 江西医药, 2018, 53(12): 1359-1361, 1379.
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43.	徐显章, 王爱林, 靖冬梅. 胫骨迁移血管再生治疗血栓闭塞性脉管炎 35 例分析. 中国实用外科杂志, 2011, 31(6): 523-524.
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1. 花奇凯, 王林, 冼呈, 等. Ilizarov 胫骨横向骨搬移微循环重建技术治疗下肢慢性缺血性疾病的临床疗效. 中国矫形外科杂志, 2015, 23(21): 2007-2011.
2. Zhang P, Lu J, Jing Y, et al. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med, 2017, 49(2): 106-116.
3. Kasiewicz LN, Whitehead KA. Recent advances in biomaterials for the treatment of diabetic foot ulcers. Biomater Sci, 2017, 5(10): 1962-1975.
4. 戴毅, 张瑞鹏, 王辉, 等. 自体外周血干细胞移植治疗慢性下肢缺血性疾病的临床疗效观察. 中国医药指南, 2019, 17(27): 17-18.
5. 李宏烨, 尤加省, 刘超, 等. 胫骨横向骨搬运术治疗糖尿病足溃疡的疗效. 中国修复重建外科杂志, 2019, 33(1): 23-27.
6. 曲龙, 王爱林, 汤福刚. 胫骨横向搬移血管再生术治疗血栓闭塞性脉管炎. 中华医学杂志, 2001, 81(10): 622-624.
7. Kulkarni S, Kulkarni G, Shyam AK, et al. Management of thromboangiitis obliterans using distraction osteogenesis: A retrospective study. Indian J Orthop, 2011, 45(5): 459-464.
8. Patwa JJ, Krishnan A. Buerger’s disease (thromboangiitis obliterans)-management by Ilizarov’s technique of horizontal distraction. A retrospective study of 60 cases. Indian J Surg, 2011, 73(1): 40-47.
9. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part Ⅰ. The influence of stability of fixation and soft-tissue preservation. Clin Orthop Relat Res, 1989, (238): 249-281.
10. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues: Part Ⅱ. The influence of the rate and frequency of distraction. Clin Orthop Relat Res, 1989, (239): 263-285.
11. 秦泗河. Ilizarov 技术概述. 中华骨科杂志, 2006, 26(9): 642-645.
12. 曲龙, 施京辉, 刘黎亮, 等. 骨搬移法治疗骨感染、骨缺损及软组织缺损. 中华外科杂志, 2004, 42(23): 1469.
13. Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature, 2008, 453(7193): 314-321.
14. Han G, Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther, 2017, 34(3): 599-610.
15. Kaplani K, Koutsi S, Armenis V, et al. Wound healing related agents: ongoing research and perspectives. Adv Drug Deliv Rev, 2018, 129: 242-253.
16. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med, 1999, 341(10): 738-746.
17. 高伟, 林震迅, 镇普祥, 等. 胫骨横向骨搬移后巨噬细胞促进重度糖尿病足创面的愈合. 中国组织工程研究, 2018, 22(36): 5811-5815.
18. 连浩宇, 花奇凯, 陈炎, 等. 重度糖尿病足胫骨横向骨搬移术治疗后创面愈合方式及机制研究. 中医正骨, 2019, 31(12): 15-19, 33.
19. Hu MS, Maan ZN, Wu JC, et al. Tissue engineering and regenerative repair in wound healing. Ann Biomed Eng, 2014, 42(7): 1494-1507.
20. Clements MP, Byrne E, Camarillo Guerrero LF, et al. The wound microenvironment reprograms schwann cells to invasive mesenchymal-like cells to drive peripheral nerve regeneration. Neuron, 2017, 96(1): 98-114.
21. Heinolainen K, Karaman S, D’Amico G, et al. VEGFR3 modulates vascular permeability by controlling VEGF/VEGFR2 signaling. Circ Res, 2017, 120(9): 1414-1425.
22. Boucher JM, Clark RP, Chong DC, et al. Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun, 2017, 8: 15699.
23. Yu Z, Witman N, Wang W, et al. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release, 2019, 310: 103-114.
24. 欧栓机, 许长鹏, 李贵涛, 等. 胫骨横向骨搬移对血清血管生成相关因子表达的影响. 中国修复重建外科杂志, 2020, 34(1): 98-101.
25. 岑忠喜, 曾高峰, 何基琛, 等. 改良骨搬移治疗糖尿病足. 中国组织工程研究, 2018, 22(36): 5766-5771.
26. 孙勇, 肖耀广, 王贺. 胫骨横向搬移治疗糖尿病足溃疡. 中国骨伤, 2018, 31(10): 949-952.
27. 项杰. 胫骨横向骨搬移对糖尿病足患者造血干细胞集落形成及 PI3K/AKT 信号通路的影响. 南宁: 广西医科大学, 2018.
28. 连浩宇. 干细胞动员在胫骨横向搬移治疗重度糖尿病足机制中的作用研究. 南宁: 广西医科大学, 2019.
29. 冼呈, 赵劲民, 苏伟, 等. 胫骨横向骨搬移微循环再生技术治疗糖尿病足的临床疗效观察. 广西医科大学学报, 2015, 32(4): 605-607.
30. 贾中伟, 余建平, 苏云星, 等. 胫骨横向骨搬移结合负压引流治疗糖尿病足溃疡的临床疗效分析. 中国骨伤, 2018, 31(3): 232-236.
31. 冼呈, 赵劲民, 苏伟, 等. 外固定架骨搬移系统修复糖尿病足: 功能与影像学评价. 中国组织工程研究, 2015, 19(46): 7539-7544.
32. 叶锋, 徐浩博, 沈凯, 等. 胫骨横向骨搬移法治疗下肢血栓闭塞性脉管炎疗效分析. 中国药物与临床, 2018, 18(12): 2205-2206.
33. 花奇凯, 秦泗河, 赵良军, 等. Ilizarov 技术胫骨横向骨搬移术治疗糖尿病足. 中国矫形外科杂志, 2017, 25(4): 303-307.
34. 欧栓机, 齐勇, 孙鸿涛, 等. 经皮微创胫骨截骨横向骨搬移术治疗糖尿病足. 中国矫形外科杂志, 2018, 26(15): 1385-1389.
35. 镇普祥, 陈炎, 高伟, 等. 应用 Ilizarov 技术胫骨横向骨搬移术治疗合并全身性炎症反应综合征的重度糖尿病足. 中国修复重建外科杂志, 2018, 32(10): 1261-1266.
36. 何立环, 陈炎, 邝晓聪, 等. 重度糖尿病足胫骨横向骨搬移术治疗后创面愈合规律分析. 中医正骨, 2019, 31(10): 70-73.
37. 中国医师协会骨科医师分会中国骨搬移糖尿病足学组. 胫骨横向骨搬移技术治疗糖尿病足的专家共识 (2020). 中国修复重建外科杂志, 2020, 34(8): 945-950.
38. 王斌, 杨漪舸. 股-股动脉旁路移植联合胫骨横向骨搬移术治疗动脉硬化闭塞症一例. 中国修复重建外科杂志, 2015, 29(9): 1188.
39. 王斌, 刘伟, 霍永新, 等. 股-股动脉旁路移植联合胫骨横向骨搬移术治疗下肢动脉硬化闭塞症或合并糖尿病足. 中国修复重建外科杂志, 2018, 32(12): 1576-1580.
40. 赵威, 鲁志超, 王新栋, 等. 介入联合胫骨横向搬移治疗下肢缺血性疾病. 中国矫形外科杂志, 2019, 27(9): 809-814.
41. 刘向东, 游木荣, 甘浩然, 等. 3D 打印导板引导的胫骨横向骨搬移术治疗糖尿病足. 江西医药, 2018, 53(12): 1359-1361, 1379.
42. 赵晓明, 张银刚. 术后联合木丹颗粒对于糖尿病足施行胫骨横向搬移患者的临床疗效. 中华全科医学, 2020, 18(4): 533-536.
43. 徐显章, 王爱林, 靖冬梅. 胫骨迁移血管再生治疗血栓闭塞性脉管炎 35 例分析. 中国实用外科杂志, 2011, 31(6): 523-524.
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