Research progress of interfacial tissue engineering in rotator cuff repair_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

HE Shukun ,  QIN Tingwu

Laboratory of Stem Cells and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;

Corresponding author：

QIN Tingwu, Email: tingwuqin@hotmail.com

Keywords：

Rotator cuff repair; interfacial tissue engineering; stem cells; biomaterial

DOI：

10.7507/1002-1892.202104064

Video：

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Objective To summarize the research progress of interfacial tissue engineering in rotator cuff repair.Methods The recent literature at home and abroad concerning interfacial tissue engineering in rotator cuff repair was analysed and summarized.Results Interfacial tissue engineering is to reconstruct complex and hierarchical interfacial tissues through a variety of methods to repair or regenerate damaged joints of different tissues. Interfacial tissue engineering in rotator cuff repair mainly includes seed cells, growth factors, biomaterials, oxygen concentration, and mechanical stimulation.Conclusion The best strategy for rotator cuff healing and regeneration requires not only the use of biomaterials with gradient changes, but also the combination of seed cells, growth factors, and specific culture conditions (such as oxygen concentration and mechanical stimulation). However, the clinical transformation of the relevant treatment is still a very slow process.

Citation： HE Shukun, QIN Tingwu. Research progress of interfacial tissue engineering in rotator cuff repair. Chinese Journal of Reparative and Reconstructive Surgery, 2021, 35(10): 1341-1351. doi: 10.7507/1002-1892.202104064 Copy

1.	Abate M, Di Carlo L, Salini V, et al. Risk factors associated to bilateral rotator cuff tears. Orthop Traumatol Surg Res, 2017, 103(6): 841-845.
2.	Tashjian RZ. Epidemiology, natural history, and indications for treatment of rotator cuff tears. Clin Sports Med, 2012, 31(4): 589-604.
3.	Baechler MF, Kim DH. “Uncoverage” of the humeral head by the anterolateral acromion and its relationship to full-thickness rotator cuff tears. Mil Med, 2006, 171(10): 1035-1038.
4.	Abraham AC, Shah SA, Thomopoulos S. Targeting inflammation in rotator cuff tendon degeneration and repair. Tech Shoulder Elb Surg, 2017, 18(3): 84-90.
5.	Naimark M, Robbins CB, Gagnier JJ, et al. Impact of smoking on patient outcomes after arthroscopic rotator cuff repair. BMJ Open Sport Exerc Med, 2018, 4(1): e000416. doi: 10.1136/bmjsem-2018-000416.
6.	Plachel F, Heuberer P, Gehwolf R, et al. MicroRNA profiling reveals distinct signatures in degenerative rotator cuff pathologies. J Orthop Res, 2020, 38(1): 202-211.
7.	Longo UG, Candela V, Berton A, et al. Genetic basis of rotator cuff injury: a systematic review. BMC Med Genet, 2019, 20(1): 149. doi: 10.1186/s12881-019-0883-y.
8.	Hein J, Reilly JM, Chae J, et al. Retear rates after arthroscopic single-row, double-row, and suture bridge rotator cuff repair at a minimum of 1 year of imaging follow-up: A systematic review. Arthroscopy, 2015, 31(11): 2274-2281.
9.	Kim JH, Hong IT, Ryu KJ, et al. Retear rate in the late postoperative period after arthroscopic rotator cuff repair. Am J Sports Med, 2014, 42(11): 2606-2613.
10.	Chung SW, Kim JY, Kim MH, et al. Arthroscopic repair of massive rotator cuff tears: outcome and analysis of factors associated with healing failure or poor postoperative function. Am J Sports Med, 2013, 41(7): 1674-1683.
11.	Chung SW, Oh JH, Gong HS, et al. Factors affecting rotator cuff healing after arthroscopic repair: osteoporosis as one of the independent risk factors. Am J Sports Med, 2011, 39(10): 2099-2107.
12.	Deniz G, Kose O, Tugay A, et al. Fatty degeneration and atrophy of the rotator cuff muscles after arthroscopic repair: does it improve, halt or deteriorate? Arch Orthop Trauma Surg, 2014, 134(7): 985-990.
13.	Bishay V, Gallo RA. The evaluation and treatment of rotator cuff pathology. Prim Care, 2013, 40(4): 889-910.
14.	Doi N, Izaki T, Miyake S, et al. Intraoperative evaluation of blood flow for soft tissues in orthopaedic surgery using indocyanine green fluorescence angiography: A pilot study. Bone Joint Res, 2019, 8(3): 118-125.
15.	Zhao S, Su W, Shah V, et al. Biomaterials based strategies for rotator cuff repair. Colloids Surf B Biointerfaces, 2017, 157: 407-416.
16.	Bonnevie ED, Mauck RL. Physiology and engineering of the graded interfaces of musculoskeletal junctions. Annu Rev Biomed Eng, 2018, 20: 403-429.
17.	Spalazzi JP, Boskey AL, Pleshko N, et al. Quantitative mapping of matrix content and distribution across the ligament-to-bone insertion. PLoS One, 2013, 8(9): e74349. doi: 10.1371/journal.pone.0074349.
18.	Rossetti L, Kuntz LA, Kunold E, et al. The microstructure and micromechanics of the tendon-bone insertion. Nat Mater, 2017, 16(6): 664-670.
19.	Calejo I, Costa-Almeida R, Reis RL, et al. Enthesis tissue engineering: Biological requirements meet at the interface. Tissue Eng Part B Rev, 2019, 25(4): 330-356.
20.	Yu Y, Lin L, Zhou Y, et al. Effect of hypoxia on self-renewal capacity and differentiation in human tendon-derived stem cells. Med Sci Monit, 2017, 23: 1334-1339.
21.	Galatz LM, Charlton N, Das R, et al. Complete removal of load is detrimental to rotator cuff healing. J Shoulder Elbow Surg, 2009, 18(5): 669-675.
22.	Lim JK, Hui J, Li L, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy, 2004, 20(9): 899-910.
23.	Kida Y, Morihara T, Matsuda K, et al. Bone marrow-derived cells from the footprint infiltrate into the repaired rotator cuff. J Shoulder Elbow Surg, 2013, 22(2): 197-205.
24.	Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop, 2014, 38(9): 1811-1818.
25.	Kanazawa T, Soejima T, Noguchi K, et al. Tendon-to-bone healing using autologous bone marrow-derived mesenchymal stem cells in ACL reconstruction without a tibial bone tunnel-A histological study-. Muscles Ligaments Tendons J, 2014, 4(2): 201-206.
26.	Lu J, Chamberlain CS, Ji ML, et al. Tendon-to-bone healing in a rat extra-articular bone tunnel model: A comparison of fresh autologous bone marrow and bone marrow-derived mesenchymal stem cells. Am J Sports Med, 2019, 47(11): 2729-2736.
27.	Gulotta LV, Kovacevic D, Ehteshami JR, et al. Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med, 2009, 37(11): 2126-2133.
28.	Gulotta LV, Kovacevic D, Packer JD, et al. Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med, 2011, 39(6): 1282-1289.
29.	Gulotta LV, Kovacevic D, Montgomery S, et al. Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site. Am J Sports Med, 2010, 38(7): 1429-1437.
30.	Gao Y, Zhang Y, Lu Y, et al. TOB1 deficiency enhances the effect of bone marrow-derived mesenchymal stem cells on tendon-bone healing in a rat rotator cuff repair model. Cell Physiol Biochem, 2016, 38(1): 319-329.
31.	Gulotta LV, Kovacevic D, Packer JD, et al. Adenoviral-mediated gene transfer of human bone morphogenetic protein-13 does not improve rotator cuff healing in a rat model. Am J Sports Med, 2011, 39(1): 180-187.
32.	Gonçalves AI, Gershovich PM, Rodrigues MT, et al. Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells. J Tissue Eng Regen Med, 2018, 12(3): 762-774.
33.	Popa EG, Santo VE, Rodrigues MT, et al. Magnetically-responsive hydrogels for modulation of chondrogenic commitment of human adipose-derived stem cells. Polymers (Basel), 2016, 8(2): 28. doi: 10.3390/polym8020028.
34.	Oh JH, Chung SW, Kim SH, et al. 2013 Neer Award: Effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model. J Shoulder Elbow Surg, 2014, 23(4): 445-455.
35.	Kosaka M, Nakase J, Hayashi K, et al. Adipose-derived regenerative cells promote tendon-bone healing in a rabbit model. Arthroscopy, 2016, 32(5): 851-859.
36.	Kim YS, Sung CH, Chung SH, et al. Does an injection of adipose-derived mesenchymal stem cells loaded in fibrin glue influence rotator cuff repair outcomes? A clinical and magnetic resonance imaging study. Am J Sports Med, 2017, 45(9): 2010-2018.
37.	Jo CH, Chai JW, Jeong EC, et al. Intratendinous injection of mesenchymal stem cells for the treatment of rotator cuff disease: A 2-year follow-up study. Arthroscopy, 2020, 36(4): 971-980.
38.	Shin MJ, Shim IK, Kim DM, et al. Engineered cell sheets for the effective delivery of adipose-derived stem cells for tendon-to-bone healing. Am J Sports Med, 2020, 48(13): 3347-3358.
39.	Franklin A, Gi Min J, Oda H, et al. Homing of adipose-derived stem cells to a tendon-derived hydrogel: A potential mechanism for improved tendon-bone interface and tendon healing. J Hand Surg (Am), 2020, 45(12): 1180.e1-1180.e12.
40.	Madhurakkat Perikamana SK, Lee J, Ahmad T, et al. Harnessing biochemical and structural cues for tenogenic differentiation of adipose derived stem cells (ADSCs) and development of an in vitro tissue interface mimicking tendon-bone insertion graft. Biomaterials, 2018, 165: 79-93.
41.	Shen W, Chen J, Yin Z, et al. Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant, 2012, 21(5): 943-958.
42.	Kawakami Y, Takayama K, Matsumoto T, et al. Anterior cruciate ligament-derived stem cells transduced with BMP2 accelerate graft-bone integration after ACL reconstruction. Am J Sports Med, 2017, 45(3): 584-597.
43.	Ju YJ, Muneta T, Yoshimura H, et al. Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing. Cell Tissue Res, 2008, 332(3): 469-478.
44.	Chang CH, Chen CH, Liu HW, et al. Bioengineered periosteal progenitor cell sheets to enhance tendon-bone healing in a bone tunnel. Biomed J, 2012, 35(6): 473-480.
45.	Chen Y, Xu Y, Li M, et al. Application of Autogenous urine-derived stem cell sheet enhances rotator cuff healing in a canine model. Am J Sports Med, 2020, 48(14): 3454-3466.
46.	Paschos NK, Brown WE, Eswaramoorthy R, et al. Advances in tissue engineering through stem cell-based co-culture. J Tissue Eng Regen Med, 2015, 9(5): 488-503.
47.	Wang IE, Shan J, Choi R, et al. Role of osteoblast-fibroblast interactions in the formation of the ligament-to-bone interface. J Orthop Res, 2007, 25(12): 1609-1620.
48.	Cooper JO, Bumgardner JD, Cole JA, et al. Co-cultured tissue-specific scaffolds for tendon/bone interface engineering. J Tissue Eng, 2014, 5: 2041731414542294. doi: 10.1177/2041731414542294.
49.	He P, Ng KS, Toh SL, et al. In vitro ligament-bone interface regeneration using a trilineage coculture system on a hybrid silk scaffold. Biomacromolecules, 2012, 13(9): 2692-2703.
50.	Calejo I, Costa-Almeida R, Gonçalves A I, et al. Bi-directional modulation of cellular interactions in an in vitro co-culture model of tendon-to-bone interface. Cell Prolif, 2018, 51(6): e12493.
51.	Lyu J, Chen L, Zhang J, et al. A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing. Biomater Sci, 2020, 8(13): 3649-3663.
52.	Kuntz LA, Rossetti L, Kunold E, et al. Biomarkers for tissue engineering of the tendon-bone interface. PLoS One, 2018, 13(1): e0189668. doi: 10.1371/journal.pone.0189668.
53.	Font Tellado S, Balmayor ER, Van Griensven M. Strategies to engineer tendon/ligament-to-bone interface: Biomaterials, cells and growth factors. Adv Drug Deliv Rev, 2015, 94: 126-140.
54.	Hirakawa Y, Manaka T, Orita K, et al. The accelerated effect of recombinant human bone morphogenetic protein 2 delivered by β-tricalcium phosphate on tendon-to-bone repair process in rabbit models. J Shoulder Elbow Surg, 2018, 27(5): 894-902.
55.	Lee-Barthel A, Lee CA, Vidal MA, et al. Localized BMP-4 release improves the enthesis of engineered bone-to-bone ligaments. Transl Sports Med, 2018, 1(2): 60-72.
56.	Kabuto Y, Morihara T, Sukenari T, et al. Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet. Tissue Eng Part A, 2015, 21(13-14): 2025-2033.
57.	Yoon JP, Lee CH, Jung JW, et al. Sustained delivery of transforming growth factor β1 by use of absorbable alginate scaffold enhances rotator cuff healing in a rabbit model. Am J Sports Med, 2018, 46(6): 1441-1450.
58.	Han B, Jones IA, Yang Z, et al. Repair of rotator cuff tendon defects in aged rats using a growth factor injectable gel scaffold. Arthroscopy, 2020, 36(3): 629-637.
59.	Tokunaga T, Ide J, Arimura H, et al. Local application of gelatin hydrogel sheets impregnated with platelet-derived growth factor BB promotes tendon-to-bone healing after rotator cuff repair in rats. Arthroscopy, 2015, 31(8): 1482-1491.
60.	Yonemitsu R, Tokunaga T, Shukunami C, et al. Fibroblast growth factor 2 enhances tendon-to-bone healing in a rat rotator cuff repair of chronic tears. Am J Sports Med, 2019, 47(7): 1701-1712.
61.	Kobayashi Y, Kida Y, Kabuto Y, et al. Healing effect of subcutaneous administration of G-CSF on acute rotator cuff injury in a rat model. Tissue Eng Part A, 2021. doi: 10.1089/ten.TEA.2020.0239.
62.	Min HK, Oh SH, Lee JM, et al. Porous membrane with reverse gradients of PDGF-BB and BMP-2 for tendon-to-bone repair: in vitro evaluation on adipose-derived stem cell differentiation. Acta Biomater, 2014, 10(3): 1272-1279.
63.	Boswell SG, Cole BJ, Sundman EA, et al. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy, 2012, 28(3): 429-439.
64.	Kesikburun S, Tan AK, Yilmaz B, et al. Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med, 2013, 41(11): 2609-2616.
65.	Shams A, El-Sayed M, Gamal O, et al. Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears. Eur J Orthop Surg Traumatol, 2016, 26(8): 837-842.
66.	Cavendish PA, Everhart JS, DiBartola AC, et al. The effect of perioperative platelet-rich plasma injections on postoperative failure rates following rotator cuff repair: a systematic review with meta-analysis. J Shoulder Elbow Surg, 2020, 29(5): 1059-1070.
67.	De Gasperi R, Hamidi S, Harlow LM, et al. Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers. Sci Rep, 2017, 7(1): 12888. doi: 10.1038/s41598-017-13105-9.
68.	Connor DE, Paulus JA, Dabestani PJ, et al. Therapeutic potential of exosomes in rotator cuff tendon healing. J Bone Miner Metab, 2019, 37(5): 759-767.
69.	Than UTT, Guanzon D, Leavesley D, et al. Association of extracellular membrane vesicles with cutaneous wound healing. Int J Mol Sci, 2017, 18(5): 956. doi: 10.3390/ijms18050956.
70.	Sevivas N, Teixeira FG, Portugal R, et al. Mesenchymal stem cell secretome improves tendon cell viability in vitro and tendon-bone healing in vivo when a tissue engineering strategy is used in a rat model of chronic massive rotator cuff tear. Am J Sports Med, 2018, 46(2): 449-459.
71.	Huang Y, He B, Wang L, et al. Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats. Stem Cell Res Ther, 2020, 11(1): 496. doi: 10.1186/s13287-020-02005-x.
72.	Wang C, Hu Q, Song W, et al. Adipose stem cell-derived exosomes decrease fatty infiltration and enhance rotator cuff healing in a rabbit model of chronic tears. Am J Sports Med, 2020, 48(6): 1456-1464.
73.	Chen W, Sun Y, Gu X, et al. Conditioned medium of human bone marrow-derived stem cells promotes tendon-bone healing of the rotator cuff in a rat model. Biomaterials, 2021, 271: 120714. doi: 10.1016/j.biomaterials.2021.120714.
74.	Li M, Jia J, Li S, et al. Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway. Biochem Biophys Res Commun, 2021, 536: 88-94.
75.	Zhang M, Liu H, Cui Q, et al. Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon. Stem Cell Res Ther, 2020, 11(1): 402. doi: 10.1186/s13287-020-01918-x.
76.	Kobayashi M, Itoi E, Minagawa H, et al. Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits. J Shoulder Elbow Surg, 2006, 15(3): 371-377.
77.	Würgler-Hauri CC, Dourte LM, Baradet TC, et al. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg, 2007, 16(5 Suppl): S198-203.
78.	Patel S, Caldwell JM, Doty SB, et al. Integrating soft and hard tissues via interface tissue engineering. J Orthop Res, 2018, 36(4): 1069-1077.
79.	Li X, Cheng R, Sun Z, et al. Flexible bipolar nanofibrous membranes for improving gradient microstructure in tendon-to-bone healing. Acta Biomater, 2017, 61: 204-216.
80.	Li X, Xie J, Lipner J, et al. Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett, 2009, 9(7): 2763-2768.
81.	Liu W, Lipner J, Xie J, et al. Nanofiber scaffolds with gradients in mineral content for spatial control of osteogenesis. ACS Appl Mater Interfaces, 2014, 6(4): 2842-2849.
82.	Samavedi S, Olsen Horton C, Guelcher SA, et al. Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface. Acta Biomater, 2011, 7(12): 4131-4138.
83.	Lipner J, Shen H, Cavinatto L, et al. In vivo evaluation of adipose-derived stromal cells delivered with a nanofiber scaffold for tendon-to-bone repair. Tissue Eng Part A, 2015, 21(21-22): 2766-2774.
84.	Calejo I, Costa-Almeida R, Reis RL, et al. A textile platform using continuous aligned and textured composite microfibers to engineer tendon-to-bone interface gradient scaffolds. Adv Healthc Mater, 2019, 8(15): e1900200. doi: 10.1002/adhm.201900200.
85.	Nishimoto H, Kokubu T, Inui A, et al. Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model. Int Orthop, 2012, 36(11): 2379-2386.
86.	Mengsteab PY, Otsuka T, McClinton A, et al. Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits. Proc Natl Acad Sci U S A, 2020, 117(46): 28655-28666.
87.	Kimura Y, Hokugo A, Takamoto T, et al. Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Eng Part C Methods, 2008, 14(1): 47-57.
88.	Gwiazda M, Kumar S, Świeszkowski W, et al. The effect of melt electrospun writing fiber orientation onto cellular organization and mechanical properties for application in Anterior Cruciate Ligament tissue engineering. J Mech Behav Biomed Mater, 2020, 104: 103631. doi: 10.1016/j.jmbbm.2020.103631.
89.	Park SH, Choi YJ, Moon SW, et al. Three-dimensional bio-printed scaffold sleeves with mesenchymal stem cells for enhancement of tendon-to-bone healing in anterior cruciate ligament reconstruction using soft-tissue tendon graft. Arthroscopy, 2018, 34(1): 166-179.
90.	Tarafder S, Brito JA, Minhas S, et al. In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells. Biofabrication, 2019, 12(1): 015008. doi: 10.1088/1758-5090/ab48ca.
91.	Jiang X, Wu S, Kuss M, et al. 3D printing of multilayered scaffolds for rotator cuff tendon regeneration. Bioact Mater, 2020, 5(3): 636-643.
92.	Cao Y, Yang S, Zhao D, et al. Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering. J Orthop Translat, 2020, 23: 89-100.
93.	Criscenti G, Longoni A, Di Luca A, et al. Triphasic scaffolds for the regeneration of the bone-ligament interface. Biofabrication, 2016, 8(1): 015009. doi: 10.1088/1758-5090/8/1/015009.
94.	Kim BS, Kim EJ, Choi JS, et al. Human collagen-based multilayer scaffolds for tendon-to-bone interface tissue engineering. J Biomed Mater Res A, 2014, 102(11): 4044-4054.
95.	Font Tellado S, Bonani W, Balmayor ER, et al. Fabrication and characterization of biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering. Tissue Eng Part A, 2017, 23(15-16): 859-872.
96.	Lee J, Choi WI, Tae G, et al. Enhanced regeneration of the ligament-bone interface using a poly(L-lactide-co-ε-caprolactone) scaffold with local delivery of cells/BMP-2 using a heparin-based hydrogel. Acta Biomater, 2011, 7(1): 244-257.
97.	Guo J, Su W, Jiang J, et al. Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study. Compos B Eng, 2019, 165: 526-536.
98.	Kubo K, Ikebukuro T, Tsunoda N, et al. Changes in oxygen consumption of human muscle and tendon following repeat muscle contractions. Eur J Appl Physiol, 2008, 104(5): 859-866.
99.	Lafage-Proust MH, Roche B, Langer M, et al. Assessment of bone vascularization and its role in bone remodeling. Bonekey Rep, 2015, 4: 662. doi: 10.1038/bonekey.2015.29.
100.	Zhang J, Wang JH. Human tendon stem cells better maintain their stemness in hypoxic culture conditions. PLoS One, 2013, 8(4): e61424. doi: 10.1371/journal.pone.0061424.
101.	Lee WY, Lui PP, Rui YF. Hypoxia-mediated efficient expansion of human tendon-derived stem cells in vitro. Tissue Eng Part A, 2012, 18(5-6): 484-498.
102.	Yu Y, Zhou Y, Cheng T, et al. Hypoxia enhances tenocyte differentiation of adipose-derived mesenchymal stem cells by inducing hypoxia-inducible factor-1α in a co-culture system. Cell Prolif, 2016, 49(2): 173-184.
103.	Gu Q, Gu Y, Shi Q, et al. Hypoxia promotes osteogenesis of human placental-derived mesenchymal stem cells. Tohoku J Exp Med, 2016, 239(4): 287-296.
104.	Hung SP, Ho JH, Shih YR, et al. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res, 2012, 30(2): 260-266.
105.	Becquart P, Cambon-Binder A, Monfoulet LE, et al. Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo. Tissue Eng Part A, 2012, 18(19-20): 2084-2094.
106.	Touri M, Moztarzadeh F, Osman NAA, et al. 3D-printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival. Mater Sci Eng C Mater Biol Appl, 2018, 84: 236-242.
107.	Montesdeoca CYC, Afewerki S, Stocco TD, et al. Oxygen-generating smart hydrogels supporting chondrocytes survival in oxygen-free environments. Colloids Surf B Biointerfaces, 2020, 194: 111192.
108.	Wang C, Xu H, Liu C, et al. CaO₂/gelatin oxygen slow-releasing microspheres facilitate tissue engineering efficiency for the osteonecrosis of femoral head by enhancing the angiogenesis and survival of grafted bone marrow mesenchymal stem cells. Biomater Sci, 2021, 9(8): 3005-3018.
109.	Tanck E, Hannink G, Ruimerman R, et al. Cortical bone development under the growth plate is regulated by mechanical load transfer. J Anat, 2006, 208(1): 73-79.
110.	Liu Q, Hu X, Zhang X, et al. Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression. Sci Rep, 2016, 6: 37268. doi: 10.1038/srep37268.
111.	Galloway MT, Lalley AL, Shearn JT. The role of mechanical loading in tendon development, maintenance, injury, and repair. J Bone Joint Surg (Am), 2013, 95(17): 1620-1628.
112.	Peroglio M, Gaspar D, Zeugolis DI, et al. Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans. J Orthop Res, 2018, 36(1): 10-21.
113.	Elashry MI, Baulig N, Wagner AS, et al. Combined macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose-derived mesenchymal stem cells. Stem Cell Res Ther, 2021, 12(1): 116. doi: 10.1186/s13287-021-02146-7.
114.	Min S, Ko MJ, Jung HJ, et al. Remote control of time-regulated stretching of ligand-presenting nanocoils in situ regulates the cyclic adhesion and differentiation of stem cells. Adv Mater, 2021, 33(11): e2008353. doi: 10.1002/adma.202008353.
115.	Camarero-Espinosa S, Moroni L. Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration. Nat Commun, 2021, 12(1): 1031. doi: 10.1038/s41467-021-21325-x.

1. Abate M, Di Carlo L, Salini V, et al. Risk factors associated to bilateral rotator cuff tears. Orthop Traumatol Surg Res, 2017, 103(6): 841-845.
2. Tashjian RZ. Epidemiology, natural history, and indications for treatment of rotator cuff tears. Clin Sports Med, 2012, 31(4): 589-604.
3. Baechler MF, Kim DH. “Uncoverage” of the humeral head by the anterolateral acromion and its relationship to full-thickness rotator cuff tears. Mil Med, 2006, 171(10): 1035-1038.
4. Abraham AC, Shah SA, Thomopoulos S. Targeting inflammation in rotator cuff tendon degeneration and repair. Tech Shoulder Elb Surg, 2017, 18(3): 84-90.
5. Naimark M, Robbins CB, Gagnier JJ, et al. Impact of smoking on patient outcomes after arthroscopic rotator cuff repair. BMJ Open Sport Exerc Med, 2018, 4(1): e000416. doi: 10.1136/bmjsem-2018-000416.
6. Plachel F, Heuberer P, Gehwolf R, et al. MicroRNA profiling reveals distinct signatures in degenerative rotator cuff pathologies. J Orthop Res, 2020, 38(1): 202-211.
7. Longo UG, Candela V, Berton A, et al. Genetic basis of rotator cuff injury: a systematic review. BMC Med Genet, 2019, 20(1): 149. doi: 10.1186/s12881-019-0883-y.
8. Hein J, Reilly JM, Chae J, et al. Retear rates after arthroscopic single-row, double-row, and suture bridge rotator cuff repair at a minimum of 1 year of imaging follow-up: A systematic review. Arthroscopy, 2015, 31(11): 2274-2281.
9. Kim JH, Hong IT, Ryu KJ, et al. Retear rate in the late postoperative period after arthroscopic rotator cuff repair. Am J Sports Med, 2014, 42(11): 2606-2613.
10. Chung SW, Kim JY, Kim MH, et al. Arthroscopic repair of massive rotator cuff tears: outcome and analysis of factors associated with healing failure or poor postoperative function. Am J Sports Med, 2013, 41(7): 1674-1683.
11. Chung SW, Oh JH, Gong HS, et al. Factors affecting rotator cuff healing after arthroscopic repair: osteoporosis as one of the independent risk factors. Am J Sports Med, 2011, 39(10): 2099-2107.
12. Deniz G, Kose O, Tugay A, et al. Fatty degeneration and atrophy of the rotator cuff muscles after arthroscopic repair: does it improve, halt or deteriorate? Arch Orthop Trauma Surg, 2014, 134(7): 985-990.
13. Bishay V, Gallo RA. The evaluation and treatment of rotator cuff pathology. Prim Care, 2013, 40(4): 889-910.
14. Doi N, Izaki T, Miyake S, et al. Intraoperative evaluation of blood flow for soft tissues in orthopaedic surgery using indocyanine green fluorescence angiography: A pilot study. Bone Joint Res, 2019, 8(3): 118-125.
15. Zhao S, Su W, Shah V, et al. Biomaterials based strategies for rotator cuff repair. Colloids Surf B Biointerfaces, 2017, 157: 407-416.
16. Bonnevie ED, Mauck RL. Physiology and engineering of the graded interfaces of musculoskeletal junctions. Annu Rev Biomed Eng, 2018, 20: 403-429.
17. Spalazzi JP, Boskey AL, Pleshko N, et al. Quantitative mapping of matrix content and distribution across the ligament-to-bone insertion. PLoS One, 2013, 8(9): e74349. doi: 10.1371/journal.pone.0074349.
18. Rossetti L, Kuntz LA, Kunold E, et al. The microstructure and micromechanics of the tendon-bone insertion. Nat Mater, 2017, 16(6): 664-670.
19. Calejo I, Costa-Almeida R, Reis RL, et al. Enthesis tissue engineering: Biological requirements meet at the interface. Tissue Eng Part B Rev, 2019, 25(4): 330-356.
20. Yu Y, Lin L, Zhou Y, et al. Effect of hypoxia on self-renewal capacity and differentiation in human tendon-derived stem cells. Med Sci Monit, 2017, 23: 1334-1339.
21. Galatz LM, Charlton N, Das R, et al. Complete removal of load is detrimental to rotator cuff healing. J Shoulder Elbow Surg, 2009, 18(5): 669-675.
22. Lim JK, Hui J, Li L, et al. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthroscopy, 2004, 20(9): 899-910.
23. Kida Y, Morihara T, Matsuda K, et al. Bone marrow-derived cells from the footprint infiltrate into the repaired rotator cuff. J Shoulder Elbow Surg, 2013, 22(2): 197-205.
24. Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop, 2014, 38(9): 1811-1818.
25. Kanazawa T, Soejima T, Noguchi K, et al. Tendon-to-bone healing using autologous bone marrow-derived mesenchymal stem cells in ACL reconstruction without a tibial bone tunnel-A histological study-. Muscles Ligaments Tendons J, 2014, 4(2): 201-206.
26. Lu J, Chamberlain CS, Ji ML, et al. Tendon-to-bone healing in a rat extra-articular bone tunnel model: A comparison of fresh autologous bone marrow and bone marrow-derived mesenchymal stem cells. Am J Sports Med, 2019, 47(11): 2729-2736.
27. Gulotta LV, Kovacevic D, Ehteshami JR, et al. Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med, 2009, 37(11): 2126-2133.
28. Gulotta LV, Kovacevic D, Packer JD, et al. Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med, 2011, 39(6): 1282-1289.
29. Gulotta LV, Kovacevic D, Montgomery S, et al. Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site. Am J Sports Med, 2010, 38(7): 1429-1437.
30. Gao Y, Zhang Y, Lu Y, et al. TOB1 deficiency enhances the effect of bone marrow-derived mesenchymal stem cells on tendon-bone healing in a rat rotator cuff repair model. Cell Physiol Biochem, 2016, 38(1): 319-329.
31. Gulotta LV, Kovacevic D, Packer JD, et al. Adenoviral-mediated gene transfer of human bone morphogenetic protein-13 does not improve rotator cuff healing in a rat model. Am J Sports Med, 2011, 39(1): 180-187.
32. Gonçalves AI, Gershovich PM, Rodrigues MT, et al. Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells. J Tissue Eng Regen Med, 2018, 12(3): 762-774.
33. Popa EG, Santo VE, Rodrigues MT, et al. Magnetically-responsive hydrogels for modulation of chondrogenic commitment of human adipose-derived stem cells. Polymers (Basel), 2016, 8(2): 28. doi: 10.3390/polym8020028.
34. Oh JH, Chung SW, Kim SH, et al. 2013 Neer Award: Effect of the adipose-derived stem cell for the improvement of fatty degeneration and rotator cuff healing in rabbit model. J Shoulder Elbow Surg, 2014, 23(4): 445-455.
35. Kosaka M, Nakase J, Hayashi K, et al. Adipose-derived regenerative cells promote tendon-bone healing in a rabbit model. Arthroscopy, 2016, 32(5): 851-859.
36. Kim YS, Sung CH, Chung SH, et al. Does an injection of adipose-derived mesenchymal stem cells loaded in fibrin glue influence rotator cuff repair outcomes? A clinical and magnetic resonance imaging study. Am J Sports Med, 2017, 45(9): 2010-2018.
37. Jo CH, Chai JW, Jeong EC, et al. Intratendinous injection of mesenchymal stem cells for the treatment of rotator cuff disease: A 2-year follow-up study. Arthroscopy, 2020, 36(4): 971-980.
38. Shin MJ, Shim IK, Kim DM, et al. Engineered cell sheets for the effective delivery of adipose-derived stem cells for tendon-to-bone healing. Am J Sports Med, 2020, 48(13): 3347-3358.
39. Franklin A, Gi Min J, Oda H, et al. Homing of adipose-derived stem cells to a tendon-derived hydrogel: A potential mechanism for improved tendon-bone interface and tendon healing. J Hand Surg (Am), 2020, 45(12): 1180.e1-1180.e12.
40. Madhurakkat Perikamana SK, Lee J, Ahmad T, et al. Harnessing biochemical and structural cues for tenogenic differentiation of adipose derived stem cells (ADSCs) and development of an in vitro tissue interface mimicking tendon-bone insertion graft. Biomaterials, 2018, 165: 79-93.
41. Shen W, Chen J, Yin Z, et al. Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant, 2012, 21(5): 943-958.
42. Kawakami Y, Takayama K, Matsumoto T, et al. Anterior cruciate ligament-derived stem cells transduced with BMP2 accelerate graft-bone integration after ACL reconstruction. Am J Sports Med, 2017, 45(3): 584-597.
43. Ju YJ, Muneta T, Yoshimura H, et al. Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing. Cell Tissue Res, 2008, 332(3): 469-478.
44. Chang CH, Chen CH, Liu HW, et al. Bioengineered periosteal progenitor cell sheets to enhance tendon-bone healing in a bone tunnel. Biomed J, 2012, 35(6): 473-480.
45. Chen Y, Xu Y, Li M, et al. Application of Autogenous urine-derived stem cell sheet enhances rotator cuff healing in a canine model. Am J Sports Med, 2020, 48(14): 3454-3466.
46. Paschos NK, Brown WE, Eswaramoorthy R, et al. Advances in tissue engineering through stem cell-based co-culture. J Tissue Eng Regen Med, 2015, 9(5): 488-503.
47. Wang IE, Shan J, Choi R, et al. Role of osteoblast-fibroblast interactions in the formation of the ligament-to-bone interface. J Orthop Res, 2007, 25(12): 1609-1620.
48. Cooper JO, Bumgardner JD, Cole JA, et al. Co-cultured tissue-specific scaffolds for tendon/bone interface engineering. J Tissue Eng, 2014, 5: 2041731414542294. doi: 10.1177/2041731414542294.
49. He P, Ng KS, Toh SL, et al. In vitro ligament-bone interface regeneration using a trilineage coculture system on a hybrid silk scaffold. Biomacromolecules, 2012, 13(9): 2692-2703.
50. Calejo I, Costa-Almeida R, Gonçalves A I, et al. Bi-directional modulation of cellular interactions in an in vitro co-culture model of tendon-to-bone interface. Cell Prolif, 2018, 51(6): e12493.
51. Lyu J, Chen L, Zhang J, et al. A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing. Biomater Sci, 2020, 8(13): 3649-3663.
52. Kuntz LA, Rossetti L, Kunold E, et al. Biomarkers for tissue engineering of the tendon-bone interface. PLoS One, 2018, 13(1): e0189668. doi: 10.1371/journal.pone.0189668.
53. Font Tellado S, Balmayor ER, Van Griensven M. Strategies to engineer tendon/ligament-to-bone interface: Biomaterials, cells and growth factors. Adv Drug Deliv Rev, 2015, 94: 126-140.
54. Hirakawa Y, Manaka T, Orita K, et al. The accelerated effect of recombinant human bone morphogenetic protein 2 delivered by β-tricalcium phosphate on tendon-to-bone repair process in rabbit models. J Shoulder Elbow Surg, 2018, 27(5): 894-902.
55. Lee-Barthel A, Lee CA, Vidal MA, et al. Localized BMP-4 release improves the enthesis of engineered bone-to-bone ligaments. Transl Sports Med, 2018, 1(2): 60-72.
56. Kabuto Y, Morihara T, Sukenari T, et al. Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet. Tissue Eng Part A, 2015, 21(13-14): 2025-2033.
57. Yoon JP, Lee CH, Jung JW, et al. Sustained delivery of transforming growth factor β1 by use of absorbable alginate scaffold enhances rotator cuff healing in a rabbit model. Am J Sports Med, 2018, 46(6): 1441-1450.
58. Han B, Jones IA, Yang Z, et al. Repair of rotator cuff tendon defects in aged rats using a growth factor injectable gel scaffold. Arthroscopy, 2020, 36(3): 629-637.
59. Tokunaga T, Ide J, Arimura H, et al. Local application of gelatin hydrogel sheets impregnated with platelet-derived growth factor BB promotes tendon-to-bone healing after rotator cuff repair in rats. Arthroscopy, 2015, 31(8): 1482-1491.
60. Yonemitsu R, Tokunaga T, Shukunami C, et al. Fibroblast growth factor 2 enhances tendon-to-bone healing in a rat rotator cuff repair of chronic tears. Am J Sports Med, 2019, 47(7): 1701-1712.
61. Kobayashi Y, Kida Y, Kabuto Y, et al. Healing effect of subcutaneous administration of G-CSF on acute rotator cuff injury in a rat model. Tissue Eng Part A, 2021. doi: 10.1089/ten.TEA.2020.0239.
62. Min HK, Oh SH, Lee JM, et al. Porous membrane with reverse gradients of PDGF-BB and BMP-2 for tendon-to-bone repair: in vitro evaluation on adipose-derived stem cell differentiation. Acta Biomater, 2014, 10(3): 1272-1279.
63. Boswell SG, Cole BJ, Sundman EA, et al. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy, 2012, 28(3): 429-439.
64. Kesikburun S, Tan AK, Yilmaz B, et al. Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy: a randomized controlled trial with 1-year follow-up. Am J Sports Med, 2013, 41(11): 2609-2616.
65. Shams A, El-Sayed M, Gamal O, et al. Subacromial injection of autologous platelet-rich plasma versus corticosteroid for the treatment of symptomatic partial rotator cuff tears. Eur J Orthop Surg Traumatol, 2016, 26(8): 837-842.
66. Cavendish PA, Everhart JS, DiBartola AC, et al. The effect of perioperative platelet-rich plasma injections on postoperative failure rates following rotator cuff repair: a systematic review with meta-analysis. J Shoulder Elbow Surg, 2020, 29(5): 1059-1070.
67. De Gasperi R, Hamidi S, Harlow LM, et al. Denervation-related alterations and biological activity of miRNAs contained in exosomes released by skeletal muscle fibers. Sci Rep, 2017, 7(1): 12888. doi: 10.1038/s41598-017-13105-9.
68. Connor DE, Paulus JA, Dabestani PJ, et al. Therapeutic potential of exosomes in rotator cuff tendon healing. J Bone Miner Metab, 2019, 37(5): 759-767.
69. Than UTT, Guanzon D, Leavesley D, et al. Association of extracellular membrane vesicles with cutaneous wound healing. Int J Mol Sci, 2017, 18(5): 956. doi: 10.3390/ijms18050956.
70. Sevivas N, Teixeira FG, Portugal R, et al. Mesenchymal stem cell secretome improves tendon cell viability in vitro and tendon-bone healing in vivo when a tissue engineering strategy is used in a rat model of chronic massive rotator cuff tear. Am J Sports Med, 2018, 46(2): 449-459.
71. Huang Y, He B, Wang L, et al. Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats. Stem Cell Res Ther, 2020, 11(1): 496. doi: 10.1186/s13287-020-02005-x.
72. Wang C, Hu Q, Song W, et al. Adipose stem cell-derived exosomes decrease fatty infiltration and enhance rotator cuff healing in a rabbit model of chronic tears. Am J Sports Med, 2020, 48(6): 1456-1464.
73. Chen W, Sun Y, Gu X, et al. Conditioned medium of human bone marrow-derived stem cells promotes tendon-bone healing of the rotator cuff in a rat model. Biomaterials, 2021, 271: 120714. doi: 10.1016/j.biomaterials.2021.120714.
74. Li M, Jia J, Li S, et al. Exosomes derived from tendon stem cells promote cell proliferation and migration through the TGF β signal pathway. Biochem Biophys Res Commun, 2021, 536: 88-94.
75. Zhang M, Liu H, Cui Q, et al. Tendon stem cell-derived exosomes regulate inflammation and promote the high-quality healing of injured tendon. Stem Cell Res Ther, 2020, 11(1): 402. doi: 10.1186/s13287-020-01918-x.
76. Kobayashi M, Itoi E, Minagawa H, et al. Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits. J Shoulder Elbow Surg, 2006, 15(3): 371-377.
77. Würgler-Hauri CC, Dourte LM, Baradet TC, et al. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg, 2007, 16(5 Suppl): S198-203.
78. Patel S, Caldwell JM, Doty SB, et al. Integrating soft and hard tissues via interface tissue engineering. J Orthop Res, 2018, 36(4): 1069-1077.
79. Li X, Cheng R, Sun Z, et al. Flexible bipolar nanofibrous membranes for improving gradient microstructure in tendon-to-bone healing. Acta Biomater, 2017, 61: 204-216.
80. Li X, Xie J, Lipner J, et al. Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett, 2009, 9(7): 2763-2768.
81. Liu W, Lipner J, Xie J, et al. Nanofiber scaffolds with gradients in mineral content for spatial control of osteogenesis. ACS Appl Mater Interfaces, 2014, 6(4): 2842-2849.
82. Samavedi S, Olsen Horton C, Guelcher SA, et al. Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface. Acta Biomater, 2011, 7(12): 4131-4138.
83. Lipner J, Shen H, Cavinatto L, et al. In vivo evaluation of adipose-derived stromal cells delivered with a nanofiber scaffold for tendon-to-bone repair. Tissue Eng Part A, 2015, 21(21-22): 2766-2774.
84. Calejo I, Costa-Almeida R, Reis RL, et al. A textile platform using continuous aligned and textured composite microfibers to engineer tendon-to-bone interface gradient scaffolds. Adv Healthc Mater, 2019, 8(15): e1900200. doi: 10.1002/adhm.201900200.
85. Nishimoto H, Kokubu T, Inui A, et al. Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model. Int Orthop, 2012, 36(11): 2379-2386.
86. Mengsteab PY, Otsuka T, McClinton A, et al. Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits. Proc Natl Acad Sci U S A, 2020, 117(46): 28655-28666.
87. Kimura Y, Hokugo A, Takamoto T, et al. Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Eng Part C Methods, 2008, 14(1): 47-57.
88. Gwiazda M, Kumar S, Świeszkowski W, et al. The effect of melt electrospun writing fiber orientation onto cellular organization and mechanical properties for application in Anterior Cruciate Ligament tissue engineering. J Mech Behav Biomed Mater, 2020, 104: 103631. doi: 10.1016/j.jmbbm.2020.103631.
89. Park SH, Choi YJ, Moon SW, et al. Three-dimensional bio-printed scaffold sleeves with mesenchymal stem cells for enhancement of tendon-to-bone healing in anterior cruciate ligament reconstruction using soft-tissue tendon graft. Arthroscopy, 2018, 34(1): 166-179.
90. Tarafder S, Brito JA, Minhas S, et al. In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells. Biofabrication, 2019, 12(1): 015008. doi: 10.1088/1758-5090/ab48ca.
91. Jiang X, Wu S, Kuss M, et al. 3D printing of multilayered scaffolds for rotator cuff tendon regeneration. Bioact Mater, 2020, 5(3): 636-643.
92. Cao Y, Yang S, Zhao D, et al. Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering. J Orthop Translat, 2020, 23: 89-100.
93. Criscenti G, Longoni A, Di Luca A, et al. Triphasic scaffolds for the regeneration of the bone-ligament interface. Biofabrication, 2016, 8(1): 015009. doi: 10.1088/1758-5090/8/1/015009.
94. Kim BS, Kim EJ, Choi JS, et al. Human collagen-based multilayer scaffolds for tendon-to-bone interface tissue engineering. J Biomed Mater Res A, 2014, 102(11): 4044-4054.
95. Font Tellado S, Bonani W, Balmayor ER, et al. Fabrication and characterization of biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering. Tissue Eng Part A, 2017, 23(15-16): 859-872.
96. Lee J, Choi WI, Tae G, et al. Enhanced regeneration of the ligament-bone interface using a poly(L-lactide-co-ε-caprolactone) scaffold with local delivery of cells/BMP-2 using a heparin-based hydrogel. Acta Biomater, 2011, 7(1): 244-257.
97. Guo J, Su W, Jiang J, et al. Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study. Compos B Eng, 2019, 165: 526-536.
98. Kubo K, Ikebukuro T, Tsunoda N, et al. Changes in oxygen consumption of human muscle and tendon following repeat muscle contractions. Eur J Appl Physiol, 2008, 104(5): 859-866.
99. Lafage-Proust MH, Roche B, Langer M, et al. Assessment of bone vascularization and its role in bone remodeling. Bonekey Rep, 2015, 4: 662. doi: 10.1038/bonekey.2015.29.
100. Zhang J, Wang JH. Human tendon stem cells better maintain their stemness in hypoxic culture conditions. PLoS One, 2013, 8(4): e61424. doi: 10.1371/journal.pone.0061424.
101. Lee WY, Lui PP, Rui YF. Hypoxia-mediated efficient expansion of human tendon-derived stem cells in vitro. Tissue Eng Part A, 2012, 18(5-6): 484-498.
102. Yu Y, Zhou Y, Cheng T, et al. Hypoxia enhances tenocyte differentiation of adipose-derived mesenchymal stem cells by inducing hypoxia-inducible factor-1α in a co-culture system. Cell Prolif, 2016, 49(2): 173-184.
103. Gu Q, Gu Y, Shi Q, et al. Hypoxia promotes osteogenesis of human placental-derived mesenchymal stem cells. Tohoku J Exp Med, 2016, 239(4): 287-296.
104. Hung SP, Ho JH, Shih YR, et al. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res, 2012, 30(2): 260-266.
105. Becquart P, Cambon-Binder A, Monfoulet LE, et al. Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo. Tissue Eng Part A, 2012, 18(19-20): 2084-2094.
106. Touri M, Moztarzadeh F, Osman NAA, et al. 3D-printed biphasic calcium phosphate scaffolds coated with an oxygen generating system for enhancing engineered tissue survival. Mater Sci Eng C Mater Biol Appl, 2018, 84: 236-242.
107. Montesdeoca CYC, Afewerki S, Stocco TD, et al. Oxygen-generating smart hydrogels supporting chondrocytes survival in oxygen-free environments. Colloids Surf B Biointerfaces, 2020, 194: 111192.
108. Wang C, Xu H, Liu C, et al. CaO₂/gelatin oxygen slow-releasing microspheres facilitate tissue engineering efficiency for the osteonecrosis of femoral head by enhancing the angiogenesis and survival of grafted bone marrow mesenchymal stem cells. Biomater Sci, 2021, 9(8): 3005-3018.
109. Tanck E, Hannink G, Ruimerman R, et al. Cortical bone development under the growth plate is regulated by mechanical load transfer. J Anat, 2006, 208(1): 73-79.
110. Liu Q, Hu X, Zhang X, et al. Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression. Sci Rep, 2016, 6: 37268. doi: 10.1038/srep37268.
111. Galloway MT, Lalley AL, Shearn JT. The role of mechanical loading in tendon development, maintenance, injury, and repair. J Bone Joint Surg (Am), 2013, 95(17): 1620-1628.
112. Peroglio M, Gaspar D, Zeugolis DI, et al. Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans. J Orthop Res, 2018, 36(1): 10-21.
113. Elashry MI, Baulig N, Wagner AS, et al. Combined macromolecule biomaterials together with fluid shear stress promote the osteogenic differentiation capacity of equine adipose-derived mesenchymal stem cells. Stem Cell Res Ther, 2021, 12(1): 116. doi: 10.1186/s13287-021-02146-7.
114. Min S, Ko MJ, Jung HJ, et al. Remote control of time-regulated stretching of ligand-presenting nanocoils in situ regulates the cyclic adhesion and differentiation of stem cells. Adv Mater, 2021, 33(11): e2008353. doi: 10.1002/adma.202008353.
115. Camarero-Espinosa S, Moroni L. Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration. Nat Commun, 2021, 12(1): 1031. doi: 10.1038/s41467-021-21325-x.

Chinese Journal of Reparative and Reconstructive Surgery

Research progress of interfacial tissue engineering in rotator cuff repair

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