Progress of pathogenesis and genetics of alcohol-induced osteonecrosis of femoral head_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

CHEN Wei , QING Liming , WU Panfeng ,  TANG Juyu

Department of Hand and Microsurgery, Xiangya Hospital Central South University, Changsha Hunan, 410008, P. R. China;

Corresponding author：

TANG Juyu, Email: tangjuyu@csu.edu.cn

Keywords：

Alcohol-induced osteonecrosis of the femoral head; pathogenesis; genetics

DOI：

10.7507/1002-1892.202206072

Video：

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Objective To review the research progress of pathogenesis and genetics of alcohol-induced osteonecrosis of the femoral head (AIONFH). Methods The relevant domestic and foreign literature in recent years was extensively reviewed. The pathogenesis, the relationship between gene polymorphism and susceptibility, the related factors of disease progression, and the potential therapeutic targets of AIONFH were summarized. Results AIONFH is a refractory orthopedic disease caused by excessive drinking, seriously affecting the daily life of patients due to its high disability rate. The pathogenesis of AIONFH includes lipid metabolism disorder, endothelial dysfunction, bone homeostasis imbalance, and et al. Gene polymorphism and non-coding RNA are also involved. The hematological and molecular changes involved in AIONFH may be used as early diagnostic markers and potential therapeutic targets of the disease. Conclusion The pathogenesis of AIONFH has not been fully elucidated. Research based on genetics, including gene polymorphism and non-coding RNA, combined with next-generation sequencing technology, may provide directions for future research on the mechanism and discovery of potential therapeutic targets.

Citation： CHEN Wei, QING Liming, WU Panfeng, TANG Juyu. Progress of pathogenesis and genetics of alcohol-induced osteonecrosis of femoral head. Chinese Journal of Reparative and Reconstructive Surgery, 2022, 36(11): 1420-1427. doi: 10.7507/1002-1892.202206072 Copy

1.	Tan B, Li W, Zeng P, et al. Epidemiological study based on China osteonecrosis of the femoral head database. Orthop Surg, 2021, 13(1): 153-160.
2.	Tsai SW, Wu PK, Chen CF, et al. Etiologies and outcome of osteonecrosis of the femoral head: Etiology and outcome study in a Taiwan population. J Chin Med Assoc, 2016, 79(1): 39-45.
3.	Yoon BH, Kim TY, Shin IS, et al. Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations: a dose-response meta-analysis of case-control studies. Clin Rheumatol, 2017, 36(11): 2517-2524.
4.	Maurel DB, Boisseau N, Benhamou CL, et al. Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int, 2012, 23(1): 1-16.
5.	Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun, 2020, 110: 102460. doi: 10.1016/j.jaut.2020.102460.
6.	Chen X, Li M, Yan J, et al. Alcohol induces cellular senescence and impairs osteogenic potential in bone marrow-derived mesenchymal stem cells. Alcohol Alcohol, 2017, 52(3): 289-297.
7.	Wang Y, Cao Y, Li Y, et al. Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head. Int J Clin Exp Pathol, 2015, 8(9): 11332-11339.
8.	Tan R, Wang W, Wang S, et al. Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets. PLoS One, 2013, 8(4): e63213. doi: 10.1371/journal.pone.0063213.
9.	Liu C, Liu X, Li X. RAB40C gene polymorphisms were associated with alcohol-induced osteonecrosis of the femoral head. Int J Gen Med, 2021, 14: 3583-3591.
10.	Oh KW, Lee WY, Rhee EJ, et al. The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. Clin Endocrinol (Oxf), 2005, 63(2): 131-138.
11.	Asano H, Izawa H, Nagata K, et al. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia, 2010, 53(2): 234-246.
12.	Osawa H, Tabara Y, Kawamoto R, et al. Plasma resistin, associated with single nucleotide polymorphism-420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care, 2007, 30(6): 1501-1506.
13.	Liu C, An F, Cao Y, et al. Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head. Mol Genet Genomic Med, 2019, 7(8): e822. doi: 10.1002/mgg3.822.
14.	Lee HJ, Choi SJ, Hong JM, et al. Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans. Ann Hum Genet, 2009, 73(1): 34-41.
15.	Guo Y, Cao Y, Feng X, et al. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population. Gene, 2021, 804: 145902. doi: 10.1016/j.gene.2021.145902.
16.	Yan Y, Wang J, Huang D, et al. Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head. Metabolomics, 2022, 18(2): 14. doi: 10.1007/s11306-022-01872-0.
17.	Zhang Y, Yuan H, Sun Y, et al. The effects of ethanol on angiogenesis after myocardial infarction, and preservation of angiogenesis with rosuvastatin after heavy drinking. Alcohol, 2016, 54: 27-32.
18.	Wang G, Zhong S, Zhang SY, et al. Angiogenesis is repressed by ethanol exposure during chick embryonic development. J Appl Toxicol, 2016, 36(5): 692-701.
19.	Ma W, Xin K, Chen K, et al. Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study. Sci Rep, 2018, 8(1): 16221. doi: 10.1038/s41598-018-34352-4.
20.	沈莹姗, 乌日莎娜, 庄至坤, 等. 基于病理表型辨析激素性与酒精性股骨头坏死的血瘀证特点. 中华中医药杂志, 2021, 36(8): 4868-4872.
21.	Hedayati N, Annambhotla S, Jiang J, et al. Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J Vasc Surg, 2009, 49(1): 199-207.
22.	Li C, Shen L, Yang Y, et al. Plasma ghrelin and von Willebrand factor levels in patients with non-traumatic osteonecrosis of the femoral head. HIP International, 2018, 25(1): 76-81.
23.	Xu L, Ashkenazi A, Chaudhuri A. Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis, 2007, 10(4): 307-318.
24.	Davis MB, Walens A, Hire R, et al. Distinct transcript isoforms of the atypical chemokine receptor 1 (ACKR1)/duffy antigen receptor for chemokines (DARC) gene are expressed in lymphoblasts and altered isoform levels are associated with genetic ancestry and the duffy-null allele. PLoS One, 2015, 10(10): e0140098. doi: 10.1371/journal.pone.0140098.
25.	Pruenster M, Mudde L, Bombosi P, et al. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol, 2009, 10(1): 101-108.
26.	Liao Z, Jin Y, Chu Y, et al. Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head. Commun Biol, 2022, 5(1): 324. doi: 10.1038/s42003-022-03271-6.
27.	Winkler IG, Barbier V, Nowlan B, et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med, 2012, 18(11): 1651-1657.
28.	Wang L, Luo H, Chen X, et al. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS One, 2014, 9(3): e90472. doi: 10.1371/journal.pone.0090472.
29.	Bornfeldt KE. 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arterioscler Thromb Vasc Biol, 2014, 34(4): 705-714.
30.	Landers-Ramos RQ, Sapp RM, Jenkins NT, et al. Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation. Am J Physiol Heart Circ Physiol, 2015, 309(3): H407-H420.
31.	Wu RW, Lian WS, Kuo CW, et al. S100 calcium binding protein A9 represses angiogenic activity and aggravates osteonecrosis of the femoral head. Int J Mol Sci, 2019, 20(22): 5786. doi: 10.3390/ijms20225786.
32.	Akagi-Kurashige Y, Yamashiro K, Gotoh N, et al. MMP20 and ARMS2/HTRA1 are associated with neovascular lesion size in age-related macular degeneration. Ophthalmology, 2015, 122(11): 2295-2302.
33.	An F, Du J, Wang J, et al. MMP20 single-nucleotide polymorphisms correlate with susceptibility to alcohol-induced osteonecrosis of the femoral head in Chinese males. Med Sci Monit, 2019, 25: 3750-3761.
34.	Jones JP Jr. Fat embolism, intravascular coagulation, and osteonecrosis. Clin Orthop Relat Res, 1993, (292): 294-308.
35.	Zalavras C, Dailiana Z, Elisaf M, et al. Potential aetiological factors concerning the development of osteonecrosis of the femoral head. Eur J Clin Invest, 2000, 30(3): 215-221.
36.	Séguin C, Kassis J, Busque L, et al. Non-traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia. Rheumatology (Oxford), 2008, 47(8): 1151-1155.
37.	Dai XL, Hong JM, Oh B, et al. Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. Mol Cells, 2008, 26(5): 490-495.
38.	Zanotti S, Canalis E. Notch signaling and the skeleton. Endocr Rev, 2016, 37(3): 223-253.
39.	Xu T, Park SS, Giaimo BD, et al. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J, 2017, 36(21): 3232-3249.
40.	Hao Q, Samten B, Ji HL, et al. Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells. Am J Physiol Cell Physiol, 2012, 303(5): C548-C553.
41.	Xiong J, Niu Y, Liu W, et al. Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population. Neurol Sci, 2022, 43(4): 2823-2830.
42.	Wang T, Wang F, Liu T, et al. OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men. J Orthop Surg Res, 2021, 16(1): 223. doi: 10.1186/s13018-021-02356-y.
43.	Li Y, Wang Y, Guo Y, et al. OPG and RANKL polymorphisms are associated with alcohol-induced osteonecrosis of the femoral head in the north area of China population in men. Medicine (Baltimore), 2016, 95(25): e3981. doi: 10.1097/MD.0000000000003981.
44.	Li Y, Guo Y, Wang Q, et al. Osteoprotegerin polymorphisms are associated with alcohol-induced osteonecrosis of femoral head in Chinese Han population from Henan province. J Genet, 2016, 95(4): 983-989.
45.	Andersen TL, del Carmen Ovejero M, Kirkegaard T, et al. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone, 2004, 35(5): 1107-1119.
46.	Gou WL, Lu Q, Wang X, et al. Key pathway to prevent the collapse of femoral head in osteonecrosis. Eur Rev Med Pharmacol Sci, 2015, 19(15): 2766-2774.
47.	Yu Y, Xie Z, Wang J, et al. Single-nucleotide polymorphisms of MMP2 in MMP/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study. Medicine (Baltimore), 2016, 95(49): e5407. doi: 10.1097/MD.0000000000005407.
48.	Cheleschi S, Tenti S, Mondanelli N, et al. MicroRNA-34a and microRNA-181a mediate visfatin-induced apoptosis and oxidative stress via NF-κB pathway in human osteoarthritic chondrocytes. Cells, 2019, 8(8): 874. doi: 10.3390/cells8080874.
49.	Liu C, Cheng P, Liang J, et al. Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis. J Orthop Surg Res, 2021, 16(1): 307. doi: 10.1186/s13018-021-02428-z.
50.	Maccarinelli G, Sibilia V, Torsello A, et al. Ghrelin regulates proliferation and differentiation of osteoblastic cells. J Endocrinol, 2005, 184(1): 249-256.
51.	Kim SW, Her SJ, Park SJ, et al. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone, 2005, 37(3): 359-369.
52.	Zhou T, Gao B, Fan Y, et al. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-β-catenin. Elife, 2020, 9: e52779. doi: 10.7554/eLife.52779.
53.	魏腾飞, 何晓铭, 韦雨柔, 等. Piezo1在激素性和酒精性股骨头坏死骨组织中的差异表达. 中国组织工程研究, 2023, 27(2): 270-275.
54.	Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
55.	Chen C, Akiyama K, Wang D, et al. mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J Exp Med, 2015, 212(1): 73-91.
56.	Hadji P, Coleman R, Gnant M. Bone effects of mammalian target of rapamycin (mTOR) inhibition with everolimus. Crit Rev Oncol Hematol, 2013, 87(2): 101-111.
57.	Liu Y, Kou X, Chen C, et al. Chronic high dose alcohol induces osteopenia via activation of mTOR signaling in bone marrow mesenchymal stem cells. Stem Cells, 2016, 34(8): 2157-2168.
58.	Yang Q, Yin W, Chen Y, et al. Betaine alleviates alcohol-induced osteonecrosis of the femoral head via mTOR signaling pathway regulation. Biomed Pharmacother, 2019, 120: 109486. doi: 10.1016/j.biopha.2019.109486.
59.	Chen YX, Zhu DY, Gao J, et al. Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis. FEBS J, 2019, 286(6): 1101-1119.
60.	Chen JR, Lazarenko OP, Shankar K, et al. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res, 2010, 25(5): 1117-1127.
61.	Wang X, Chen X, Lu L, et al. Alcoholism and osteoimmunology. Curr Med Chem, 2021, 28(9): 1815-1828.
62.	Zeng CM, Chen Z, Fu L. Frizzled receptors as potential therapeutic targets in human cancers. Int J Mol Sci, 2018, 19(5): 1543. doi: 10.3390/ijms19051543.
63.	Ko JY, Wang FS, Wang CJ, et al. Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis. Bone, 2010, 46(3): 584-591.
64.	Yang C, Liu X, Zhao K, et al. miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects. Stem Cell Res Ther, 2019, 10(1): 65. doi: 10.1186/s13287-019-1168-2.
65.	Elkenani M, Nyamsuren G, Raju P, et al. Pelota regulates epidermal differentiation by modulating BMP and PI3K/AKT signaling pathways. J Invest Dermatol, 2016, 136(8): 1664-1671.
66.	Luo J. Autophagy and ethanol neurotoxicity. Autophagy, 2014, 10(12): 2099-2108.
67.	Yu H, Liu P, Zhu D, et al. Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head. Cell Prolif, 2020, 53(8): e12871. doi: 10.1111/cpr.12871.
68.	Luo Z, Liu Y, Liu Y, et al. Cellular and molecular mechanisms of alcohol-induced osteopenia. Cell Mol Life Sci, 2017, 74(24): 4443-4453.
69.	Howe KS, Iwaniec UT, Turner RT. The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse. Osteoporos Int, 2011, 22(4): 1175-1181.
70.	Okamura M, Kudo H, Wakabayashi K, et al. COUP-TFⅡ acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A, 2009, 106(14): 5819-5824.
71.	Xie X, Qin J, Lin SH, et al. Nuclear receptor chicken ovalbumin upstream promoter-transcription factor Ⅱ(COUP-TFⅡ) modulates mesenchymal cell commitment and differentiation. Proc Natl Acad Sci U S A, 2011, 108(36): 14843-14848.
72.	Jeong BC, Kang IH, Hwang YC, et al. MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFⅡ expression. Cell Death Dis, 2014, 5(11): e1532. doi: 10.1038/cddis.2014.485.
73.	Wang SH, Gou GH, Wu CC, et al. Increased COUP-TFⅡ expression mediates the differentiation imbalance of bone marrow-derived mesenchymal stem cells in femoral head osteonecrosis. Biomed Res Int, 2019, 2019: 9262430. doi: 10.1155/2019/9262430.
74.	Li J, Wang Y, Li Y, et al. The effect of combined regulation of the expression of peroxisome proliferator-activated receptor-γ and calcitonin gene-related peptide on alcohol-induced adipogenic differentiation of bone marrow mesenchymal stem cells. Mol Cell Biochem, 2014, 392(1-2): 39-48.
75.	Li Z, Yang B, Weng X, et al. Emerging roles of MicroRNAs in osteonecrosis of the femoral head. Cell Prolif, 2018, 51(1): e12405. doi: 10.1111/cpr.12405.
76.	Hong G, Han X, He W, et al. Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head. Sci Rep, 2019, 9(1): 18926. doi: 10.1038/s41598-019-55188-6.
77.	Jiang B, Zhu SH, Zeng JY, et al. Plasma and local expressions of CircRNA CDR1as are linked with disease severity in patients with non-traumatic osteonecrosis of femoral head. J Orthop Surg Res, 2020, 15(1): 592. doi: 10.1186/s13018-020-02129-z.
78.	Guo Y, Cao Y, Gong S, et al. Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population. BMC Musculoskelet Disord, 2020, 21(1): 547. doi: 10.1186/s12891-020-03553-2.
79.	Li L, Ding Y, Liu B, et al. Transcriptome landscape of the late-stage alcohol-induced osteonecrosis of the human femoral head. Bone, 2021, 150: 116012. doi: 10.1016/j.bone.2021.116012.
80.	钱晓芬, 曾平, 刘金富, 等. 酒精性股骨头坏死竞争性内源RNA网络及潜在生物标志物的综合分析. 中国组织工程研究, 2022, 26(23): 3670-3675.
81.	Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
82.	Li H, Borinskaya S, Yoshimura K, et al. Refined geographic distribution of the oriental ALDH2*504Lys (nee487Lys) variant. Ann Hum Genet, 2009, 73(Pt 3): 335-345.
83.	Hamada H, Ando W, Takao M, et al. Gamma-glutamyl transferase: A useful marker of habitual drinking in cases of alcohol-associated osteonecrosis of the femoral head. Alcohol Alcohol, 2021, 56(2): 175-180.
84.	Sugano N, Nishii T, Shibuya T, et al. Contralateral hip in patients with unilateral nontraumatic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1997, (334): 85-90.
85.	Ma J, Ge J, Gao F, et al. The role of immune regulatory cells in nontraumatic osteonecrosis of the femoral head: A retrospective clinical study. Biomed Res Int, 2019, 2019: 1302015. doi: 10.1155/2019/1302015.
86.	Yang SY, Zeng LY, Li C, et al. Correlation between an ABO blood group and primary femoral head necrosis: A case-control study. Orthop Surg, 2020, 12(2): 450-456.
87.	Liu M, Zhao G, Wei BF. Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head. J Orthop Surg Res, 2021, 16(1): 325. doi: 10.1186/s13018-021-02486-3.
88.	郑小龙, 何晓铭, 龚水帝, 等. 酒精性股骨头坏死患者的骨转换特点. 中国组织工程研究, 2021, 25(5): 657-661.
89.	Wang C, Liu W, Liu Z, et al. Hypoxia inhibits myogenic differentiation through p53 protein-dependent induction of Bhlhe40 protein. J Biol Chem, 2015, 290(50): 29707-29716.
90.	Cui M, Kanemoto S, Cui X, et al. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep, 2015, 5: 16455. doi: 10.1038/srep16455.
91.	Nishii T, Sugano N, Miki H, et al. Does alendronate prevent collapse in osteonecrosis of the femoral head? Clin Orthop Relat Res, 2006, 443: 273-279.
92.	Lai KA, Shen WJ, Yang CY, et al. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg (Am), 2005, 87(10): 2155-2159.
93.	Kang P, Pei F, Shen B, et al. Are the results of multiple drilling and alendronate for osteonecrosis of the femoral head better than those of multiple drilling? A pilot study. Joint Bone Spine, 2012, 79(1): 67-72.
94.	Nozaki Y, Kumagai K, Miyata N, et al. Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats. Acta Orthop, 2012, 83(1): 87-92.
95.	Jiang Y, Zhang Y, Zhang H, et al. Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway. Exp Biol Med (Maywood), 2014, 239(3): 347-355.
96.	谢克恭, 唐毓金, 黄可, 等. 普伐他汀对酒精性股骨头坏死早期干预作用的实验研究. 实用临床医药杂志, 2015, 19(1): 65-67, 71.
97.	黄可. 普伐他汀钠对兔酒精性股骨头坏死干预作用的实验研究. 桂林: 桂林医学院, 2013.
98.	陆咨儒, 谢林, 相萍萍, 等. 辛伐他汀治疗酒精性股骨头坏死的效果及机制初步探讨. 实用临床医药杂志, 2021, 25(8): 96-100.
99.	Villa I, Senesi P, Montesano A, et al. Betaine promotes cell differentiation of human osteoblasts in primary culture. J Transl Med, 2017, 15(1): 132. doi: 10.1186/s12967-017-1233-5.
100.	Tang DZ, Hou W, Zhou Q, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res, 2010, 25(6): 1234-1245.
101.	Chen YX, Tao SC, Xu ZL, et al. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. Oncotarget, 2017, 8(19): 31065-31078.
102.	Chen YX, Zhu DY, Xu ZL, et al. The protective effect of cordycepin on alcohol-induced osteonecrosis of the femoral head. Cell Physiol Biochem, 2017, 42(6): 2391-2403.
103.	Wang Y, Yin L, Li Y, et al. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin Orthop Relat Res, 2008, 466(5): 1059-1067.
104.	Liu S, Cheng Y, Rao M, et al. Muscone induces CYP1A2 and CYP3A4 enzyme expression in L02 human liver cells and CYP1A2 and CYP3A11 enzyme expression in Kunming mice. Pharmacology, 2017, 99(5-6): 205-215.
105.	Wang X, Meng H, Chen P, et al. Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction. Int J Mol Med, 2014, 34(1): 103-111.
106.	Tanaka E, Funae Y, Imaoka S, et al. Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3-methylcyclopentadecanone). Biochem Pharmacol, 1991, 41(3): 472-473.
107.	Peng R, Zhu XY, Yang CS. Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone). Biochem Pharmacol, 1986, 35(8): 1391-1394.
108.	Guo YJ, Luo SH, Tang MJ, et al. Muscone exerts protective roles on alcohol-induced osteonecrosis of the femoral head. Biomed Pharmacother, 2018, 97: 825-832.
109.	Chen J, Yang C, Yang Y, et al. Targeting DKK1 prevents development of alcohol-induced osteonecrosis of the femoral head in rats. Am J Transl Res, 2021, 13(4): 2320-2330.
110.	杜振宁, 王冰一, 高强, 等. 血红素氧合酶1和骨形态发生蛋白2共表达腺病毒载体构建及其对酒精性股骨头坏死治疗的研究. 中华实验外科杂志, 2022, 39(3): 535-537.

1. Tan B, Li W, Zeng P, et al. Epidemiological study based on China osteonecrosis of the femoral head database. Orthop Surg, 2021, 13(1): 153-160.
2. Tsai SW, Wu PK, Chen CF, et al. Etiologies and outcome of osteonecrosis of the femoral head: Etiology and outcome study in a Taiwan population. J Chin Med Assoc, 2016, 79(1): 39-45.
3. Yoon BH, Kim TY, Shin IS, et al. Alcohol intake and the risk of osteonecrosis of the femoral head in Japanese populations: a dose-response meta-analysis of case-control studies. Clin Rheumatol, 2017, 36(11): 2517-2524.
4. Maurel DB, Boisseau N, Benhamou CL, et al. Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int, 2012, 23(1): 1-16.
5. Chang C, Greenspan A, Gershwin ME. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis. J Autoimmun, 2020, 110: 102460. doi: 10.1016/j.jaut.2020.102460.
6. Chen X, Li M, Yan J, et al. Alcohol induces cellular senescence and impairs osteogenic potential in bone marrow-derived mesenchymal stem cells. Alcohol Alcohol, 2017, 52(3): 289-297.
7. Wang Y, Cao Y, Li Y, et al. Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head. Int J Clin Exp Pathol, 2015, 8(9): 11332-11339.
8. Tan R, Wang W, Wang S, et al. Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets. PLoS One, 2013, 8(4): e63213. doi: 10.1371/journal.pone.0063213.
9. Liu C, Liu X, Li X. RAB40C gene polymorphisms were associated with alcohol-induced osteonecrosis of the femoral head. Int J Gen Med, 2021, 14: 3583-3591.
10. Oh KW, Lee WY, Rhee EJ, et al. The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men. Clin Endocrinol (Oxf), 2005, 63(2): 131-138.
11. Asano H, Izawa H, Nagata K, et al. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia, 2010, 53(2): 234-246.
12. Osawa H, Tabara Y, Kawamoto R, et al. Plasma resistin, associated with single nucleotide polymorphism-420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population. Diabetes Care, 2007, 30(6): 1501-1506.
13. Liu C, An F, Cao Y, et al. Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head. Mol Genet Genomic Med, 2019, 7(8): e822. doi: 10.1002/mgg3.822.
14. Lee HJ, Choi SJ, Hong JM, et al. Association of a polymorphism in the intron 7 of the SREBF1 gene with osteonecrosis of the femoral head in Koreans. Ann Hum Genet, 2009, 73(1): 34-41.
15. Guo Y, Cao Y, Feng X, et al. The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population. Gene, 2021, 804: 145902. doi: 10.1016/j.gene.2021.145902.
16. Yan Y, Wang J, Huang D, et al. Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head. Metabolomics, 2022, 18(2): 14. doi: 10.1007/s11306-022-01872-0.
17. Zhang Y, Yuan H, Sun Y, et al. The effects of ethanol on angiogenesis after myocardial infarction, and preservation of angiogenesis with rosuvastatin after heavy drinking. Alcohol, 2016, 54: 27-32.
18. Wang G, Zhong S, Zhang SY, et al. Angiogenesis is repressed by ethanol exposure during chick embryonic development. J Appl Toxicol, 2016, 36(5): 692-701.
19. Ma W, Xin K, Chen K, et al. Relationship of common variants in VEGFA gene with osteonecrosis of the femoral head: A Han Chinese population based association study. Sci Rep, 2018, 8(1): 16221. doi: 10.1038/s41598-018-34352-4.
20. 沈莹姗, 乌日莎娜, 庄至坤, 等. 基于病理表型辨析激素性与酒精性股骨头坏死的血瘀证特点. 中华中医药杂志, 2021, 36(8): 4868-4872.
21. Hedayati N, Annambhotla S, Jiang J, et al. Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J Vasc Surg, 2009, 49(1): 199-207.
22. Li C, Shen L, Yang Y, et al. Plasma ghrelin and von Willebrand factor levels in patients with non-traumatic osteonecrosis of the femoral head. HIP International, 2018, 25(1): 76-81.
23. Xu L, Ashkenazi A, Chaudhuri A. Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis, 2007, 10(4): 307-318.
24. Davis MB, Walens A, Hire R, et al. Distinct transcript isoforms of the atypical chemokine receptor 1 (ACKR1)/duffy antigen receptor for chemokines (DARC) gene are expressed in lymphoblasts and altered isoform levels are associated with genetic ancestry and the duffy-null allele. PLoS One, 2015, 10(10): e0140098. doi: 10.1371/journal.pone.0140098.
25. Pruenster M, Mudde L, Bombosi P, et al. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol, 2009, 10(1): 101-108.
26. Liao Z, Jin Y, Chu Y, et al. Single-cell transcriptome analysis reveals aberrant stromal cells and heterogeneous endothelial cells in alcohol-induced osteonecrosis of the femoral head. Commun Biol, 2022, 5(1): 324. doi: 10.1038/s42003-022-03271-6.
27. Winkler IG, Barbier V, Nowlan B, et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med, 2012, 18(11): 1651-1657.
28. Wang L, Luo H, Chen X, et al. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS One, 2014, 9(3): e90472. doi: 10.1371/journal.pone.0090472.
29. Bornfeldt KE. 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arterioscler Thromb Vasc Biol, 2014, 34(4): 705-714.
30. Landers-Ramos RQ, Sapp RM, Jenkins NT, et al. Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation. Am J Physiol Heart Circ Physiol, 2015, 309(3): H407-H420.
31. Wu RW, Lian WS, Kuo CW, et al. S100 calcium binding protein A9 represses angiogenic activity and aggravates osteonecrosis of the femoral head. Int J Mol Sci, 2019, 20(22): 5786. doi: 10.3390/ijms20225786.
32. Akagi-Kurashige Y, Yamashiro K, Gotoh N, et al. MMP20 and ARMS2/HTRA1 are associated with neovascular lesion size in age-related macular degeneration. Ophthalmology, 2015, 122(11): 2295-2302.
33. An F, Du J, Wang J, et al. MMP20 single-nucleotide polymorphisms correlate with susceptibility to alcohol-induced osteonecrosis of the femoral head in Chinese males. Med Sci Monit, 2019, 25: 3750-3761.
34. Jones JP Jr. Fat embolism, intravascular coagulation, and osteonecrosis. Clin Orthop Relat Res, 1993, (292): 294-308.
35. Zalavras C, Dailiana Z, Elisaf M, et al. Potential aetiological factors concerning the development of osteonecrosis of the femoral head. Eur J Clin Invest, 2000, 30(3): 215-221.
36. Séguin C, Kassis J, Busque L, et al. Non-traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia. Rheumatology (Oxford), 2008, 47(8): 1151-1155.
37. Dai XL, Hong JM, Oh B, et al. Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. Mol Cells, 2008, 26(5): 490-495.
38. Zanotti S, Canalis E. Notch signaling and the skeleton. Endocr Rev, 2016, 37(3): 223-253.
39. Xu T, Park SS, Giaimo BD, et al. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. EMBO J, 2017, 36(21): 3232-3249.
40. Hao Q, Samten B, Ji HL, et al. Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells. Am J Physiol Cell Physiol, 2012, 303(5): C548-C553.
41. Xiong J, Niu Y, Liu W, et al. Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population. Neurol Sci, 2022, 43(4): 2823-2830.
42. Wang T, Wang F, Liu T, et al. OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men. J Orthop Surg Res, 2021, 16(1): 223. doi: 10.1186/s13018-021-02356-y.
43. Li Y, Wang Y, Guo Y, et al. OPG and RANKL polymorphisms are associated with alcohol-induced osteonecrosis of the femoral head in the north area of China population in men. Medicine (Baltimore), 2016, 95(25): e3981. doi: 10.1097/MD.0000000000003981.
44. Li Y, Guo Y, Wang Q, et al. Osteoprotegerin polymorphisms are associated with alcohol-induced osteonecrosis of femoral head in Chinese Han population from Henan province. J Genet, 2016, 95(4): 983-989.
45. Andersen TL, del Carmen Ovejero M, Kirkegaard T, et al. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone, 2004, 35(5): 1107-1119.
46. Gou WL, Lu Q, Wang X, et al. Key pathway to prevent the collapse of femoral head in osteonecrosis. Eur Rev Med Pharmacol Sci, 2015, 19(15): 2766-2774.
47. Yu Y, Xie Z, Wang J, et al. Single-nucleotide polymorphisms of MMP2 in MMP/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study. Medicine (Baltimore), 2016, 95(49): e5407. doi: 10.1097/MD.0000000000005407.
48. Cheleschi S, Tenti S, Mondanelli N, et al. MicroRNA-34a and microRNA-181a mediate visfatin-induced apoptosis and oxidative stress via NF-κB pathway in human osteoarthritic chondrocytes. Cells, 2019, 8(8): 874. doi: 10.3390/cells8080874.
49. Liu C, Cheng P, Liang J, et al. Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis. J Orthop Surg Res, 2021, 16(1): 307. doi: 10.1186/s13018-021-02428-z.
50. Maccarinelli G, Sibilia V, Torsello A, et al. Ghrelin regulates proliferation and differentiation of osteoblastic cells. J Endocrinol, 2005, 184(1): 249-256.
51. Kim SW, Her SJ, Park SJ, et al. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone, 2005, 37(3): 359-369.
52. Zhou T, Gao B, Fan Y, et al. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-β-catenin. Elife, 2020, 9: e52779. doi: 10.7554/eLife.52779.
53. 魏腾飞, 何晓铭, 韦雨柔, 等. Piezo1在激素性和酒精性股骨头坏死骨组织中的差异表达. 中国组织工程研究, 2023, 27(2): 270-275.
54. Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
55. Chen C, Akiyama K, Wang D, et al. mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J Exp Med, 2015, 212(1): 73-91.
56. Hadji P, Coleman R, Gnant M. Bone effects of mammalian target of rapamycin (mTOR) inhibition with everolimus. Crit Rev Oncol Hematol, 2013, 87(2): 101-111.
57. Liu Y, Kou X, Chen C, et al. Chronic high dose alcohol induces osteopenia via activation of mTOR signaling in bone marrow mesenchymal stem cells. Stem Cells, 2016, 34(8): 2157-2168.
58. Yang Q, Yin W, Chen Y, et al. Betaine alleviates alcohol-induced osteonecrosis of the femoral head via mTOR signaling pathway regulation. Biomed Pharmacother, 2019, 120: 109486. doi: 10.1016/j.biopha.2019.109486.
59. Chen YX, Zhu DY, Gao J, et al. Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3β/β-catenin axis. FEBS J, 2019, 286(6): 1101-1119.
60. Chen JR, Lazarenko OP, Shankar K, et al. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res, 2010, 25(5): 1117-1127.
61. Wang X, Chen X, Lu L, et al. Alcoholism and osteoimmunology. Curr Med Chem, 2021, 28(9): 1815-1828.
62. Zeng CM, Chen Z, Fu L. Frizzled receptors as potential therapeutic targets in human cancers. Int J Mol Sci, 2018, 19(5): 1543. doi: 10.3390/ijms19051543.
63. Ko JY, Wang FS, Wang CJ, et al. Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis. Bone, 2010, 46(3): 584-591.
64. Yang C, Liu X, Zhao K, et al. miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects. Stem Cell Res Ther, 2019, 10(1): 65. doi: 10.1186/s13287-019-1168-2.
65. Elkenani M, Nyamsuren G, Raju P, et al. Pelota regulates epidermal differentiation by modulating BMP and PI3K/AKT signaling pathways. J Invest Dermatol, 2016, 136(8): 1664-1671.
66. Luo J. Autophagy and ethanol neurotoxicity. Autophagy, 2014, 10(12): 2099-2108.
67. Yu H, Liu P, Zhu D, et al. Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head. Cell Prolif, 2020, 53(8): e12871. doi: 10.1111/cpr.12871.
68. Luo Z, Liu Y, Liu Y, et al. Cellular and molecular mechanisms of alcohol-induced osteopenia. Cell Mol Life Sci, 2017, 74(24): 4443-4453.
69. Howe KS, Iwaniec UT, Turner RT. The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse. Osteoporos Int, 2011, 22(4): 1175-1181.
70. Okamura M, Kudo H, Wakabayashi K, et al. COUP-TFⅡ acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A, 2009, 106(14): 5819-5824.
71. Xie X, Qin J, Lin SH, et al. Nuclear receptor chicken ovalbumin upstream promoter-transcription factor Ⅱ(COUP-TFⅡ) modulates mesenchymal cell commitment and differentiation. Proc Natl Acad Sci U S A, 2011, 108(36): 14843-14848.
72. Jeong BC, Kang IH, Hwang YC, et al. MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFⅡ expression. Cell Death Dis, 2014, 5(11): e1532. doi: 10.1038/cddis.2014.485.
73. Wang SH, Gou GH, Wu CC, et al. Increased COUP-TFⅡ expression mediates the differentiation imbalance of bone marrow-derived mesenchymal stem cells in femoral head osteonecrosis. Biomed Res Int, 2019, 2019: 9262430. doi: 10.1155/2019/9262430.
74. Li J, Wang Y, Li Y, et al. The effect of combined regulation of the expression of peroxisome proliferator-activated receptor-γ and calcitonin gene-related peptide on alcohol-induced adipogenic differentiation of bone marrow mesenchymal stem cells. Mol Cell Biochem, 2014, 392(1-2): 39-48.
75. Li Z, Yang B, Weng X, et al. Emerging roles of MicroRNAs in osteonecrosis of the femoral head. Cell Prolif, 2018, 51(1): e12405. doi: 10.1111/cpr.12405.
76. Hong G, Han X, He W, et al. Analysis of circulating microRNAs aberrantly expressed in alcohol-induced osteonecrosis of femoral head. Sci Rep, 2019, 9(1): 18926. doi: 10.1038/s41598-019-55188-6.
77. Jiang B, Zhu SH, Zeng JY, et al. Plasma and local expressions of CircRNA CDR1as are linked with disease severity in patients with non-traumatic osteonecrosis of femoral head. J Orthop Surg Res, 2020, 15(1): 592. doi: 10.1186/s13018-020-02129-z.
78. Guo Y, Cao Y, Gong S, et al. Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population. BMC Musculoskelet Disord, 2020, 21(1): 547. doi: 10.1186/s12891-020-03553-2.
79. Li L, Ding Y, Liu B, et al. Transcriptome landscape of the late-stage alcohol-induced osteonecrosis of the human femoral head. Bone, 2021, 150: 116012. doi: 10.1016/j.bone.2021.116012.
80. 钱晓芬, 曾平, 刘金富, 等. 酒精性股骨头坏死竞争性内源RNA网络及潜在生物标志物的综合分析. 中国组织工程研究, 2022, 26(23): 3670-3675.
81. Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
82. Li H, Borinskaya S, Yoshimura K, et al. Refined geographic distribution of the oriental ALDH2*504Lys (nee487Lys) variant. Ann Hum Genet, 2009, 73(Pt 3): 335-345.
83. Hamada H, Ando W, Takao M, et al. Gamma-glutamyl transferase: A useful marker of habitual drinking in cases of alcohol-associated osteonecrosis of the femoral head. Alcohol Alcohol, 2021, 56(2): 175-180.
84. Sugano N, Nishii T, Shibuya T, et al. Contralateral hip in patients with unilateral nontraumatic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1997, (334): 85-90.
85. Ma J, Ge J, Gao F, et al. The role of immune regulatory cells in nontraumatic osteonecrosis of the femoral head: A retrospective clinical study. Biomed Res Int, 2019, 2019: 1302015. doi: 10.1155/2019/1302015.
86. Yang SY, Zeng LY, Li C, et al. Correlation between an ABO blood group and primary femoral head necrosis: A case-control study. Orthop Surg, 2020, 12(2): 450-456.
87. Liu M, Zhao G, Wei BF. Attenuated serum vasoactive intestinal peptide concentrations are correlated with disease severity of non-traumatic osteonecrosis of femoral head. J Orthop Surg Res, 2021, 16(1): 325. doi: 10.1186/s13018-021-02486-3.
88. 郑小龙, 何晓铭, 龚水帝, 等. 酒精性股骨头坏死患者的骨转换特点. 中国组织工程研究, 2021, 25(5): 657-661.
89. Wang C, Liu W, Liu Z, et al. Hypoxia inhibits myogenic differentiation through p53 protein-dependent induction of Bhlhe40 protein. J Biol Chem, 2015, 290(50): 29707-29716.
90. Cui M, Kanemoto S, Cui X, et al. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep, 2015, 5: 16455. doi: 10.1038/srep16455.
91. Nishii T, Sugano N, Miki H, et al. Does alendronate prevent collapse in osteonecrosis of the femoral head? Clin Orthop Relat Res, 2006, 443: 273-279.
92. Lai KA, Shen WJ, Yang CY, et al. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg (Am), 2005, 87(10): 2155-2159.
93. Kang P, Pei F, Shen B, et al. Are the results of multiple drilling and alendronate for osteonecrosis of the femoral head better than those of multiple drilling? A pilot study. Joint Bone Spine, 2012, 79(1): 67-72.
94. Nozaki Y, Kumagai K, Miyata N, et al. Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats. Acta Orthop, 2012, 83(1): 87-92.
95. Jiang Y, Zhang Y, Zhang H, et al. Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway. Exp Biol Med (Maywood), 2014, 239(3): 347-355.
96. 谢克恭, 唐毓金, 黄可, 等. 普伐他汀对酒精性股骨头坏死早期干预作用的实验研究. 实用临床医药杂志, 2015, 19(1): 65-67, 71.
97. 黄可. 普伐他汀钠对兔酒精性股骨头坏死干预作用的实验研究. 桂林: 桂林医学院, 2013.
98. 陆咨儒, 谢林, 相萍萍, 等. 辛伐他汀治疗酒精性股骨头坏死的效果及机制初步探讨. 实用临床医药杂志, 2021, 25(8): 96-100.
99. Villa I, Senesi P, Montesano A, et al. Betaine promotes cell differentiation of human osteoblasts in primary culture. J Transl Med, 2017, 15(1): 132. doi: 10.1186/s12967-017-1233-5.
100. Tang DZ, Hou W, Zhou Q, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res, 2010, 25(6): 1234-1245.
101. Chen YX, Tao SC, Xu ZL, et al. Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head. Oncotarget, 2017, 8(19): 31065-31078.
102. Chen YX, Zhu DY, Xu ZL, et al. The protective effect of cordycepin on alcohol-induced osteonecrosis of the femoral head. Cell Physiol Biochem, 2017, 42(6): 2391-2403.
103. Wang Y, Yin L, Li Y, et al. Preventive effects of puerarin on alcohol-induced osteonecrosis. Clin Orthop Relat Res, 2008, 466(5): 1059-1067.
104. Liu S, Cheng Y, Rao M, et al. Muscone induces CYP1A2 and CYP3A4 enzyme expression in L02 human liver cells and CYP1A2 and CYP3A11 enzyme expression in Kunming mice. Pharmacology, 2017, 99(5-6): 205-215.
105. Wang X, Meng H, Chen P, et al. Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction. Int J Mol Med, 2014, 34(1): 103-111.
106. Tanaka E, Funae Y, Imaoka S, et al. Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3-methylcyclopentadecanone). Biochem Pharmacol, 1991, 41(3): 472-473.
107. Peng R, Zhu XY, Yang CS. Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone). Biochem Pharmacol, 1986, 35(8): 1391-1394.
108. Guo YJ, Luo SH, Tang MJ, et al. Muscone exerts protective roles on alcohol-induced osteonecrosis of the femoral head. Biomed Pharmacother, 2018, 97: 825-832.
109. Chen J, Yang C, Yang Y, et al. Targeting DKK1 prevents development of alcohol-induced osteonecrosis of the femoral head in rats. Am J Transl Res, 2021, 13(4): 2320-2330.
110. 杜振宁, 王冰一, 高强, 等. 血红素氧合酶1和骨形态发生蛋白2共表达腺病毒载体构建及其对酒精性股骨头坏死治疗的研究. 中华实验外科杂志, 2022, 39(3): 535-537.

Chinese Journal of Reparative and Reconstructive Surgery

Progress of pathogenesis and genetics of alcohol-induced osteonecrosis of femoral head

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