Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LEI Shuting ^1,2,3 ,  HU Juanjuan ^1,2 , TANG Yingqi ⁴ , GAN Weigang ² , SONG Yuting ¹ , JIANG Yanlin ¹ , ZHANG Honghui ² , GAO Yaya ^1,2 , YANG Hui ² , XIE Huiqi ¹

1. Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
2. Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
3. Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
4. West China School of Public Health, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

HU Juanjuan, Email: hujuanjuan2017@163.com

Keywords：

Atrophic rhinitis; tissue engineering technology; repair and reconstruction

DOI：

10.7507/1002-1892.202301064

Video：

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Objective To review the research progress of the feasibility of a new treatment method for atrophic rhinitis (ATR) based on tissue engineering technology (seed cells, scaffold materials, and growth factors), and provide new ideas for the treatment of ATR. Methods The literature related to ATR was extensively reviewed. Focusing on the three aspects of seed cells, scaffold materials, and growth factors, the recent research progress of ATR treatment was reviewed, and the future directions of tissue engineering technology to treat ATR were proposed. Results The pathogenesis and etiology of ATR are still unclear, and the effectiveness of the current treatments are still unsatisfactory. The construction of a cell-scaffold complex with sustained and controlled release of exogenous cytokines is expected to reverse the pathological changes of ATR, promoting the regeneration of normal nasal mucosa and reconstructing the atrophic turbinate. In recent years, the research progress of exosomes, three-dimensional printing, and organoids will promote the development of tissue engineering technology for ATR. Conclusion Tissue engineering technology can provide a new treatment method for ATR.

Citation： LEI Shuting, HU Juanjuan, TANG Yingqi, GAN Weigang, SONG Yuting, JIANG Yanlin, ZHANG Honghui, GAO Yaya, YANG Hui, XIE Huiqi. Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis. Chinese Journal of Reparative and Reconstructive Surgery, 2023, 37(6): 727-731. doi: 10.7507/1002-1892.202301064 Copy

1.	赵霞. 多方案联合治疗萎缩性鼻炎的临床疗效及安全性. 河南医学研究, 2015, 24(3): 97-98.
2.	Pace-Balzan A, Shankar L, Hawke M. Computed tomographic findings in atrophic rhinitis. J Otolaryngol, 1991, 20(6): 428-432.
3.	Bunnag C, Jareoncharsri P, Tansuriyawong P, et al. Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital. Rhinology, 1999, 37(3): 125-130.
4.	Ghosh P. Vestibuloplasty (a new one-stage operation for atrophic rhinitis). J Laryngol Otol, 1987, 101(9): 905-909.
5.	Garcia GJ, Bailie N, Martins DA, et al. Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J Appl Physiol (1985), 2007, 103(3): 1082-1092.
6.	Medina L, Benazzo M, Bertino G, et al. Clinical, genetic and immunologic analysis of a family affected by ozena. Eur Arch Otorhinolaryngol, 2003, 260(7): 390-394.
7.	Fouad H, Afifi N, Fatt-Hi A, et al. Altered cell mediated immunity in atrophic rhinitis. J Laryngol Otol, 1980, 94(5): 507-514.
8.	李欣. 京万红软膏治疗萎缩性鼻炎100例临床疗效分析. 内蒙古中医药, 2017, 36(10): 110-111.
9.	Abdel-Naby Awad OG, Hasan MM. Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. Am J Otolaryngol, 2019, 40(2): 137-142.
10.	Testa D, Marcuccio G, Lombardo N, et al. Role of α-tocopherol acetate on nasal respiratory functions: Mucociliary clearance and rhinomanometric evaluations in primary atrophic rhinitis. Ear Nose Throat J, 2021, 100(6): NP290-NP295.
11.	Kang X, Sun Y, Yi B, et al. Based on network pharmacology and molecular dynamics simulations, baicalein, an active ingredient of Yiqi Qingre Ziyin method, potentially protects patients with atrophic rhinitis from cognitive impairment. Front Aging Neurosci, 2022, 14: 880794. doi: 10.3389/fnagi.2022.880794.
12.	Dutt SN, Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol, 2005, 119(11): 843-852.
13.	Park MJ, Jang YJ. Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. Auris Nasus Larynx, 2018, 45(3): 613-616.
14.	Hassan CH, Malheiro E, Béquignon E, et al. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique. Laryngoscope Investig Otolaryngol, 2021, 7(1): 6-11.
15.	刘文军, 梁灼萍, 陈祖尧, 等. 萎缩性鼻炎治疗及基础研究现状. 中国中西医结合耳鼻咽喉科杂志, 2008, 16(5): 398-400,397.
16.	侯琳琳. 改良前鼻孔缩窄术联合表皮生长因子治疗萎缩性鼻炎患者的疗效. 医疗装备, 2018, 31(14): 20-21.
17.	殷晓雪, 陈仲强, 郭昭庆, 等. 人骨髓间充质干细胞定向诱导分化为成骨细胞及其鉴定. 中国修复重建外科杂志, 2004, 18(2): 88-91.
18.	杨大鉴, 黄定强, 何成松, 等. 组织工程骨技术在萎缩性鼻炎治疗中的应用. 中国康复, 2006, 21(4): 225-226.
19.	Mende W, Götzl R, Kubo Y, et al. The role of adipose stem cells in bone regeneration and bone tissue engineering. Cells, 2021, 10(5): 975.
20.	Friji MT, Gopalakrishnan S, Verma SK, et al. New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. Clin Otolaryngol, 2014, 39(5): 289-292.
21.	Hass R, Kasper C, Böhm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal, 2011, 9: 12. doi: 10.1186/1478-811X-9-12.
22.	董金辉, 任秀敏, 徐鸥, 等. 人脐血干细胞分化为鼻黏膜纤毛上皮细胞. 中国组织工程研究, 2016, 20(32): 4764-4770.
23.	Sun L, Sha J, Meng C, et al. Mesenchymal stem cell-based therapy for allergic rhinitis. Stem Cells Int, 2020, 2020: 2367524. doi: 10.1155/2020/2367524.
24.	Drela K, Stanaszek L, Nowakowski A, et al. Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes. Stem Cells Int, 2019, 2019: 7012692. doi: 10.1155/2019/7012692.
25.	陈晓旭, 罗雅馨, 毕浩然, 等. 脱细胞支架制备及其在组织工程和再生医学中的应用. 中国组织工程研究, 2022, 26(4): 591-596.
26.	Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Semin Immunol, 2017, 29: 72-91.
27.	石润杰, 吴晴伟, 赵影颖, 等. 自体骨髓基质干细胞构建下鼻甲. 中国耳鼻咽喉头颈外科, 2009, 16(1): 13-16.
28.	许航, 何其泽, 黄为. 组织工程关节软骨的研究进展. 中国骨与关节损伤杂志, 2022, 37(5): 558-560.
29.	Singh BN, Veeresh V, Mallick SP, et al. Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering. Int J Biol Macromol, 2019, 133: 817-830.
30.	Cakmak AM, Unal S, Sahin A, et al. 3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering. Polymers (Basel), 2020, 12(9): 1962. doi: 10.3390/polym12091962.
31.	Iglesias-Mejuto A, García-González CA. 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2021, 131: 112525. doi: 10.1016/j.msec.2021.112525.
32.	杨君英. 重组牛碱性成纤维细胞生长因子治疗萎缩性鼻炎临床观察. 医药论坛杂志, 2013, 34(7): 115-116.
33.	尤景敏, 汪建, 彭华, 等. 表皮生长因子治疗萎缩性鼻炎的效果观察. 广东医学, 2003, 24(10): 1057.
34.	杨晓燕, 吴宏洲, 钱美. 鼻腔冲洗配合表皮生长因子治疗萎缩性鼻炎56例体会. 中国医学工程, 2010, 18(2): 152-153.
35.	张心如, 鲁文龙, 冯超, 等. 血管内皮生长因子纳米微球-细菌纤维素复合支架与多种细胞构建组织工程膀胱. 中国组织工程研究, 2016, 20(21): 3088-3096.
36.	张志文, 黄玉良, 张理选, 等. 碱性成纤维细胞生长因子复合脱细胞骨基质/壳聚糖支架修复骨缺损. 中国组织工程研究, 2021, 25(34): 5439-5444.
37.	刘士博, 刘显. 不同源性外泌体在骨缺损修复中的研究进展. 华西口腔医学杂志, 2020, 38(2): 193-197.
38.	Du YM, Zhuansun YX, Chen R, et al. Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Exp Cell Res, 2018, 363(1): 114-120.
39.	Li W, Liu Y, Zhang P, et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS Appl Mater Interfaces, 2018, 10(6): 5240-5254.
40.	蔡超莹, 陈学鹏, 胡济安. 外泌体复合支架用于口腔组织工程的研究进展. 国际口腔医学杂志, 2022, 49(4): 489-496.
41.	Ganbold B, Heo SJ, Koak JY, et al. Human stem cell responses and surface characteristics of 3D printing co-cr dental material. Materials (Basel), 2019, 12(20): 3419. doi: 10.3390/ma12203419.
42.	徐晨阳, 李祎, 刘晓雯, 等. 3D打印技术在耳鼻咽喉科的应用进展. 中华耳科学杂志, 2022, 20(4): 645-648.
43.	孙开瑜, 徐铭恩, 周永勇. 基于3D打印的Ⅰ型胶原涂覆β-TCP骨组织工程支架研究. 中国生物医学工程学报, 2018, 37(3): 335-343.
44.	路冬冬, 朱天峰, 张一健, 等. 3D生物打印甲基丙烯酰化明胶水凝胶支架促进软骨下骨缺损的修复. 中国组织工程研究, 2022, 26(34): 5454-5460.
45.	李潇萌, 管若羽, 高建军, 等. 类器官在再生医学中的应用. 中国细胞生物学学报, 2021, 43(6): 1120-1131.
46.	Park Y, Cheong E, Kwak JG, et al. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv, 2021, 7(4): eabd6495. doi: 10.1126/sciadv.abd6495.
47.	Chen S, Chen X, Geng Z, et al. The horizon of bone organoid: A perspective on construction and application. Bioact Mater, 2022, 18: 15-25.
48.	陈晓, 苏佳灿. 骨缺损治疗新技术: 骨类器官. 中华创伤杂志, 2022, 38(4): 293-296.

1. 赵霞. 多方案联合治疗萎缩性鼻炎的临床疗效及安全性. 河南医学研究, 2015, 24(3): 97-98.
2. Pace-Balzan A, Shankar L, Hawke M. Computed tomographic findings in atrophic rhinitis. J Otolaryngol, 1991, 20(6): 428-432.
3. Bunnag C, Jareoncharsri P, Tansuriyawong P, et al. Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital. Rhinology, 1999, 37(3): 125-130.
4. Ghosh P. Vestibuloplasty (a new one-stage operation for atrophic rhinitis). J Laryngol Otol, 1987, 101(9): 905-909.
5. Garcia GJ, Bailie N, Martins DA, et al. Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J Appl Physiol (1985), 2007, 103(3): 1082-1092.
6. Medina L, Benazzo M, Bertino G, et al. Clinical, genetic and immunologic analysis of a family affected by ozena. Eur Arch Otorhinolaryngol, 2003, 260(7): 390-394.
7. Fouad H, Afifi N, Fatt-Hi A, et al. Altered cell mediated immunity in atrophic rhinitis. J Laryngol Otol, 1980, 94(5): 507-514.
8. 李欣. 京万红软膏治疗萎缩性鼻炎100例临床疗效分析. 内蒙古中医药, 2017, 36(10): 110-111.
9. Abdel-Naby Awad OG, Hasan MM. Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis. Am J Otolaryngol, 2019, 40(2): 137-142.
10. Testa D, Marcuccio G, Lombardo N, et al. Role of α-tocopherol acetate on nasal respiratory functions: Mucociliary clearance and rhinomanometric evaluations in primary atrophic rhinitis. Ear Nose Throat J, 2021, 100(6): NP290-NP295.
11. Kang X, Sun Y, Yi B, et al. Based on network pharmacology and molecular dynamics simulations, baicalein, an active ingredient of Yiqi Qingre Ziyin method, potentially protects patients with atrophic rhinitis from cognitive impairment. Front Aging Neurosci, 2022, 14: 880794. doi: 10.3389/fnagi.2022.880794.
12. Dutt SN, Kameswaran M. The aetiology and management of atrophic rhinitis. J Laryngol Otol, 2005, 119(11): 843-852.
13. Park MJ, Jang YJ. Successful management of primary atrophic rhinitis by turbinate reconstruction using autologous costal cartilage. Auris Nasus Larynx, 2018, 45(3): 613-616.
14. Hassan CH, Malheiro E, Béquignon E, et al. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique. Laryngoscope Investig Otolaryngol, 2021, 7(1): 6-11.
15. 刘文军, 梁灼萍, 陈祖尧, 等. 萎缩性鼻炎治疗及基础研究现状. 中国中西医结合耳鼻咽喉科杂志, 2008, 16(5): 398-400,397.
16. 侯琳琳. 改良前鼻孔缩窄术联合表皮生长因子治疗萎缩性鼻炎患者的疗效. 医疗装备, 2018, 31(14): 20-21.
17. 殷晓雪, 陈仲强, 郭昭庆, 等. 人骨髓间充质干细胞定向诱导分化为成骨细胞及其鉴定. 中国修复重建外科杂志, 2004, 18(2): 88-91.
18. 杨大鉴, 黄定强, 何成松, 等. 组织工程骨技术在萎缩性鼻炎治疗中的应用. 中国康复, 2006, 21(4): 225-226.
19. Mende W, Götzl R, Kubo Y, et al. The role of adipose stem cells in bone regeneration and bone tissue engineering. Cells, 2021, 10(5): 975.
20. Friji MT, Gopalakrishnan S, Verma SK, et al. New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. Clin Otolaryngol, 2014, 39(5): 289-292.
21. Hass R, Kasper C, Böhm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal, 2011, 9: 12. doi: 10.1186/1478-811X-9-12.
22. 董金辉, 任秀敏, 徐鸥, 等. 人脐血干细胞分化为鼻黏膜纤毛上皮细胞. 中国组织工程研究, 2016, 20(32): 4764-4770.
23. Sun L, Sha J, Meng C, et al. Mesenchymal stem cell-based therapy for allergic rhinitis. Stem Cells Int, 2020, 2020: 2367524. doi: 10.1155/2020/2367524.
24. Drela K, Stanaszek L, Nowakowski A, et al. Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes. Stem Cells Int, 2019, 2019: 7012692. doi: 10.1155/2019/7012692.
25. 陈晓旭, 罗雅馨, 毕浩然, 等. 脱细胞支架制备及其在组织工程和再生医学中的应用. 中国组织工程研究, 2022, 26(4): 591-596.
26. Morris AH, Stamer DK, Kyriakides TR. The host response to naturally-derived extracellular matrix biomaterials. Semin Immunol, 2017, 29: 72-91.
27. 石润杰, 吴晴伟, 赵影颖, 等. 自体骨髓基质干细胞构建下鼻甲. 中国耳鼻咽喉头颈外科, 2009, 16(1): 13-16.
28. 许航, 何其泽, 黄为. 组织工程关节软骨的研究进展. 中国骨与关节损伤杂志, 2022, 37(5): 558-560.
29. Singh BN, Veeresh V, Mallick SP, et al. Design and evaluation of chitosan/chondroitin sulfate/nano-bioglass based composite scaffold for bone tissue engineering. Int J Biol Macromol, 2019, 133: 817-830.
30. Cakmak AM, Unal S, Sahin A, et al. 3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering. Polymers (Basel), 2020, 12(9): 1962. doi: 10.3390/polym12091962.
31. Iglesias-Mejuto A, García-González CA. 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl, 2021, 131: 112525. doi: 10.1016/j.msec.2021.112525.
32. 杨君英. 重组牛碱性成纤维细胞生长因子治疗萎缩性鼻炎临床观察. 医药论坛杂志, 2013, 34(7): 115-116.
33. 尤景敏, 汪建, 彭华, 等. 表皮生长因子治疗萎缩性鼻炎的效果观察. 广东医学, 2003, 24(10): 1057.
34. 杨晓燕, 吴宏洲, 钱美. 鼻腔冲洗配合表皮生长因子治疗萎缩性鼻炎56例体会. 中国医学工程, 2010, 18(2): 152-153.
35. 张心如, 鲁文龙, 冯超, 等. 血管内皮生长因子纳米微球-细菌纤维素复合支架与多种细胞构建组织工程膀胱. 中国组织工程研究, 2016, 20(21): 3088-3096.
36. 张志文, 黄玉良, 张理选, 等. 碱性成纤维细胞生长因子复合脱细胞骨基质/壳聚糖支架修复骨缺损. 中国组织工程研究, 2021, 25(34): 5439-5444.
37. 刘士博, 刘显. 不同源性外泌体在骨缺损修复中的研究进展. 华西口腔医学杂志, 2020, 38(2): 193-197.
38. Du YM, Zhuansun YX, Chen R, et al. Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Exp Cell Res, 2018, 363(1): 114-120.
39. Li W, Liu Y, Zhang P, et al. Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS Appl Mater Interfaces, 2018, 10(6): 5240-5254.
40. 蔡超莹, 陈学鹏, 胡济安. 外泌体复合支架用于口腔组织工程的研究进展. 国际口腔医学杂志, 2022, 49(4): 489-496.
41. Ganbold B, Heo SJ, Koak JY, et al. Human stem cell responses and surface characteristics of 3D printing co-cr dental material. Materials (Basel), 2019, 12(20): 3419. doi: 10.3390/ma12203419.
42. 徐晨阳, 李祎, 刘晓雯, 等. 3D打印技术在耳鼻咽喉科的应用进展. 中华耳科学杂志, 2022, 20(4): 645-648.
43. 孙开瑜, 徐铭恩, 周永勇. 基于3D打印的Ⅰ型胶原涂覆β-TCP骨组织工程支架研究. 中国生物医学工程学报, 2018, 37(3): 335-343.
44. 路冬冬, 朱天峰, 张一健, 等. 3D生物打印甲基丙烯酰化明胶水凝胶支架促进软骨下骨缺损的修复. 中国组织工程研究, 2022, 26(34): 5454-5460.
45. 李潇萌, 管若羽, 高建军, 等. 类器官在再生医学中的应用. 中国细胞生物学学报, 2021, 43(6): 1120-1131.
46. Park Y, Cheong E, Kwak JG, et al. Trabecular bone organoid model for studying the regulation of localized bone remodeling. Sci Adv, 2021, 7(4): eabd6495. doi: 10.1126/sciadv.abd6495.
47. Chen S, Chen X, Geng Z, et al. The horizon of bone organoid: A perspective on construction and application. Bioact Mater, 2022, 18: 15-25.
48. 陈晓, 苏佳灿. 骨缺损治疗新技术: 骨类器官. 中华创伤杂志, 2022, 38(4): 293-296.

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Research status and prospect of tissue engineering technology in treatment of atrophic rhinitis

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