• Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
SHEN Bin, Email: shenbin_1971@163.com
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Objective  To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases. Methods The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis. Results  OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma. Conclusion  OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.

Citation: SUN Kaibo, WU Yuangang, ZENG Yi, LI Mingyang, WU Limin, SHEN Bin. Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases. Chinese Journal of Reparative and Reconstructive Surgery, 2023, 37(6): 758-763. doi: 10.7507/1002-1892.202302056 Copy

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