Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

XIADao-kui ,  LIUYun , HUXu

Department of Cardiothoracic Surgery, Yichang Central People's Hospital, the First College of Clinical Medicine, China Three Gorges University, Yichang 443003, Hubei, P. R. China;

Corresponding author：

LIUYun, Email: ly.1982_818@163.com

Keywords：

Extracorporeal circulation; Acute lung injury/acute respiratory distress syndrome; Platelet activating factor; Interleukin-8; Interferon-γ

DOI：

10.7507/1007-4848.20140062

Video：

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Objective To investigate the changes of plasma platelet activating factor (PAF) interleukin-8(IL-8) and interferon-γ (IFN-γ) in patients after surgery with extracorporeal circulation (ECC) and their clinical significance. Methods Seventy-five patients undergoing surgery with ECC in the First College of Clinical Medicine,China Three Gorges University from June 2012 to June 2013 were enrolled in this study. According to the presence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) all the 75 patients were divided into 2 groups. In ALI/ARDS group, there were 28 patients including 20 male and 8 female patients with their age of 53.6±8.2 years. In the control group,there were 47 patients without postoperative ALI/ARDS,including 32 male and 15 female patients with their age of 56.9±11.8 years. Dynamic variations of plasma PAF,IL-8 and IFN-γ of these patients were examined with enzyme-linked immunosorbent assay (ELISA) and compared between the 2 groups. Results In ALI/ARDS group,plasma IL-8 and IFN-γ reached peak levels at 48 hours after surgery and gradually decreased after that;plasma PAF reached the peak level at 96 hours after surgery and gradually decreased after that. Postoperative plasma PAF (96 hours after surgery:16 029.5±4 203.7 mU/ml vs. 4 520.1±312.2 mU/ml,P<0.05) IL-8 (48 hours after surgery:48 580.5±8 095.8 pg/ml vs. 5 990.5±1 179.0 pg/ml,P<0.05) and IFN-γ (48 hours after surgery:258.5±76.1 pg/ml vs. 26.1±11.5 pg/ml,P<0.05) of ALI/ARDS group were significantly higher than those of the control group at 48 hours,96 hours and 144 hours after surgery. Conclusion Plasma PAF,IL-8 and IFN-γ change significantly after surgery with ECC,which may play an important role in the pathogenesis of postoperative ALI/ARDS.

Citation： XIADao-kui, LIUYun, HUXu. Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(2): 212-215. doi: 10.7507/1007-4848.20140062 Copy

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2.	Lee JW,Fang XH,Gupta N,et al.Allogeneic human mesenchymal stem cells for treatment of E.coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.Proc Natl Acad Sci U S A,2009,106 (38):16357-16362.
3.	中华医学会呼吸病学分会.急性肺损伤/急性呼吸窘迫综合征的诊断标准 (草案).中华结核和呼吸杂志,2007,16 (4):343-349.
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18.	黄宏,周萍,刘友生,等.PAF拮抗剂BN50739对大鼠急性肺损伤的作用研究.第三军医大学学报,2002,24 (8):919-920.
19.	Lee JH,Jo YH,Kim K,et al.Effect of N-acetylcysteine (NAC) on acute lung injury and acute kidney injury in hemorrhagic shock.Resuscitation,2013,84 (1):121-127.
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21.	钱桂生.急性肺损伤和急性呼吸窘迫综合征研究现状与进展.解放军医学杂志,2009,34 (4):371-371.
22.	邰文琳,董昭兴,张丹丹,等.骨髓间充质干细胞对脂多糖诱导的急性肺损伤小鼠的早期治疗作用.南方医科大学学报,2012,32 (3):283-290.
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24.	王茁,齐同谦,李鸣,等.胸部创伤患者免疫功能变化的临床研究.世界今日医学杂志,2002,3 (6):498-499.
25.	Babusyte A,Jeroch J,Stakauskas R,et al.The effect of induced sputum and bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease on neutrophil migration in vitro.Medicina (Kaunas),2010,46 (5):315-322.
26.	Eickmeier O,Huebner M,Herrmann E,et al.Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function.Cytokine,2010,50 (2):152-157.
27.	吴其夏,余应年,卢建.病理生理学.北京:中国协和医科大学出版社,2003.341-347.
28.	董思远,谷天祥,喻磊,等.依达拉奉对深低温停循环肺的保护作用.中国胸心血管外科临床杂志,2013,2 (2):192-197.

1. 白春学.急性呼吸窘迫综合征,危重医学的重点.内科理论与实践,2010,5 (6):453-454.
2. Lee JW,Fang XH,Gupta N,et al.Allogeneic human mesenchymal stem cells for treatment of E.coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.Proc Natl Acad Sci U S A,2009,106 (38):16357-16362.
3. 中华医学会呼吸病学分会.急性肺损伤/急性呼吸窘迫综合征的诊断标准 (草案).中华结核和呼吸杂志,2007,16 (4):343-349.
4. 林慧庆,黄杰,毛志福.先天性心脏病体外循环心内直视手术死亡率的相关因素分析.临床外科杂志,2003,11 (5):340-340.
5. 罗滨,张卫星,扶志敏,等.双水平正压通气对急性肺损伤患者血气及血流动力学指标的影响.中国胸心血管外科临床杂志,2009,16 (6):454-458.
6. 刘伟,金发光.急性肺损伤/急性呼吸窘迫综合征的治疗新进展.中华肺部疾病杂志,2013,6 (1):61-63.
7. Dushianthan A,Grocott M,Postle AD,et al.Acute respiratory distress syndrome and acute lung injury.Postgrad Med J,2011,87 (1031):612-622.
8. Pierrakos C,Karanikolas M,Scolletta S,et al.Acute respiratory distress syndrome:pathophysiology and therapeutic options.J Clin Med Res,2012,4 (1):7-16.
9. Caironi P,Cressoni M,Chiumello D,et al.Lung opening and closing during ventilation of acute respiratory distress syndrome.Am J Respir Crit Care Med,2010,181 (6):578-586.
10. 贾雪梅,杨光福.急性肺损伤/急性呼吸窘迫综合征发病机制的研究进展.中国实用医药,2011,6 (32):242-244.
11. Hart SP,Dransfield I,Rossi AG.Phagocytosis of apoptotic cells.Methods,2008,44 (3):280-285.
12. Briel M,Meade M,Mercat A,et al.Higher vs lower positive endexpiratory pressure in patients with acute lung injury and acute respiratory distress syndrome:systematic review and eta-analysis.JAMA,2010,303 (9):865-873.
13. Meng HY,Sun Y,Lu J,et al.Exogenous surfactant May improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome:a meta-analysis of 9 clinical trials.J Cardiothorac Vasc Anesth,2012,26 (5):849-856.
14. 常亚丽,郭农建.血小板活化因子参与血小板-中性粒细胞活化的研究.医学综述,2007,13 (21):1612-1614.
15. Lee YM,Hybertson BM,Cho HG,et al.Platelet-activating factor induces lung inflammation and leak in rats:Hydrogen peroxide production along neutrophil-lung endothelial cell interfaces.J Lab Clin Med,2002,140 (5):312-319.
16. Bulger EM,Arbabi S,Garcia I,et al.The macrophage response to endotoxin requires platelet activating factor.Shock,2002,17 (3):173-179.
17. 王刚,孙备,孟庆辉,等.血小板活化因子乙酰水解酶对大鼠重症急性胰腺炎肺损伤的影响.中华实验外科杂志,2006,23 (1):34-35.
18. 黄宏,周萍,刘友生,等.PAF拮抗剂BN50739对大鼠急性肺损伤的作用研究.第三军医大学学报,2002,24 (8):919-920.
19. Lee JH,Jo YH,Kim K,et al.Effect of N-acetylcysteine (NAC) on acute lung injury and acute kidney injury in hemorrhagic shock.Resuscitation,2013,84 (1):121-127.
20. Yubero S,Ramudo L,Manso MA,et al.Evaluation of N-acetylcysteine treatment in acute pancreatitis-induced lung injury.Inflamm Res,2012,61 (7):699-705.
21. 钱桂生.急性肺损伤和急性呼吸窘迫综合征研究现状与进展.解放军医学杂志,2009,34 (4):371-371.
22. 邰文琳,董昭兴,张丹丹,等.骨髓间充质干细胞对脂多糖诱导的急性肺损伤小鼠的早期治疗作用.南方医科大学学报,2012,32 (3):283-290.
23. Taccone P,Pesenti A,Latini R,et al.Prone positioning in patients with moderate and severe acute respiratory distress syndrome:a randomized controlled trial.JAMA,2009,302 (18):1977-1984.
24. 王茁,齐同谦,李鸣,等.胸部创伤患者免疫功能变化的临床研究.世界今日医学杂志,2002,3 (6):498-499.
25. Babusyte A,Jeroch J,Stakauskas R,et al.The effect of induced sputum and bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease on neutrophil migration in vitro.Medicina (Kaunas),2010,46 (5):315-322.
26. Eickmeier O,Huebner M,Herrmann E,et al.Sputum biomarker profiles in cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) and association between pulmonary function.Cytokine,2010,50 (2):152-157.
27. 吴其夏,余应年,卢建.病理生理学.北京:中国协和医科大学出版社,2003.341-347.
28. 董思远,谷天祥,喻磊,等.依达拉奉对深低温停循环肺的保护作用.中国胸心血管外科临床杂志,2013,2 (2):192-197.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Changes of Plasma Platelet Activating Factor,Interleukin-8 and Interferon-γ after Surgery with Extracorporeal Circulation and Their Clinical Significance

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