Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHENGXi , YUANYong , HUYang ,  ZHAOYong-fan

Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

ZHAOYong-fan, Email: doctorzhaoyongfan@hotmail.com

Keywords：

Esophageal carcinoma; Lymphatic chemotherapy; Immunoglobulin; T cell subgroup

DOI：

10.7507/1007-4848.20140067

Video：

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Objective To explore the effects of intraoperative lymphatic chemotherapy (LC) on immune functions of patients after esophageal carcinoma resection. Methods Patients who underwent intraoperative LC during esophageal carcinoma resection in the Department of Thoracic Surgery of West China Hospital from March to October,2013 were prospectively included in this study, and patients who underwent esophageal carcinoma resection without intraoperative LC during the same period were also included as the control group. All the patients were divided into a pacitaxel LC group,a fluorouracil LC group,and a control group without LC. A total of 37 patients were included in this study including 25 male and 12 female patients with their age of 42-76 (61.89±7.95) years. There were 15 patients in the pacitaxel LC group,15 patients in the fluorouracil LC group,and 7 patients in the control group. Representative indexes of humoral immunity and cellular immunity in peripheral blood of all the patients were examined preoperatively and on the third and seventh postoperative day, and then compared among the 3 groups. Results All the immune indexes of the 3 groups decreased after surgery to different extent. There was no statistical difference in preoperative and postoperative difference of immunoglobulin concentration between LC groups and the control group (P>0.05). CD8⁺ T cell count recovered more rapidly after surgery in LC groups than the control group. CD3⁺ T cells recovered most rapidly after surgery in the fluorouracil LC group. Conclusion LC is beneficial for the recovery of cytotoxic effects of T lymphocytes but may not promote humoral immunity for patients after esophageal carcinoma resection.

Citation： ZHENGXi, YUANYong, HUYang, ZHAOYong-fan. Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(2): 233-237. doi: 10.7507/1007-4848.20140067 Copy

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2.	纪志鹏,张建良.淋巴化疗及其在消化道恶性肿瘤中的应用.中国现代普通外科进展,2008,11 (5):422-424.
3.	蔡长茂,李威.纳米炭在普外科恶性肿瘤诊治中的应用.中华实用诊断与治疗杂志,2010,24 (9):833-834.
4.	Ortner MA,Taha AA,Schreiber S,et al.Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer:a pilot study.Endoscopy,2004,36 (5):421-425.
5.	杨凯,温玉明.口腔癌淋巴化疗.临床口腔医学杂志,2004,20 (1):59-60.
6.	高红,郑春雷,庞达.载药国产纳米活性炭在胃癌根治术中的应用.齐齐哈尔医学院学报,2010,31 (18):2859-2861.
7.	李义生,王书奎,吕进,等.术前淋巴化疗对乳腺癌的临床治疗研究.中国现代医生,2011,49 (30):28-29.
8.	邵丽玮,温艳惠,李慧运,等.内镜下淋巴化疗对胃癌淋巴转移的疗效研究.现代肿瘤医学,2011,19 (6):1153-1156.
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10.	程邦昌,梅强.食管癌患者外周血T淋巴细胞亚群、肿瘤坏死因子的改变及其相关因素研究.中华实验外科杂志,1998,15 (3):226-228.
11.	张治,张伟,许林,等.食管癌、贲门癌患者T细胞亚群水平及临床意义.江苏医药,2007,33 (3):231-232.
12.	姜云,骆金华.食管癌免疫学研究现状及进展.江苏医药,2011,37 (3):341-343.
13.	孟强,孟荣贵,崔龙,等.直肠癌术前淋巴化疗安全性分析.中华消化外科杂志,2008,7 (2):137-139.
14.	Edge SB,Compton CC.The American Joint Committee on Cancer:the 7th edition of the AJCC cancer staging manual and the future of TNM.Ann Surg Oncol,2010,17 (6):1471-1474.
15.	蒲敏,黄斌,任明扬,等.纳米炭在腹腔镜下食管胃交界腺癌手术中的应用.中国普外基础与临床杂志,2013,20 (2):147-151.
16.	吴三明,郑国凡,蒋述均,等.AT-C型活性炭载附丝裂霉素对食管/胃癌的靶向化疗.现代消化病及内镜杂志,1997,2 (1):52-53.
17.	吴三明,郑国凡,蒋述均,等.活性炭载附丝裂霉素内镜下注射治疗26例老年食管、胃癌患者疗效分析.中国中西医结合脾胃杂志,1997,5 (4):242-243.
18.	刘建芳,潘霞,王铁武,等.内镜下注射活性炭加丝裂霉素治疗食道癌、胃癌42例报道.胃肠病学,2001,6 (增刊):151-152.
19.	周军,辛旭,齐磊.白芨混合微粒在食道中下段癌术中淋巴化疗的应用研究.陕西中医,2004,25 (1):30-31.
20.	侯建民,陈克能,胡兴云,等.全麻对食管癌手术患者体液免疫功能的影响.中华实验外科杂志,1999,16 (6):587.
21.	邢翠燕,吴明毅,范海鹏.不同麻醉和镇痛方法对食管癌手术患者细胞免疫功能及应激激素水平的影响.南方医科大学学报,2010,30 (2):284-287.
22.	蒲强,马林,梅建东,等.全胸腔镜与后外侧开胸对肺癌患者免疫功能影响的对比研究.四川大学学报:医学版,2013,44 (1):126-129.
23.	韩东景,李伟,金哲,等.ω-3多不饱和脂肪酸及谷氨酰胺对食管癌手术患者免疫功能及营养状况的影响.中华实用诊断与治疗杂志,2013,27 (9):905-906.
24.	漆奋强,左传田.影响食管癌围手术期体液免疫变化的因素.中国癌症防治杂志,2010,2 (3):236-238.
25.	王忠民,乔刚,李汉臣.食管癌切除患者胸导管预防性结扎的细胞免疫及临床研究.中国医师杂志,2003,5 (11):1506-1507.
26.	孙汶生,王福庆,主编.医学免疫学.北京:高等教育出版社,2006.51-52,117-120,124.
27.	洪超群,陈炯玉,杨卫平,等.食管鳞癌患者手术前后外周血T细胞亚群与NK、NKT细胞检测的临床意义.现代肿瘤医学,2010,18 (6):1113-1115.

1. 孟强,李会晨,崔龙,等.消化道恶性肿瘤淋巴化疗的现状.中国实用外科杂志,2006,26 (2):145-147.
2. 纪志鹏,张建良.淋巴化疗及其在消化道恶性肿瘤中的应用.中国现代普通外科进展,2008,11 (5):422-424.
3. 蔡长茂,李威.纳米炭在普外科恶性肿瘤诊治中的应用.中华实用诊断与治疗杂志,2010,24 (9):833-834.
4. Ortner MA,Taha AA,Schreiber S,et al.Endoscopic injection of mitomycin adsorbed on carbon particles for advanced esophageal cancer:a pilot study.Endoscopy,2004,36 (5):421-425.
5. 杨凯,温玉明.口腔癌淋巴化疗.临床口腔医学杂志,2004,20 (1):59-60.
6. 高红,郑春雷,庞达.载药国产纳米活性炭在胃癌根治术中的应用.齐齐哈尔医学院学报,2010,31 (18):2859-2861.
7. 李义生,王书奎,吕进,等.术前淋巴化疗对乳腺癌的临床治疗研究.中国现代医生,2011,49 (30):28-29.
8. 邵丽玮,温艳惠,李慧运,等.内镜下淋巴化疗对胃癌淋巴转移的疗效研究.现代肿瘤医学,2011,19 (6):1153-1156.
9. 李义生,王书奎,王和明,等.术前联合奥曲肽行淋巴化疗对大肠癌的治疗研究.中华临床医师杂志:电子版,2012,6 (11):203-204.
10. 程邦昌,梅强.食管癌患者外周血T淋巴细胞亚群、肿瘤坏死因子的改变及其相关因素研究.中华实验外科杂志,1998,15 (3):226-228.
11. 张治,张伟,许林,等.食管癌、贲门癌患者T细胞亚群水平及临床意义.江苏医药,2007,33 (3):231-232.
12. 姜云,骆金华.食管癌免疫学研究现状及进展.江苏医药,2011,37 (3):341-343.
13. 孟强,孟荣贵,崔龙,等.直肠癌术前淋巴化疗安全性分析.中华消化外科杂志,2008,7 (2):137-139.
14. Edge SB,Compton CC.The American Joint Committee on Cancer:the 7th edition of the AJCC cancer staging manual and the future of TNM.Ann Surg Oncol,2010,17 (6):1471-1474.
15. 蒲敏,黄斌,任明扬,等.纳米炭在腹腔镜下食管胃交界腺癌手术中的应用.中国普外基础与临床杂志,2013,20 (2):147-151.
16. 吴三明,郑国凡,蒋述均,等.AT-C型活性炭载附丝裂霉素对食管/胃癌的靶向化疗.现代消化病及内镜杂志,1997,2 (1):52-53.
17. 吴三明,郑国凡,蒋述均,等.活性炭载附丝裂霉素内镜下注射治疗26例老年食管、胃癌患者疗效分析.中国中西医结合脾胃杂志,1997,5 (4):242-243.
18. 刘建芳,潘霞,王铁武,等.内镜下注射活性炭加丝裂霉素治疗食道癌、胃癌42例报道.胃肠病学,2001,6 (增刊):151-152.
19. 周军,辛旭,齐磊.白芨混合微粒在食道中下段癌术中淋巴化疗的应用研究.陕西中医,2004,25 (1):30-31.
20. 侯建民,陈克能,胡兴云,等.全麻对食管癌手术患者体液免疫功能的影响.中华实验外科杂志,1999,16 (6):587.
21. 邢翠燕,吴明毅,范海鹏.不同麻醉和镇痛方法对食管癌手术患者细胞免疫功能及应激激素水平的影响.南方医科大学学报,2010,30 (2):284-287.
22. 蒲强,马林,梅建东,等.全胸腔镜与后外侧开胸对肺癌患者免疫功能影响的对比研究.四川大学学报:医学版,2013,44 (1):126-129.
23. 韩东景,李伟,金哲,等.ω-3多不饱和脂肪酸及谷氨酰胺对食管癌手术患者免疫功能及营养状况的影响.中华实用诊断与治疗杂志,2013,27 (9):905-906.
24. 漆奋强,左传田.影响食管癌围手术期体液免疫变化的因素.中国癌症防治杂志,2010,2 (3):236-238.
25. 王忠民,乔刚,李汉臣.食管癌切除患者胸导管预防性结扎的细胞免疫及临床研究.中国医师杂志,2003,5 (11):1506-1507.
26. 孙汶生,王福庆,主编.医学免疫学.北京:高等教育出版社,2006.51-52,117-120,124.
27. 洪超群,陈炯玉,杨卫平,等.食管鳞癌患者手术前后外周血T细胞亚群与NK、NKT细胞检测的临床意义.现代肿瘤医学,2010,18 (6):1113-1115.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Effects of Lymphatic Chemotherapy on Immune Functions of Patients after Esophageal Carcinoma Resection

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