Research Progress of Constructing Tissue Engineered Trachea <i>in Vivo</i>_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

PANShu ^1,2 , SUNFei ^1,2 ,  SHIHong-can ^1,2

1. Department of Thoracic Surgery, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, P. R. China;
2. Translational Medicine Research Center of Yangzhou University, Yangzhou 225001, Jiangsu, P. R. China;

Corresponding author：

SHIHong-can, Email: shihongcan@hotmail.com

Keywords：

Tissue engineering; Trachea; In vivo transplantation; Natural bioreactor

DOI：

10.7507/1007-4848.20140149

Video：

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In vivo transplantation of tracheal grafts utilizes natural environment in vivo to improve cell adhesion, growth and scaffold properties, which can not only promote graft revascularization, but also induce immune tolerance and increase postoperative survival rate. Decellularized trachea with stem cells covering the outside layer and airway epithelial cells covering the inside layer can achieve complete mucosa re-epithelialization, cartilage cell growth and revascularization, using own body as a natural bioreactor to boost the maturity of tissue engineered trachea. Then transplantation at a normotopic in situ positioning is performed. This transplantation strategy provides a promising approach for the treatment of long-segment tracheal defects. This review focuses on the significance and research progress of constructing tissue engineered trachea in vivo.

Citation： PANShu, SUNFei, SHIHong-can. Research Progress of Constructing Tissue Engineered Trachea in Vivo. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(4): 527-530. doi: 10.7507/1007-4848.20140149 Copy

1.	Wright CD, Grillo HC, Wain JC, et al. Anastomotic complications after tracheal resection:prognostic factors and management. J Thorac Cardiovasc Surg, 2004, 128 (5), 731-739.
2.	Hinderer S, Schenke-Layland K. Tracheal tissue engineering:building on a strong foundation. Expert Rev Med Devices, 2013, 10 (1):33-35.
3.	Bijonowski BM, Miller WM, Wertheim JA. Bioreactor design for perfusion-based, highly-vascularized organ regeneration. Curr Opin Chem Eng, 2013, 2 (1):32-40.
4.	Delaere P, Goeleven A, Poorten VV, et al. Organ preservation surgery for advanced unilateral glottic and subglottic cancer. Laryngoscope, 2007, 117 (10):1764-1769.
5.	Rainer C, Wechselberger G, Bauer T, et al. Transplantation of tracheal epithelial cells onto a prefabricated capsule pouch with fibrin glue as a delivery vehicle. J Thorac Cardiovasc Surg, 2001, 121 (6):1187-1193.
6.	Remlinger NT, Czajka CA, Juhas ME, et al. Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal Reconstruction. Biomaterials, 2010, 31 (13):3520-3526.
7.	Deuse T, Schrepfer S, Reichenspurner H, et al. Techniques for experimental heterotopic and orthotopic tracheal transplantations-when to use which model? Transpl Immunol, 2007, 17 (4):255-261.
8.	Zang MQ, Zhang QX, Chang EI, et al. Decellularized tracheal matrix scaffold for tracheal tissue engineering:in vivo host response. Plast Reconstr Surg, 2013, 132 (4):549e-559e.
9.	Dupuit F, Gaillard D, Hinnrasky J, et al. Differentiated and functional human airway epithelium regeneration in tracheal xenografts. Am J Physiol Lung Cell Mol Physiol, 2000, 278 (1):L165-L176.
10.	Genden EM, Govindaraj S, Chaboki H, et al. Reepithelialization of orthotopic tracheal allografts prevents rejection after withdrawal of immunosuppression. Ann Otol Rhinol Laryngol, 2005, 114 (4):279-288.
11.	Vacanti CA, Paige KT, Kim WS, et al. Experimental tracheal repla-cement using tissue-engineered cartilage. J Pediatr Surg, 1994, 29 (2):201-205.
12.	Kojima K, Bonassar LJ, Roy AK, et al. Autologous tissue-engin-eered trachea with sheep nasal chondrocytes. J Thorac Cardiovasc Surg, 2002, 123 (6):1177-1184.
13.	王万鹏, 史宏灿, 陆妍, 等.气管软骨细胞和羧乙基壳聚糖一羟基磷灰石泡沫支架复合及裸鼠皮下植入.中华生物医学工程, 2010, 16 (6):557-560.
14.	Delaere P, Vranckx J, Verleden G, et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy. N Engl J Med, 2010, 362 (2):138-145.
15.	Baiguera S, D'innocenzo B, macchiarini P. Current status of regenerative replacement of the airway.Expert Rev Respir Med, 2011, 5 (4):487-494.
16.	Rose KG, Sesterhenn K, Wustrow F. Tracheal allotransplantation in man. Lancet, 1979, 1 (8113):433.
17.	Kato R, Onuki AS, Watanabe M, et al. Tracheal Reconstruction by esophageal interposition:an experimental study. Ann Thorac Surg, 1990, 49 (6):951-954.
18.	Martinod E, Radu DM, Chouahnia K, et al. Human transplantation of a biologic airway substitute in conservative lung cancer surgery. Ann Thorac Surg, 2011, 91 (3):837-842.
19.	Maciejewski A, Szymczyk C, Półtorak S, et al. Tracheal Reconstru-ction with the use of radial forearm free flap combined with biodegradative mesh suspension. Ann Thorac Surg, 2009, 87 (2):608-610.
20.	Ott LM, Weatherly RA, Detamore MS. Overview of tracheal tissue engineering:clinical need drives the laboratory approach. Ann Biomed Eng, 2011, 39 (8):2091-2113.
21.	Luo XS, Zhou GD, Liu W, et al. In vitro precultivation alleviates post-implantation inflammation and enhances development of tissue-engineered tubular cartilage. Biomed Mater, 2009, 4 (2):025006.
22.	Jungebluth P, Alici E, Baiguera S, et al. Tracheobronchial transplan-tation with a stem-cell-seeded bioartificial nanocomposite:a proof-of-concept study. Lancet, 2011, 378 (988):1997-2004.
23.	章方彪, 张卫东, 史宏灿.细胞外基质在长段气管病损治疗中的应用与研究进展.中国胸心血管外科临床杂志, 2013, 6 (3):334-337.
24.	Jungebluth P, Go T, Asnaghi A, et al. Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix. J Thorac Cardiovasc Surg, 2009, 138 (3):586-593.
25.	Bader A, Macchiarini P. Moving towards in situ tracheal regeneration:the bionic tissue engineered transplantation approach. J Cell Mol Med, 2010, 14 (7):1877-1889.
26.	Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372 (9655):2023-2030.
27.	Haag JC, Jungebluth P, Macchiarini P. Tracheal replacement for primary tracheal Cancer. Curr Opin Otolaryngol Head Neck Surg, 2013, 21 (2):171-177.
28.	Tan Q, Steiner R, Yang L, et al. Accelerated angiogenesis by continuous medium flow with vascular endothelial growth factor inside tissue-engineered trachea. Eur J Cardiothorac Surg, 2007, 31 (5):806-811.
29.	Delaere P. Stem-cell "hype" in tracheal transplantation? Transplantation, 2010, 90 (8):927-928.
30.	Luo XS, Liu Y, Zhang ZY, et al. Long-term functional Reconstruc-tion of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits. Biomaterials, 2013, 34 (13):3336-3344.

1. Wright CD, Grillo HC, Wain JC, et al. Anastomotic complications after tracheal resection:prognostic factors and management. J Thorac Cardiovasc Surg, 2004, 128 (5), 731-739.
2. Hinderer S, Schenke-Layland K. Tracheal tissue engineering:building on a strong foundation. Expert Rev Med Devices, 2013, 10 (1):33-35.
3. Bijonowski BM, Miller WM, Wertheim JA. Bioreactor design for perfusion-based, highly-vascularized organ regeneration. Curr Opin Chem Eng, 2013, 2 (1):32-40.
4. Delaere P, Goeleven A, Poorten VV, et al. Organ preservation surgery for advanced unilateral glottic and subglottic cancer. Laryngoscope, 2007, 117 (10):1764-1769.
5. Rainer C, Wechselberger G, Bauer T, et al. Transplantation of tracheal epithelial cells onto a prefabricated capsule pouch with fibrin glue as a delivery vehicle. J Thorac Cardiovasc Surg, 2001, 121 (6):1187-1193.
6. Remlinger NT, Czajka CA, Juhas ME, et al. Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal Reconstruction. Biomaterials, 2010, 31 (13):3520-3526.
7. Deuse T, Schrepfer S, Reichenspurner H, et al. Techniques for experimental heterotopic and orthotopic tracheal transplantations-when to use which model? Transpl Immunol, 2007, 17 (4):255-261.
8. Zang MQ, Zhang QX, Chang EI, et al. Decellularized tracheal matrix scaffold for tracheal tissue engineering:in vivo host response. Plast Reconstr Surg, 2013, 132 (4):549e-559e.
9. Dupuit F, Gaillard D, Hinnrasky J, et al. Differentiated and functional human airway epithelium regeneration in tracheal xenografts. Am J Physiol Lung Cell Mol Physiol, 2000, 278 (1):L165-L176.
10. Genden EM, Govindaraj S, Chaboki H, et al. Reepithelialization of orthotopic tracheal allografts prevents rejection after withdrawal of immunosuppression. Ann Otol Rhinol Laryngol, 2005, 114 (4):279-288.
11. Vacanti CA, Paige KT, Kim WS, et al. Experimental tracheal repla-cement using tissue-engineered cartilage. J Pediatr Surg, 1994, 29 (2):201-205.
12. Kojima K, Bonassar LJ, Roy AK, et al. Autologous tissue-engin-eered trachea with sheep nasal chondrocytes. J Thorac Cardiovasc Surg, 2002, 123 (6):1177-1184.
13. 王万鹏, 史宏灿, 陆妍, 等.气管软骨细胞和羧乙基壳聚糖一羟基磷灰石泡沫支架复合及裸鼠皮下植入.中华生物医学工程, 2010, 16 (6):557-560.
14. Delaere P, Vranckx J, Verleden G, et al. Tracheal allotransplantation after withdrawal of immunosuppressive therapy. N Engl J Med, 2010, 362 (2):138-145.
15. Baiguera S, D'innocenzo B, macchiarini P. Current status of regenerative replacement of the airway.Expert Rev Respir Med, 2011, 5 (4):487-494.
16. Rose KG, Sesterhenn K, Wustrow F. Tracheal allotransplantation in man. Lancet, 1979, 1 (8113):433.
17. Kato R, Onuki AS, Watanabe M, et al. Tracheal Reconstruction by esophageal interposition:an experimental study. Ann Thorac Surg, 1990, 49 (6):951-954.
18. Martinod E, Radu DM, Chouahnia K, et al. Human transplantation of a biologic airway substitute in conservative lung cancer surgery. Ann Thorac Surg, 2011, 91 (3):837-842.
19. Maciejewski A, Szymczyk C, Półtorak S, et al. Tracheal Reconstru-ction with the use of radial forearm free flap combined with biodegradative mesh suspension. Ann Thorac Surg, 2009, 87 (2):608-610.
20. Ott LM, Weatherly RA, Detamore MS. Overview of tracheal tissue engineering:clinical need drives the laboratory approach. Ann Biomed Eng, 2011, 39 (8):2091-2113.
21. Luo XS, Zhou GD, Liu W, et al. In vitro precultivation alleviates post-implantation inflammation and enhances development of tissue-engineered tubular cartilage. Biomed Mater, 2009, 4 (2):025006.
22. Jungebluth P, Alici E, Baiguera S, et al. Tracheobronchial transplan-tation with a stem-cell-seeded bioartificial nanocomposite:a proof-of-concept study. Lancet, 2011, 378 (988):1997-2004.
23. 章方彪, 张卫东, 史宏灿.细胞外基质在长段气管病损治疗中的应用与研究进展.中国胸心血管外科临床杂志, 2013, 6 (3):334-337.
24. Jungebluth P, Go T, Asnaghi A, et al. Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix. J Thorac Cardiovasc Surg, 2009, 138 (3):586-593.
25. Bader A, Macchiarini P. Moving towards in situ tracheal regeneration:the bionic tissue engineered transplantation approach. J Cell Mol Med, 2010, 14 (7):1877-1889.
26. Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372 (9655):2023-2030.
27. Haag JC, Jungebluth P, Macchiarini P. Tracheal replacement for primary tracheal Cancer. Curr Opin Otolaryngol Head Neck Surg, 2013, 21 (2):171-177.
28. Tan Q, Steiner R, Yang L, et al. Accelerated angiogenesis by continuous medium flow with vascular endothelial growth factor inside tissue-engineered trachea. Eur J Cardiothorac Surg, 2007, 31 (5):806-811.
29. Delaere P. Stem-cell "hype" in tracheal transplantation? Transplantation, 2010, 90 (8):927-928.
30. Luo XS, Liu Y, Zhang ZY, et al. Long-term functional Reconstruc-tion of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits. Biomaterials, 2013, 34 (13):3336-3344.

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