Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 WUPei-ren ¹ , ZHUANGYan-zhen ² , LUXiao-hui ³ , CHENBo ¹ , ZHANGHai-fang ² , LUChuan-hui ¹ , HUANGHong-lang ² , LIUKai-hua ¹

1. Department of Oncology Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;
2. Department of Pathology, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;
3. Department of Clinical Laboratory, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;

Corresponding author：

WUPei-ren, Email: wpr20001@126.com

Keywords：

Human papilloma virus; Esophageal carcinoma; Minnan

DOI：

10.7507/1007-4848.20140229

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Objective To detect human papilloma virus (HPV)infection with fluorescent quantitative real-time polymerase chain reaction (FQ-PCR)in Minnan population, and explore the correlation between HPV infection and carcinogenesis of esophageal carcinoma (EC)of Minnan patients. Methods FQ-PCR was performed to examine HPV-6, HPV-11, HPV-16 and HPV-18 in 100 healthy Minnan people (healthy group, 66 males and 34 females with their age of 52.35±6.72 years)and 100 Minnan patients with squamous EC (EC group and tumor-adjacent normal tissue group, 64 males and 36 females with their age of 51.62±6.37 years)between October 2009 and December 2012. Results The incidences of HPV infection in 100 EC tissues, 100 tumor-adjacent normal tissues and 100 esophageal mucosa tissues of healthy people were 22/100, 8/100 and 6/100 respectively, which were statistically different (χ²=10.63, P < 0.01). Positive infection of HPV-6, HPV-11, HPV-16 and HPV-18 was observed in 11 cases, 11 cases, 14 cases and 15 cases in EC group respectively, 5 cases, 6 cases, 7 cases and 8 cases in tumor-adjacent normal tissue group respectively, and 5 cases, 5 cases, 6 cases and 6 cases in the healthy group respectively (P > 0.05). Positive HPV infection was observed in 1 patients with well differentiated squamous EC, 21 patients with moderately differentiated squamous EC and 5 patients with poorly differentiated squamous EC (P > 0.05). Conclusion HPV infection may exist in tumor tissue of Minnan patients with squamous EC, and may be correlated with carcinogenesis and development of squamous EC.

Citation： WUPei-ren, ZHUANGYan-zhen, LUXiao-hui, CHENBo, ZHANGHai-fang, LUChuan-hui, HUANGHong-lang, LIUKai-hua. Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(6): 799-802. doi: 10.7507/1007-4848.20140229 Copy

1.	Syrjänen KJ. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. J Arch Geschwulstforsch, 1982, 52(4):283-292.
2.	Mammas IN, Sourvinos G, Zaravinos A, et al. Vaccination against human papilloma virus(HPV):epidemiological evidence of HPV in nongenital cancer. Pathol Oncol Res, 2011, 17(2):103-109.
3.	Afonso LA, Moyses N, Cavalcanti SM. Human papilloma virus detection and p16 methylation pattern in a case of esophageal papilloma. Braz J Med Biol Res, 2010, 43(6):694-696.
4.	Kusumoto-Matsuo R, Kanda T, Kukimoto I. Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts. Genes Cells, 2011, 16(1):23-33.
5.	Raybould R, Fiander A, Hibbitts S. Human papillomavirus integration and its role in cervical malignant progression. Open Clinic Can J, 2011, 5(1):1-7.
6.	Steben M, Duarte-Franco E. Human papillomavirus infection:epide-miology and pathophysiology. Gynecol Oncol, 2007, 107(1):S2-S5.
7.	Alba A, Cararach M, Rodriguez-Cerdeira C. The human papillomavirus in human pathology:Description, pathogenesis, oncogenic role, epidemiology and detection techniques. Open Dermatol J, 2009, 12(3):90-102.
8.	Duensing S, Duensing A, Crum CP, et al. Human papillomavirus type 16E7 oncoprotein induced abnormal centrosomesythesis is an earlyevent in the evolving malignamt phenotype. Cancer Res, 2001, 61(10):2356-2360.
9.	曹邦伟, 于晶琳, 荷欢.中国人群中HPV感染与食管癌发生关联的Meta分析.首都医科大学学报, 2010, 31(2):258-263.
10.	刘琳, 李锋, 徐康宁, 等.人乳头状瘤病毒检测与食管癌的研究进展.现代肿瘤医学, 2011, 19(5):1005-1008.
11.	崔金环, 杨光, 苏锡康, 等.实时荧光PCR技术检测高危型HPV的临床应用评价.现代预防医学. 2011, 38(23):4948-4952.
12.	Bohn OL, Navarro L, Saldivar J, et al. Identif cation of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol, 2008, 14(3):7107-7111.
13.	陈卫刚, 杨春梅, 徐丽红, 等.通用引物巢式PCR法对哈萨克族食管鳞癌HPV感染的检测.世界华人消化杂志, 2012, 20(12):1049-1053.
14.	吴发福, 章镜平, 孙苏安, 等.江苏省淮安地区食管癌组织中HPV的检测及其临床意义.江苏临床医学杂志, 2002, 6(4):334-336.
15.	王悦冬, 张开鄂, 周臻涛, 等.梅州市客家人食管癌与人乳头状瘤病毒感染的关系.肿瘤基础与临床, 2010, 23(5):377-378.
16.	崔明辰, 岳鹤声, 张冬云, 等.漯河地区食管癌患者组织中人乳头状瘤病毒感染的检测.医学研究杂志, 2011, 40(11):73-74.
17.	杨兰, 陈玲, 孙振柱, 等.新疆哈萨克族食管癌中HPV感染状况分析.世界华人消化杂志, 2007, 15(19):2114-2119.
18.	姚品芳, 黄环元, 付由高, 等.湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中HPV感染的比较.肿瘤防治研究, 2005, 32(1):46-48.
19.	陈云昭, 姚恩生, 杨兰, 等.人乳头状病毒感染与新疆哈萨克族食管癌发生关系的探讨.现代预防医学, 2008, 35(13):2407-2409.
20.	周素明, 伊力亚尔, 夏合丁, 等. HPV16与新疆维吾尔族食管鳞癌的相关性.世界华人消化杂志, 2009, 17(31):3214-3217.

1. Syrjänen KJ. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. J Arch Geschwulstforsch, 1982, 52(4):283-292.
2. Mammas IN, Sourvinos G, Zaravinos A, et al. Vaccination against human papilloma virus(HPV):epidemiological evidence of HPV in nongenital cancer. Pathol Oncol Res, 2011, 17(2):103-109.
3. Afonso LA, Moyses N, Cavalcanti SM. Human papilloma virus detection and p16 methylation pattern in a case of esophageal papilloma. Braz J Med Biol Res, 2010, 43(6):694-696.
4. Kusumoto-Matsuo R, Kanda T, Kukimoto I. Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts. Genes Cells, 2011, 16(1):23-33.
5. Raybould R, Fiander A, Hibbitts S. Human papillomavirus integration and its role in cervical malignant progression. Open Clinic Can J, 2011, 5(1):1-7.
6. Steben M, Duarte-Franco E. Human papillomavirus infection:epide-miology and pathophysiology. Gynecol Oncol, 2007, 107(1):S2-S5.
7. Alba A, Cararach M, Rodriguez-Cerdeira C. The human papillomavirus in human pathology:Description, pathogenesis, oncogenic role, epidemiology and detection techniques. Open Dermatol J, 2009, 12(3):90-102.
8. Duensing S, Duensing A, Crum CP, et al. Human papillomavirus type 16E7 oncoprotein induced abnormal centrosomesythesis is an earlyevent in the evolving malignamt phenotype. Cancer Res, 2001, 61(10):2356-2360.
9. 曹邦伟, 于晶琳, 荷欢.中国人群中HPV感染与食管癌发生关联的Meta分析.首都医科大学学报, 2010, 31(2):258-263.
10. 刘琳, 李锋, 徐康宁, 等.人乳头状瘤病毒检测与食管癌的研究进展.现代肿瘤医学, 2011, 19(5):1005-1008.
11. 崔金环, 杨光, 苏锡康, 等.实时荧光PCR技术检测高危型HPV的临床应用评价.现代预防医学. 2011, 38(23):4948-4952.
12. Bohn OL, Navarro L, Saldivar J, et al. Identif cation of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol, 2008, 14(3):7107-7111.
13. 陈卫刚, 杨春梅, 徐丽红, 等.通用引物巢式PCR法对哈萨克族食管鳞癌HPV感染的检测.世界华人消化杂志, 2012, 20(12):1049-1053.
14. 吴发福, 章镜平, 孙苏安, 等.江苏省淮安地区食管癌组织中HPV的检测及其临床意义.江苏临床医学杂志, 2002, 6(4):334-336.
15. 王悦冬, 张开鄂, 周臻涛, 等.梅州市客家人食管癌与人乳头状瘤病毒感染的关系.肿瘤基础与临床, 2010, 23(5):377-378.
16. 崔明辰, 岳鹤声, 张冬云, 等.漯河地区食管癌患者组织中人乳头状瘤病毒感染的检测.医学研究杂志, 2011, 40(11):73-74.
17. 杨兰, 陈玲, 孙振柱, 等.新疆哈萨克族食管癌中HPV感染状况分析.世界华人消化杂志, 2007, 15(19):2114-2119.
18. 姚品芳, 黄环元, 付由高, 等.湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中HPV感染的比较.肿瘤防治研究, 2005, 32(1):46-48.
19. 陈云昭, 姚恩生, 杨兰, 等.人乳头状病毒感染与新疆哈萨克族食管癌发生关系的探讨.现代预防医学, 2008, 35(13):2407-2409.
20. 周素明, 伊力亚尔, 夏合丁, 等. HPV16与新疆维吾尔族食管鳞癌的相关性.世界华人消化杂志, 2009, 17(31):3214-3217.

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Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population

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