Research Progress of Tissue-engineered Trachea Regeneration_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANGSi-quan ^1,2 , ZHONGChong-hao ^1,2 ,  SHIHong-can ^1,2

1. Department of Thoracic and Cardiovascular Surgery, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, P. R. China;
2. Transforming medicine center, Yangzhou University, Yangzhou 225001, Jiangsu, P. R. China;

Corresponding author：

SHIHong-can, Email: shihongcan@hotmail.com

Keywords：

Tissue engineering; Tracheal transplantation; Angiogenesis; Epithelial regeneration; Cartilage regeneration

DOI：

10.7507/1007-4848.20150069

Video：

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Abstract Full text Figures/Tables Video References Cited by

Tissue-engineered tracheal transplantation has been reported and the technique of decellularized scaffold's preparation is mature. Regeneration of epithelium, cartilage and blood vessel is particularly important during tracheal transplantation. With the increasing improvement on cell acquisition and cell culture, as well as the factor of auxesis and cell differentiation, tissue-engineered technique provided possibility and clinical value for regeneration of epithelium, cartilage and blood vessel. This review focuses on the improvement and prospect of regeneration of epithelium, cartilage and blood vessel during tracheal transplantation.

Citation： ZHANGSi-quan, ZHONGChong-hao, SHIHong-can. Research Progress of Tissue-engineered Trachea Regeneration. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(3): 257-260. doi: 10.7507/1007-4848.20150069 Copy

1.	Macchiarini P, Jungebluth P, Go T, et al.Clinical transplantation of a tissue-engineered airway.Lancet, 2008, 372(9655):2023-2030.
2.	He X, Fu W, Zheng J.Cell sources for trachea tissue engineering:past, present and future.Regen Med, 2012, 7(6):851-863.
3.	Elliott MJ, De Coppi P, Speggiorin S, et al.Stem-cell-based, tissue engineered tracheal replacement in a child:a 2-year follow-up study.Lancet, 2012, 380(9846):994-1000.
4.	Jungebluth P, Bader A, Baiguera S, et al.The concept of in vivo airway tissue engineering.Biomaterials, 2012, 33(17):4319-4326.
5.	Kojima K, Vacanti CA.Tissue engineering in the trachea.Anat Rec, 2014, 297(1):44-50.
6.	Isogai N, Kusuhara H, Ikada Y, et al.Comparison of different chondrocytes for use in tissue engineering of cartilage model structures.Tissue Eng, 2006, 12(4):691-703.
7.	Kalathur M, Baiguera S, Macchiarini P.Translating tissue-engineered tracheal replacement from bench to bedside.Cell Mol Life Sci, 2010, 67(24):4185-4196.
8.	Zang M, Zhang Q, Chang EI, et al.Decellularized tracheal matrix scaffold for tracheal tissue engineering:in vivo host response.Plast Reconstr Surg, 2013, 132(4):549e-559e.
9.	Grimmer JF, Gunnlaugsson CB, Alsberg E, et al.Tracheal reconstru ction using tissue-engineered cartilage.Arch Otolaryngol Head Neck Surg, 2004, 130(10):1191-1196.
10.	Walles T, Giere B, Macchiarini P, et al.Expansion of chondrocytes in a three-dimensional matrix for tracheal tissue engineering.Ann Thorac Surg, 2004, 78(2):444-448.
11.	Bianchi G, Banfi A, Mastrogiacomo M, et al.Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2.Exp Cell Res, 2003, 287(1):98-105.
12.	Ronzière MC, Perrier E, Mallein-Gerin F, et al.Chondrogenic potential of bone marrow-and adipose tissue-derived adult human mesenchymal stem cells.Biomed Mater Eng, 2010, 20(3):145-158.
13.	Tsutsumi S, Shimazu A, Miyazaki K, et al.Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF.Biochem Biophys Res Commun, 2001, 288(2):413-419.
14.	Cals FL, Hellingman CA, Koevoet W, et al.Effects of transforming growth factor-βsubtypes on in vitro cartilage production and mineralization of human bone marrow stromal-derived mesench ymal stem cells.J Tissue Eng Regen Med, 2012, 6(1):68-76.
15.	Shi H, Xu Z, Qin X, et al.Experimental study of replacing circum ferential tracheal defects with new prosthesis.Ann Thorac Surg, 2005, 79(2):672-676.
16.	Bader A, Macchiarini P.Moving towards in situ tracheal regenera tion:the bionic tissue engineered transplantation approach.J Cell Mol Med, 2010, 14(7):1877-1889.
17.	Baiguera S, Birchall MA, Macchiarini P.Tissue-engineered tracheal transplantation.Transplantation, 2010, 89(5):485-491.
18.	Jungebluth P, Macchiarini P.Airway Transplantation.Thorac Surg Clin, 2014, 24(1):97-106.
19.	Rees LE, Gunasekaran S, Sipaul F, et al.The isolation and characterisa tion of primary human laryngeal epithelial cells.Mol Immunol, 2006, 43(6):725-730.
20.	Crowley C, Birchall M, Seifalian AM.Trachea transplantation:from laboratory to patient.J Tissue Eng Regen Med, 2014.doi:10.1002/term.1847.[Epubaheadofprint].
21.	Atala A, Bauer SB, Soker S, et al.Tissue-engineered autologous bladders for patients needing cystoplasty.Lancet, 2006, 367(9518):1241-1246.
22.	Martinod E, Seguin A, Pfeuty K, et al.Long-term evaluation of the replacement of the trachea with an autologous aortic graft.Ann Thorac Surg, 2003, 75(5):1572-1578.
23.	Gray TE, Guzman K, Davis CW, et al.Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells.Am J Respir Cell Mol Biol, 1996, 14(1):104-112.
24.	Weidenbecher M, Tucker HM, Awadallah A, et al.Fabrication of a neotrachea using engineered cartilage.Laryngoscope, 2008, 118(4):593-598.
25.	Baiguera S, D'Innocenzo B, Macchiarini P.Current status of regener ative replacement of the airway.Expert Rev Respir Med, 2011, 5(4):487-494.
26.	Fishman JM, De Coppi P, Elliott MJ, et al.Airway tissue engineering.Expert Opin Biol Ther, 2011, 11(12):1623-1635.
27.	Haag J, Baiguera S, Jungebluth P, et al.Biomechanical and angiogenicproperties of tissue-engineered rat trachea using genipin cross-linkeddecellularized tissue.Biomaterials, 2012, 33(3):780-789.
28.	Baiguera S, Jungebluth P, Burns A, et al.Tissue engineered human tracheas for in vivo implantation.Biomaterials, 2010, 31(34):8931-8938.
29.	Jungebluth P, Moll G, Baiguera S, et al.Tissue-engineered airway:a regenerative solution.Clin Pharmacol Ther, 2012, 91(1):81-93.
30.	Partington L, Mordan NJ, Knowles J, et al.Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal scaffolds.Acta Biomater, 2013, 9(2):5251-5261.

1. Macchiarini P, Jungebluth P, Go T, et al.Clinical transplantation of a tissue-engineered airway.Lancet, 2008, 372(9655):2023-2030.
2. He X, Fu W, Zheng J.Cell sources for trachea tissue engineering:past, present and future.Regen Med, 2012, 7(6):851-863.
3. Elliott MJ, De Coppi P, Speggiorin S, et al.Stem-cell-based, tissue engineered tracheal replacement in a child:a 2-year follow-up study.Lancet, 2012, 380(9846):994-1000.
4. Jungebluth P, Bader A, Baiguera S, et al.The concept of in vivo airway tissue engineering.Biomaterials, 2012, 33(17):4319-4326.
5. Kojima K, Vacanti CA.Tissue engineering in the trachea.Anat Rec, 2014, 297(1):44-50.
6. Isogai N, Kusuhara H, Ikada Y, et al.Comparison of different chondrocytes for use in tissue engineering of cartilage model structures.Tissue Eng, 2006, 12(4):691-703.
7. Kalathur M, Baiguera S, Macchiarini P.Translating tissue-engineered tracheal replacement from bench to bedside.Cell Mol Life Sci, 2010, 67(24):4185-4196.
8. Zang M, Zhang Q, Chang EI, et al.Decellularized tracheal matrix scaffold for tracheal tissue engineering:in vivo host response.Plast Reconstr Surg, 2013, 132(4):549e-559e.
9. Grimmer JF, Gunnlaugsson CB, Alsberg E, et al.Tracheal reconstru ction using tissue-engineered cartilage.Arch Otolaryngol Head Neck Surg, 2004, 130(10):1191-1196.
10. Walles T, Giere B, Macchiarini P, et al.Expansion of chondrocytes in a three-dimensional matrix for tracheal tissue engineering.Ann Thorac Surg, 2004, 78(2):444-448.
11. Bianchi G, Banfi A, Mastrogiacomo M, et al.Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2.Exp Cell Res, 2003, 287(1):98-105.
12. Ronzière MC, Perrier E, Mallein-Gerin F, et al.Chondrogenic potential of bone marrow-and adipose tissue-derived adult human mesenchymal stem cells.Biomed Mater Eng, 2010, 20(3):145-158.
13. Tsutsumi S, Shimazu A, Miyazaki K, et al.Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF.Biochem Biophys Res Commun, 2001, 288(2):413-419.
14. Cals FL, Hellingman CA, Koevoet W, et al.Effects of transforming growth factor-βsubtypes on in vitro cartilage production and mineralization of human bone marrow stromal-derived mesench ymal stem cells.J Tissue Eng Regen Med, 2012, 6(1):68-76.
15. Shi H, Xu Z, Qin X, et al.Experimental study of replacing circum ferential tracheal defects with new prosthesis.Ann Thorac Surg, 2005, 79(2):672-676.
16. Bader A, Macchiarini P.Moving towards in situ tracheal regenera tion:the bionic tissue engineered transplantation approach.J Cell Mol Med, 2010, 14(7):1877-1889.
17. Baiguera S, Birchall MA, Macchiarini P.Tissue-engineered tracheal transplantation.Transplantation, 2010, 89(5):485-491.
18. Jungebluth P, Macchiarini P.Airway Transplantation.Thorac Surg Clin, 2014, 24(1):97-106.
19. Rees LE, Gunasekaran S, Sipaul F, et al.The isolation and characterisa tion of primary human laryngeal epithelial cells.Mol Immunol, 2006, 43(6):725-730.
20. Crowley C, Birchall M, Seifalian AM.Trachea transplantation:from laboratory to patient.J Tissue Eng Regen Med, 2014.doi:10.1002/term.1847.[Epubaheadofprint].
21. Atala A, Bauer SB, Soker S, et al.Tissue-engineered autologous bladders for patients needing cystoplasty.Lancet, 2006, 367(9518):1241-1246.
22. Martinod E, Seguin A, Pfeuty K, et al.Long-term evaluation of the replacement of the trachea with an autologous aortic graft.Ann Thorac Surg, 2003, 75(5):1572-1578.
23. Gray TE, Guzman K, Davis CW, et al.Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells.Am J Respir Cell Mol Biol, 1996, 14(1):104-112.
24. Weidenbecher M, Tucker HM, Awadallah A, et al.Fabrication of a neotrachea using engineered cartilage.Laryngoscope, 2008, 118(4):593-598.
25. Baiguera S, D'Innocenzo B, Macchiarini P.Current status of regener ative replacement of the airway.Expert Rev Respir Med, 2011, 5(4):487-494.
26. Fishman JM, De Coppi P, Elliott MJ, et al.Airway tissue engineering.Expert Opin Biol Ther, 2011, 11(12):1623-1635.
27. Haag J, Baiguera S, Jungebluth P, et al.Biomechanical and angiogenicproperties of tissue-engineered rat trachea using genipin cross-linkeddecellularized tissue.Biomaterials, 2012, 33(3):780-789.
28. Baiguera S, Jungebluth P, Burns A, et al.Tissue engineered human tracheas for in vivo implantation.Biomaterials, 2010, 31(34):8931-8938.
29. Jungebluth P, Moll G, Baiguera S, et al.Tissue-engineered airway:a regenerative solution.Clin Pharmacol Ther, 2012, 91(1):81-93.
30. Partington L, Mordan NJ, Knowles J, et al.Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal scaffolds.Acta Biomater, 2013, 9(2):5251-5261.

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Research Progress of Tissue-engineered Trachea Regeneration

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