Research Progress of Pulmonary Ground-glass Opacity_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

TIANLong , SHENCheng ,  CHEGuo-wei

Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding author：

CHEGuo-wei, Email: chebenben2005@163.com

Keywords：

Lung cancer; Ground-glass opacity; Diagnosis; Treatment; Surgery

DOI：

10.7507/1007-4848.20150098

Video：

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Abstract Full text Figures/Tables Video References Cited by

Increasing evidence suggests that there is a close relationship between pulmonary ground-glass opacity (GGO) and early-stage lung cancer, especially bronchial alveolar carcinoma in the early stage. With the use of high-resolution computed tomography (HRCT) and positron emission tomography/computed tomography (PET/CT), more and more GGO patients have been identified. Correct diagnosis and surgical indications should be determined according to the image characteristics including proportion and size of GGO in a pulmonary nodule as well as intraoperative quick pathological examination to avoid unnecessary surgical resection. Therefore, early detection and correct diagnosis of GGO are very important to improve patient prognosis.

Citation： TIANLong, SHENCheng, CHEGuo-wei. Research Progress of Pulmonary Ground-glass Opacity. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(4): 371-374. doi: 10.7507/1007-4848.20150098 Copy

1.	Miura A, Akagi S, Nakamura K, et al.Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis.Cardiovascular Pathology, 2013, 22(4):287-293.
2.	雷志丹, 葛英辉, 史大鹏.肺部弥漫性磨玻璃阴影的CT诊断与鉴别诊断.中国医学影像技术, 2007, 23(8):1147-1151.
3.	雷志丹, 王思勤, 史大鹏.特发性间质性肺炎的HRCT诊断.实用诊断与治疗杂志, 2006, 20(3):198-201.
4.	刘建东, 廖强, 李建国.肺部磨玻璃密度影的CT诊断与鉴别诊断.中国当代医药, 2011, 18(13):94-97.
5.	Nakamura S, Fukui T, Taniguchi T, et al.Prognostic impact of tumor size eliminating the ground glass opacity component modi-fied clinical T descriptors of the tumor, node, metastasis classifica——tion of lung cancer.J Thorac Oncol, 2013, 8(12):1551-1557.
6.	Miao XH, Yao YW, Yuan DM, et al.Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma:A meta-analysis.J Thorac Dis, 2012, 4(3):265-271.
7.	张丽萍, 徐海, 杜春华, 等.肺磨玻璃样病变HRCT征象的诊断价值.江苏医药, 2013, 39(8):969-970.
8.	张善华, 王和平, 王善军, 等.肺部局灶性磨玻璃影的CT诊断.医学影像学杂志, 2012, 22(8):1329-1332.
9.	Kim HY, Shim YM, Lee KS, et al.Persistent pulmonary nodular ground-glass opacity at thin-section CT:histopathologic compari-sons.Radiology, 2007, 245(1):267-275.
10.	Park JH, Lee KS, Kim JH, et al.Malignant pure pulmonary ground-glass opacity nodules:prognostic implications.Kor J Radio, 2009, 10(1):12-20.
11.	王琦, 时高峰, 王士杰.薄层CT和动态观察对肺部磨玻璃结节的诊断价值.临床荟萃, 2011, 26(6):512-515, 封3.
12.	Henschke CI, Yankelevitz DF, Mirtcheva R, et al.CT screening for lung cancer:Frequency and significance of part-solid and nonsolid nodules.Am J Roentgenol, 2002, 178(5):1053-1057.
13.	Lee HY, Choi YL, Lee KS, et al.Pure ground-glass opacity neoplastic lung nodules:histopathology, imaging, and management.Am J Roentgenol, 2014, 202(3):W224-W233.
14.	Fischer BM, Mortensen J.The future in diagnosis and staging of lung cancer:Positron emission tomography.Respiration, 2006, 73(3):267-276.
15.	柳伟坤, 李向东, 全江涛, 等.18F-FDG PET/CT显像对孤立结节型细支气管肺泡癌的诊断价值.南方医科大学学报, 2013, 33(1):114-116.
16.	Tao W, Chang P, Changhai Y, et al.FDG-PET in bronchial alveolar carcinoma.Chinese-German J Clin Oncol, 2006, 5(1):54-57.
17.	潘建虎, 郝建, 欧小波, 等.18F-FDG PET/CT扫描对孤立性肺结节病诊断价值的探讨.临床肺科杂志, 2011, 16(10):1490-1491.
18.	Bruzzi JF, Munden RF.PET/CT imaging of lung cancer.J Thorac Imaging, 2006, 21(2):123-136.
19.	何宝明, 王志忠, 刘晓飞, 等.细支气管肺泡癌18F FDG PET/CT SUV值与HRCT形态学的相关性研究.科学技术与工程, 2011, 11(35):8858-8861.
20.	Nakayama H, Okumura S, Daisaki H, et al.Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma a multicenter study.Cancer, 2010, 116(13):3170-3177.
21.	Takeda A, Kunieda E, Fujii H, et al.Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer.Lung Cancer, 2013, 79(3):248-253.
22.	Uehara H, Tsutani Y, Okumura S, et al.Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma.Ann Thorac Surg, 2013, 96(6):1958-1965.
23.	Chun EJ, Lee HJ, Kang WJ, et al.Differentiation between malignancy and inflammation in pulmonary ground-glass nodules:The feasibility of integrated 18F-FDG PET/CT.Lung Cancer, 2009, 65(2):180-186.
24.	Ichinose J, Kohno T, Fujimori S, et al.Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities.Ann Thorac Cardiovas Surg, 2014, 20(5):347-352.
25.	Sakata I, Ozeki Y, Tamura K, et al.A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography.Oncol Lett, 2012, 3(2):297-299.
26.	张丽萍, 陈成水.肺部单发磨玻璃样结节的最新研究进展.医学研究杂志, 2011, 40(2):13-15, 2.
27.	郭峰, 张志庸, 崔玉尚, 等.肺局限性磨玻璃样病灶的外科处理.中国肺癌杂志, 2008, 11(5):739-741.
28.	虞桂平, 黄斌, 陈国强, 等.电视胸腔镜在肺部局限性磨玻璃样病灶手术中的应用.江苏医药, 2012, 38(22):2768-2768.
29.	潘小杰, 郭天兴, 叶明凡, 等.胸腔镜手术联合PET/CT诊疗44例肺磨玻璃样病变临床分析.肿瘤防治研究, 2013, 40(7):706-708.
30.	Yan TD, Black D, Bannon PG, et al.Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer.J Clin Oncol, 2009, 27(15):2553-2562.
31.	Kohno T, Fujimori S, Kishi K, et al.Safe and effective minimally invasive approaches for small ground glass opacity.Ann Thorac Surg, 2010, 89(6):S2114-S2117.
32.	Tsutani Y, Miyata Y, Nakayama HA, et al.Prediction of pathologic node-negative clinical stage IA lung adenocarcinoma for optimal candidates undergoing sublobar resection.J Thorac Cardiovasc Surg, 2012, 144(6):1365-1371.
33.	魏立, 赵松, 陈明耀, 等.精确CT引导定位局限性肺磨玻璃影的临床病理和手术模式探讨.实用医学杂志, 2012, 28(22):3723-3725.
34.	Tsutani Y, Miyata Y, Nakayama H, et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma.Chest, 2014, 145(1):66-71.
35.	Sugi K, Kobayashi S, Sudou M, et al.Long-term prognosis of video-assisted limited surgery for early lung cancer.Eur J Cardio-Thorac Surg, 2010, 37(2):456-460.
36.	Yoshida J, Nagai K, Yokose T, et al.Limited resection trial for pulmonary ground-glass opacity nodules:fifty-case experience.J Thorac Cardiovasc Surg, 2005, 129(5):991-996.
37.	Matsuguma H, Nakahara R, Anraku M, et al.Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung.Euro J Cardio-Thorac Surg, 2004, 25(6):1102-1105.
38.	Ohtsuka T, Watanabe KI, Kaji M, et al.A clinicopathological study of resected putmonary nodules with focal pure ground-glass opacity.Euro J Cardio-Thorac Surg, 2006, 30(1):160-163.

1. Miura A, Akagi S, Nakamura K, et al.Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis.Cardiovascular Pathology, 2013, 22(4):287-293.
2. 雷志丹, 葛英辉, 史大鹏.肺部弥漫性磨玻璃阴影的CT诊断与鉴别诊断.中国医学影像技术, 2007, 23(8):1147-1151.
3. 雷志丹, 王思勤, 史大鹏.特发性间质性肺炎的HRCT诊断.实用诊断与治疗杂志, 2006, 20(3):198-201.
4. 刘建东, 廖强, 李建国.肺部磨玻璃密度影的CT诊断与鉴别诊断.中国当代医药, 2011, 18(13):94-97.
5. Nakamura S, Fukui T, Taniguchi T, et al.Prognostic impact of tumor size eliminating the ground glass opacity component modi-fied clinical T descriptors of the tumor, node, metastasis classifica——tion of lung cancer.J Thorac Oncol, 2013, 8(12):1551-1557.
6. Miao XH, Yao YW, Yuan DM, et al.Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma:A meta-analysis.J Thorac Dis, 2012, 4(3):265-271.
7. 张丽萍, 徐海, 杜春华, 等.肺磨玻璃样病变HRCT征象的诊断价值.江苏医药, 2013, 39(8):969-970.
8. 张善华, 王和平, 王善军, 等.肺部局灶性磨玻璃影的CT诊断.医学影像学杂志, 2012, 22(8):1329-1332.
9. Kim HY, Shim YM, Lee KS, et al.Persistent pulmonary nodular ground-glass opacity at thin-section CT:histopathologic compari-sons.Radiology, 2007, 245(1):267-275.
10. Park JH, Lee KS, Kim JH, et al.Malignant pure pulmonary ground-glass opacity nodules:prognostic implications.Kor J Radio, 2009, 10(1):12-20.
11. 王琦, 时高峰, 王士杰.薄层CT和动态观察对肺部磨玻璃结节的诊断价值.临床荟萃, 2011, 26(6):512-515, 封3.
12. Henschke CI, Yankelevitz DF, Mirtcheva R, et al.CT screening for lung cancer:Frequency and significance of part-solid and nonsolid nodules.Am J Roentgenol, 2002, 178(5):1053-1057.
13. Lee HY, Choi YL, Lee KS, et al.Pure ground-glass opacity neoplastic lung nodules:histopathology, imaging, and management.Am J Roentgenol, 2014, 202(3):W224-W233.
14. Fischer BM, Mortensen J.The future in diagnosis and staging of lung cancer:Positron emission tomography.Respiration, 2006, 73(3):267-276.
15. 柳伟坤, 李向东, 全江涛, 等.18F-FDG PET/CT显像对孤立结节型细支气管肺泡癌的诊断价值.南方医科大学学报, 2013, 33(1):114-116.
16. Tao W, Chang P, Changhai Y, et al.FDG-PET in bronchial alveolar carcinoma.Chinese-German J Clin Oncol, 2006, 5(1):54-57.
17. 潘建虎, 郝建, 欧小波, 等.18F-FDG PET/CT扫描对孤立性肺结节病诊断价值的探讨.临床肺科杂志, 2011, 16(10):1490-1491.
18. Bruzzi JF, Munden RF.PET/CT imaging of lung cancer.J Thorac Imaging, 2006, 21(2):123-136.
19. 何宝明, 王志忠, 刘晓飞, 等.细支气管肺泡癌18F FDG PET/CT SUV值与HRCT形态学的相关性研究.科学技术与工程, 2011, 11(35):8858-8861.
20. Nakayama H, Okumura S, Daisaki H, et al.Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma a multicenter study.Cancer, 2010, 116(13):3170-3177.
21. Takeda A, Kunieda E, Fujii H, et al.Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer.Lung Cancer, 2013, 79(3):248-253.
22. Uehara H, Tsutani Y, Okumura S, et al.Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma.Ann Thorac Surg, 2013, 96(6):1958-1965.
23. Chun EJ, Lee HJ, Kang WJ, et al.Differentiation between malignancy and inflammation in pulmonary ground-glass nodules:The feasibility of integrated 18F-FDG PET/CT.Lung Cancer, 2009, 65(2):180-186.
24. Ichinose J, Kohno T, Fujimori S, et al.Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities.Ann Thorac Cardiovas Surg, 2014, 20(5):347-352.
25. Sakata I, Ozeki Y, Tamura K, et al.A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography.Oncol Lett, 2012, 3(2):297-299.
26. 张丽萍, 陈成水.肺部单发磨玻璃样结节的最新研究进展.医学研究杂志, 2011, 40(2):13-15, 2.
27. 郭峰, 张志庸, 崔玉尚, 等.肺局限性磨玻璃样病灶的外科处理.中国肺癌杂志, 2008, 11(5):739-741.
28. 虞桂平, 黄斌, 陈国强, 等.电视胸腔镜在肺部局限性磨玻璃样病灶手术中的应用.江苏医药, 2012, 38(22):2768-2768.
29. 潘小杰, 郭天兴, 叶明凡, 等.胸腔镜手术联合PET/CT诊疗44例肺磨玻璃样病变临床分析.肿瘤防治研究, 2013, 40(7):706-708.
30. Yan TD, Black D, Bannon PG, et al.Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer.J Clin Oncol, 2009, 27(15):2553-2562.
31. Kohno T, Fujimori S, Kishi K, et al.Safe and effective minimally invasive approaches for small ground glass opacity.Ann Thorac Surg, 2010, 89(6):S2114-S2117.
32. Tsutani Y, Miyata Y, Nakayama HA, et al.Prediction of pathologic node-negative clinical stage IA lung adenocarcinoma for optimal candidates undergoing sublobar resection.J Thorac Cardiovasc Surg, 2012, 144(6):1365-1371.
33. 魏立, 赵松, 陈明耀, 等.精确CT引导定位局限性肺磨玻璃影的临床病理和手术模式探讨.实用医学杂志, 2012, 28(22):3723-3725.
34. Tsutani Y, Miyata Y, Nakayama H, et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma.Chest, 2014, 145(1):66-71.
35. Sugi K, Kobayashi S, Sudou M, et al.Long-term prognosis of video-assisted limited surgery for early lung cancer.Eur J Cardio-Thorac Surg, 2010, 37(2):456-460.
36. Yoshida J, Nagai K, Yokose T, et al.Limited resection trial for pulmonary ground-glass opacity nodules:fifty-case experience.J Thorac Cardiovasc Surg, 2005, 129(5):991-996.
37. Matsuguma H, Nakahara R, Anraku M, et al.Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung.Euro J Cardio-Thorac Surg, 2004, 25(6):1102-1105.
38. Ohtsuka T, Watanabe KI, Kaji M, et al.A clinicopathological study of resected putmonary nodules with focal pure ground-glass opacity.Euro J Cardio-Thorac Surg, 2006, 30(1):160-163.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Pulmonary Ground-glass Opacity

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