Bone Marrow Mesenchymal Stem Cells for Treatment of Seawater Drowning Induced Acute Lung Injury_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

GUOShuai ,  ZENGZhi-yong , YANGSheng-sheng , XUChi , YEShi-xin

Department of Cardio-Thoracic Surgery, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University, Fuzhou 350025, P. R. China;

Corresponding author：

ZENGZhi-yong, Email: zengzhiyong623@sina.com

Keywords：

Bone marrow mesenchymal stem cells; Seawater drowning; Acute lung injury; Acute respiratory distress syndrome

DOI：

10.7507/1007-4848.20150099

Video：

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With the growth of offshore activities, the incidence rates of seawater drowning (SWD) induced acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) increase significantly higher than before. Pulmonary interstitial edema, alveolar septum fracture, red blood cells, and inflammatory cells infiltration can be seen under light microscope in the pathologic changes of lungs. The major clinical manifestations are continual hyoxemia and acidosis, which lead to a severe condition, a high death rate, and a poor treatment effect. Bone marrow mesenchymal stem cells are capable of self-renewal, multilineage differentiation and injured lung-homing, which are induced to differentiate into alveolar epithelial cells and pulmonary vascular endothelial cells for tissues repairing. This may be a new way to treat SWD-ALI and SW-ARDS.

Citation： GUOShuai, ZENGZhi-yong, YANGSheng-sheng, XUChi, YEShi-xin. Bone Marrow Mesenchymal Stem Cells for Treatment of Seawater Drowning Induced Acute Lung Injury. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(4): 375-379. doi: 10.7507/1007-4848.20150099 Copy

1.	芮萌, 段蕴铀, 王海龙, 等.地塞米松对兔海水淹溺型急性肺损伤肺组织NF-κB活性改变的影响.第二军医大学学报, 2010, 31(4):394-398.
2.	Mann A, Early GL.Acute respiratory distress syndrome.Mo Med, 2012, 109(5):371-375.
3.	Szpilman D.Near-drowing and drowing classification:a proposal to stratify mortality based on the analysis of 1 831 cases.Chest, 1997, 112(3):660.
4.	金发光, 郭佑民.地塞米松调节claudin-4减轻海水淹溺性肺水肿的机制研究.中华肺部疾病杂志, 2013, 6(2):124-129.
5.	马李杰, 李艳燕, 赵诣林, 等.乙酰化白藜芦醇通过调节缝隙连接蛋白43表达减轻海水淹溺型急性肺损伤.中华肺部疾病杂志, 2013, 6(1):15-19.
6.	古妙宁, 肖金仿, 黄毅然, 等.海水和淡水直接肺损伤作用的比较.中华麻醉学杂志, 2003, 23(8):608-612.
7.	梁源, 楚东岭, 金发光, 等.猪肺表面活性物质对海水淹溺性肺损伤大鼠治疗的量效关系.现代生物医学进展, 2008, 8(4):619-621.
8.	韩志海, 段蕴铀, 胡明.机械通气对海水淹溺肺水肿兔肺组织学的影响.中华航海医学与高气压医学杂志, 2004, 1(1):12-16.
9.	杨昱, 王关嵩, 邓朝霞, 等.海水淹溺型肺损伤与淡水淹溺型肺损伤特征的比较.解放军医学杂志, 2009, 34(4):393-396.
10.	周长喜, 钱桂生, 王关嵩.海水淹溺机制研究进展.人民军医, 2008, 51(10):630-631.
11.	李天林, 文文, 赖国祥, 等.血管紧张素转化酶2在海水淹溺诱导大鼠急性肺损伤中的作用.中国呼吸与危重监护杂志, 2012, 11(6):537-540.
12.	Kingma PS, Unitsett JA, Waters P, et al.In defense of the lung:surfactant protein A and surfactant protein D.Curr Opin Pharmacol, 2006, 6(3):277-283.
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14.	黄毅然, 古妙宁, 肖金仿, 等.早期肺灌洗治疗犬海水淹溺肺损伤的实验研究.第一军医大学学报, 2003, 23(10):1062-1065.
15.	Huang TY, Tsai PS, Wang TY, et al.Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute lung injury involves heme oxygenase-1.Acta Anaesthesiol Scand, 2005, 49(9):1293-1301.
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22.	Ortiz LA, Dutreil M, Fattman C, et al.Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury.Proc Natl Acad Sci USA, 2007, 104(26):11002-11007.
23.	Rojas M, Xu J, Woods CR, et al.Bone marrow-drived mesenchymal stem cells in repair of the injured lung.Am J Respir Cell Mol Biol, 2005, 33(2):145-152.
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25.	Xu J, Woods CR, Mora AL, et al.Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.Am J Physiol Lung Cell Mol Physiol, 2007, 293(1):L131-L141.
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27.	Aslam M, Baveja R, Liang OD, et al.Bone marrow stromal cells attenuate lung injury in amurine model of neonatal chronic lung disease.Am J Respir Crit Care Med, 2009, 180(11):1122-1130.
28.	Van Haaften T, Byrne R, Bonnet S, et al.Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.Am J Respir Crit Care Med, 2009, 180(11):1131-1142.
29.	Chang YS, Oh W, Choi SJ, et al.Human umbilical cord blood derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats.Cell Transplant, 2009, 18(8):869-886.
30.	Weiss DJ, Kolls JK, Ortiz LA, et al.Stem cells and cell therapies in lung biology and lung diseases.Proc Am Thorac Soc, 2008, 5(5):637-667.
31.	Zhen G, Liu H, Gu N, et al.Mesenchymal stem cells transplantation protects against rat pulmonary emphysema.Front Biosci, 2008, 13:3415-3422.
32.	华静, 冯华松, 王庆, 等.海水淹溺致大鼠急性肺损伤模型的建立.现代生物医学进展, 2013, 13(27):5242-5246.
33.	张红霞, 王蒙蒙, 李惠萍, 等.白藜芦醇对博来霉素诱导小鼠肺损伤的保护作用.第二军医大学学报, 2013, 34(12):1287-1290.
34.	张祺嘉钰, 王国全, 余林中, 等.两种内毒素经支气管给药致急性肺损伤模型再评价研究.中药药理与临床, 2012, 28(5):226-229.
35.	Loebinger MR, Sage EK, Janes SM.Mesenchymal stem cells as vectors for lung disease.Proc Am Thorac Soc, 2008, 5(6):711-716.
36.	张兵华, 费晋秀, 赵亚玲, 等.兔海水淹溺性肺水肿与钠钾-ATP酶的关系及不同剂量地塞米松对其影响.陕西医学杂志, 2011, 40(1):11-14.
37.	张红珊, 方建培.骨髓间充质干细胞修复肺损伤研究进展.中国呼吸与危重监护杂志, 2011, 10(5):505-508.
38.	Ohno N, Kajiume T, Sear Y, et al.Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression.Stem Cells Dev, 2009, 18(8):1221-1226.
39.	顾兴, 金发光, 刘同刚.三七总皂苷对海水淹溺兔肺泡巨噬细胞TNF-αmRNA表达的影响.中国中医急症, 2011, 20(10):1608-1610.
40.	张新红, 段蕴铀, 芮萌.海水淹溺型急性肺损伤兔血管内皮生长因子及其受体的表达.解放军医学杂志, 2009, 34(7):819-822.
41.	Krause DS.Bone marrow-derived cells and stem cells in lung repair.Proc Am Thorac Soc, 2008, 5(3):323-327.
42.	Prockop DJ.Marrow stromal cells as stem cells for non-hematopoietic tissues.Science, 1997, 276(5309):71-74.
43.	王关嵩, 张志远, 钱桂生.溺海肺损伤的发病机制和治疗的研究进展.中国急救医学, 2008, 28(3):262-266.
44.	赵峰, 李圣青, 张宇飞, 等.骨髓间充质干细胞在肺损伤大鼠肺组织的分化.解放军医学杂志, 2007, 32(2):131-133.
45.	Snyder JC, Teisanu RM, Stripp BR.Endogenous lung stem cells and contribution to disease.J Pathol, 2009, 217(2):254-264.
46.	赵诣林, 马李杰, 陈向军, 等.核转录因子-5在海水淹溺性肺水肿中的作用及机制.中华肺部疾病杂志:电子版, 2013, 6(1):25-29.
47.	刘秋平, 卢晓昭, 费晋秀, 等.骨髓间充质干细胞移植对急性肺水肿大鼠肺组织的影响.中华危重症医学杂志:电子版, 2011, 4(3):150-154.
48.	Németh K, Leelahavanichkul A, Yuen PS, et al.Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production.Nat Med, 2009, 15(1):42-49.
49.	Chen L, Tredget EE, Wu PY, et al.Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing.PLoS One, 2008, 3(4):e1886.
50.	Corcione A, Benvenuto F, Ferretti E, et al.Human mesenchymal stem cells modulate B-cell functions.Blood, 2006, 107(1):367-372.
51.	曹万英, 金发光, 罗颖等.乌司他丁治疗大鼠海水淹溺型急性肺损伤的实验观察.中国呼吸与危重监护杂志, 2011, 10(2):139-143.
52.	Rasmusson I, Ringdén O, Sundberg B, et al.Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.Transplantation, 2003, 76(8):1208-1219.
53.	Wong AP, Dutly AE, Sacher A, et al.Targeted cell replacement with bone marrow cells for airway epithelial regeneration.Am J Physi-Lung Cell Mole Physi, 2007, 293(3):L740-L752.
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1. 芮萌, 段蕴铀, 王海龙, 等.地塞米松对兔海水淹溺型急性肺损伤肺组织NF-κB活性改变的影响.第二军医大学学报, 2010, 31(4):394-398.
2. Mann A, Early GL.Acute respiratory distress syndrome.Mo Med, 2012, 109(5):371-375.
3. Szpilman D.Near-drowing and drowing classification:a proposal to stratify mortality based on the analysis of 1 831 cases.Chest, 1997, 112(3):660.
4. 金发光, 郭佑民.地塞米松调节claudin-4减轻海水淹溺性肺水肿的机制研究.中华肺部疾病杂志, 2013, 6(2):124-129.
5. 马李杰, 李艳燕, 赵诣林, 等.乙酰化白藜芦醇通过调节缝隙连接蛋白43表达减轻海水淹溺型急性肺损伤.中华肺部疾病杂志, 2013, 6(1):15-19.
6. 古妙宁, 肖金仿, 黄毅然, 等.海水和淡水直接肺损伤作用的比较.中华麻醉学杂志, 2003, 23(8):608-612.
7. 梁源, 楚东岭, 金发光, 等.猪肺表面活性物质对海水淹溺性肺损伤大鼠治疗的量效关系.现代生物医学进展, 2008, 8(4):619-621.
8. 韩志海, 段蕴铀, 胡明.机械通气对海水淹溺肺水肿兔肺组织学的影响.中华航海医学与高气压医学杂志, 2004, 1(1):12-16.
9. 杨昱, 王关嵩, 邓朝霞, 等.海水淹溺型肺损伤与淡水淹溺型肺损伤特征的比较.解放军医学杂志, 2009, 34(4):393-396.
10. 周长喜, 钱桂生, 王关嵩.海水淹溺机制研究进展.人民军医, 2008, 51(10):630-631.
11. 李天林, 文文, 赖国祥, 等.血管紧张素转化酶2在海水淹溺诱导大鼠急性肺损伤中的作用.中国呼吸与危重监护杂志, 2012, 11(6):537-540.
12. Kingma PS, Unitsett JA, Waters P, et al.In defense of the lung:surfactant protein A and surfactant protein D.Curr Opin Pharmacol, 2006, 6(3):277-283.
13. 杜娟, 高伟良, 左右, 等.早期机械通气治疗海水淹溺肺水肿.实用医学杂志, 2008, 24(10):1777-1778.
14. 黄毅然, 古妙宁, 肖金仿, 等.早期肺灌洗治疗犬海水淹溺肺损伤的实验研究.第一军医大学学报, 2003, 23(10):1062-1065.
15. Huang TY, Tsai PS, Wang TY, et al.Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute lung injury involves heme oxygenase-1.Acta Anaesthesiol Scand, 2005, 49(9):1293-1301.
16. 张新红, 段蕴铀, 芮萌, 等.不同剂量地塞米松对海水淹溺型急性肺损伤的治疗作用观察.解放军医学杂志, 2009, 34(7):815-818.
17. Xinmin D, Yunyou D, Chaosheng P, et al.Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits.Pharmacol Res, 2006, 53(4):372-379.
18. 刁孟元, 张斌, 黄凤楼.血管内皮生长因子与海水淹溺型急性肺损伤的关系.中国疗养医学, 2013, 22(3):237-239.
19. Beyer Nardi N, da Silva Meirelles L.Mesenchymal stem cells:isolation, in vitro expansion and characterization.Handb ExpPharmacol, 2006, (174):249-282.
20. García-Castro J, Trigueros C, Madrenas J, et al.Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.J Cell Mol Med, 2008, 12(6B):2552-2565.
21. Ortiz LA, Gambelli F, McBride C, et al.Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.Proc Natl Acad Sci USA, 2003, 100(14):8407-8411.
22. Ortiz LA, Dutreil M, Fattman C, et al.Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury.Proc Natl Acad Sci USA, 2007, 104(26):11002-11007.
23. Rojas M, Xu J, Woods CR, et al.Bone marrow-drived mesenchymal stem cells in repair of the injured lung.Am J Respir Cell Mol Biol, 2005, 33(2):145-152.
24. Gupta N, Su X, Popov B, et al.Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.J Immunol, 2007, 179(3):1855-1863.
25. Xu J, Woods CR, Mora AL, et al.Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.Am J Physiol Lung Cell Mol Physiol, 2007, 293(1):L131-L141.
26. Sueblinvong V, Weiss DJ.Cell therapy approaches for lung diseases:current status.Curr OpinPharmacol, 2009, 9(3):268-273.
27. Aslam M, Baveja R, Liang OD, et al.Bone marrow stromal cells attenuate lung injury in amurine model of neonatal chronic lung disease.Am J Respir Crit Care Med, 2009, 180(11):1122-1130.
28. Van Haaften T, Byrne R, Bonnet S, et al.Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.Am J Respir Crit Care Med, 2009, 180(11):1131-1142.
29. Chang YS, Oh W, Choi SJ, et al.Human umbilical cord blood derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats.Cell Transplant, 2009, 18(8):869-886.
30. Weiss DJ, Kolls JK, Ortiz LA, et al.Stem cells and cell therapies in lung biology and lung diseases.Proc Am Thorac Soc, 2008, 5(5):637-667.
31. Zhen G, Liu H, Gu N, et al.Mesenchymal stem cells transplantation protects against rat pulmonary emphysema.Front Biosci, 2008, 13:3415-3422.
32. 华静, 冯华松, 王庆, 等.海水淹溺致大鼠急性肺损伤模型的建立.现代生物医学进展, 2013, 13(27):5242-5246.
33. 张红霞, 王蒙蒙, 李惠萍, 等.白藜芦醇对博来霉素诱导小鼠肺损伤的保护作用.第二军医大学学报, 2013, 34(12):1287-1290.
34. 张祺嘉钰, 王国全, 余林中, 等.两种内毒素经支气管给药致急性肺损伤模型再评价研究.中药药理与临床, 2012, 28(5):226-229.
35. Loebinger MR, Sage EK, Janes SM.Mesenchymal stem cells as vectors for lung disease.Proc Am Thorac Soc, 2008, 5(6):711-716.
36. 张兵华, 费晋秀, 赵亚玲, 等.兔海水淹溺性肺水肿与钠钾-ATP酶的关系及不同剂量地塞米松对其影响.陕西医学杂志, 2011, 40(1):11-14.
37. 张红珊, 方建培.骨髓间充质干细胞修复肺损伤研究进展.中国呼吸与危重监护杂志, 2011, 10(5):505-508.
38. Ohno N, Kajiume T, Sear Y, et al.Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression.Stem Cells Dev, 2009, 18(8):1221-1226.
39. 顾兴, 金发光, 刘同刚.三七总皂苷对海水淹溺兔肺泡巨噬细胞TNF-αmRNA表达的影响.中国中医急症, 2011, 20(10):1608-1610.
40. 张新红, 段蕴铀, 芮萌.海水淹溺型急性肺损伤兔血管内皮生长因子及其受体的表达.解放军医学杂志, 2009, 34(7):819-822.
41. Krause DS.Bone marrow-derived cells and stem cells in lung repair.Proc Am Thorac Soc, 2008, 5(3):323-327.
42. Prockop DJ.Marrow stromal cells as stem cells for non-hematopoietic tissues.Science, 1997, 276(5309):71-74.
43. 王关嵩, 张志远, 钱桂生.溺海肺损伤的发病机制和治疗的研究进展.中国急救医学, 2008, 28(3):262-266.
44. 赵峰, 李圣青, 张宇飞, 等.骨髓间充质干细胞在肺损伤大鼠肺组织的分化.解放军医学杂志, 2007, 32(2):131-133.
45. Snyder JC, Teisanu RM, Stripp BR.Endogenous lung stem cells and contribution to disease.J Pathol, 2009, 217(2):254-264.
46. 赵诣林, 马李杰, 陈向军, 等.核转录因子-5在海水淹溺性肺水肿中的作用及机制.中华肺部疾病杂志:电子版, 2013, 6(1):25-29.
47. 刘秋平, 卢晓昭, 费晋秀, 等.骨髓间充质干细胞移植对急性肺水肿大鼠肺组织的影响.中华危重症医学杂志:电子版, 2011, 4(3):150-154.
48. Németh K, Leelahavanichkul A, Yuen PS, et al.Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production.Nat Med, 2009, 15(1):42-49.
49. Chen L, Tredget EE, Wu PY, et al.Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing.PLoS One, 2008, 3(4):e1886.
50. Corcione A, Benvenuto F, Ferretti E, et al.Human mesenchymal stem cells modulate B-cell functions.Blood, 2006, 107(1):367-372.
51. 曹万英, 金发光, 罗颖等.乌司他丁治疗大鼠海水淹溺型急性肺损伤的实验观察.中国呼吸与危重监护杂志, 2011, 10(2):139-143.
52. Rasmusson I, Ringdén O, Sundberg B, et al.Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells.Transplantation, 2003, 76(8):1208-1219.
53. Wong AP, Dutly AE, Sacher A, et al.Targeted cell replacement with bone marrow cells for airway epithelial regeneration.Am J Physi-Lung Cell Mole Physi, 2007, 293(3):L740-L752.
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