Expression of Vascular Endothelial Growth Factor Receptor-2 in Uygur Patients with Esophageal Squamous Cell Carcinoma and Their Clinical Significance_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIGang ¹ , SUNQing-chao ¹ , LIDe-sheng ¹ , JulaitiAiniwaer ¹ , ZHANGLi-wei ¹ ,  MadiniyetiNiyaz ²

1. Department of Thoracic Surgery of The First Affiliated Hospital of Xinjiang Medical University, Uruqmqi 830054, P. R. China;
2. The First Affiliated Clinical Medical Research College, Xinjiang Medical University, Uruqumqi 830054, P. R. China;

Corresponding author：

MadiniyetiNiyaz, Email: mdnyn5@yahoo.com

Keywords：

Vascular enddothelial growth factor receptor-2; Esophageal squamous cell carcinoma; Immunohistochemistry; Uygur

DOI：

10.7507/1007-4848.20150193

Video：

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Objective To explore the expression of vascular endothelial growth factor receptor-2(VEGFR-2) protein in esophageal squamous cell carcinoma (ESCC) and to analyze the relationship between VEGFR-2 and prognostic of esophageal cancer in Uygur of Xinjiang. Methods The expression of VEGFR-2 protein including 72 patients with ESCC[with 56 males and 16 females at age of 57 (43-79) years] and paracarcinomatous tissues of 28 patients were detected by immunohistochemistry staining (SP) between January 2007 and september 2009 in this hospital. The Kaplan-Meier and Cox proportional hazards analysis were used to analyze the prognosis of ESCC. Results The positive expression rate of VEGFR-2 protein in 72 patients with ESCC was 80.56% (58/72) and 0 in paracarcinomatous tissues. The expression of VEGFR-2 protein in the ESCC was much higher than that in paracarcinomatous tissues with a statistical difference (P<0.05). The expression of VEGFR-2 protein was significantly correlated with depth of invasion, lymph node metastasis, distant metastasis and TNM staging (P<0.05). Tumor size was no correlation with expression of VEGFR-2 protein (P>0.05). Kaplan-Meier survival analysis indicated that five-year survival rate in positive expression of VEGFR-2 was higher than that in the negative group. Lymph node metastasis, TNM staging, and the positive expression of VEGFR-2 protein were independent prognostic factors. Conclusion VEGFR-2 protein is expressed more in ESCC and might be used as the index to predict prognosis and metastasis of esophagedal carcinoma in Uygur.

Citation： LIGang, SUNQing-chao, LIDe-sheng, JulaitiAiniwaer, ZHANGLi-wei, MadiniyetiNiyaz. Expression of Vascular Endothelial Growth Factor Receptor-2 in Uygur Patients with Esophageal Squamous Cell Carcinoma and Their Clinical Significance. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(8): 773-777. doi: 10.7507/1007-4848.20150193 Copy

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14.	Scharpfenecker M, Fiedler U, Reiss Y, et al. The Tie 2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci, 2005, 118(Pt 4):771-780.
15.	蒋晓东, 戴鹏, 宋大安, 等. HIF-1α、VEGF、VEGFR-2 在非小细胞肺癌组织中的表达及临床意义. 临床肺科杂志, 2011, 16(3):386-388.
16.	蒙玉刚, 梁春燕, 曾雅畅, 等. 血管内皮生长因子 A 及其受体VEGFR-2 在宫颈癌血清中的表达及其临床意义. 广西医科大学学报, 2013, 30(1):45-47.
17.	李新春, 李新国. NK、VEGF-A 在原发性输卵管腺癌中的表达及其意义. 实用预防医学, 2010, 17(6):1065-1066.
18.	樊晴伶, 尹一童. 血管内皮生长因子与胃癌转移及预后的研究进展. 中国实用医药, 2009, 4(24):248-249.
19.	Mohammde RA, Green A, El-shikhs, et al. Prognostic significance of vascular endothelial cell growth factor -A,-C, and -D in breast cancer and their relationship with angio-and lymphangio-genesis. Br J Cancer, 2007, 96(7):1092-1100.

1. 殷蔚伯, 余子豪, 徐国镇, 等. 肿瘤放射治疗学. 北京:中国协和医科大学出版社, 2007. 546.
2. Schoppmann SF, Asari R, Riegler M. Barrett's esophagus as a marker for increased risk for esophageal cancer and cardiorespiratory disease. Endoscopy, 2013, 45(2):152.
3. 居来提·艾尼瓦尔, 李德生, 张力为, 等. 2005~2008 年伊犁地区食管癌患病情况调查研究. 新疆医学, 2011, 41:112-114.
4. Gridelli C, Rossi A. Malone P. Non-small cell lung cancer. New antiangiogenetic agents and non-small cell lung cancer. Cat Rev Oncol Hemat, 2006, 60(1):76-86.
5. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med, 2003, 9(6):669-676.
6. Donnem T, AI-Shibli K, Andersen S, et al. Combination of low vascular endothelial growth factor A(VEGF-A)/VEGF receptor.
7. expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with non small cell lung cancer. Cancer, 2010, l 16(18):4318-4325.
8. Ghosh S, Sullivan CA, Zerkowski MP, et al. High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1)are associated with worse outcome in breast cancer. Hum Pathol, 2008, 39(12):1835-1843.
9. 张莹, 蒋晓东, 乔云, 等. 不同肺癌细胞株中 VEGFR-2 mRNA 表达的实验研究. 临床肿瘤学杂志, 2013, 18(10):879-881.
10. Sinicrope FA, Ruan SB, Cleary KR, et al. Bcl-2 and p53 oncoprotein expression during colorectal tu morigenesis. Cancer Res, 1995, 55(2):237-241.
11. Ranieri G, Patruno R, Ruggieri E, et al.Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer:from the biology to the clinic. Curr Med Chem, 2006, 13(16):B1 845.
12. Al-Moundhri MS, Al-Shukaili A, Al-Nabhani M. Measurement of circulating levels of VEGF-A, -C and -D and their receptor, VEGFR-1 and-2 in gastric adenocarcinoma. World J Gastroenterol, 2008, 14(24):3879-3883.
13. Yoshiji H, Kuriyama S, Noguchi R, et al. Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice. Gut, 2005, 54(12):1768-1775.
14. Scharpfenecker M, Fiedler U, Reiss Y, et al. The Tie 2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci, 2005, 118(Pt 4):771-780.
15. 蒋晓东, 戴鹏, 宋大安, 等. HIF-1α、VEGF、VEGFR-2 在非小细胞肺癌组织中的表达及临床意义. 临床肺科杂志, 2011, 16(3):386-388.
16. 蒙玉刚, 梁春燕, 曾雅畅, 等. 血管内皮生长因子 A 及其受体VEGFR-2 在宫颈癌血清中的表达及其临床意义. 广西医科大学学报, 2013, 30(1):45-47.
17. 李新春, 李新国. NK、VEGF-A 在原发性输卵管腺癌中的表达及其意义. 实用预防医学, 2010, 17(6):1065-1066.
18. 樊晴伶, 尹一童. 血管内皮生长因子与胃癌转移及预后的研究进展. 中国实用医药, 2009, 4(24):248-249.
19. Mohammde RA, Green A, El-shikhs, et al. Prognostic significance of vascular endothelial cell growth factor -A,-C, and -D in breast cancer and their relationship with angio-and lymphangio-genesis. Br J Cancer, 2007, 96(7):1092-1100.

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Expression of Vascular Endothelial Growth Factor Receptor-2 in Uygur Patients with Esophageal Squamous Cell Carcinoma and Their Clinical Significance

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