Research Progress of C4.4A in Non-small Cell Lung Cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANGFeng-yi ,  LIDing-biao

Department of Toracic Surgery, Yanan Hospital, Kunming medical University, Kunming 650500, P. R. China;

Corresponding author：

LIDing-biao, Email: lidb88@163.com

Keywords：

Non-small cell lung cancer(NSCLC); Protein C4.4A; Liver kinase B1(LKB1)

DOI：

10.7507/1007-4848.20150286

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Lung cancer is one of the most malignant common tumor worldwidely and it's the most popular cancer in China. Both the prevalence and mortality of it are higher than other cancers. And its 5-year survival rate is 15%. Non-small cell lung cancer(NSCLC) accounts for about 85% lung cancer and its pathogenesis has not been elucidated. Therefore, early prediction and detection are very important for improving the effect of treatment and prognosis. Recently, dysregulation and excessive activity of the C4.4A as a member of the LY6/uPAR family of membrane proteins has been shown to associate with multiple cancer types. And previous studies suggest that the C4.4A participates in the invasion and metastasis of NSCLC. At the same time, circumstantial evidence proves that C4.4A and liver kinase B1(LKB1) tumor suppressor gene have a negative regulatory relationship. This article will briefly summarize the recent research progresses of C4.4A in NSCLC.

Citation： ZHANGFeng-yi, LIDing-biao. Research Progress of C4.4A in Non-small Cell Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(12): 1152-1156. doi: 10.7507/1007-4848.20150286 Copy

1.	Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin, 2014, 64(1):9-29.
2.	陈万青, 张思维, 邹小农. 中国肺癌发病死亡的估计和流行趋势研究. 中国肺癌杂志, 2010, 13(5):488-493.
3.	Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013.CA Cancer J Clin, 2013, 63(1):11-30.
4.	Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer:a decade of progress. Chest, 2002, 122(3):1037-1057.
5.	Jacobsen B, Muley T, Meister M, et al. Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma. Thorac Oncol, 2013, 8(2):152-160.
6.	Rosel M, Claas C, Seiter S, et al. Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene, 1998, 17(15):1989-2002.
7.	Galat A. The three-fingered protein domain of the human genome. Cell Mol Life Sci, 2008, 65(21):3481-3493.
8.	Tlin V. Snake venom α-neurotoxins and other "three-finger" proteins. Eur J Biochem, 1999, 264(2):281-286.
9.	Fry BG. From genome to "venome":molecular origin and evolutionof the snake venom proteome inferred from phylogenetic analysis of toxinsequences and related body proteins. Genome Res, 2005, 15(3):403-420.
10.	Jacobsen B, Ploug M. The urokinase receptor and its structuralhomologue C4.4A in human cancer:expression, prognosis and pharmacologicalinhibition. Curr Med Chem, 2008, 15(25):2559-2573.
11.	Hansen LV, Gardsvoll H, Nielsen BS, et al. Structural analysis and tissue localization of human C4.4A:a protein homologue of the urokinase receptor. Biochem, 2004, 380(Pt 3):845-857.
12.	Hansen LV, Laerum OD, Illemann M, et al. Altered expression ofthe urokinase receptor homologue, C4.4A, in invasive areas of human esophagealsquamous cell carcinoma. Int J Cancer, 2008, 122(4):734-741.
13.	Kriegbaum MC, Jacobsen B, Hald A, et al. Expression of C4.4A, a structural uPARhomolog, reflects squamous epithelial differentiation in the adult mouse andduring embryogenesis. Histochem Cytochem, 2011, 59(2):188-201.
14.	Jacobsen B, Santoni-Rugiu E, Illemann M, et al. Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma. Int J Cancer, 2012, 130(11):2734-2739.
15.	Ohtsuka M, Yamamoto H, Masuzawa T, et al. C4.4A expression is associated with a poor prognosis of esophageal squamous cell carcinoma. Ann Surg Oncol, 2013, 20(8):2699-2705.
16.	Seiter S, Stassar M, Rappl G, et al. Upregulation of C4.4A expression duringprogression of melanoma. J Invest Dermatol, 2001, 116(2):344-347.
17.	Paret C, Hildebrand D, Weitz J, et al. C4.4A as a candidate marker in the diagnosis of colorectalcancer. Br J Cancer, 2007, 97(8):1146-1156.
18.	Smith BA, Kennedy WJ, Harnden P, et al. Identification of genes involved inhuman urothelial cell matrix interactions:implications for the progression pathways ofmalignant urothelium. Cancer Res, 2001, 61(4):1678-1685.
19.	Paret C, Bourouba M, Beer A, et al. Ly6 family member C4.4A binds laminins1 and 5, associates with galectin-3 and supports cell migration. Int J Cancer, 2005, 115(5):724-733.
20.	Frank DE, Carter WG. Laminin 5 deposition regulates keratinocyte polarizationand persistent migration. Cell Sci, 2004, 117(Pt 8):1351-1363.
21.	Masaki T, Matsuoka H, Sugiyama M, et al. Laminin-5 gamma2 chain expressionas a possible determinant of tumor aggressiveness in T1 colorectal carcinomas. Dig Dis Sci, 2003, 48(2):272-278.
22.	Hanahan D, Weinberg RA. Hallmarks of Cancer:The Next Generation. Cell, 2011, 144(5):646-674.
23.	Fries F, Nazarenko I, Hess J, et al. CEBP beta, JunD andc-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer, 2007, 120(10):213-214.
24.	Meir O, Dvash E, Werman A, et al. C/EBP-β regulates endoplasmic reticulum stress-triggered cell death in mouse and human models. PLoS One, 2010, 5(3):e9516.
25.	Staiger J, Lueben MJ, Berrigan D, et al. C/EBPβ regulates body composition, energy balance-related hormones and tumor growth. Carcinogenesis, 2009, 30(5):832-840.
26.	Kirstetter P, Schuster MB, Bereshchenko O, et al. Modeling of C/EBPα mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell, 2008, 13(4):299-310.
27.	Gu Y, Lin S, Li JL, et al. Altered LKB1/CREB-regulated transcription coactivator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. Oncogene, 2012, 31(4):469-479.
28.	Ji H, Ramsey MR, Hayes DN, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature, 2007, 448(7155):807-810.
29.	Gao Y, Ge G, Ji H. LKB1 in lung cancerigenesis:a serine/threonine kinase as tumor suppressor. Protein Cell, 2011, 2(2):99-107.
30.	Sanchez-Cespedes M, Parrella P, Esteller M, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res, 2002, 62(13):3659-3662.
31.	Sanchez-Cespedes M. The role of LKB1 in lung cancer. Fam Cancer, 2011, 10(3):447-453.
32.	Ghaffar H, Sahin F, Sanchez-Cepedes M, et al. LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res, 2003, 9(8): 2998-3003.
33.	Seiter S, Stassar M, Rappl G, et al. Upregulation of C4.4A expression during progression of melanoma. Invest Dermatol, 2001, 116(2):344-347.
34.	Paret C, Hildebrand D, Weitz J, et al. C4.4A as a candidate marker in the diagnosis of colorectal cancer. Br J Cancer, 2007, 97(8): 1146-1156.
35.	Jacobsen B, Muley T, Meister M, et al. Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma. J Thorac Oncol, 2013, 8(2): 152-160.
36.	Esselens CW, Malapeira J, Colomé N, et al. Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17, Biol Chem, 2008, 389(8): 1075-1084.
37.	Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/EuropeanRespiratory Society International Multidisciplinary Classification of LungAdenocarcinoma. Thorac Oncol, 2011, 6(2):244-285.
38.	Jacobsen B, Santoni-Rugiu E, Illemann M, et al. Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma. Int J Cancer, 2012, 130(11): 2734-2739.
39.	王竞, 韩瑞丽, 钟殿胜. LKB1 信号通路在非小细胞肺癌相关靶向治疗中的研究进展. 中国肺癌杂志, 2012, 15(7): 435-438.

1. Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin, 2014, 64(1):9-29.
2. 陈万青, 张思维, 邹小农. 中国肺癌发病死亡的估计和流行趋势研究. 中国肺癌杂志, 2010, 13(5):488-493.
3. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013.CA Cancer J Clin, 2013, 63(1):11-30.
4. Brundage MD, Davies D, Mackillop WJ. Prognostic factors in non-small cell lung cancer:a decade of progress. Chest, 2002, 122(3):1037-1057.
5. Jacobsen B, Muley T, Meister M, et al. Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma. Thorac Oncol, 2013, 8(2):152-160.
6. Rosel M, Claas C, Seiter S, et al. Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene, 1998, 17(15):1989-2002.
7. Galat A. The three-fingered protein domain of the human genome. Cell Mol Life Sci, 2008, 65(21):3481-3493.
8. Tlin V. Snake venom α-neurotoxins and other "three-finger" proteins. Eur J Biochem, 1999, 264(2):281-286.
9. Fry BG. From genome to "venome":molecular origin and evolutionof the snake venom proteome inferred from phylogenetic analysis of toxinsequences and related body proteins. Genome Res, 2005, 15(3):403-420.
10. Jacobsen B, Ploug M. The urokinase receptor and its structuralhomologue C4.4A in human cancer:expression, prognosis and pharmacologicalinhibition. Curr Med Chem, 2008, 15(25):2559-2573.
11. Hansen LV, Gardsvoll H, Nielsen BS, et al. Structural analysis and tissue localization of human C4.4A:a protein homologue of the urokinase receptor. Biochem, 2004, 380(Pt 3):845-857.
12. Hansen LV, Laerum OD, Illemann M, et al. Altered expression ofthe urokinase receptor homologue, C4.4A, in invasive areas of human esophagealsquamous cell carcinoma. Int J Cancer, 2008, 122(4):734-741.
13. Kriegbaum MC, Jacobsen B, Hald A, et al. Expression of C4.4A, a structural uPARhomolog, reflects squamous epithelial differentiation in the adult mouse andduring embryogenesis. Histochem Cytochem, 2011, 59(2):188-201.
14. Jacobsen B, Santoni-Rugiu E, Illemann M, et al. Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma. Int J Cancer, 2012, 130(11):2734-2739.
15. Ohtsuka M, Yamamoto H, Masuzawa T, et al. C4.4A expression is associated with a poor prognosis of esophageal squamous cell carcinoma. Ann Surg Oncol, 2013, 20(8):2699-2705.
16. Seiter S, Stassar M, Rappl G, et al. Upregulation of C4.4A expression duringprogression of melanoma. J Invest Dermatol, 2001, 116(2):344-347.
17. Paret C, Hildebrand D, Weitz J, et al. C4.4A as a candidate marker in the diagnosis of colorectalcancer. Br J Cancer, 2007, 97(8):1146-1156.
18. Smith BA, Kennedy WJ, Harnden P, et al. Identification of genes involved inhuman urothelial cell matrix interactions:implications for the progression pathways ofmalignant urothelium. Cancer Res, 2001, 61(4):1678-1685.
19. Paret C, Bourouba M, Beer A, et al. Ly6 family member C4.4A binds laminins1 and 5, associates with galectin-3 and supports cell migration. Int J Cancer, 2005, 115(5):724-733.
20. Frank DE, Carter WG. Laminin 5 deposition regulates keratinocyte polarizationand persistent migration. Cell Sci, 2004, 117(Pt 8):1351-1363.
21. Masaki T, Matsuoka H, Sugiyama M, et al. Laminin-5 gamma2 chain expressionas a possible determinant of tumor aggressiveness in T1 colorectal carcinomas. Dig Dis Sci, 2003, 48(2):272-278.
22. Hanahan D, Weinberg RA. Hallmarks of Cancer:The Next Generation. Cell, 2011, 144(5):646-674.
23. Fries F, Nazarenko I, Hess J, et al. CEBP beta, JunD andc-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer, 2007, 120(10):213-214.
24. Meir O, Dvash E, Werman A, et al. C/EBP-β regulates endoplasmic reticulum stress-triggered cell death in mouse and human models. PLoS One, 2010, 5(3):e9516.
25. Staiger J, Lueben MJ, Berrigan D, et al. C/EBPβ regulates body composition, energy balance-related hormones and tumor growth. Carcinogenesis, 2009, 30(5):832-840.
26. Kirstetter P, Schuster MB, Bereshchenko O, et al. Modeling of C/EBPα mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell, 2008, 13(4):299-310.
27. Gu Y, Lin S, Li JL, et al. Altered LKB1/CREB-regulated transcription coactivator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. Oncogene, 2012, 31(4):469-479.
28. Ji H, Ramsey MR, Hayes DN, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature, 2007, 448(7155):807-810.
29. Gao Y, Ge G, Ji H. LKB1 in lung cancerigenesis:a serine/threonine kinase as tumor suppressor. Protein Cell, 2011, 2(2):99-107.
30. Sanchez-Cespedes M, Parrella P, Esteller M, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res, 2002, 62(13):3659-3662.
31. Sanchez-Cespedes M. The role of LKB1 in lung cancer. Fam Cancer, 2011, 10(3):447-453.
32. Ghaffar H, Sahin F, Sanchez-Cepedes M, et al. LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res, 2003, 9(8): 2998-3003.
33. Seiter S, Stassar M, Rappl G, et al. Upregulation of C4.4A expression during progression of melanoma. Invest Dermatol, 2001, 116(2):344-347.
34. Paret C, Hildebrand D, Weitz J, et al. C4.4A as a candidate marker in the diagnosis of colorectal cancer. Br J Cancer, 2007, 97(8): 1146-1156.
35. Jacobsen B, Muley T, Meister M, et al. Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma. J Thorac Oncol, 2013, 8(2): 152-160.
36. Esselens CW, Malapeira J, Colomé N, et al. Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17, Biol Chem, 2008, 389(8): 1075-1084.
37. Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/EuropeanRespiratory Society International Multidisciplinary Classification of LungAdenocarcinoma. Thorac Oncol, 2011, 6(2):244-285.
38. Jacobsen B, Santoni-Rugiu E, Illemann M, et al. Expression of C4.4A in precursor lesions of pulmonary adenocarcinoma and squamous cell carcinoma. Int J Cancer, 2012, 130(11): 2734-2739.
39. 王竞, 韩瑞丽, 钟殿胜. LKB1 信号通路在非小细胞肺癌相关靶向治疗中的研究进展. 中国肺癌杂志, 2012, 15(7): 435-438.

Previous Article
Dynamic Changes of TNF-α in Isolated Rat Heart at Different Time Points afer Myocardial Hypoxia/Reoxygenation
Next Article
Te Progress of the Pulmonary Artiral Hypertension Treatment

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of C4.4A in Non-small Cell Lung Cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content