Diagnosis and Treatment of Lymphoepithelial-like Carcinoma_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANGYun ^1,2 , HUYang ² , SHENCheng ² , WANGXin ² , ZHOUSHENG-chuan ¹ ,  CHEGuo-wei ²

1. Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;
2. Xuanhan County People's Hospital, XuanHan 636150 Sichuan, P. R. China;

Corresponding author：

CHEGuo-wei, Email: cheguowei_hx@aliyun.com

Keywords：

Lymphoepithelial-like carcinoma; Surgical treatment; Prognosis

DOI：

10.7507/1007-4848.20160111

Video：

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Objective To investigate the validity of diagnosis and treatment for lymphoepithelial-like carcinoma (LELC). Methods We retrospectively analyzed the clinical data of 8 LELC patients underwent surgical treatment between January 2008 and December 2014 in our hospital. There were 4 males and 4 females at an average age of 57 years ranging from 48 to 67 years. There were 4 patients underwent thoracoscopic lobectomy and another 4 patients underwent ordinary open-chest lobectomy. Results In the patients underwent thoracoscopic lobectomy, the average operation time was 93.75 minutes and the average time of hospital stay was 4.5 days. In the patients underwent ordinary open-chest lobectomy group, the average operation time was 106.25 minutes and the average time of hospital stay was 5.25 days. All 8 patients discharged. One patient suffered from tumor matastasis in contralateral lung and another suffered from tumor matastasis in brain 1 year after operation. Conclusion The result of surgical treatment for lung LELC is satisfatory. For the patients who are not suitable for surgical treatment, we should consider the comprehensive treatment.

Citation： WANGYun, HUYang, SHENCheng, WANGXin, ZHOUSHENG-chuan, CHEGuo-wei. Diagnosis and Treatment of Lymphoepithelial-like Carcinoma. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(5): 472-475. doi: 10.7507/1007-4848.20160111 Copy

1.	Aoki R, Mitsui H, Harada K, et al. A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. J Am Acad Dermatol, 2010, 62(4):681-684.
2.	Wong JF, Teo MC. Case report:lymphoepithelial-like carcinoma of the lung——a chronic disease? World J Surg Oncol, 2012, 10:91.
3.	Higashiyama M, Doi O, Kodama K, et al. Lymphoepithelioma-like carcinoma of lungs:Analysis of 2 cases for Epstein-Barr virus infection. Human Pathol, 1995, 26(11):1278-1282.
4.	Pittaluga S, Wong MP, Chung LP, et al. Clonal epstein-barr virus in lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol, 1993, 17(7):678-682.
5.	黎庆梅,陈辉,庄碧英.实时荧光定量PCR在EB病毒DNA检测中的应用.国际检验医学杂志, 2011, 32(13):1423-1424.
6.	张冬坤,苏晓东,龙浩,等.原发性肺淋巴上皮瘤样癌的临床分析.中华肿瘤杂志, 2008, 30(1):72-74.
7.	Ho JC, Lam WK, Ooi GC, et al. Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis. Eur Respir J, 2003, 22(2):383-386.
8.	Hoxworth JM, Hanks DK, Araoz PA, et al. Lymphoepithelioma-like carcinoma of the lung:radiologic features of an uncommon primary pulmonary neoplasm. Am J Roentgenol, 2006, 186(5):1294-1299.
9.	Chan JK, Hui PK, Tsang WY, et al. Primary lymphoepithelioma-like carcinoma of the lung:a clinicopathologic study of 11 cases. Cancer, 1995, 76(3):413-422.
10.	Blasi MA, Ventura L, Laguardia M, et al. Lymphoepithelioma-like carcinoma involving the lacrimal gland and infiltrating the eyelids. Eur J Ophthalmol, 2010, 21(3):320-323.
11.	Ooi C, Ho M, Khong L, et al. Computed tomography characteristics of advanced primary pulmonary lympheepithelioma-like carcinoma. Eur Radio, 2003, 13(3):522-526.
12.	Cheng CS, Yeung WH, Kwok WK, et al. Lymphoepithelial-like Carcinoma of the Lung. J HK Coll Radiol, 2002, 5(5):47-49.
13.	Chan AT, Teo PM, Lam KC, et al. Multimodalitytreatment of primary lymphoepithelioma-like carcinomaofthelung. Cancer, 1998, 83(5):925-929.
14.	Han AJ, Xiong M, Gu YY, et al. Clinical pathologic features and progonosis of lymphoepithelioma-like carcinoma of the lung. Am J Clin Pathol, 2001, 30(5):328-331.
15.	Williamson SR, Zhang S, Lopez-Beltran A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder:clinicopathologic, immuno-histochemical, and molecular features. Am J Surg Pathol, 2011, 35(4):474-483.
16.	Chang YL, Wu CT, Shih JY, et al. New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas. Am J Surg Pathol, 2002, 26(6):715-723.
17.	Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
18.	Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
19.	Viklund P, Lindblad M, Lu M, et al. Risk factors for complications after esophageal cancer resection:A prospective population-based study in sweden. Ann Surg, 2006, 243(2):204-211.
20.	Yoon HH, Lewis MA, Shi Q, et al. Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma. J clin Oncol, 2011, 29(34):4561-4567.

1. Aoki R, Mitsui H, Harada K, et al. A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. J Am Acad Dermatol, 2010, 62(4):681-684.
2. Wong JF, Teo MC. Case report:lymphoepithelial-like carcinoma of the lung——a chronic disease? World J Surg Oncol, 2012, 10:91.
3. Higashiyama M, Doi O, Kodama K, et al. Lymphoepithelioma-like carcinoma of lungs:Analysis of 2 cases for Epstein-Barr virus infection. Human Pathol, 1995, 26(11):1278-1282.
4. Pittaluga S, Wong MP, Chung LP, et al. Clonal epstein-barr virus in lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol, 1993, 17(7):678-682.
5. 黎庆梅,陈辉,庄碧英.实时荧光定量PCR在EB病毒DNA检测中的应用.国际检验医学杂志, 2011, 32(13):1423-1424.
6. 张冬坤,苏晓东,龙浩,等.原发性肺淋巴上皮瘤样癌的临床分析.中华肿瘤杂志, 2008, 30(1):72-74.
7. Ho JC, Lam WK, Ooi GC, et al. Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis. Eur Respir J, 2003, 22(2):383-386.
8. Hoxworth JM, Hanks DK, Araoz PA, et al. Lymphoepithelioma-like carcinoma of the lung:radiologic features of an uncommon primary pulmonary neoplasm. Am J Roentgenol, 2006, 186(5):1294-1299.
9. Chan JK, Hui PK, Tsang WY, et al. Primary lymphoepithelioma-like carcinoma of the lung:a clinicopathologic study of 11 cases. Cancer, 1995, 76(3):413-422.
10. Blasi MA, Ventura L, Laguardia M, et al. Lymphoepithelioma-like carcinoma involving the lacrimal gland and infiltrating the eyelids. Eur J Ophthalmol, 2010, 21(3):320-323.
11. Ooi C, Ho M, Khong L, et al. Computed tomography characteristics of advanced primary pulmonary lympheepithelioma-like carcinoma. Eur Radio, 2003, 13(3):522-526.
12. Cheng CS, Yeung WH, Kwok WK, et al. Lymphoepithelial-like Carcinoma of the Lung. J HK Coll Radiol, 2002, 5(5):47-49.
13. Chan AT, Teo PM, Lam KC, et al. Multimodalitytreatment of primary lymphoepithelioma-like carcinomaofthelung. Cancer, 1998, 83(5):925-929.
14. Han AJ, Xiong M, Gu YY, et al. Clinical pathologic features and progonosis of lymphoepithelioma-like carcinoma of the lung. Am J Clin Pathol, 2001, 30(5):328-331.
15. Williamson SR, Zhang S, Lopez-Beltran A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder:clinicopathologic, immuno-histochemical, and molecular features. Am J Surg Pathol, 2011, 35(4):474-483.
16. Chang YL, Wu CT, Shih JY, et al. New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas. Am J Surg Pathol, 2002, 26(6):715-723.
17. Yang B, Ni YF, Wang WC, et al. Melatonin attenuates intestinal ischemia-reperfusion-induced lung injury in rats by upregulating N-myc downstream-regulated gene 2. J Surg Res, 2015, 194(1):273-280.
18. Lloyd MS, Wallis C, Muthialu N, et al. Treatment of postpneumone-ctomy syndrome with tissue expanders:the Great Ormond Street Hospital experience. J Plast Reconstr Aesthet Surg, 2014, 67(5):725-728.
19. Viklund P, Lindblad M, Lu M, et al. Risk factors for complications after esophageal cancer resection:A prospective population-based study in sweden. Ann Surg, 2006, 243(2):204-211.
20. Yoon HH, Lewis MA, Shi Q, et al. Prognostic impact of body mass index stratified by smoking status in patients with esophageal adenocarcinoma. J clin Oncol, 2011, 29(34):4561-4567.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Diagnosis and Treatment of Lymphoepithelial-like Carcinoma

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