Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 刘勇恩 , 马幸生

四川省遂宁市中心医院胸外科（四川遂宁 629000）;

Corresponding author：

刘勇恩, Email: 494988921@qq.com

Keywords：

微波消融; 周围性肺癌; CT 引导

DOI：

10.7507/1007-4848.201605017

Video：

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目的探索无法行手术及化放疗等治疗措施的原发性周围性肺癌患者行微波消融治疗的安全性及效果。方法我院 2013 年 12 月至 2015 年 11 月 39 例原发性肺癌患者（其中男 24 例、女 15 例，年龄 44～83 岁，中位年龄 67 岁）行微波消融治疗，肿瘤平均直径 3.5 cm。评价肿瘤局部疗效，随访时间 0.5～2.0 年。结果全组 39 例患者进行病灶消融后，病灶立即均质化，CT 值下降，供血终止，6 个月后病灶开始逐步缩小，瘢痕化。随访 39 例患者中有 3 例手术后生存 1.0～1.5 年因肿瘤全身广泛转移死亡；2 例患者手术后 6 个月复查增强 CT 见局部有少许血供予以再次消融；全组患者无 1 例严重并发症发生。结论微波消融对原发性小细胞肺癌患者的治疗效果佳、创伤小、手术风险小、安全性高。

Citation： 刘勇恩, 马幸生. Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(6): 488-490. doi: 10.7507/1007-4848.201605017 Copy

1.	Gillams AR. Image guided tumour ablation. Cancer Imaging, 2005, 5: 103-109.
2.	Goldberg SN, Gazelle GS, Compton CC, et al.Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer, 2000, 88(11): 2452-2463.
3.	Soto Parra H, Latteri F, Cavina R, et al. Treatment perspectives in advanced non-small cell lung cancer. Tumori, 2000, 86(1): S36-41.
4.	仲楼, 丁怀银, 曹飞, 等. CT 引导经皮穿刺微波消融治疗周围型肺癌 27 例临床分析. 海南医学, 2015, 7(26): 988-992.
5.	Fernarido HC, De Hoyos A, Landrenean RJ, et al. Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. J Thorac Cardiovasc Surg, 2005, 129(3): 639-644.
6.	支修益. 中国原发性肺癌诊疗规范. 中华肿瘤杂志, 2015, 37(1): 67-78.
7.	支修益, 刘宝东. 肺癌射频消融的治疗现状与进展. 中华临床肺癌杂志(电子版), 2009, 3(11): 1771-1778.
8.	卢强, 李小飞, 韩勇. 微波消融治疗肺部恶性肿瘤的临床疗效分析. 中国医药, 2012, 7(5): 557-559.
9.	郭亚, 孙亚红, 宋鹏远, 等. CT 引导经皮穿刺微波消融肺部恶性肿瘤的临床观察. 临床肿瘤学杂志, 2013, 18(7): 640-643.
10.	Wolf FJ, Aswad B, Ng T, et al. Intraoperative microwave ablation of pulmonary malignancies with tumor permittivity feedback control: ablation and resection study in 10 consecutive patients. Radiology, 2012, 262(1): 353-360.
11.	Schneider T, Heussel CP, Herth FJ, et al. Thermal ablation of malignant lung tumors. Dtsch Arztebl Int, 2013, 110(22): 394-400.
12.	郭晨阳, 胡鸿涛, 李海亮. CT 引导经皮穿刺微波治疗周围型肺癌. 当代医学, 2009, 15(35): 674-676.
13.	Lencioni R, Crocetti I, Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat. multicentre clinical trial(the RAPTURE study).Lancet Oncol, 2008, 9(7): 621-628.
14.	Abbas G, Pennathur A, Landreneau RJ, et al. Radiofrequency and microwave ablation of lung tumors. J Surg Oncol, 2009, 100(8): 645-650.
15.	Wright AS, Sampson LA, Warner TF, et al. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 2005, 236(1): 132-139.
16.	李京华, 崔石昌, 孙健, 等. 原发性肝癌患者 CT 引导下经皮微波消融术肿瘤位置与疼痛程度的关系. 临床肝胆病杂志, 2015, 31(C6): 903-906.
17.	Dupuy De, DiPetrillo T, Gandhi S, et al. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage 1 non-small cell lung cancer. Chest, 2006, 129(3): 738-745.
18.	Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol, 2009, 20(7 Suppl): S377-S390.
19.	Lu Q, Cao W, Huang L, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases. World J Surg Oncol, 2012, 10: 80.
20.	Vogl TJ, Naguib NN, Gruber-Rouh T, et al. MicrowaVe ablation therapy: clinical utility in treatment of pulmonary metastases.Rdiology, 2011, 261(2): 643-651.

1. Gillams AR. Image guided tumour ablation. Cancer Imaging, 2005, 5: 103-109.
2. Goldberg SN, Gazelle GS, Compton CC, et al.Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer, 2000, 88(11): 2452-2463.
3. Soto Parra H, Latteri F, Cavina R, et al. Treatment perspectives in advanced non-small cell lung cancer. Tumori, 2000, 86(1): S36-41.
4. 仲楼, 丁怀银, 曹飞, 等. CT 引导经皮穿刺微波消融治疗周围型肺癌 27 例临床分析. 海南医学, 2015, 7(26): 988-992.
5. Fernarido HC, De Hoyos A, Landrenean RJ, et al. Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. J Thorac Cardiovasc Surg, 2005, 129(3): 639-644.
6. 支修益. 中国原发性肺癌诊疗规范. 中华肿瘤杂志, 2015, 37(1): 67-78.
7. 支修益, 刘宝东. 肺癌射频消融的治疗现状与进展. 中华临床肺癌杂志(电子版), 2009, 3(11): 1771-1778.
8. 卢强, 李小飞, 韩勇. 微波消融治疗肺部恶性肿瘤的临床疗效分析. 中国医药, 2012, 7(5): 557-559.
9. 郭亚, 孙亚红, 宋鹏远, 等. CT 引导经皮穿刺微波消融肺部恶性肿瘤的临床观察. 临床肿瘤学杂志, 2013, 18(7): 640-643.
10. Wolf FJ, Aswad B, Ng T, et al. Intraoperative microwave ablation of pulmonary malignancies with tumor permittivity feedback control: ablation and resection study in 10 consecutive patients. Radiology, 2012, 262(1): 353-360.
11. Schneider T, Heussel CP, Herth FJ, et al. Thermal ablation of malignant lung tumors. Dtsch Arztebl Int, 2013, 110(22): 394-400.
12. 郭晨阳, 胡鸿涛, 李海亮. CT 引导经皮穿刺微波治疗周围型肺癌. 当代医学, 2009, 15(35): 674-676.
13. Lencioni R, Crocetti I, Cioni R, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat. multicentre clinical trial(the RAPTURE study).Lancet Oncol, 2008, 9(7): 621-628.
14. Abbas G, Pennathur A, Landreneau RJ, et al. Radiofrequency and microwave ablation of lung tumors. J Surg Oncol, 2009, 100(8): 645-650.
15. Wright AS, Sampson LA, Warner TF, et al. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology, 2005, 236(1): 132-139.
16. 李京华, 崔石昌, 孙健, 等. 原发性肝癌患者 CT 引导下经皮微波消融术肿瘤位置与疼痛程度的关系. 临床肝胆病杂志, 2015, 31(C6): 903-906.
17. Dupuy De, DiPetrillo T, Gandhi S, et al. Radiofrequency ablation followed by conventional radiotherapy for medically inoperable stage 1 non-small cell lung cancer. Chest, 2006, 129(3): 738-745.
18. Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol, 2009, 20(7 Suppl): S377-S390.
19. Lu Q, Cao W, Huang L, et al. CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases. World J Surg Oncol, 2012, 10: 80.
20. Vogl TJ, Naguib NN, Gruber-Rouh T, et al. MicrowaVe ablation therapy: clinical utility in treatment of pulmonary metastases.Rdiology, 2011, 261(2): 643-651.

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Clinical analysis of CT-guided percutaneous microwave ablation therapy for 39 patients with primary lung cancer

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