Podoplanin expression and clinical prognosis of patients with esophageal squamous cell carcinoma: A retrospective cohort study_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

GUO Hai ¹ , YUAN Yang ² , QIN Sheng ³ , HUANG Jianming ³ , XIAO Bo ³ , FANG Qiang ³ ,  REN Guangguo ³

1. Graduate School of Guangxi Medical University, Nanning, 530021, P.R.China;
2. Intensive Care Unit, First People’s Hospital of Chengdu, Chengdu, 630041, P.R.China;
3. Department of Thoracic Surgery, Sichuan Provincial Cancer Hospital, Chengdu, 630041, P.R.China;

Corresponding author：

REN Guangguo, Email: rengg2091@163.com

Keywords：

Esophagus squamous cancer; vascular tumor embolus; Podoplanin; disease-free survival

DOI：

10.7507/1007-4848.201608039

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the Podoplanin expression in patients with esophageal squamous cell carcinoma and to find out the relationship between Podoplanin expression and tumor embolus, lymph node metastasis, tumor differentiation as well as prognosis, and to provide clinical evidence for reducing the recurrence of esophageal squamous cell carcinoma and prolonging the disease-free survival and overall survival. Methods A retrospective analysis of 70 patients with esophageal squamous cell carcinoma in our hospital from June 2010 to June 2012 was conducted, including 39 males and 31 females, with a mean age of 63.6 years. Positive diagnosis of tumor thrombus was achieved in 35 patients and negative in 35 patients. Postoperative pathological specimens were examined and normal esophageal tissues (esophageal tissue more than 5 cm from the edge of the tumor) of patients were excised as a control group. Results The positive rate of Podoplanin was 34.2% in normal esophageal tissues and 62.8% in tumor tissues. The positive rate of Podoplanin expression was 77.1% and 48.6% in esophageal squamous cell carcinoma patients with or without tumor embolus, respectively. The positive rate of Podoplanin expression in tumor cells of patients with positive and negative lymph node metastasis was 71.9% and 23.1%, respectively (P<0.05). The mean disease-free survival of patients with Podoplanin expression-negative esophageal squamous cell carcinoma was 15.2 months, which was significantly longer than that of patients with Podoplanin expression-positive esophageal squamous cell carcinoma (P<0.05). Conclusion Podoplanin expression in the tumor cells and vessels can be an important reference index to the prognosis of patients with esophageal squamous cell carcinoma.

Citation： GUO Hai, YUAN Yang, QIN Sheng, HUANG Jianming, XIAO Bo, FANG Qiang, REN Guangguo. Podoplanin expression and clinical prognosis of patients with esophageal squamous cell carcinoma: A retrospective cohort study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2018, 25(2): 148-152. doi: 10.7507/1007-4848.201608039 Copy

1.	Chen MQ, Xu BH, Zhang YY. Analysis of prognostic factors for esophageal squamous cell carcinoma with distant organ metastasis at initial diagnosis. J Chin Med Assoc, 2014, 77(11): 562-566.
2.	Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol (Berl), 1995, 191(5): 381-396.
3.	Wang YD, Wu P, Mao JD, et al. Relationship between vascular invasion and microvessel density and micrometastasis. World J Gastroenterol, 2007, 13(46): 6269-6273.
4.	Saharinen P, Eklund L, Pulkki K, et al. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med, 2011, 17(7): 347-362.
5.	Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol, 1999, 154(2): 385-394.
6.	Zhang HL, Chen LQ, Liu RL. The number of lymph node metastases influences survival and International Union Against Cancer tumor-node-metastas is classification for esophageal squamous cell carcinoma. Dis Esophagus, 2010, 23(1): 53-58.
7.	Chuang WY, Yeh CJ, Wu YC, et al. Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma. Histol Histopathol, 2009, 24(8): 1021-1027.
8.	Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer, 2007, 96(1): 1-5.
9.	Yuan P, Temam S, El-Naggar A, et al. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer, 2006, 107(3): 563-569.
10.	Martín-Villar E, Megías D, Castel S, et al. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci, 2006, 119(Pt 21): 4541-4553.
11.	Kato Y, Fujita N, Kunita A, et al. Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem, 2003, 278(51): 51599-51605.
12.	Wicki A, Lehembre F, Wick N, et al. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell, 2006, 9(4): 261-272.
13.	Noble S, Pasi J. Epidemiology and pathophysiology of cancer-associated thrombosis. Br J Cancer, 2010, 102 Suppl 1: S2-S9.
14.	Nakayama Y, Matsumoto K, Nagato M, et al. Significance of lymphangiogenesis as assessed by immunohistochemistry for podoplanin in patients with esophageal carcinoma. Anticancer Res, 2007, 27(1B): 619-625.

1. Chen MQ, Xu BH, Zhang YY. Analysis of prognostic factors for esophageal squamous cell carcinoma with distant organ metastasis at initial diagnosis. J Chin Med Assoc, 2014, 77(11): 562-566.
2. Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol (Berl), 1995, 191(5): 381-396.
3. Wang YD, Wu P, Mao JD, et al. Relationship between vascular invasion and microvessel density and micrometastasis. World J Gastroenterol, 2007, 13(46): 6269-6273.
4. Saharinen P, Eklund L, Pulkki K, et al. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med, 2011, 17(7): 347-362.
5. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol, 1999, 154(2): 385-394.
6. Zhang HL, Chen LQ, Liu RL. The number of lymph node metastases influences survival and International Union Against Cancer tumor-node-metastas is classification for esophageal squamous cell carcinoma. Dis Esophagus, 2010, 23(1): 53-58.
7. Chuang WY, Yeh CJ, Wu YC, et al. Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma. Histol Histopathol, 2009, 24(8): 1021-1027.
8. Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer, 2007, 96(1): 1-5.
9. Yuan P, Temam S, El-Naggar A, et al. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer, 2006, 107(3): 563-569.
10. Martín-Villar E, Megías D, Castel S, et al. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci, 2006, 119(Pt 21): 4541-4553.
11. Kato Y, Fujita N, Kunita A, et al. Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem, 2003, 278(51): 51599-51605.
12. Wicki A, Lehembre F, Wick N, et al. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell, 2006, 9(4): 261-272.
13. Noble S, Pasi J. Epidemiology and pathophysiology of cancer-associated thrombosis. Br J Cancer, 2010, 102 Suppl 1: S2-S9.
14. Nakayama Y, Matsumoto K, Nagato M, et al. Significance of lymphangiogenesis as assessed by immunohistochemistry for podoplanin in patients with esophageal carcinoma. Anticancer Res, 2007, 27(1B): 619-625.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Podoplanin expression and clinical prognosis of patients with esophageal squamous cell carcinoma: A retrospective cohort study

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content