Change of Th17 cells, Treg cells and their related cytokines in patients with postoperative atrial fibrillation after coronary artery bypass graft_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HE Yi ,  MEI Ju , TANG Min , LIU Hao , JIANG Zhaolei

Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, P.R.China;

Corresponding author：

MEI Ju, Email: ju_mei63@126.com

Keywords：

Coronary artery bypass graft; atrial fibrillation; T helpers 17 cells; regulatory T cells

DOI：

10.7507/1007-4848.201609009

Video：

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Objective To investigate the influence of T helpers 17 (Th17) cells, regulatory T (Treg) cells and their related cytokines on postoperative atrial fibrillation (POAF) after coronary artery bypass graft (CABG). Methods A total of 132 consecutive patients undergoing CABG between May 2013 and July 2016 were recruited. There were 82 males and 50 females with the age ranging from 39-76 years. Venous blood samples were collected within 2 hours after surgery. The expression of Th17 cells, Treg cells and their related cytokines in the peripheral blood was determined. Results POAF occurred in 35 patients (a POAF group) and 97 patients did not develop POAF (a No POAF group). Compared to the No POAF group, the proportion of Th17 cells and Th17/Treg ratio in the peripheral blood significantly increased in the POAF group (P>0.05) while proportion of Treg cells remained no significant change (P>0.05). The expression of Th17-related cytokines (IL-6, IL-8 and IL-17) all obviously increased in the POAF group (P>0.05). However, no significant difference was found in the expression of Treg-related cytokines (IL-10 and TGF-β) between the two groups (P>0.05). Conclusion Th17/Treg is unbanlanced in POAF patients and regulation of this imbalance may decrease the occurrence of POAF.

Citation： HE Yi, MEI Ju, TANG Min, LIU Hao, JIANG Zhaolei. Change of Th17 cells, Treg cells and their related cytokines in patients with postoperative atrial fibrillation after coronary artery bypass graft. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(8): 598-601. doi: 10.7507/1007-4848.201609009 Copy

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2.	Maisel WH, Rawn JD, Stevenson WG, et al. Atrial fibrillation after cardiac surgery. Ann Intern Med, 2001, 135(12): 1061-1073.
3.	Hagiwara N. Inflammation and atrial fibrillation. Circ J, 2010, 74(2): 246-247.
4.	Hirota K, Martin B, Veldhoen M, et al. Development, regulation and functional capacities of Th17 cells. Semin Immunopathol, 2010, 32(1): 3-16.
5.	Lee YK, Mukasa R, Hatton RD, et al. Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol, 2009, 21(3): 274-280.
6.	Sun X, Boyce SW, Hill PC, et al. Association of body mass index with new-onset atrial fibrillation after coronary artery bypass grafting operations. Ann Thorac Surg, 2011, 91(6): 1852-1858.
7.	Almassi GH, Schowalter T, Nicolosi AC, et al. Atrial fibrillation after cardiac surgery: a major morbid event? Ann Surg, 1997, 226(4): 501-511.
8.	Hakala T, Hedman A, Turpeinen A, et al. Prediction of atrial fibrillation after coronary artery bypass grafting by measuring atrial peptide levels and preoperative atrial dimensions. Eur J Cardiothorac Surg, 2002, 22(6): 939-943.
9.	Maesen B, Nijs J, Maessen J, et al. Post-operative atrial fibrillation: a maze of mechanisms. Europace, 2012, 14(2): 159-174.
10.	Girerd N, Pibarot P, Fournier D, et al. Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery. Eur Heart J, 2009, 30(10): 1270-1278.
11.	Hak L, Mysliwska J, Wieckiewicz J, et al. Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG). J Interferon Cytokine Res, 2009, 29(6): 327-332.
12.	Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev, 2014, 13(6): 668-677.
13.	Meng X, Yang J, Dong M, et al. Regulatory T cells in cardiovascular diseases. Nat Rev Cardiol, 2016, 13(3): 167-179.
14.	Yang XO, Nurieva R, Martinez GL, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity, 2008, 29(1): 44-56.
15.	Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev, 2013, 252(1): 52-77.
16.	Fu XX, Zhao N, Dong Q, et al. Interleukin-17A contributes to the development of post-operative atrial fibrillation by regulating inflammation and fibrosis in rats with sterile pericarditis. Int J Mol Med, 2015, 36(1): 83-92.

1. Kaireviciute D, Aidietis A, Gregory YH, et al. Atrial fibrillation following cardiac surgery: clinical features and preventative strategies. Eur Heart J, 2009, 30(4): 410-425.
2. Maisel WH, Rawn JD, Stevenson WG, et al. Atrial fibrillation after cardiac surgery. Ann Intern Med, 2001, 135(12): 1061-1073.
3. Hagiwara N. Inflammation and atrial fibrillation. Circ J, 2010, 74(2): 246-247.
4. Hirota K, Martin B, Veldhoen M, et al. Development, regulation and functional capacities of Th17 cells. Semin Immunopathol, 2010, 32(1): 3-16.
5. Lee YK, Mukasa R, Hatton RD, et al. Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol, 2009, 21(3): 274-280.
6. Sun X, Boyce SW, Hill PC, et al. Association of body mass index with new-onset atrial fibrillation after coronary artery bypass grafting operations. Ann Thorac Surg, 2011, 91(6): 1852-1858.
7. Almassi GH, Schowalter T, Nicolosi AC, et al. Atrial fibrillation after cardiac surgery: a major morbid event? Ann Surg, 1997, 226(4): 501-511.
8. Hakala T, Hedman A, Turpeinen A, et al. Prediction of atrial fibrillation after coronary artery bypass grafting by measuring atrial peptide levels and preoperative atrial dimensions. Eur J Cardiothorac Surg, 2002, 22(6): 939-943.
9. Maesen B, Nijs J, Maessen J, et al. Post-operative atrial fibrillation: a maze of mechanisms. Europace, 2012, 14(2): 159-174.
10. Girerd N, Pibarot P, Fournier D, et al. Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery. Eur Heart J, 2009, 30(10): 1270-1278.
11. Hak L, Mysliwska J, Wieckiewicz J, et al. Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG). J Interferon Cytokine Res, 2009, 29(6): 327-332.
12. Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev, 2014, 13(6): 668-677.
13. Meng X, Yang J, Dong M, et al. Regulatory T cells in cardiovascular diseases. Nat Rev Cardiol, 2016, 13(3): 167-179.
14. Yang XO, Nurieva R, Martinez GL, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity, 2008, 29(1): 44-56.
15. Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev, 2013, 252(1): 52-77.
16. Fu XX, Zhao N, Dong Q, et al. Interleukin-17A contributes to the development of post-operative atrial fibrillation by regulating inflammation and fibrosis in rats with sterile pericarditis. Int J Mol Med, 2015, 36(1): 83-92.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Change of Th17 cells, Treg cells and their related cytokines in patients with postoperative atrial fibrillation after coronary artery bypass graft

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