Clinical application of positron emission tomography/computed tomography in detecting hibernating myocardium_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIU Donghui ,  LIU Hongyu

Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, P.R.China;

Corresponding author：

LIU Hongyu, Email: hyliu1963@163.com

Keywords：

Positron emission tomography/computed tomography; hibernating myocardium; revascularization therapy

DOI：

10.7507/1007-4848.201811060

Video：

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With the in-depth study of the pathophysiological changes of ischemic myocardium, some experimental studies have found that in many patients with coronary heart disease, severe lesions and long duration of diseases which do not recover due to revascularization, are mainly related to the viable myocardium in the affected area. Survival myocardium refers to those perfusion defect-induced dysfunctional but not dead cardiomyocytes, including stunned myocardium and hibernating myocardium. Therefore, accurate assessment of viable myocardium is important for the development of clinical treatment options and prognosis assessment of such patients. Positron emission tomography/computed tomography (PET/CT) can evaluate the survival of hibernating myocardium and quantitatively analyze it. Thus PET/CT can provide useful information for the possibility of myocardial function recovery after revascularization, treatment options and prognosis evaluation.

Citation： LIU Donghui, LIU Hongyu. Clinical application of positron emission tomography/computed tomography in detecting hibernating myocardium. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(9): 916-919. doi: 10.7507/1007-4848.201811060 Copy

1.	Rees G, Bristow JD, Kremkau EL, et al. Influence of aortocoronary bypass surgery on left ventricular performance. N Engl J Med, 1971, 284(20): 1116-1120.
2.	Sarikaya I. Cardiac applications of PET. Nucl Med Commun, 2015, 36(10): 971-985.
3.	Baker JE, Su J, Hsu A, et al. Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. Cardiovasc Res, 2008, 77(1): 44-53.
4.	Høyer C, Aagaard SR, Pedersen TF, et al. Apical myocardial stunning in a large size porcine model assessed by strain and strain rate echocardiography. Echocardiography, 2007, 24(9): 923-932.
5.	Mollerus M, Naslund L. Myocardial stunning following defibrillation threshold testing. J Interv Card Electrophysiol, 2007, 19(3): 213-216.
6.	Brendt P, Behrends M, Peters J. Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. Resuscitation, 2008, 76(1): 95-102.
7.	Parasher PS, Daher IN. Myocardial recovery after hypoxia: stunning recovery. Echocardiography, 2008, 25(9): 1011-1013.
8.	Mahmoud H, Forni LG, McIntyre CW, et al. Myocardial stunning occurs during intermittent haemodialysis for acute kidney injury. Intensive Care Med, 2017, 43(6): 942-944.
9.	颜姝. 心肌顿抑的防治机制新进展. 中国动脉硬化杂志, 2013, 21(12): 1149-1152.
10.	胡旭东. 心肌顿抑和冬眠的临床意义及机制. 中华内科杂志, 1996, 35(6): 7.
11.	刘金来, 张书刚. 冬眠心肌检测方法的评价. 国际内科学杂志, 2000, 27(1): 25-27.
12.	任臻, 钟栩. 心肌细胞能量代谢障碍及药物治疗研究进展. 中医临床研究, 2016, 8(35): 51-54.
13.	宋涛, 李臣文, 赵文秀, 等. 心肌缺血的能量代谢及代谢药物治疗. 实用心脑肺血管病杂志, 2006, 14(10): 766-768.
14.	Wong CY, Tatini VR, Bis K. Combined CT-PET criteria for myocardial viability and scar: a preliminary report. Int J Cardiovasc Imaging, 2004, 20(6): 487-491.
15.	Schinkel AF, Bax JJ, Poldermans D, et al. Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol, 2007, 32(7): 375-410.
16.	胡红波, 邵高峰, 丘志芬. 一种PET/CT呼吸门控系统的设计. 医疗卫生装备, 2016, 37(2): 29-31.
17.	Brunken RC, Mody FV, Hawkins RA, et al. Persistent twenty-four hour SPECT thallium-201 defects, plasma thallium-201 concentrations and PET metabolic viability. Herz, 1994, 19(1): 28-41.
18.	Patterson RE, Sigman SR, O'Donnell RE, et al. Viability assessment with MRI is superior to FDG-PET for viability: Con. J Nucl Cardiol, 2010, 17(2): 298-309.
19.	Yoshida K, Gould KL. Quantitative relation of myocardial infarct size and myocardial viability by positron emission tomography to left ventricular ejection fraction and 3-year mortality with and without revascularization. J Am Coll Cardiol, 1993, 22(4): 984-997.
20.	Tian M, Koyama K, Zhang H, et al. Assessment of myocardial viability with a positron coincidence gamma camera using fluorodeoxyglucose in comparison with dedicated PET. Nucl Med Commun, 2003, 24(4): 367-374.
21.	Allman KC, Shaw LJ, Hachamovitch R, et al. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol, 2002, 39(7): 1151-1158.
22.	Beanlands RS, Nichol G, Huszti E, et al. F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2). J Am Coll Cardiol, 2007, 50(20): 2002-2012.
23.	Abraham A, Nichol G, Williams KA, et al. 18F-FDG PET imaging of myocardial viability in an experienced center with access to 18F-FDG and integration with clinical management teams: the Ottawa-FIVE substudy of the PARR 2 trial. J Nucl Med, 2010, 51(4): 567-574.
24.	D'Egidio G, Nichol G, Williams KA, et al. Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 trial. JACC Cardiovasc Imaging, 2009, 2(9): 1060-1068.
25.	Ling LF, Marwick TH, Flores DR, et al. Identification of therapeutic benefit from revascularization in patients with left ventricular systolic dysfunction: inducible ischemia versus hibernating myocardium. Circ Cardiovasc Imaging, 2013, 6(3): 363-372.
26.	孙茉茉, 李剑明, 等. 冠状动脉旁路移植术前13N-NH3/18f-FDGPET显像检测冬眠心肌的临床研究. 中国医学影像技术, 2018, 34(7): 1003-1008.
27.	任少阳, 侯先存, 周青, 等. 双核素心肌灌注-代谢显像评价存活心肌对心肌梗死患者择期血运重建术后左心功能的影响. 中华核医学杂志, 2011, 31(3): 169-173.
28.	Partington SL, Kwong RY, Dorbala S. Multimodality imaging in the assessment of myocardial viability. Heart Fail Rev, 2011, 16(4): 381-395.
29.	Perrone-Filardi P, Pinto FJ. Looking for myocardial viability after a STICH trial: not enough to close the door. J Nucl Med, 2012, 53(3): 349-352.
30.	Bonow RO, Maurer G, Lee KL, et al. Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med, 2011, 364(17): 1617-1625.
31.	Schinkel AF, Poldermans D, Vanoverschelde JL, et al. Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction. Am J Cardiol, 2004, 93(1): 14-17.
32.	Inaba Y, Chen JA, Bergmann SR. Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: A meta-analysis. J Nucl Cardiol, 2010, 17(4): 646-654.
33.	Desideri A, Cortigiani L, Christen AI, et al. The extent of perfusion-F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left ventricular dysfunction. J Am Coll Cardiol, 2005, 46(7): 1264-1269.
34.	李东野. 存活心肌检测对冠心病血运重建治疗决策的影响. 中华临床医师杂志(电子版), 2009, 3(7): 1094-1099.

1. Rees G, Bristow JD, Kremkau EL, et al. Influence of aortocoronary bypass surgery on left ventricular performance. N Engl J Med, 1971, 284(20): 1116-1120.
2. Sarikaya I. Cardiac applications of PET. Nucl Med Commun, 2015, 36(10): 971-985.
3. Baker JE, Su J, Hsu A, et al. Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. Cardiovasc Res, 2008, 77(1): 44-53.
4. Høyer C, Aagaard SR, Pedersen TF, et al. Apical myocardial stunning in a large size porcine model assessed by strain and strain rate echocardiography. Echocardiography, 2007, 24(9): 923-932.
5. Mollerus M, Naslund L. Myocardial stunning following defibrillation threshold testing. J Interv Card Electrophysiol, 2007, 19(3): 213-216.
6. Brendt P, Behrends M, Peters J. Myocardial stunning following no flow ischaemia is diminished by levosimendan or cariporide, without benefits of combined administration. Resuscitation, 2008, 76(1): 95-102.
7. Parasher PS, Daher IN. Myocardial recovery after hypoxia: stunning recovery. Echocardiography, 2008, 25(9): 1011-1013.
8. Mahmoud H, Forni LG, McIntyre CW, et al. Myocardial stunning occurs during intermittent haemodialysis for acute kidney injury. Intensive Care Med, 2017, 43(6): 942-944.
9. 颜姝. 心肌顿抑的防治机制新进展. 中国动脉硬化杂志, 2013, 21(12): 1149-1152.
10. 胡旭东. 心肌顿抑和冬眠的临床意义及机制. 中华内科杂志, 1996, 35(6): 7.
11. 刘金来, 张书刚. 冬眠心肌检测方法的评价. 国际内科学杂志, 2000, 27(1): 25-27.
12. 任臻, 钟栩. 心肌细胞能量代谢障碍及药物治疗研究进展. 中医临床研究, 2016, 8(35): 51-54.
13. 宋涛, 李臣文, 赵文秀, 等. 心肌缺血的能量代谢及代谢药物治疗. 实用心脑肺血管病杂志, 2006, 14(10): 766-768.
14. Wong CY, Tatini VR, Bis K. Combined CT-PET criteria for myocardial viability and scar: a preliminary report. Int J Cardiovasc Imaging, 2004, 20(6): 487-491.
15. Schinkel AF, Bax JJ, Poldermans D, et al. Hibernating myocardium: diagnosis and patient outcomes. Curr Probl Cardiol, 2007, 32(7): 375-410.
16. 胡红波, 邵高峰, 丘志芬. 一种PET/CT呼吸门控系统的设计. 医疗卫生装备, 2016, 37(2): 29-31.
17. Brunken RC, Mody FV, Hawkins RA, et al. Persistent twenty-four hour SPECT thallium-201 defects, plasma thallium-201 concentrations and PET metabolic viability. Herz, 1994, 19(1): 28-41.
18. Patterson RE, Sigman SR, O'Donnell RE, et al. Viability assessment with MRI is superior to FDG-PET for viability: Con. J Nucl Cardiol, 2010, 17(2): 298-309.
19. Yoshida K, Gould KL. Quantitative relation of myocardial infarct size and myocardial viability by positron emission tomography to left ventricular ejection fraction and 3-year mortality with and without revascularization. J Am Coll Cardiol, 1993, 22(4): 984-997.
20. Tian M, Koyama K, Zhang H, et al. Assessment of myocardial viability with a positron coincidence gamma camera using fluorodeoxyglucose in comparison with dedicated PET. Nucl Med Commun, 2003, 24(4): 367-374.
21. Allman KC, Shaw LJ, Hachamovitch R, et al. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. J Am Coll Cardiol, 2002, 39(7): 1151-1158.
22. Beanlands RS, Nichol G, Huszti E, et al. F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2). J Am Coll Cardiol, 2007, 50(20): 2002-2012.
23. Abraham A, Nichol G, Williams KA, et al. 18F-FDG PET imaging of myocardial viability in an experienced center with access to 18F-FDG and integration with clinical management teams: the Ottawa-FIVE substudy of the PARR 2 trial. J Nucl Med, 2010, 51(4): 567-574.
24. D'Egidio G, Nichol G, Williams KA, et al. Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: a substudy of the PARR-2 trial. JACC Cardiovasc Imaging, 2009, 2(9): 1060-1068.
25. Ling LF, Marwick TH, Flores DR, et al. Identification of therapeutic benefit from revascularization in patients with left ventricular systolic dysfunction: inducible ischemia versus hibernating myocardium. Circ Cardiovasc Imaging, 2013, 6(3): 363-372.
26. 孙茉茉, 李剑明, 等. 冠状动脉旁路移植术前13N-NH3/18f-FDGPET显像检测冬眠心肌的临床研究. 中国医学影像技术, 2018, 34(7): 1003-1008.
27. 任少阳, 侯先存, 周青, 等. 双核素心肌灌注-代谢显像评价存活心肌对心肌梗死患者择期血运重建术后左心功能的影响. 中华核医学杂志, 2011, 31(3): 169-173.
28. Partington SL, Kwong RY, Dorbala S. Multimodality imaging in the assessment of myocardial viability. Heart Fail Rev, 2011, 16(4): 381-395.
29. Perrone-Filardi P, Pinto FJ. Looking for myocardial viability after a STICH trial: not enough to close the door. J Nucl Med, 2012, 53(3): 349-352.
30. Bonow RO, Maurer G, Lee KL, et al. Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med, 2011, 364(17): 1617-1625.
31. Schinkel AF, Poldermans D, Vanoverschelde JL, et al. Incidence of recovery of contractile function following revascularization in patients with ischemic left ventricular dysfunction. Am J Cardiol, 2004, 93(1): 14-17.
32. Inaba Y, Chen JA, Bergmann SR. Quantity of viable myocardium required to improve survival with revascularization in patients with ischemic cardiomyopathy: A meta-analysis. J Nucl Cardiol, 2010, 17(4): 646-654.
33. Desideri A, Cortigiani L, Christen AI, et al. The extent of perfusion-F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left ventricular dysfunction. J Am Coll Cardiol, 2005, 46(7): 1264-1269.
34. 李东野. 存活心肌检测对冠心病血运重建治疗决策的影响. 中华临床医师杂志(电子版), 2009, 3(7): 1094-1099.

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