Predictive value of inflammation-based Glasgow prognostic score for the prognosis in patients with ST-segment elevation myocardial infarction_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YUAN Jianying ^1,2,3 , CHENG Yisong ^1,2,4 , JIA Yu ^1,2 , LI Dongze ^1,2 , LIU Hong ⁴ , LI Fanghui ⁴ , ZENG Rui ⁴ , LIAO Xiaoyang ⁵ , WAN Zhi ^1,2 , CAO Yu ^1,2 ,  ZENG Zhi ⁴

1. Department of Emergency Medicine, Emergency Medical Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. Disaster Medical Center, Sichuan University, Chengdu, 610041, P.R.China;
3. Department of Emergency and Trauma Nursing,West China Nursing School, Sichuan University, Chengdu, 610041, P.R.China;
4. Department of Cardiology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
5. Department of General Practice, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

ZENG Zhi, Email: zengzhi2013@qq.com

Keywords：

Glasgow prognostic score; ST-segment elevation myocardial infarction; prognosis prediction

DOI：

10.7507/1007-4848.201907058

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Objective To analyze prognostic ability of inflammation-based Glasgow prognostic score (GPS) in patients with ST-segment elevation myocardial infarction (STEMI).Methods We retrospectively analyzed the clinical data of 289 patients with STEMI admitted to the Department of Emergency in West China Hospital from April 2015 to January 2016. All study subjects were divided into three groups: a group of GPS 0 (190 patients including 150 males and 40 females aged 62.63±12.98 years), a group of GPS 1 (78 patients including 58 males and 20 females aged 66.57±15.25 years), and a group of GPS 2 (21 patients including 16 males and 5 females aged 70.95±9.58 years). Cox regression analysis was conducted to analyze the independent risk factors of predicting long-term mortality of patients with STEMI.Results There was a statistical difference in long-term mortality (9.5% vs. 23.1% vs. 61.9%, P<0.001) and in-hospital mortality (3.7% vs. 7.7% vs. 23.8%, P<0.001) among the three groups. The Global Registry of Acute Coronary Events (GRACE) scores and Gensini scores increased in patients with higher GPS scores, and the differences were statistically different (P<0.001). Multivariable Cox regression analysis showed that the GPS was independently associated with STEMI long-term all-cause mortality (1 vs. 0, HR: 2.212, P=0.037; 2 vs. 0, HR: 8.286, P<0.001).Conclusion GPS score is helpful in predicting the long-term and in-hospital prognosis of STEMI patients, and thus may guide clinical precise intervention by early risk stratification.

Citation： YUAN Jianying, CHENG Yisong, JIA Yu, LI Dongze, LIU Hong, LI Fanghui, ZENG Rui, LIAO Xiaoyang, WAN Zhi, CAO Yu, ZENG Zhi. Predictive value of inflammation-based Glasgow prognostic score for the prognosis in patients with ST-segment elevation myocardial infarction. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(1): 14-19. doi: 10.7507/1007-4848.201907058 Copy

1.	Kristensen SD, Laut KG, Fajadet J, et al. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries. Eur Heart J, 2014, 35(29): 1957-1970.
2.	Pedersen F, Butrymovich V, Kelbæk H, et al. Short- and long-term cause of death in patients treated with primary PCI for STEMI. J Am Coll Cardiol, 2014, 64(20): 2101-2108.
3.	Ibanez B, James S, Agewall S, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2018, 39(2): 119-177.
4.	Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics-2019 update: A report from the American Heart Association. Circulation, 2019, 139(10): e56-e528.
5.	Widera C, Pencina MJ, Meisner A, et al. Adjustment of the GRACE score by growth differentiation factor 15 enables a more accurate appreciation of risk in non-ST-elevation acute coronary syndrome. Eur Heart J, 2012, 33(9): 1095-1104.
6.	Zhang S, Wan Z, Zhang Y, et al. Neutrophil count improves the GRACE risk score prediction of clinical outcomes in patients with ST-elevation myocardial infarction. Atherosclerosis, 2015, 241(2): 723-728.
7.	Fordjour PA, Wang Y, Shi Y, et al. Possible mechanisms of C-reactive protein mediated acute myocardial infarction. Eur J Pharmacol, 2015, 760: 72-80.
8.	Wada H, Dohi T, Miyauchi K, et al. Independent and combined effects of serum albumin and C-reactive protein on long-term outcomes of patients undergoing percutaneous coronary intervention. Circ J, 2017, 81(9): 1293-1300.
9.	Chien SC, Chen CY, Lin CF, et al. Critical appraisal of the role of serum albumin in cardiovascular disease. Biomark Res, 2017, 5: 31.
10.	中华医学会心血管病学分会中华心血管病杂志编辑委员会. 急性 ST 段抬高型心肌梗死诊断和治疗指南. 中华心血管病杂志, 2015, 43(5): 380-393.
11.	Polterauer S, Grimm C, Seebacher V, et al. The inflammation-based Glasgow prognostic score predicts survival in patients with cervical cancer. Int J Gynecol Cancer, 2010, 20(6): 1052-1057.
12.	Iwasaki Y, Ishizuka M, Takagi K, et al. A high preoperative Glasgow prognostic score predicts a high likelihood of conversion from laparoscopic to open surgery in patients with colon cancer. Surg Endosc, 2019, 33(4): 1111-1116.
13.	Hao X, Wei Y, Wei X, et al. Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma. Oncotarget, 2017, 8(44): 76740-76748.
14.	Yotsukura M, Ohtsuka T, Kaseda K, et al. Value of the Glasgow prognostic score as a prognostic factor in resectable non-small cell lung cancer. J Thorac Oncol, 2016, 11(8): 1311-1318.
15.	Saito I, Maruyama K, Eguchi E. C-reactive protein and cardiovascular disease in East Asians: a systematic review. Clin Med Insights Cardiol, 2015, 8(Suppl 3): 35-42.
16.	Berg IJ, Semb AG, van der Heijde D, et al. CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up. Ann Rheum Dis, 2015, 74(8): 1562-1566.
17.	Wang CH, Li SH, Weisel RD, et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation, 2003, 107(13): 1783-1790.
18.	Kosmas CE, Silverio D, Sourlas A, et al. Anti-inflammatory therapy for cardiovascular disease. Ann Transl Med, 2019, 7(7): 147.
19.	Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med, 2018, 52: 8-12.

1. Kristensen SD, Laut KG, Fajadet J, et al. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries. Eur Heart J, 2014, 35(29): 1957-1970.
2. Pedersen F, Butrymovich V, Kelbæk H, et al. Short- and long-term cause of death in patients treated with primary PCI for STEMI. J Am Coll Cardiol, 2014, 64(20): 2101-2108.
3. Ibanez B, James S, Agewall S, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2018, 39(2): 119-177.
4. Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics-2019 update: A report from the American Heart Association. Circulation, 2019, 139(10): e56-e528.
5. Widera C, Pencina MJ, Meisner A, et al. Adjustment of the GRACE score by growth differentiation factor 15 enables a more accurate appreciation of risk in non-ST-elevation acute coronary syndrome. Eur Heart J, 2012, 33(9): 1095-1104.
6. Zhang S, Wan Z, Zhang Y, et al. Neutrophil count improves the GRACE risk score prediction of clinical outcomes in patients with ST-elevation myocardial infarction. Atherosclerosis, 2015, 241(2): 723-728.
7. Fordjour PA, Wang Y, Shi Y, et al. Possible mechanisms of C-reactive protein mediated acute myocardial infarction. Eur J Pharmacol, 2015, 760: 72-80.
8. Wada H, Dohi T, Miyauchi K, et al. Independent and combined effects of serum albumin and C-reactive protein on long-term outcomes of patients undergoing percutaneous coronary intervention. Circ J, 2017, 81(9): 1293-1300.
9. Chien SC, Chen CY, Lin CF, et al. Critical appraisal of the role of serum albumin in cardiovascular disease. Biomark Res, 2017, 5: 31.
10. 中华医学会心血管病学分会中华心血管病杂志编辑委员会. 急性 ST 段抬高型心肌梗死诊断和治疗指南. 中华心血管病杂志, 2015, 43(5): 380-393.
11. Polterauer S, Grimm C, Seebacher V, et al. The inflammation-based Glasgow prognostic score predicts survival in patients with cervical cancer. Int J Gynecol Cancer, 2010, 20(6): 1052-1057.
12. Iwasaki Y, Ishizuka M, Takagi K, et al. A high preoperative Glasgow prognostic score predicts a high likelihood of conversion from laparoscopic to open surgery in patients with colon cancer. Surg Endosc, 2019, 33(4): 1111-1116.
13. Hao X, Wei Y, Wei X, et al. Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma. Oncotarget, 2017, 8(44): 76740-76748.
14. Yotsukura M, Ohtsuka T, Kaseda K, et al. Value of the Glasgow prognostic score as a prognostic factor in resectable non-small cell lung cancer. J Thorac Oncol, 2016, 11(8): 1311-1318.
15. Saito I, Maruyama K, Eguchi E. C-reactive protein and cardiovascular disease in East Asians: a systematic review. Clin Med Insights Cardiol, 2015, 8(Suppl 3): 35-42.
16. Berg IJ, Semb AG, van der Heijde D, et al. CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up. Ann Rheum Dis, 2015, 74(8): 1562-1566.
17. Wang CH, Li SH, Weisel RD, et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation, 2003, 107(13): 1783-1790.
18. Kosmas CE, Silverio D, Sourlas A, et al. Anti-inflammatory therapy for cardiovascular disease. Ann Transl Med, 2019, 7(7): 147.
19. Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med, 2018, 52: 8-12.

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Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Predictive value of inflammation-based Glasgow prognostic score for the prognosis in patients with ST-segment elevation myocardial infarction

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