Clinical effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery: A randomized controlled study_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LI Donghang ,  GENG Qing , ZHANG Lin , WANG Wei , JIANG Wenyang , LU Zilong , FENG Haojie

Department of Thoracic Surgery, Renmin Hosptial of Wuhan University, Wuhan, 430060, P.R.China;

Corresponding author：

GENG Qing, Email: szgqing@126.com

Keywords：

Microecological preparation; esophageal cancer; complications; nutritional status

DOI：

10.7507/1007-4848.201908009

Video：

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Objective To analyze the effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery.Methods A total of 146 patients with esophageal cancer admitted to the Department of Thoracic Surgery, Renmin Hospital of Wuhan University from October 2017 to June 2019 were selected. There were 91 males and 55 females, aged 65 (61.9±8.2) years. They were randomly divided into two groups (an observation group and a control group, n=73 in each group) according to whether microecological preparation was given when they could take food one week after the surgery. Nutritional status and the incidence of gastrointestinal complications including anorexia, acid reflux, nausea, vomiting and diarrhea (≥3 times per day) in the first month after operation were compared between the two groups.Results The incidence of anorexia, nausea, diarrhea (≥3 times per day), anastomotic fistula and stenosis in the observation group was lower and the index of nutritional status was higher than those in the control group within one month after the operation (all P<0.05). There was no statistically significant difference in acid reflux, vomiting, lung infection and incision infection between the two groups (all P>0.05).Conclusion Microecological preparation can regulate gastrointestinal microecological balance, improve nutritional status, reduce the incidence of gastrointestinal complications and accelerate the postoperative rehabilitation.

Citation： LI Donghang, GENG Qing, ZHANG Lin, WANG Wei, JIANG Wenyang, LU Zilong, FENG Haojie. Clinical effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery: A randomized controlled study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(3): 312-317. doi: 10.7507/1007-4848.201908009 Copy

1.	Hu J. Esophageal cancer nutrition therapy. Hangzhou: Zhejiang University Press, 2016. 115-121.
2.	Bozzetti F, Mariani L, Lo Vullo S, et al. The nutritional risk in oncology: a study of 1,453 cancer outpatients. Support Care Cancer, 2012, 20(8): 1919-1928.
3.	Nakamura Y, Momoki C, Okada G, et al. Preoperative depressive mood of patients with esophageal cancer might delay recovery from operation-related malnutrition. J Clin Med Res, 2019, 11(3): 188-195.
4.	Na BG, Han SS, Cho YA, et al. Nutritional status of patients with cancer: a prospective cohort study of 1,588 hospitalized patients. Nutr Cancer, 2018, 70(8): 1228-1236.
5.	Heller AR, Rössler S, Litz RJ, et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med, 2006, 34(4): 972-979.
6.	Yu GP, Chen GQ, Huang B, et al. Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer. Chin J Cancer Res, 2013, 25(3): 299-305.
7.	Zhang H, Shang X, Ren P, et al. The predictive value of a preoperative systemic immune-inflammation index and prognostic nutritional index in patients with esophageal squamous cell cell carcinoma. J Cell Physiol, 2019, 234(2): 1794-1802.
8.	Schwegler I, von Holzen A, Gutzwiller JP, et al. Nutritional risk is a clinical predictor of post-operative mortality and morbidity in surgery for colorectal cancer. Br J Surg, 2010, 97(1): 92-97.
9.	Sobotk L, Cai W. Clinical nutrition foundation. 4th edition. Shanghai: Shanghai Jiaotong University Press, 2013. 23-26.
10.	Guo JT, Liang ZY. Effect of early enteral nutrition on the recovery of gastrointestinal and immune function after esophageal cancer surgery. Mil Med Res, 2016, 37(10): 1060-1063.
11.	胡海贇, 庄晓岚, 马燕雅, 等. 微生态制剂防治儿童感染性腹泻的有效性评价. 中国微生态学杂志, 2019, 31(5): 577-580.
12.	Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol, 2014, 14(3): 141-153.
13.	LI JC, Qian CY, Cai YM, et al. Influence of probiotics combined with enteral nutrition on Inflammation, bacterial translocation and immune function in severe acute pancreatitis patients. Chin J Mod Med, 2018, 28(6): 85-89.
14.	施庆彤, 刁亚利, 姚光怀. 鼻饲流质对改善食管癌患者术后营养状况和胃肠道耐受性的作用. 中华胸部外科电子杂志, 2017, 4(2): 87-91.
15.	黄卫强, 张和平. 饲用微生态制剂替代抗生素的研究进展. 中国微生态学杂志, 2015, 27(4): 488-494.
16.	Kassis ES, Kosinski AS, Ross P Jr, et al. Predictors of anastomotic leak after esophagectomy:an analysis of the society of thoracic surgeons general thoracic database. Ann Thorac Surg, 2013, 96(6): 1919-1926.
17.	Kotzarnpassi K, Stavrou G, Damoraki G, et al. A four-probiotics regimen reduces postoperative complications after colorectal surgery: a randomized, double-blind, placebo-controlled study. World J Surg, 2015, 39(11): 2776-2783.
18.	Bakhos CT, Fabian T, Oyasiji TO, et al. Impact of the surgical technique on pulmonarymorbidity after esophagectomy. Ann Thorac Surg, 2012, 93(1): 221-226.
19.	图尔霍·麦图松, 张昌明, 朱辉. 食管癌切除术后围术期死亡危险因素的分析及预测模型的建立. 世界华人消化杂志, 2016, 24(24): 3587-3597.
20.	姚源山, 沈海波, 黄鸿渤, 等. 高龄食管癌患者术后肺部感染的相关因素分析. 中华医院感染学杂志, 2018, 28(6): 887-889.
21.	Jin Y, Xie G, Wang H, et al. Incidence and risk factors of postoperative pulmonary complications in noncardiac Chinese patients: a multicenter observational study in university hospitals. Biomed Res Int, 2015, 2015: 265165.
22.	Kim ES, Kim YT, Kang CH, et al. Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD. Int J Chron Obstruct Pulmon Dis, 2016, 11(6): 1317-1326.
23.	吕顺. 术前口服益生菌对结直肠癌患者术后早期并发症影响的研究. 辽宁: 中国医科大学, 2017.
24.	Liu Z, Qin H, Yang Z, et al. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery-a double-blind study. Aliment Pharmacol Ther, 2011, 33(1): 50-63.
25.	Liu ZH, Huang MJ, Zhang XW, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr, 2013, 97(1): 117-126.
26.	Sadahiro S, Suzuki T, Tanaka A, et al. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial. Surgery, 2014, 155(3): 493-503.
27.	谷光洁, 景春梅. 重庆地区儿童感染患者 11039 株大肠埃希菌的临床分布及耐药性. 中国微生态学杂志, 2017, 29(6): 696-699, 703.
28.	Raymond DP, Seder CW, Wright CD, et al. Predictors of major morbidity or mortality after resection for esophageal cancer:a society of thoracic surgeons general thoracic surgery database risk adjustment model. Ann Thorac Surg, 2016, 102(1): 207-214.
29.	Gangadharan A, Choi SE, Hassan A, et al. Protein calorie malnutrition, nutritional intervention and personalized cancer care. Oncotarget, 2017, 8(14): 24009-24030.
30.	Okada G, Momoki C, Habu D, et al. Effect of postoperative oral intake on prognosis for esophageal cancer. Nutrients, 2019, 11(6): pii E1338.
31.	郭明发. 食管癌病人术后早期肠内营养的疗效观察. 肠外与肠内营养, 2011, 18(4): 218-220, 224.
32.	张毅, 谭黎杰, 钱成, 等. 食管癌病人术后早期肠内营养支持的作用. 肠外与肠内营养, 2007, 14(5): 282-285.

1. Hu J. Esophageal cancer nutrition therapy. Hangzhou: Zhejiang University Press, 2016. 115-121.
2. Bozzetti F, Mariani L, Lo Vullo S, et al. The nutritional risk in oncology: a study of 1,453 cancer outpatients. Support Care Cancer, 2012, 20(8): 1919-1928.
3. Nakamura Y, Momoki C, Okada G, et al. Preoperative depressive mood of patients with esophageal cancer might delay recovery from operation-related malnutrition. J Clin Med Res, 2019, 11(3): 188-195.
4. Na BG, Han SS, Cho YA, et al. Nutritional status of patients with cancer: a prospective cohort study of 1,588 hospitalized patients. Nutr Cancer, 2018, 70(8): 1228-1236.
5. Heller AR, Rössler S, Litz RJ, et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med, 2006, 34(4): 972-979.
6. Yu GP, Chen GQ, Huang B, et al. Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer. Chin J Cancer Res, 2013, 25(3): 299-305.
7. Zhang H, Shang X, Ren P, et al. The predictive value of a preoperative systemic immune-inflammation index and prognostic nutritional index in patients with esophageal squamous cell cell carcinoma. J Cell Physiol, 2019, 234(2): 1794-1802.
8. Schwegler I, von Holzen A, Gutzwiller JP, et al. Nutritional risk is a clinical predictor of post-operative mortality and morbidity in surgery for colorectal cancer. Br J Surg, 2010, 97(1): 92-97.
9. Sobotk L, Cai W. Clinical nutrition foundation. 4th edition. Shanghai: Shanghai Jiaotong University Press, 2013. 23-26.
10. Guo JT, Liang ZY. Effect of early enteral nutrition on the recovery of gastrointestinal and immune function after esophageal cancer surgery. Mil Med Res, 2016, 37(10): 1060-1063.
11. 胡海贇, 庄晓岚, 马燕雅, 等. 微生态制剂防治儿童感染性腹泻的有效性评价. 中国微生态学杂志, 2019, 31(5): 577-580.
12. Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol, 2014, 14(3): 141-153.
13. LI JC, Qian CY, Cai YM, et al. Influence of probiotics combined with enteral nutrition on Inflammation, bacterial translocation and immune function in severe acute pancreatitis patients. Chin J Mod Med, 2018, 28(6): 85-89.
14. 施庆彤, 刁亚利, 姚光怀. 鼻饲流质对改善食管癌患者术后营养状况和胃肠道耐受性的作用. 中华胸部外科电子杂志, 2017, 4(2): 87-91.
15. 黄卫强, 张和平. 饲用微生态制剂替代抗生素的研究进展. 中国微生态学杂志, 2015, 27(4): 488-494.
16. Kassis ES, Kosinski AS, Ross P Jr, et al. Predictors of anastomotic leak after esophagectomy:an analysis of the society of thoracic surgeons general thoracic database. Ann Thorac Surg, 2013, 96(6): 1919-1926.
17. Kotzarnpassi K, Stavrou G, Damoraki G, et al. A four-probiotics regimen reduces postoperative complications after colorectal surgery: a randomized, double-blind, placebo-controlled study. World J Surg, 2015, 39(11): 2776-2783.
18. Bakhos CT, Fabian T, Oyasiji TO, et al. Impact of the surgical technique on pulmonarymorbidity after esophagectomy. Ann Thorac Surg, 2012, 93(1): 221-226.
19. 图尔霍·麦图松, 张昌明, 朱辉. 食管癌切除术后围术期死亡危险因素的分析及预测模型的建立. 世界华人消化杂志, 2016, 24(24): 3587-3597.
20. 姚源山, 沈海波, 黄鸿渤, 等. 高龄食管癌患者术后肺部感染的相关因素分析. 中华医院感染学杂志, 2018, 28(6): 887-889.
21. Jin Y, Xie G, Wang H, et al. Incidence and risk factors of postoperative pulmonary complications in noncardiac Chinese patients: a multicenter observational study in university hospitals. Biomed Res Int, 2015, 2015: 265165.
22. Kim ES, Kim YT, Kang CH, et al. Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD. Int J Chron Obstruct Pulmon Dis, 2016, 11(6): 1317-1326.
23. 吕顺. 术前口服益生菌对结直肠癌患者术后早期并发症影响的研究. 辽宁: 中国医科大学, 2017.
24. Liu Z, Qin H, Yang Z, et al. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery-a double-blind study. Aliment Pharmacol Ther, 2011, 33(1): 50-63.
25. Liu ZH, Huang MJ, Zhang XW, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr, 2013, 97(1): 117-126.
26. Sadahiro S, Suzuki T, Tanaka A, et al. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial. Surgery, 2014, 155(3): 493-503.
27. 谷光洁, 景春梅. 重庆地区儿童感染患者 11039 株大肠埃希菌的临床分布及耐药性. 中国微生态学杂志, 2017, 29(6): 696-699, 703.
28. Raymond DP, Seder CW, Wright CD, et al. Predictors of major morbidity or mortality after resection for esophageal cancer:a society of thoracic surgeons general thoracic surgery database risk adjustment model. Ann Thorac Surg, 2016, 102(1): 207-214.
29. Gangadharan A, Choi SE, Hassan A, et al. Protein calorie malnutrition, nutritional intervention and personalized cancer care. Oncotarget, 2017, 8(14): 24009-24030.
30. Okada G, Momoki C, Habu D, et al. Effect of postoperative oral intake on prognosis for esophageal cancer. Nutrients, 2019, 11(6): pii E1338.
31. 郭明发. 食管癌病人术后早期肠内营养的疗效观察. 肠外与肠内营养, 2011, 18(4): 218-220, 224.
32. 张毅, 谭黎杰, 钱成, 等. 食管癌病人术后早期肠内营养支持的作用. 肠外与肠内营养, 2007, 14(5): 282-285.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Clinical effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery: A randomized controlled study

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