• 1. The 10th Ward of Deparment of Infection, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China;
  • 2. Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, P.R.China;
  • 3. Department of Respiratory, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China;
  • 4. The 23rd Ward of Department of Infection, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China;
  • 5. Department of Respiratory, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P.R.China;
  • 6. Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China;
  • 7. Department of Infection, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, P.R.China;
  • 8. Department of Cadre Health, Renmin Hospital of Wuhan University, Wuhan, 430060, P.R.China;
ZHENG Jian, Email: 404498342@qq.com; XU Yaqing, Email: 15392885220@163.com
Export PDF Favorites Scan Get Citation

Objective To investigate the characteristics and prognostic value of cellular immune function in severe patients with coronavirus disease 2019 (COVID-19).Methods A cohort study was conducted to collect the clinical data of 119 severe patients admitted to the Renmin Hospital of Wuhan University (Eastern District) including 60 males (50.4%) and 59 females (49.6%), with an average age of 60.9±14.2 years. The primary endpoint of follow-up was death in the hospital, and the disease outcome classification was the secondary endpoint of follow-up within 30 days after admission. We analyzed the correlation between cellular immune function and COVID-19 prognosis.Results  A total of 22 patients died during this process, and 47 patients were severe/critical during the follow-up period. The counts of CD3+, CD4+, CD8+, and CD19+ in the primary endpoint events were significantly different between the survival group and the death group (all P<0.05). The counts of CD3+, CD4+, CD8+, CD19+ in the secondary endpoint events were significantly different between the normal group and the severe/critical group (all P<0.05). The results of the receiver operating characteristic (ROC) curve showed that the area under the cellular immune function curve of dead patients and severe/critical patients had good predictive value (all P<0.05).Conclusion Cell immune function has good clinical and prognostic value for COVID-19.

Citation: CHEN You, LUO Yuchuan, WANG Kaijie, CAO Hui, LV Jianhong, ZHENG Jian, XU Yaqing. Clinical and prognostic value of cellular immune function in severe patients with coronavirus disease 2019 (COVID-19): A cohort study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(6): 603-608. doi: 10.7507/1007-4848.202003133 Copy

  • Next Article

    先天性心脏病外科治疗中国专家共识(五):再次开胸手术