Treatment for resectable cervical esophageal carcinoma: A surgical perspective_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANG Zhen , QIN Jianjun , LI Yong , CHEN Xiankai ,  LI Yin

Department of Thoracic Surgery, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, P.R.China;

Corresponding author：

LI Yin, Email: liyin825@aliyun.com

Keywords：

Cervical esophageal carcinoma; surgery; treatment; review

DOI：

10.7507/1007-4848.202004093

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Definitive chemoradiotherapy (dCRT) is the general recommendation for the treatment of cervical esophageal cancer for organ preservation. However, the long-term survival of dCRT is not satisfactory. Surgical resection alone is not superior to dCRT in the treatment of cervical esophageal cancer. Surgical resection is often combined with laryngectomy, which will affect the quality of life. Recent evidence suggests that neoadjuvant therapy combined with surgery improves the long-term survival of cervical esophageal cancer. On the other hand, the development of technologies such as laryngeal preservation surgery and minimally invasive esophagectomy has reduced the risk of operation and improved the quality of life. This article will review the new progress in the comprehensive treatment of cervical esophageal cancer from the perspective of surgery.

Citation： WANG Zhen, QIN Jianjun, LI Yong, CHEN Xiankai, LI Yin. Treatment for resectable cervical esophageal carcinoma: A surgical perspective. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(10): 1217-1222. doi: 10.7507/1007-4848.202004093 Copy

1.	Bray F, Ferlay J, Soerjomataram I, <italic>et al</italic>. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Lee DJ, Harris A, Gillette A, <italic>et al</italic>. Carcinoma of the cervical esophagus: diagnosis, management, and results. South Med J, 1984, 77(11): 1365-1367.
3.	Ajani JA, D'Amico TA, Bentrem DJ, <italic>et al</italic>. Esophageal and esophagogastric junction cancers, version 2. 2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw, 2019, 17(7): 855-883.
4.	Buckstein M, Liu J. Cervical esophageal cancers: challenges and opportunities. Curr Oncol Rep. 2019, 21(5): 46.
5.	Burmeister BH, Dickie G, Smithers BM, <italic>et al</italic>. Thirty-four patients with carcinoma of the cervical esophagus treated with chemoradiation therapy. Arch Otolaryngol Head Neck Surg, 2000, 126(2): 205-208.
6.	Yamada K, Murakami M, Okamoto Y, <italic>et al</italic>. Treatment results of radiotherapy for carcinoma of the cervical esophagus. Acta Oncol, 2006, 45(8): 1120-1125.
7.	Huang SH, Lockwood G, Brierley J, <italic>et al</italic>. Effect of concurrent high-dose cisplatin chemotherapy and conformal radiotherapy on cervical esophageal cancer survival. Int J Radiat Oncol Biol Phys, 2008, 71(3): 735-740.
8.	Gkika E, Gauler T, Eberhardt W, <italic>et al</italic>. Long-term results of definitive radiochemotherapy in locally advanced cancers of the cervical esophagus. Dis Esophagus, 2014, 27(7): 678-684.
9.	Grass GD, Cooper SL, Armeson K, <italic>et al</italic>. Cervical esophageal cancer: a population-based study. Head Neck, 2015, 37(6): 808-814.
10.	De B, Rhome R, Doucette J, <italic>et al</italic>. Dose escalation of definitive radiation is not associated with improved survival for cervical esophageal cancer: a National Cancer Data Base (NCDB) analysis. Dis Esophagus, 2017, 30(4): 1-10.
11.	Takebayashi K, Tsubosa Y, Matsuda S, <italic>et al</italic>. Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer. Dis Esophagus, 2017, 30(2): 1-5.
12.	Zhang P, Xi M, Zhao L, <italic>et al</italic>. Clinical efficacy and failure pattern in patients with cervical esophageal cancer treated with definitive chemoradiotherapy. Radiother Oncol, 2015, 116(2): 257-261.
13.	Herrmann E, Mertineit N, De Bari B, et al. Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study. Radiat Oncol. 2017, 12(1): 97.
14.	Daiko H, Hayashi R, Saikawa M, <italic>et al</italic>. Surgical management of carcinoma of the cervical esophagus. J Surg Oncol, 2007, 96(2): 166-172.
15.	Wang HW, Chu PY, Kuo KT, <italic>et al</italic>. A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction. J Surg Oncol, 2006, 93(6): 468-476.
16.	Ott K, Lordick F, Molls M, <italic>et al</italic>. Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus. Br J Surg, 2009, 96(3): 258-266.
17.	Miyata H, Yamasaki M, Takahashi T, <italic>et al</italic>. Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World J Surg, 2013, 37(3): 551-557.
18.	Saeki H, Tsutsumi S, Yukaya T, <italic>et al</italic>. Clinicopathological features of cervical esophageal cancer: retrospective analysis of 63 consecutive patients who underwent surgical resection. Ann Surg, 2017, 265(1): 130-136.
19.	Cao CN, Luo JW, Gao L, <italic>et al</italic>. Primary radiotherapy compared with primary surgery in cervical esophageal cancer. JAMA Otolaryngol Head Neck Surg, 2014, 140(10): 918-926.
20.	Ando N, Kato H, Igaki H, <italic>et al</italic>. A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol, 2012, 19(1): 68-74.
21.	Chou SH, Li HP, Lee JY, et al. Radical resection or chemoradiotherapy for cervical esophageal cancer? World J Surg. 2010, 34(8): 1832-1839.
22.	Petersen JF, Arends CR, van der Noort V, <italic>et al</italic>. Laryngo-esophageal dysfunction free survival and propensity score matched analysis comparing organ preservation and total laryngectomy in hypopharynx cancer. Oral Oncol, 2019, 95: 143-149.
23.	Kraaijenga SA, Oskam IM, van der Molen L, <italic>et al</italic>. Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral Oncol, 2015, 51(8): 787-794.
24.	Makino T, Yamasaki M, Miyazaki Y, <italic>et al</italic>. Short- and long-term outcomes of larynx-preserving surgery for cervical esophageal cancer: Analysis of 100 consecutive cases. Ann Surg Oncol, 2016, 23(Suppl 5): 858-865.
25.	Jiang M, He X, Wu D, <italic>et al</italic>. Reconstruction techniques for hypopharyngeal and cervical esophageal carcinoma. J Thorac Dis, 2015, 7(3): 449-454.
26.	Biere SS, van Berge Henegouwen MI, Maas KW, <italic>et al</italic>. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: A multicentre, open-label, randomised controlled trial. Lancet, 2012, 379(9829): 1887-1892.
27.	Sugawara K, Yoshimura S, Yagi K, <italic>et al</italic>. Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy. Surg Endosc, 2020, 34(4): 1602-1611.
28.	张葆勋, 于磊, 伍冀湘, 等. 两种微创手术方式治疗颈段食管癌的对比研究. 中国医刊, 2019, 54(5): 516-520.
29.	Nakata Y, Hanai N, Nishikawa D, <italic>et al</italic>. Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma. Int J Clin Oncol, 2017, 22(6): 1034-1041.
30.	Takebayashi K, Tsubosa Y, Kamijo T, <italic>et al</italic>. Comparison of salvage total pharyngolaryngectomy and cervical esophagectomy between hypopharyngeal cancer and cervical esophageal cancer. Ann Surg Oncol, 2017, 24(3): 778-784.
31.	Markar S, Gronnier C, Duhamel A, <italic>et al</italic>. Salvage surgery after chemoradiotherapy in the management of esophageal cancer: Is it a viable therapeutic option? J Clin Oncol, 2015, 33(33): 3866-3873.

1. Bray F, Ferlay J, Soerjomataram I, <italic>et al</italic>. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Lee DJ, Harris A, Gillette A, <italic>et al</italic>. Carcinoma of the cervical esophagus: diagnosis, management, and results. South Med J, 1984, 77(11): 1365-1367.
3. Ajani JA, D'Amico TA, Bentrem DJ, <italic>et al</italic>. Esophageal and esophagogastric junction cancers, version 2. 2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw, 2019, 17(7): 855-883.
4. Buckstein M, Liu J. Cervical esophageal cancers: challenges and opportunities. Curr Oncol Rep. 2019, 21(5): 46.
5. Burmeister BH, Dickie G, Smithers BM, <italic>et al</italic>. Thirty-four patients with carcinoma of the cervical esophagus treated with chemoradiation therapy. Arch Otolaryngol Head Neck Surg, 2000, 126(2): 205-208.
6. Yamada K, Murakami M, Okamoto Y, <italic>et al</italic>. Treatment results of radiotherapy for carcinoma of the cervical esophagus. Acta Oncol, 2006, 45(8): 1120-1125.
7. Huang SH, Lockwood G, Brierley J, <italic>et al</italic>. Effect of concurrent high-dose cisplatin chemotherapy and conformal radiotherapy on cervical esophageal cancer survival. Int J Radiat Oncol Biol Phys, 2008, 71(3): 735-740.
8. Gkika E, Gauler T, Eberhardt W, <italic>et al</italic>. Long-term results of definitive radiochemotherapy in locally advanced cancers of the cervical esophagus. Dis Esophagus, 2014, 27(7): 678-684.
9. Grass GD, Cooper SL, Armeson K, <italic>et al</italic>. Cervical esophageal cancer: a population-based study. Head Neck, 2015, 37(6): 808-814.
10. De B, Rhome R, Doucette J, <italic>et al</italic>. Dose escalation of definitive radiation is not associated with improved survival for cervical esophageal cancer: a National Cancer Data Base (NCDB) analysis. Dis Esophagus, 2017, 30(4): 1-10.
11. Takebayashi K, Tsubosa Y, Matsuda S, <italic>et al</italic>. Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer. Dis Esophagus, 2017, 30(2): 1-5.
12. Zhang P, Xi M, Zhao L, <italic>et al</italic>. Clinical efficacy and failure pattern in patients with cervical esophageal cancer treated with definitive chemoradiotherapy. Radiother Oncol, 2015, 116(2): 257-261.
13. Herrmann E, Mertineit N, De Bari B, et al. Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study. Radiat Oncol. 2017, 12(1): 97.
14. Daiko H, Hayashi R, Saikawa M, <italic>et al</italic>. Surgical management of carcinoma of the cervical esophagus. J Surg Oncol, 2007, 96(2): 166-172.
15. Wang HW, Chu PY, Kuo KT, <italic>et al</italic>. A reappraisal of surgical management for squamous cell carcinoma in the pharyngoesophageal junction. J Surg Oncol, 2006, 93(6): 468-476.
16. Ott K, Lordick F, Molls M, <italic>et al</italic>. Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus. Br J Surg, 2009, 96(3): 258-266.
17. Miyata H, Yamasaki M, Takahashi T, <italic>et al</italic>. Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World J Surg, 2013, 37(3): 551-557.
18. Saeki H, Tsutsumi S, Yukaya T, <italic>et al</italic>. Clinicopathological features of cervical esophageal cancer: retrospective analysis of 63 consecutive patients who underwent surgical resection. Ann Surg, 2017, 265(1): 130-136.
19. Cao CN, Luo JW, Gao L, <italic>et al</italic>. Primary radiotherapy compared with primary surgery in cervical esophageal cancer. JAMA Otolaryngol Head Neck Surg, 2014, 140(10): 918-926.
20. Ando N, Kato H, Igaki H, <italic>et al</italic>. A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol, 2012, 19(1): 68-74.
21. Chou SH, Li HP, Lee JY, et al. Radical resection or chemoradiotherapy for cervical esophageal cancer? World J Surg. 2010, 34(8): 1832-1839.
22. Petersen JF, Arends CR, van der Noort V, <italic>et al</italic>. Laryngo-esophageal dysfunction free survival and propensity score matched analysis comparing organ preservation and total laryngectomy in hypopharynx cancer. Oral Oncol, 2019, 95: 143-149.
23. Kraaijenga SA, Oskam IM, van der Molen L, <italic>et al</italic>. Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral Oncol, 2015, 51(8): 787-794.
24. Makino T, Yamasaki M, Miyazaki Y, <italic>et al</italic>. Short- and long-term outcomes of larynx-preserving surgery for cervical esophageal cancer: Analysis of 100 consecutive cases. Ann Surg Oncol, 2016, 23(Suppl 5): 858-865.
25. Jiang M, He X, Wu D, <italic>et al</italic>. Reconstruction techniques for hypopharyngeal and cervical esophageal carcinoma. J Thorac Dis, 2015, 7(3): 449-454.
26. Biere SS, van Berge Henegouwen MI, Maas KW, <italic>et al</italic>. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: A multicentre, open-label, randomised controlled trial. Lancet, 2012, 379(9829): 1887-1892.
27. Sugawara K, Yoshimura S, Yagi K, <italic>et al</italic>. Long-term health-related quality of life following robot-assisted radical transmediastinal esophagectomy. Surg Endosc, 2020, 34(4): 1602-1611.
28. 张葆勋, 于磊, 伍冀湘, 等. 两种微创手术方式治疗颈段食管癌的对比研究. 中国医刊, 2019, 54(5): 516-520.
29. Nakata Y, Hanai N, Nishikawa D, <italic>et al</italic>. Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma. Int J Clin Oncol, 2017, 22(6): 1034-1041.
30. Takebayashi K, Tsubosa Y, Kamijo T, <italic>et al</italic>. Comparison of salvage total pharyngolaryngectomy and cervical esophagectomy between hypopharyngeal cancer and cervical esophageal cancer. Ann Surg Oncol, 2017, 24(3): 778-784.
31. Markar S, Gronnier C, Duhamel A, <italic>et al</italic>. Salvage surgery after chemoradiotherapy in the management of esophageal cancer: Is it a viable therapeutic option? J Clin Oncol, 2015, 33(33): 3866-3873.

Previous Article
Clinical application of “Double R” pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy
Next Article
Clinical effect report of 200 cases of Da Vinci robotic radical gastrectomy

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Treatment for resectable cervical esophageal carcinoma: A surgical perspective

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content