Experimental study of magnetic compression technique for anastomosis reconstruction of esophagus_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANG Miaomiao ^1,2 , JI Lin ^1,2 , LIU Peinan ^2,3 , ZHANG Hanzhi ^2,3 , MOU Xingyi ^2,4 , XU Shuqin ^2,4 , ZHANG Yong ⁵ , LV Yi ^1,2 ,  YAN Xiaopeng ^1,2

1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
2. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
3. Qide College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
4. Zonglian College, Xi’an Jiaotong University, Xi’an, 710061, P.R.China;
5. Department of Thoracic Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, P.R.China;

Corresponding author：

YAN Xiaopeng, Email: yanxiaopeng99@163.com

Keywords：

Magnetic surgery; magnetic compression technique; magnamosis; esophageal anastomosis; experimental study

DOI：

10.7507/1007-4848.202103066

Video：

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Objective To investigate the feasibility of magnamosis rings designed based on magnetic compression technique in esophageal anastomosis reconstruction.Methods According to the anatomical characteristics of esophagus in SD rats, the esophageal magnamosis rings were designed. SD rats were used as animal models (n=10, 5 males and 5 females) to complete the magnetic anastomosis reconstruction of the cervical esophagus using magnamosis rings, and the operation time, animal survival, postoperative complications, magnetic rings excretion time were recorded. Two weeks after operation, the rats were killed, and the esophageal anastomotic specimens were obtained. The blasting pressure of the anastomotic site was measured and the formation of the anastomotic site was observed with naked eyes.Results Esophageal magnamosis was successfully performed in 10 SD rats, and the median operation time was 11 (8-13) min. All rats survived without anastomotic leakage, anastomotic stenosis, or magnetic rings incarceration. The magnetic rings were discharged after 8 (5-10) days and the burst pressure was higher than 300 mm Hg. Visual observation showed that the anastomotic muscle healed well and the mucosa was smooth.Conclusion The magnetic compression technique can be used for anastomosis reconstruction of esophagus, which has the advantages of simple operation and reliable anastomosis effect, and has clinical application prospect.

Citation： ZHANG Miaomiao, JI Lin, LIU Peinan, ZHANG Hanzhi, MOU Xingyi, XU Shuqin, ZHANG Yong, LV Yi, YAN Xiaopeng. Experimental study of magnetic compression technique for anastomosis reconstruction of esophagus. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022, 29(1): 95-99. doi: 10.7507/1007-4848.202103066 Copy

1.	习林云, 吴春, 潘征夏, 等. Ⅲ型先天性食管闭锁手术后并发症的危险因素分析. 临床小儿外科杂志, 2019, 18(6): 462-466.
2.	刘仕琪, 吕毅, 赵静儒, 等. 磁吻合技术治疗先天性食管闭锁与狭窄疗效分析. 中华普通外科杂志, 2020, 35(5): 412-414.
3.	严小鹏, 商澎, 史爱华, 等. 磁外科学体系的探索与建立. 科学通报, 2019, 64(8): 815-826.
4.	张苗苗, 吉琳, 牟星宜, 等. 磁吻合研究现状与发展趋势. 中国医疗设备, 2020, 35(11): 45-48.
5.	严小鹏, 马佳, 吕毅, 等. 无缝线化门腔侧-侧吻合磁性装置的研制. 生物医学工程学进展, 2013, 34(4): 218-220.
6.	刘仕琪, 雷鹏, 吕毅, 等. 利用磁吻合技术实现犬下腔静脉端端吻合. 中华普通外科杂志, 2013, 28(12): 931-934.
7.	严小鹏, 张苗苗, 吉琳, 等. 基于磁吻合技术的经自然腔道胃结肠吻合实验研究. 中国医疗设备, 2020, 35(11): 58-60.
8.	吝怡, 吉琳, 樊茜, 等. 磁压榨技术建立胃肠吻合的动物实验研究. 中华消化内镜杂志, 2020, 37(9): 652-656.
9.	吉琳, 常凯曦, 王俊翔, 等. 磁环构建大鼠胆肠吻合模型的实验研究. 中国医疗设备, 2020, 35(11): 49-51.
10.	Yan XP, Zou YL, She ZF, et al. Magnet compression technique: A novel method for rectovaginal fistula repair. Int J Colorectal Dis, 2016, 31(4): 937-938.
11.	付珊, 马佳, 赵广宾, 等. 磁压榨直肠阴道瘘闭合修补装置的改良设计. 中国医疗设备, 2018, 33(4): 46-49.
12.	李益行, 刘培楠, 张至轩, 等. 基于磁压榨技术的气管食管瘘闭合修补装置的设计. 医疗卫生装备, 2020, 41(4): 14-17, 38.
13.	叶丹, 邱明龙, 高慧敏, 等. 磁压榨技术治疗小儿食管闭锁和狭窄的临床应用探索. 中华小儿外科杂志, 2020, 41(4): 370-374.
14.	严小鹏, 史爱华, 王善佩, 等. 磁压榨技术治疗复杂性胆道狭窄的临床应用探索. 中华肝胆外科杂志, 2019, 25(3): 237-240.
15.	Obora Y, Tamaki N, Matsumoto S. Nonsuture microvascular anastomosis using magnet rings: Preliminary report. Surg Neurol, 1978, 9(2): 117-20.
16.	Jamshidi R, Stephenson JT, Clay JG, et al. Magnamosis: Magnetic compression anastomosis with comparison to suture and staple techniques. J Pediatr Surg, 2009, 44(1): 222-228.
17.	严小鹏, 刘雯雁, 李涤尘, 等. 消化外科手术的内镜化途径: 磁吻合联合内镜. 世界华人消化杂志, 2014, 22(19): 2716-2721.
18.	李建辉, 吕毅, 张智勇, 等. 急性胆管损伤后应用磁性胆肠吻合支架一期修复胆肠连续性的实验研究. 中华肝胆外科杂志, 2007, 13(11): 767-770.
19.	马海军, 王善佩, 樊超, 等. 应用磁压榨吻合术行肠瘘一期修补的实验研究. 中华消化外科杂志, 2011, 10(1): 64-67.
20.	严小鹏, 高燕凤, 邹余粮, 等. 基于磁压榨技术的直肠阴道瘘一期修补装置. 生物医学工程学杂志, 2015, 32(5): 1096-1099.
21.	吝怡, 樊茜, 朱森林, 等. 磁吻合环建立兔小肠侧侧吻合的实验研究. 医疗卫生装备, 2020, 41(4): 18-21.
22.	Muensterer OJ, Sterlin A, Oetzmann von Sochaczewski C, et al. An experimental study on magnetic esophageal compression anastomosis in piglets. J Pediatr Surg, 2020, 55(3): 425-432.

1. 习林云, 吴春, 潘征夏, 等. Ⅲ型先天性食管闭锁手术后并发症的危险因素分析. 临床小儿外科杂志, 2019, 18(6): 462-466.
2. 刘仕琪, 吕毅, 赵静儒, 等. 磁吻合技术治疗先天性食管闭锁与狭窄疗效分析. 中华普通外科杂志, 2020, 35(5): 412-414.
3. 严小鹏, 商澎, 史爱华, 等. 磁外科学体系的探索与建立. 科学通报, 2019, 64(8): 815-826.
4. 张苗苗, 吉琳, 牟星宜, 等. 磁吻合研究现状与发展趋势. 中国医疗设备, 2020, 35(11): 45-48.
5. 严小鹏, 马佳, 吕毅, 等. 无缝线化门腔侧-侧吻合磁性装置的研制. 生物医学工程学进展, 2013, 34(4): 218-220.
6. 刘仕琪, 雷鹏, 吕毅, 等. 利用磁吻合技术实现犬下腔静脉端端吻合. 中华普通外科杂志, 2013, 28(12): 931-934.
7. 严小鹏, 张苗苗, 吉琳, 等. 基于磁吻合技术的经自然腔道胃结肠吻合实验研究. 中国医疗设备, 2020, 35(11): 58-60.
8. 吝怡, 吉琳, 樊茜, 等. 磁压榨技术建立胃肠吻合的动物实验研究. 中华消化内镜杂志, 2020, 37(9): 652-656.
9. 吉琳, 常凯曦, 王俊翔, 等. 磁环构建大鼠胆肠吻合模型的实验研究. 中国医疗设备, 2020, 35(11): 49-51.
10. Yan XP, Zou YL, She ZF, et al. Magnet compression technique: A novel method for rectovaginal fistula repair. Int J Colorectal Dis, 2016, 31(4): 937-938.
11. 付珊, 马佳, 赵广宾, 等. 磁压榨直肠阴道瘘闭合修补装置的改良设计. 中国医疗设备, 2018, 33(4): 46-49.
12. 李益行, 刘培楠, 张至轩, 等. 基于磁压榨技术的气管食管瘘闭合修补装置的设计. 医疗卫生装备, 2020, 41(4): 14-17, 38.
13. 叶丹, 邱明龙, 高慧敏, 等. 磁压榨技术治疗小儿食管闭锁和狭窄的临床应用探索. 中华小儿外科杂志, 2020, 41(4): 370-374.
14. 严小鹏, 史爱华, 王善佩, 等. 磁压榨技术治疗复杂性胆道狭窄的临床应用探索. 中华肝胆外科杂志, 2019, 25(3): 237-240.
15. Obora Y, Tamaki N, Matsumoto S. Nonsuture microvascular anastomosis using magnet rings: Preliminary report. Surg Neurol, 1978, 9(2): 117-20.
16. Jamshidi R, Stephenson JT, Clay JG, et al. Magnamosis: Magnetic compression anastomosis with comparison to suture and staple techniques. J Pediatr Surg, 2009, 44(1): 222-228.
17. 严小鹏, 刘雯雁, 李涤尘, 等. 消化外科手术的内镜化途径: 磁吻合联合内镜. 世界华人消化杂志, 2014, 22(19): 2716-2721.
18. 李建辉, 吕毅, 张智勇, 等. 急性胆管损伤后应用磁性胆肠吻合支架一期修复胆肠连续性的实验研究. 中华肝胆外科杂志, 2007, 13(11): 767-770.
19. 马海军, 王善佩, 樊超, 等. 应用磁压榨吻合术行肠瘘一期修补的实验研究. 中华消化外科杂志, 2011, 10(1): 64-67.
20. 严小鹏, 高燕凤, 邹余粮, 等. 基于磁压榨技术的直肠阴道瘘一期修补装置. 生物医学工程学杂志, 2015, 32(5): 1096-1099.
21. 吝怡, 樊茜, 朱森林, 等. 磁吻合环建立兔小肠侧侧吻合的实验研究. 医疗卫生装备, 2020, 41(4): 18-21.
22. Muensterer OJ, Sterlin A, Oetzmann von Sochaczewski C, et al. An experimental study on magnetic esophageal compression anastomosis in piglets. J Pediatr Surg, 2020, 55(3): 425-432.

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