Research progress on autologous blood patch pleurodesis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HUANG Jiawei , LIANG Hanping , XIE Xihao ,  LIN Wanli

Department of Thoracic Surgery, Gaozhou People’s Hospital, Maoming, 525200, Guangdong, P. R. China;

Corresponding author：

LIN Wanli, Email: qgw752@163.com

Keywords：

Autologous blood patch pleurodesis; persistent air leak; pneumothorax; review

DOI：

10.7507/1007-4848.202302003

Video：

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Autologous blood patch pleurodesis (ABPP) was first proposed in 1987. Now it is mainly used to treat intractable pneumothorax and persistent air leakage after pneumonectomy, and also used to treat pneumothorax in children and other rare secondary pneumothorax. Persistent air leakage and pneumothorax of various causes are essentially alveolar pleural fistula. It can usually be treated by closed thoracic drainage, continuous negative pressure suction and surgery. Pleurodesis is a safe and effective alternative to surgery for patients who have failed conventional conservative treatment and can not receive operations. Compared with other pleurodesis adhesives, autologous blood (ABPP) is safer and more effective, and it is simple, painless, cheap and easy to be accepted by patients. But in the domestic and foreign researches in recent years, many details of ABPP treatment have not been standardized. For further research and popularization of ABPP, this article reviews the detailed regulations, efficacy and safety of this technology.

Citation： HUANG Jiawei, LIANG Hanping, XIE Xihao, LIN Wanli. Research progress on autologous blood patch pleurodesis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2025, 32(1): 136-140. doi: 10.7507/1007-4848.202302003 Copy

1.	Robinson CL. Autologous blood for pleurodesis in recurrent and chronic spontaneous pneumothorax. Can J Surg, 1987, 30(6): 428-429.
2.	Karampinis I, Galata C, Arani A, et al. Autologous blood pleurodesis for the treatment of postoperative air leaks. A systematic review and meta-analysis. Thorac Cancer, 2021, 12(20): 2648-2654.
3.	李宝重, 张旭刚, 李维青, 等. 自体血“补片”胸膜固定术治疗肺切除术后持续性漏气的疗效分析. 中国医学科学院学报, 2021, 43(2): 211-215.Li BZ, Zhang XG, Li WQ, et al. Pleurodesis with an autologous blood patch in the treatment of persistent air leak after lung resection. Acta Acad Med Sin, 2021, 43(2): 211-215.
4.	Hallifax RJ, Yousuf A, Jones HE, et al. Effectiveness of chemical pleurodesis in spontaneous pneumothorax recurrence prevention: A systematic review. Thorax, 2017, 72(12): 1121-1131.
5.	Ibrahim IM, Elaziz MEA, El-Hag-Aly MA. Early autologous blood-patch pleurodesis versus conservative management for treatment of secondary spontaneous pneumothorax. Thorac Cardiovasc Surg, 2019, 67(3): 222-226.
6.	Campisi A, Dell'Amore A, Gabryel P, et al. Autologous blood patch pleurodesis: A large retrospective multicenter cohort study. Ann Thorac Surg, 2022, 114(1): 273-279.
7.	Campisi A, Dell'Amore A, Zhang Y, et al. Autologous blood pleurodesis: What is the optimal time interval and amount of blood? Thorac Cardiovasc Surg, 2022, 70(8): 671-676.
8.	Rinaldi S, Felton T, Bentley A. Blood pleurodesis for the medical management of pneumothorax. Thorax, 2009, 64(3): 258-260.
9.	曲博, 姜威, 梁磊, 等. 早期自体血补片胸膜固定术治疗难治性气胸的临床研究. 临床肺科杂志, 2022, 27(7): 1010-1014.Qu B, Jiang W, Liang L, et al. Clinical study of early autologous blood patch pleurodesis in the treatment of refractorypneumothorax. J Clin Pulm Med, 2022, 27(7): 1010-1014.
10.	Aihara K, Handa T, Nagai S, et al. Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. Intern Med, 2011, 50(11): 1157-1162.
11.	Kagohashi K, Ohara G, Shiozawa T, et al. Blood-patch pleurodesis for pneumothorax in lung fibrosis due to progressive systemic sclerosis: A case report. Exp Ther Med, 2014, 8(6): 1919-1921.
12.	Mitsuyama Y, Tanaka S, Ike A, et al. Refractory pneumothorax secondary to COVID-19 treated by autologous blood patch pleurodesis. QJM, 2022, 114(11): 803-804.
13.	Yasuda I, Hidaka T, Kusabiraki T, et al. Chemical pleurodesis with autologous blood and freeze-dried concentrated human thrombin improved spontaneous pneumothorax and thoracic endometriosis: The first case involving a pregnant woman. Taiwan J Obstet Gynecol, 2018, 57(3): 449-451.
14.	Lillegard JB, Kennedy RD, Ishitani MB, et al. Autologous blood patch for persistent air leak in children. J Pediatr Surg, 2013, 48(9): 1862-1866.
15.	Pruitt LCC, Kastenberg ZJ, Fenton SJ, et al. Early use of autologous blood patch pleurodesis in children is successful in resolving persistent air leaks. J Pediatr Surg, 2021, 56(3): 629-631.
16.	王信杰, 徐玉荣, 马晓辉. 负压吸引辅助自体血胸腔注射治疗顽固性气胸的有效性及安全性观察. 山东医药, 2012, 52(18): 13-15.Wang XJ, Xu YR, Ma XH. Evaluation of the efficacy and safety of autologous blood pleurodesis assisted with vacuum aspiration in treatment of intractable pneumothorax. Shandong Med J, 2012, 52(18): 13-15.
17.	Coughlin SM, Emmerton-Coughlin HM, Malthaner R. Management of chest tubes after pulmonary resection: A systematic review and meta-analysis. Can J Surg, 2012, 55(4): 264-270.
18.	Qiu T, Shen Y, Wang MZ, et al. External suction versus water seal after selective pulmonary resection for lung neoplasm: A systematic review. PLoS One, 2013, 8(7): e68087.
19.	Akar E, Haberal MA, Şengören Dikiş Ö. The effectiveness of blood amount used in pleurodesis to prevent prolonged air leakage. Turk Gogus Kalp Damar Cerrahisi Derg, 2020, 28(1): 175-180.
20.	Khan M, Bhat M, Majeed A, et al. Intrapleural therapy for the prevention of recurrent spontaneous pneumothorax—A randomized comparative evaluation of bleomycin pleurodesis & autologous blood pleurodesis. IJARIIT, 2017, 3(3): 955-959.
21.	熊伟, 吴艺根, 钟宏源. 胸腔内灌注自体血联合粗管负压吸引治疗难治性气胸的临床研究. 医学理论与实践, 2017, 30(13): 1881-1883.Xiong W, Wu YG, Zhong HY. Clinical analysis of pleural infusion of autologous blood under vacuum suction in treatment of intractable pneumothorax. J Med Theory Pract, 2017, 30(13): 1881-1883.
22.	沈查. 粗管闭式引流联合胸腔内灌注自体血对难治性气胸的治疗价值. 重庆医学, 2012, 41(14): 1375-1376.Shen C. Value of thoracic closed drainage of thick tube in combination with pleural infusion of autologous blood for treating refractory pneumothorax. Chongqing Med J, 2012, 41(14): 1375-1376.
23.	Oliveira FH, Cataneo DC, Ruiz RL, et al. Persistent pleuropulmonary air leak treated with autologous blood: Results from a university hospital and review of literature. Respiration, 2010, 79(4): 302-306.
24.	Ahmed A, Page RD. The utility of intrapleural instillation of autologous blood for prolonged air leak after lobectomy. Curr Opin Pulm Med, 2008, 14(4): 343-347.
25.	Hasan IS, Allen MS, Cassivi SD, et al. Autologous blood patch pleurodesis for prolonged postoperative air leaks. J Thorac Dis, 2021, 13(6): 3347-3358.
26.	Chambers A, Routledge T, Billè A, et al. Is blood pleurodesis effective for determining the cessation of persistent air leak? Interact Cardiovasc Thorac Surg, 2010, 11(4): 468-472.
27.	Huseynov M. A first case report of neonatal persistent pneumothorax treated with an autologous blood patch. Turk Pediatri Ars, 2020, 55(4): 438-440.
28.	Ng BH, Tan JK, Andrea BY, et al. Intra-pleural instillation of autologous blood-fine-tuning techniques for better success rate: Two case reports. Med J Malaysia, 2020, 75(2): 181-183.
29.	Narenchandra V, Vishnukanth G, Dwivedi DP, et al. Comparison of efficacy of autologous blood patch pleurodesis versus doxycycline pleurodesis in the management of persistent air leak in patients with secondary spontaneous pneumothorax. A randomized control trial. Monaldi Arch Chest Dis, 2022. [Epub ahead of print].
30.	高治庆, 姜学智, 毕聪珍. 一次性无菌留置引流导管闭式引流或负压吸引治疗气胸110例分析. 临床肺科杂志, 2011, 16(12): 1944.Gao ZQ, Jiang XZ, Bi CZ. Analysis of 110 cases of pneumothorax treated with disposable sterile indwelling drainage catheter closed drainage or negative pressure suction. J Clin Pulm Med, 2011, 16(12): 1944.

1. Robinson CL. Autologous blood for pleurodesis in recurrent and chronic spontaneous pneumothorax. Can J Surg, 1987, 30(6): 428-429.
2. Karampinis I, Galata C, Arani A, et al. Autologous blood pleurodesis for the treatment of postoperative air leaks. A systematic review and meta-analysis. Thorac Cancer, 2021, 12(20): 2648-2654.
3. 李宝重, 张旭刚, 李维青, 等. 自体血“补片”胸膜固定术治疗肺切除术后持续性漏气的疗效分析. 中国医学科学院学报, 2021, 43(2): 211-215.Li BZ, Zhang XG, Li WQ, et al. Pleurodesis with an autologous blood patch in the treatment of persistent air leak after lung resection. Acta Acad Med Sin, 2021, 43(2): 211-215.
4. Hallifax RJ, Yousuf A, Jones HE, et al. Effectiveness of chemical pleurodesis in spontaneous pneumothorax recurrence prevention: A systematic review. Thorax, 2017, 72(12): 1121-1131.
5. Ibrahim IM, Elaziz MEA, El-Hag-Aly MA. Early autologous blood-patch pleurodesis versus conservative management for treatment of secondary spontaneous pneumothorax. Thorac Cardiovasc Surg, 2019, 67(3): 222-226.
6. Campisi A, Dell'Amore A, Gabryel P, et al. Autologous blood patch pleurodesis: A large retrospective multicenter cohort study. Ann Thorac Surg, 2022, 114(1): 273-279.
7. Campisi A, Dell'Amore A, Zhang Y, et al. Autologous blood pleurodesis: What is the optimal time interval and amount of blood? Thorac Cardiovasc Surg, 2022, 70(8): 671-676.
8. Rinaldi S, Felton T, Bentley A. Blood pleurodesis for the medical management of pneumothorax. Thorax, 2009, 64(3): 258-260.
9. 曲博, 姜威, 梁磊, 等. 早期自体血补片胸膜固定术治疗难治性气胸的临床研究. 临床肺科杂志, 2022, 27(7): 1010-1014.Qu B, Jiang W, Liang L, et al. Clinical study of early autologous blood patch pleurodesis in the treatment of refractorypneumothorax. J Clin Pulm Med, 2022, 27(7): 1010-1014.
10. Aihara K, Handa T, Nagai S, et al. Efficacy of blood-patch pleurodesis for secondary spontaneous pneumothorax in interstitial lung disease. Intern Med, 2011, 50(11): 1157-1162.
11. Kagohashi K, Ohara G, Shiozawa T, et al. Blood-patch pleurodesis for pneumothorax in lung fibrosis due to progressive systemic sclerosis: A case report. Exp Ther Med, 2014, 8(6): 1919-1921.
12. Mitsuyama Y, Tanaka S, Ike A, et al. Refractory pneumothorax secondary to COVID-19 treated by autologous blood patch pleurodesis. QJM, 2022, 114(11): 803-804.
13. Yasuda I, Hidaka T, Kusabiraki T, et al. Chemical pleurodesis with autologous blood and freeze-dried concentrated human thrombin improved spontaneous pneumothorax and thoracic endometriosis: The first case involving a pregnant woman. Taiwan J Obstet Gynecol, 2018, 57(3): 449-451.
14. Lillegard JB, Kennedy RD, Ishitani MB, et al. Autologous blood patch for persistent air leak in children. J Pediatr Surg, 2013, 48(9): 1862-1866.
15. Pruitt LCC, Kastenberg ZJ, Fenton SJ, et al. Early use of autologous blood patch pleurodesis in children is successful in resolving persistent air leaks. J Pediatr Surg, 2021, 56(3): 629-631.
16. 王信杰, 徐玉荣, 马晓辉. 负压吸引辅助自体血胸腔注射治疗顽固性气胸的有效性及安全性观察. 山东医药, 2012, 52(18): 13-15.Wang XJ, Xu YR, Ma XH. Evaluation of the efficacy and safety of autologous blood pleurodesis assisted with vacuum aspiration in treatment of intractable pneumothorax. Shandong Med J, 2012, 52(18): 13-15.
17. Coughlin SM, Emmerton-Coughlin HM, Malthaner R. Management of chest tubes after pulmonary resection: A systematic review and meta-analysis. Can J Surg, 2012, 55(4): 264-270.
18. Qiu T, Shen Y, Wang MZ, et al. External suction versus water seal after selective pulmonary resection for lung neoplasm: A systematic review. PLoS One, 2013, 8(7): e68087.
19. Akar E, Haberal MA, Şengören Dikiş Ö. The effectiveness of blood amount used in pleurodesis to prevent prolonged air leakage. Turk Gogus Kalp Damar Cerrahisi Derg, 2020, 28(1): 175-180.
20. Khan M, Bhat M, Majeed A, et al. Intrapleural therapy for the prevention of recurrent spontaneous pneumothorax—A randomized comparative evaluation of bleomycin pleurodesis & autologous blood pleurodesis. IJARIIT, 2017, 3(3): 955-959.
21. 熊伟, 吴艺根, 钟宏源. 胸腔内灌注自体血联合粗管负压吸引治疗难治性气胸的临床研究. 医学理论与实践, 2017, 30(13): 1881-1883.Xiong W, Wu YG, Zhong HY. Clinical analysis of pleural infusion of autologous blood under vacuum suction in treatment of intractable pneumothorax. J Med Theory Pract, 2017, 30(13): 1881-1883.
22. 沈查. 粗管闭式引流联合胸腔内灌注自体血对难治性气胸的治疗价值. 重庆医学, 2012, 41(14): 1375-1376.Shen C. Value of thoracic closed drainage of thick tube in combination with pleural infusion of autologous blood for treating refractory pneumothorax. Chongqing Med J, 2012, 41(14): 1375-1376.
23. Oliveira FH, Cataneo DC, Ruiz RL, et al. Persistent pleuropulmonary air leak treated with autologous blood: Results from a university hospital and review of literature. Respiration, 2010, 79(4): 302-306.
24. Ahmed A, Page RD. The utility of intrapleural instillation of autologous blood for prolonged air leak after lobectomy. Curr Opin Pulm Med, 2008, 14(4): 343-347.
25. Hasan IS, Allen MS, Cassivi SD, et al. Autologous blood patch pleurodesis for prolonged postoperative air leaks. J Thorac Dis, 2021, 13(6): 3347-3358.
26. Chambers A, Routledge T, Billè A, et al. Is blood pleurodesis effective for determining the cessation of persistent air leak? Interact Cardiovasc Thorac Surg, 2010, 11(4): 468-472.
27. Huseynov M. A first case report of neonatal persistent pneumothorax treated with an autologous blood patch. Turk Pediatri Ars, 2020, 55(4): 438-440.
28. Ng BH, Tan JK, Andrea BY, et al. Intra-pleural instillation of autologous blood-fine-tuning techniques for better success rate: Two case reports. Med J Malaysia, 2020, 75(2): 181-183.
29. Narenchandra V, Vishnukanth G, Dwivedi DP, et al. Comparison of efficacy of autologous blood patch pleurodesis versus doxycycline pleurodesis in the management of persistent air leak in patients with secondary spontaneous pneumothorax. A randomized control trial. Monaldi Arch Chest Dis, 2022. [Epub ahead of print].
30. 高治庆, 姜学智, 毕聪珍. 一次性无菌留置引流导管闭式引流或负压吸引治疗气胸110例分析. 临床肺科杂志, 2011, 16(12): 1944.Gao ZQ, Jiang XZ, Bi CZ. Analysis of 110 cases of pneumothorax treated with disposable sterile indwelling drainage catheter closed drainage or negative pressure suction. J Clin Pulm Med, 2011, 16(12): 1944.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research progress on autologous blood patch pleurodesis

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