GUO Zhipeng 1,2,3 , ZHANG Jian 2 , SHI Fengyan 1,2 , LI Rui 2 , XIN Fangran 2 , YIN Zongtao 2 , HAN Jinsong 1,2
  • 1. Graduate School, General Hospital of Northern Theater Command, China Medical University, Shenyang, 110016, P. R. China;
  • 2. Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, 110016, P. R. China;
  • 3. Xiongan Xuanwu Hospital, Xiongan New Area, 071702, P. R. China;
HAN Jinsong, Email: hanjs0216@sina.com
Remote ischemic preconditioning; cardiac valve surgery; heart rate variability
10.7507/1007-4848.202401072
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Objective  Explore the effect of remote ischemic preconditioning (RIPC) on preoperative heart rate variability in patients with heart valves. Methods  From January 2022 to July 2022, screening was conducted among 118 patients based on inclusion/exclusion criteria. Fifty-eight patients were excluded, and 60 patients participated in this trial with informed consent and were randomly divided into a RIPC group (n=30) and a control group (n=30). Due to the cancellation of surgery, HRV data was missing. 7 patients in the control group were excluded, and 5 patients in the RIPC group were excluded, 23 patients in the final control group and 25 patients in the RIPC group were included in the analysis. Comparison of relevant indicators of heart rate variability (standard deviation of NN interval (SDNN), standard deviation of mean value of NN interval in every five minutes (SDANN), mean square root of difference between consecutive NN intervals (RMSSD), percentage of adjacent RR interval>50 ms (PNN50), low frequency component (LF), high frequency component (HF) and LF/HF) at 8 hours in the morning on the surgical day between two groups of patients. Results  There was no statistical difference in baseline characteristics between the two groups, and there was no significant difference in heart rate variability 24 hours before intervention (P>0.05). After the intervention measures were taken, the comparison of the results of heart rate variability at 8 hours on the day of operation showed that SDNN and SDANN of patients in the RIPC group were higher than those in the control group, with statistical differences (P<0.05). Conclusion  RIPC can stabilize the preoperative heart rate variability of patients undergoing cardiac valve surgery.